Meptin (BioDeep_00000014437)
代谢物信息卡片
Procaterol hydrochloride
化学式: C16H22N2O3. HCl (326.13971180000004)
中文名称: 盐酸丙卡特罗半水合物, 丙卡特罗盐酸盐, 盐酸丙卡特罗
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C(C1=C2C=CC(=O)NC2=C(C=C1)O)O)NC(C)C.Cl
InChI: 1H
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
Same as: D02404
同义名列表
3 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:32056
- KEGG: C13235
- KEGGdrug: D02404
- PubChem: 656601
- ChEMBL: CHEMBL1322218
- MeSH: Procaterol
- CAS: 59828-07-8
- CAS: 81262-93-3
- CAS: 62929-91-3
- PubChem: 585979
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dexian Kong, Qizhao Zhuang, Yejian Han, Lanping Xu, Zeming Wang, Lili Jiang, Jinwei Su, Chun-Hua Lu, Yuwu Chi. Simultaneous voltammetry detection of dopamine and uric acid in human serum and urine with a poly(procaterol hydrochloride) modified glassy carbon electrode.
Talanta.
2018 Aug; 185(?):203-212. doi:
10.1016/j.talanta.2018.03.078. [PMID: 29759190] - Haruka Kogiso, Yukiko Ikeuchi, Masako Sumiya, Shigekuni Hosogi, Saori Tanaka, Chikao Shimamoto, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari. Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca2+ Modulation of cAMP-Stimulated Ciliary Beatings via PDE1.
International journal of molecular sciences.
2018 Feb; 19(3):. doi:
10.3390/ijms19030658. [PMID: 29495403] - Dexian Kong, Lili Jiang, Yijun Liu, Zeming Wang, Libin Han, Rixin Lv, Jiandi Lin, Chun-Hua Lu, Yuwu Chi, Guonan Chen. Electrochemical investigation and determination of procaterol hydrochloride on poly(glutamic acid)/carboxyl functionalized multiwalled carbon nanotubes/polyvinyl alcohol modified glassy carbon electrode.
Talanta.
2017 Nov; 174(?):436-443. doi:
10.1016/j.talanta.2017.06.047. [PMID: 28738604] - Haruka Kogiso, Shigekuni Hosogi, Yukiko Ikeuchi, Saori Tanaka, Chikao Shimamoto, Hitoshi Matsumura, Takashi Nakano, Koh-Ichi Sano, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari. A low [Ca2+]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia.
Pflugers Archiv : European journal of physiology.
2017 09; 469(9):1215-1227. doi:
10.1007/s00424-017-1988-9. [PMID: 28477148] - Nanna Krogh, Vibeke Backer, Sebastian Rzeppa, Peter Hemmersbach, Morten Hostrup. Pharmacokinetics of nebulized and oral procaterol in asthmatic and non-asthmatic subjects in relation to doping analysis.
Drug testing and analysis.
2016 Oct; 8(10):1056-1064. doi:
10.1002/dta.1935. [PMID: 26990656] - K Kusano, M Nomura, K Toju, Y Ishikawa, Y Minamijima, S Yamashita, S Nagata. Pharmacokinetics of procaterol in thoroughbred horses.
Journal of veterinary pharmacology and therapeutics.
2016 Jun; 39(3):264-70. doi:
10.1111/jvp.12272. [PMID: 26538319] - Kohei Tahara, Hiromasa Tomida, Yousuke Ito, Suguru Tachikawa, Risako Onodera, Hiroyuki Tanaka, Yuichi Tozuka, Hirofumi Takeuchi. Pulmonary liposomal formulations encapsulated procaterol hydrochloride by a remote loading method achieve sustained release and extended pharmacological effects.
International journal of pharmaceutics.
2016 May; 505(1-2):139-46. doi:
10.1016/j.ijpharm.2016.03.031. [PMID: 27012982] - Yongjing Liu, Miaoduo Deng, Jia Yu, Zhen Jiang, Xingjie Guo. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism.
Journal of separation science.
2016 May; 39(9):1766-75. doi:
10.1002/jssc.201501026. [PMID: 26935589] - Jia-Ming Liu, Qitong Huang, Zhen-Bo Liu, Li-Hong Zhang, Zhi-Yong Zheng, Chang-Qing Lin. Design of highly sensitive phosphorescence sensor for determination of procaterol hydrochloride based on inhibition of KClO3 oxidation fluorescein isothiocyanate.
