D-Ornithine (BioDeep_00000014489)

 

Secondary id: BioDeep_00000399920

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2R)-2,5-Diaminopentanoic acid

化学式: C5H12N2O2 (132.0898732)
中文名称: D-鸟氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.24%

分子结构信息

SMILES: C(CC(C(=O)O)N)CN
InChI: InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m1/s1

描述信息

D-Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen. D-Ornithine has been identified in the human placenta (PMID: 32033212).
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
KEIO_ID O005

同义名列表

6 个代谢物同义名

(2R)-2,5-Diaminopentanoic acid; (2R)-2,5-Diaminopentanoate; L-(-)-Ornithine; (R)-Ornithine; D-ornithine; Ornithine



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

7 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(6)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shinichi Demura, Koji Morishita, Takayoshi Yamada, Shunsuke Yamaji, Miho Komatsu. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. European journal of applied physiology. 2011 Nov; 111(11):2837-43. doi: 10.1007/s00421-011-1896-1. [PMID: 21431425]
  • Jean Matthieu Prot, Anne-Sophie Briffaut, Franck Letourneur, Philippe Chafey, Franck Merlier, Yves Grandvalet, Cécile Legallais, Eric Leclerc. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip. PloS one. 2011; 6(8):e21268. doi: 10.1371/journal.pone.0021268. [PMID: 21857903]
  • S Demura, T Yamada, S Yamaji, M Komatsu, K Morishita. The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise. European journal of clinical nutrition. 2010 Oct; 64(10):1166-71. doi: 10.1038/ejcn.2010.149. [PMID: 20717126]
  • Tomohiro Sugino, Tomoko Shirai, Yoshitaka Kajimoto, Osami Kajimoto. L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism. Nutrition research (New York, N.Y.). 2008 Nov; 28(11):738-43. doi: 10.1016/j.nutres.2008.08.008. [PMID: 19083482]
  • Giuseppe Fiermonte, Vincenza Dolce, Laura David, Filippo Maria Santorelli, Carlo Dionisi-Vici, Ferdinando Palmieri, John E Walker. The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. The Journal of biological chemistry. 2003 Aug; 278(35):32778-83. doi: 10.1074/jbc.m302317200. [PMID: 12807890]
  • James P McCarter, Makedonka Dautova Mitreva, John Martin, Mike Dante, Todd Wylie, Uma Rao, Deana Pape, Yvette Bowers, Brenda Theising, Claire V Murphy, Andrew P Kloek, Brandi J Chiapelli, Sandra W Clifton, David Mck Bird, Robert H Waterston. Analysis and functional classification of transcripts from the nematode Meloidogyne incognita. Genome biology. 2003; 4(4):R26. doi: 10.1186/gb-2003-4-4-r26. [PMID: 12702207]