D-myo-Inositol 1,4,5,6-tetrakisphosphate (BioDeep_00000014524)

 

Secondary id: BioDeep_00001872166

human metabolite Endogenous


代谢物信息卡片


{[(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid

化学式: C6H16O18P4 (499.92871560000003)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 40%

分子结构信息

SMILES: C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)O)O
InChI: InChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m1/s1

描述信息

Inositol phosphates are a family of water-soluble intracellular signalling molecules derived from membrane inositol phospholipids. They undergo a variety of complex interconversion pathways, and their levels are dynamically regulated within the cytosol in response to a variety of agonists. Their biological actions can be quite specific to particular inositol phosphates. D-myo-Inositol 3,4,5,6-tetrakisphosphate, also known as Ins(1,4,5,6)P4 is phosphorylated by inositolphosphate-multikinase (IMPK). Ins(1,4,5,6)P4 has been shown to regulate Cl- transport, to be a phosphoinositide 3-kinase antagonist, and to bind tightly to some pleckstrin homology domains. It may also contribute to transcriptional regulation (PMID: 16376887, 10720331, 8809047, 9405634).
1D-Myo-inositol 1,4,5,6-tetrakisphosphate has been shown to regulate Cl- transport, to be a phosphoinositide 3-kinase antagonist, and to bind tightly to some pleckstrin homology domains, and finally, it may contribute to transcriptional regulation. Inositol phosphates comprise a large family of intracellular signals which play many important roles in cell biology. These biological actions can be quite specific to one particular inositol phosphate. 1D-myo-Inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) is phosphorylated by inositolphosphate-multikinase (IPMK; this enzyme has the capacity to regulate the cellular levels of Ins(1,4,5,6)P4 in mammalian cells. (PMID: 16376887, 10720331, 8809047, 9405634) [HMDB]

同义名列表

16 个代谢物同义名

{[(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid; [(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxyphosphonic acid; D-myo-inositol-1,4,5,6-tetra(hydrogen phosphate), tetrasodium salt; 1D-myo-Inositol 1,4,5,6-tetrakisphosphoric acid; D-Myo-inositol 1,4,5,6-tetrakisphosphoric acid; 1D-myo-Inositol 1,4,5,6-tetrakisphosphate; Inositol 1,4,5,6-tetrakisphosphoric acid; D-myo-Inositol 1,4,5,6-tetrakisphosphate; L-myo-Inositol 3,4,5,6-tetrakisphosphate; D-myo-Inositol 1,4,5,6-tetraphosphate; D-myo-Inositol-1,4,5,6-tetraphosphate; Inositol 1,4,5,6-tetrakis(phosphate); Inositol 1,4,5,6-tetrakisphosphate; Inositol 1,4,5,6-tetraphosphate; Ins(1,4,5,6)P3; Ins(1,4,5,6)P4



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

76 个相关的代谢反应过程信息。

Reactome(61)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(14)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • J Navarro-Fernández, H Pérez-Sánchez, I Martínez-Martínez, I Meliciani, J A Guerrero, V Vicente, J Corral, W Wenzel. In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity. Journal of medicinal chemistry. 2012 Jul; 55(14):6403-12. doi: 10.1021/jm300621j. [PMID: 22742452]
  • A Craxton, C Erneux, S B Shears. Inositol 1,4,5,6-tetrakisphosphate is phosphorylated in rat liver by a 3-kinase that is distinct from inositol 1,4,5-trisphosphate 3-kinase. The Journal of biological chemistry. 1994 Feb; 269(6):4337-42. doi: . [PMID: 8308002]
  • R R Mattingly, L R Stephens, R F Irvine, J C Garrison. Effects of transformation with the v-src oncogene on inositol phosphate metabolism in rat-1 fibroblasts. D-myo-inositol 1,4,5,6-tetrakisphosphate is increased in v-src-transformed rat-1 fibroblasts and can be synthesized from D-myo-inositol 1,3,4-trisphosphate in cytosolic extracts. The Journal of biological chemistry. 1991 Aug; 266(23):15144-53. doi: . [PMID: 1869546]