Luminescence : the journal of biological and chemical luminescence.
2015 Jun; 30(4):382-7. doi:
10.1002/bio.2743. [PMID: 25044504] - Norihito Yokoe, Etsuro Yamaguchi, Masaki Nishimura, Hiroyuki Tanaka, Ayumu Takahashi, Kenji Baba, Masahiko Gosho, Shoshiro Okada. UGT1A1*28 is associated with greater decrease in serum K⁺ levels following oral intake of procaterol.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2015 Apr; 52(3):240-5. doi:
10.3109/02770903.2014.957766. [PMID: 25171434] - Zongbao Chen, Yan Cai, Lin Zhang, Lan Zhang. Capillary electrochromatography of three β2-agonists in human urine using a lauryl methacrylate-based monolithic column.
Journal of separation science.
2012 May; 35(9):1138-45. doi:
10.1002/jssc.201101005. [PMID: 22689490] - Daniel M Rosenbaum, Cheng Zhang, Joseph A Lyons, Ralph Holl, David Aragao, Daniel H Arlow, Søren G F Rasmussen, Hee-Jung Choi, Brian T Devree, Roger K Sunahara, Pil Seok Chae, Samuel H Gellman, Ron O Dror, David E Shaw, William I Weis, Martin Caffrey, Peter Gmeiner, Brian K Kobilka. Structure and function of an irreversible agonist-β(2) adrenoceptor complex.
Nature.
2011 Jan; 469(7329):236-40. doi:
10.1038/nature09665. [PMID: 21228876] - H Kobayashi, M Masuda, E Kashiyama, N Koga, Y Yasuda, T Shibutani, K Endo, T Funaki, T Miyamoto. Pharmacokinetic study of the oral administration of procaterol hydrochloride hydrate 50 µg in healthy adult Japanese men.
International journal of clinical pharmacology and therapeutics.
2010 Nov; 48(11):744-50. doi:
10.5414/cpp48744. [PMID: 20979933] - Tadashi Kohyama, Yasuhiro Yamauchi, Hajime Takizawa, Susumu Itakura, Sumiko Kamitani, Masashi Desaki, Shin Kawasaki, Takahide Nagase. Procaterol inhibits lung fibroblast migration.
Inflammation.
2009 Dec; 32(6):387-92. doi:
10.1007/s10753-009-9147-x. [PMID: 19728063] - Somsak Sirichai, Proespichaya Khanatharana. Rapid analysis of clenbuterol, salbutamol, procaterol, and fenoterol in pharmaceuticals and human urine by capillary electrophoresis.
Talanta.
2008 Sep; 76(5):1194-8. doi:
10.1016/j.talanta.2008.05.026. [PMID: 18761177] - Masaru Kishida, Hiroki Nakazono, Rei Kuroiwa, Hidenori Dokai, Junko Nakazato, Hiroaki Nakamura, Itsuo Suzuki, Noriaki Shinomiya. [Therapy with nebulized beta2 agonists (procaterol) in asthmatic children: pulmonary function and plasma levels after inhalation].
Arerugi = [Allergy].
2007 Nov; 56(11):1372-7. doi:
NULL. [PMID: 18059150] - T-W Yu, R R-L Chen, C-S Gau. Production of an extremly low dose procaterol HCl preparation by fluidized-bed coating method: in vitro and in vivo evaluation.
Drug development and industrial pharmacy.
2006 Jul; 32(6):651-60. doi:
10.1080/03639040600623317. [PMID: 16885120] - Katsumi Ikezono, Masayuki Kamata, Toyoki Mori. Adrenal influences on the inhibitory effects of procaterol, a selective Beta-two-adrenoceptor agonist, on antigen-induced airway microvascular leakage and bronchoconstriction in Guinea pigs.
Pharmacology.
2005 Mar; 73(4):209-15. doi:
10.1159/000083299. [PMID: 15650321] - A L Katynski, M M Vijayan, S W Kennedy, T W Moon. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) impacts hepatic lipid peroxidation, membrane fluidity and beta-adrenoceptor kinetics in chick embryos.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2004 Jan; 137(1):81-93. doi:
10.1016/j.cca.2003.11.004. [PMID: 14984707] - Kouichi Kaidoh, Yasuhiko Igawa, Hiroo Takeda, Yoshinobu Yamazaki, Satoshi Akahane, Hiroshi Miyata, Yukiyoshi Ajisawa, Osamu Nishizawa, Karl-Erik Andersson. Effects of selective beta2 and beta3-adrenoceptor agonists on detrusor hyperreflexia in conscious cerebral infarcted rats.
