17-beta-Estradiol-3-glucuronide (BioDeep_00000014555)

 

Secondary id: BioDeep_00000638200, BioDeep_00001868863

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,10R,11S,14S,15S)-14-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-trien-5-yl]oxy}oxane-2-carboxylic acid

化学式: C24H32O8 (448.20970719999997)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 1.05%

分子结构信息

SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC5C(C(C(C(O5)C(=O)O)O)O)O
InChI: InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1

描述信息

17beta-Estradiol 3-glucuronide belongs to the class of organic compounds known as steroid glucuronide conjugates. These are sterol lipids containing a glucuronide moiety linked to the steroid skeleton. 17beta-Estradiol 3-glucuronide is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Estradiol glucuronide is believed to play an important role in the mechanism of 17beta-estradiol(E2)-mediated tumour formation. Conjugation with glucuronic acid lowers tissue levels by facilitating excretion. Heterotropic activation by daidzein appears to be specific for the glucuronidation of E2 because daidzein did not affect the glucuronidation of the 2- and 4-hydroxy metabolites of E2 (PMID: 16598814).
Estradiol glucuronide is believed to play important roles in the mechanism of 17beta-estradiol(E2)-mediated tumor formation. Conjugation with glucuronic acid lowers tissue levels by facilitating excretion.The heterotropic activation by daidzein appears to be specific for the glucuronidation of E2 because daidzein did not affect the glucuronidation of the 2- and 4-hydroxy metabolites of E2. (PMID: 16598814) [HMDB]
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

24 个代谢物同义名

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,10R,11S,14S,15S)-14-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-trien-5-yl]oxy}oxane-2-carboxylic acid; (17beta)-17-Hydroxyestra-1,3,5(10)-trien-3-yl beta-D-glucopyranosiduronic acid; (17Β)-17-hydroxyestra-1,3,5(10)-trien-3-yl β-D-glucopyranosiduronic acid; estra-1,3,5(10)-triene-3,17beta-diol 3-D-glucuronide; 17β-Estradiol 3-(β-D-glucuronide); Estradiol-17beta-3-(beta-D-glucuronide); 17beta-Estradiol 3-(beta-D-glucuronide); 17beta-Estradiol 3-glucosiduronate; 17b-Estradiol 3-(b-D-glucuronide); 17Β-estradiol 3-(β-D-glucuronide); Estradiol-17β-3-(β-D-glucuronide); 17Β-estradiol 3-glucosiduronate; 17-beta-Estradiol-3-glucuronide; Estradiol-17beta 3-glucuronide; 17beta-Estradiol 3-glucuronide; 17-b-Estradiol-3-glucuronide; 17-Β-estradiol-3-glucuronide; Estradiol 3-glucosiduronate; 17b-Estradiol 3-glucuronide; 17Β-estradiol 3-glucuronide; Estradiol-17b 3-glucuronide; Estradiol-17β 3-glucuronide; Estradiol 3-glucuronide; Estradiol-3-glucuronide



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Muren, Satoshi Kusuda, Osamu Doi, Hitomi Naito, Hisashi Hashikawa. Puberty, ovarian cycle, pregnancy, and postpartum ovulation in captive Sichuan golden monkeys (Rhinopithecus roxellana) based on changes in urinary and fecal gonadal steroid metabolites. Theriogenology. 2017 Jan; 87(?):179-186. doi: 10.1016/j.theriogenology.2016.08.020. [PMID: 27743688]
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  • M-K Choi, H Kim, Y-H Han, I-S Song, C-K Shim. Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. Xenobiotica; the fate of foreign compounds in biological systems. 2009 Feb; 39(2):171-81. doi: 10.1080/00498250802642256. [PMID: 19255943]
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  • Carina Ankarberg-Lindgren, Ensio Norjavaara. Twenty-four hours secretion pattern of serum estradiol in healthy prepubertal and pubertal boys as determined by a validated ultra-sensitive extraction RIA. BMC endocrine disorders. 2008 Sep; 8(?):10. doi: 10.1186/1472-6823-8-10. [PMID: 18817534]
  • Lauren Oleson, Michael H Court. Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases. The Journal of pharmacy and pharmacology. 2008 Sep; 60(9):1175-82. doi: 10.1211/jpp.60.9.0009. [PMID: 18718121]
  • Chunshan Gui, Yi Miao, Lucas Thompson, Bret Wahlgren, Melissa Mock, Bruno Stieger, Bruno Hagenbuch. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. European journal of pharmacology. 2008 Apr; 584(1):57-65. doi: 10.1016/j.ejphar.2008.01.042. [PMID: 18321482]
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