The Journal of urology.
2002 Sep; 168(3):1247-52. doi:
10.1097/01.ju.0000023414.15425.5a. [PMID: 12187276] - Takao Fujisawa, Yoshiko Kato, Akihiko Terada, Kosei Iguchi, Hitoshi Kamiya. Synergistic effect of theophylline and procaterol on interleukin-5-induced degranulation from human eosinophils.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2002 Feb; 39(1):21-7. doi:
10.1081/jas-120000803. [PMID: 11883736] - S L Huang, W Wang, D S Ou-Yang, H H Zhou. Determination of procaterol in human plasma by gas chromatography/electron impact ionization mass spectrometry.
Acta pharmacologica Sinica.
2000 Jun; 21(6):564-6. doi:
NULL. [PMID: 11360692] - T J Visser, E A van der Wouden, A van Waarde, P Doze, P H Elsinga, W Vaalburg. Synthesis and biodistribution of [11c]procaterol, a beta2-adrenoceptor agonist for positron emission tomography.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2000 Apr; 52(4):857-63. doi:
10.1016/s0969-8043(99)00267-5. [PMID: 10800722] - P Mauriège, P Imbeault, D Langin, M Lacaille, N Alméras, A Tremblay, J P Després. Regional and gender variations in adipose tissue lipolysis in response to weight loss.
Journal of lipid research.
1999 Sep; 40(9):1559-71. doi:
10.1016/s0022-2275(20)33402-7. [PMID: 10484603] - C Atgié, F D'Allaire, L J Bukowiecki. Role of beta1- and beta3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes.
The American journal of physiology.
1997 10; 273(4):C1136-42. doi:
10.1152/ajpcell.1997.273.4.c1136. [PMID: 9357756] - J Tamaoki, M Kondo, N Sakai, J Nakata, H Takemura, A Nagai, T Takizawa, K Konno. Leukotriene antagonist prevents exacerbation of asthma during reduction of high-dose inhaled corticosteroid. The Tokyo Joshi-Idai Asthma Research Group.
American journal of respiratory and critical care medicine.
1997 Apr; 155(4):1235-40. doi:
10.1164/ajrccm.155.4.9105060. [PMID: 9105060] - S Horikoshi, F Kokubu, M Adachi. [Anti-allergic effects of beta-adrenoceptor agonists in the clinical pharmacological studies].
Nihon rinsho. Japanese journal of clinical medicine.
1996 Nov; 54(11):3068-72. doi:
NULL. [PMID: 8950956] - Y Nakahara, M Murata, T Suzuki, F Ohtsu, K Nagasawa. Significance of the therapeutic range of serum theophylline concentration in the treatment of an attack of bronchial asthma.
Biological & pharmaceutical bulletin.
1996 May; 19(5):710-5. doi:
10.1248/bpb.19.710. [PMID: 8741580] - L Kong, Z Li, R Yu. [The effect of salmeterol on the activity of neutrophil chemotactic factor in patients with asthma].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
1996 Apr; 19(2):88-90. doi:
NULL. [PMID: 9388846] - T Ebihara, K Sekizawa, T Ohrui, H Nakazawa, H Sasaki. Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs.
American journal of respiratory and critical care medicine.
1996 Feb; 153(2):812-9. doi:
10.1164/ajrccm.153.2.8564137. [PMID: 8564137] - K Tsukioka, M Matsuzaki, M Nakamata, H Kayahara, T Nakagawa. Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma.
Journal of investigational allergology & clinical immunology.
1996 Jan; 6(1):22-9. doi:
NULL. [PMID: 8833165] - K Tokuyama, S Maeda, H Arakawa, A Morikawa. Effect of procaterol, a beta 2-adrenoceptor agonist, on skin whealing response caused by inflammatory mediators in asthmatic children.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
1995 Aug; 75(2):139-41. doi:
NULL. [PMID: 7544228] - P Kotsonis, H Majewski. Facilitation by procaterol, a beta-adrenoceptor agonist, of noradrenaline release in the pithed rat independently of angiotensin II formation.
British journal of pharmacology.
1994 Nov; 113(3):781-8. doi:
10.1111/j.1476-5381.1994.tb17061.x. [PMID: 7858867] - M A Eldon, M M Battle, M J Coon, G D Nordblom, A J Sedman, W A Colburn. Clinical pharmacokinetics and relative bioavailability of oral procaterol.
Pharmaceutical research.
1993 Apr; 10(4):603-5. doi:
10.1023/a:1018966506819. [PMID: 8483846] - K Ikeda, M Tsukino, A Nakashima. [Clinical study on benefit and safety of frequent inhalation of aerosolized procaterol hydrochloride in aged acute asthmatics].
Nihon Kyobu Shikkan Gakkai zasshi.
1992 Dec; 30(12):2105-11. doi:
NULL. [PMID: 1289631] - M A Eldon, D S Blake, M J Coon, G D Nordblom, A J Sedman, W A Colburn. Clinical pharmacokinetics of procaterol: dose proportionality after administration of single oral doses.
Biopharmaceutics & drug disposition.
1992 Dec; 13(9):663-9. doi:
10.1002/bdd.2510130904. [PMID: 1467453] - Y Z Lin, K H Hsieh, W Chen, K W Wu. Clinical trial of corticosteroid and beta-2 bronchodilator in acute wheezing infants.
Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui.
1991 Nov; 32(6):333-40. doi:
NULL. [PMID: 1688065] - P Valet, M Taouis, M A Tran, P Montastruc, M Lafontan, M Berlan. Lipomobilizing effects of procaterol and yohimbine in the conscious dog: comparison of endocrinological, metabolic and cardiovascular effects.
British journal of pharmacology.
1989 May; 97(1):229-39. doi:
10.1111/j.1476-5381.1989.tb11946.x. [PMID: 2566353] - W R Williams, S Kagamimori, T Shimizu, H Kakiuchi, Y Naruse. Effects of theophylline, beta-adrenergic stimulants and prednisolone on platelet and urine cyclic guanosine monophosphate (cGMP).
The Tohoku journal of experimental medicine.
1988 Dec; 156(4):331-40. doi:
10.1620/tjem.156.331. [PMID: 2907685] - Y Iikura, T Nagakura, G M Walsh, K Akimoto, M Kisida, T Kondou, Y Odajima, M Okuma, A Akazawa, T Yukishita. Role of chemical mediators after antigen and exercise challenge in children with asthma.
The Journal of allergy and clinical immunology.
1988 May; 81(5 Pt 2):1050-5. doi:
10.1016/0091-6749(88)90179-0. [PMID: 2967315] - R P Baughman, R G Loudon. The utility of a long-acting sympathomimetic agent, procaterol, for nocturnal asthma.
Chest.
1988 Feb; 93(2):285-8. doi:
10.1378/chest.93.2.285. [PMID: 2962837] - D S Wright, L A Pachla, D M Gibson, R A Jordan. Sensitive high-performance liquid chromatographic method for procaterol in human urine.
Journal of chromatography.
1987 Jun; 417(1):223-8. doi:
10.1016/0378-4347(87)80112-3. [PMID: 2887580] - D L Spangler, C N Lutz, D Tinkelman. The effect of diet on the efficacy onset and duration of action of procaterol hydrochloride tablets.
Annals of allergy.
1987 Jan; 58(1):59-62. doi:
NULL. [PMID: 2948431] - N Rubio, M Lizaso, J Mateo, F L Elorza. [Changes in histamine liberation induced by house dust mites after the administration of procaterol].
Allergologia et immunopathologia.
1986 Mar; 14(2):127-32. doi:
NULL. [PMID: 2424293] - V Grassi, S Daniotti, M Schiassi, M Dottorini, C Tantucci. Oral beta 2-selective adrenergic bronchodilators.
International journal of clinical pharmacology research.
1986; 6(2):93-103. doi:
. [PMID: 2873108] - T Chimura. [Preclinical study of third generation beta 2-stimulant (procaterol) on inhibition of uterine contraction (author's transl)].
Nihon Sanka Fujinka Gakkai zasshi.
1982 Jul; 34(7):899-904. doi:
NULL. [PMID: 6125547] - K Hashimoto, S Shintani, S Yamashita, S Tei, M Takai, M Tsutsui, K Kawamura, T Ohkawa, T Hiyama, Y Yabuuchi. [Pharmacological properties of procaterol, a newly synthesized, specific beta 2-adrenoceptor stimulant. Part II. Effects on the peripheral organs (author's transl)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1979 May; 75(4):333-64. doi:
NULL. [PMID: 43822]