Dolichol diphosphate (BioDeep_00000014429)

 

Secondary id: BioDeep_00001869026


代谢物信息卡片


alpha-(3-methylbut-2-en-1-yl)-omega-(4-{[hydroxy(phosphonooxy)phosphoryl]oxy}-2-methylbutyl)poly[(2E)-2-methylbut-2-ene-1,4-diyl]

化学式: C25H46O7P2 (520.2718626)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C)C/C(=C\CCC(CCOP(=O)(O)OP(=O)(O)O)C)/C
InChI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-

描述信息

同义名列表

5 个代谢物同义名

alpha-(3-methylbut-2-en-1-yl)-omega-(4-{[hydroxy(phosphonooxy)phosphoryl]oxy}-2-methylbutyl)poly[(2E)-2-methylbut-2-ene-1,4-diyl]; Dolichyl pyrophosphate; Dolichol pyrophosphate; Dolichol diphosphate; dolichyl diphosphate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(10)

BioCyc(0)

PlantCyc(0)

代谢反应

85 个相关的代谢反应过程信息。

Reactome(84)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Michaël Bosco, Ahmad Massarweh, Soria Iatmanen-Harbi, Ahmed Bouhss, Isabelle Chantret, Patricia Busca, Stuart E H Moore, Christine Gravier-Pelletier. Synthesis and biological evaluation of chemical tools for the study of Dolichol Linked Oligosaccharide Diphosphatase (DLODP). European journal of medicinal chemistry. 2017 Jan; 125(?):952-964. doi: 10.1016/j.ejmech.2016.10.013. [PMID: 27769035]
  • Antoni W James, Ramachandran Gowsalya, Vasanthi Nachiappan. Dolichyl pyrophosphate phosphatase-mediated N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae. Biochimica et biophysica acta. 2016 Nov; 1861(11):1705-1718. doi: 10.1016/j.bbalip.2016.08.004. [PMID: 27524515]
  • Kazue Kanehara, Yueh Cho, Ying-Chen Lin, Chia-En Chen, Chao-Yuan Yu, Yuki Nakamura. Arabidopsis DOK1 encodes a functional dolichol kinase involved in reproduction. The Plant journal : for cell and molecular biology. 2015 Jan; 81(2):292-303. doi: 10.1111/tpj.12727. [PMID: 25406445]
  • Michelle M Chang, Barbara Imperiali, Jerry Eichler, Ziqiang Guan. N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus. PloS one. 2015; 10(6):e0130482. doi: 10.1371/journal.pone.0130482. [PMID: 26098850]
  • Ningguo Gao, Jie Shang, Dang Huynh, Vijaya L Manthati, Carolina Arias, Heather P Harding, Randal J Kaufman, Ian Mohr, David Ron, John R Falck, Mark A Lehrman. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Molecular biology of the cell. 2011 Sep; 22(17):2994-3009. doi: 10.1091/mbc.e11-04-0286. [PMID: 21737679]
  • Ningguo Gao. Application of fluorophore-assisted carbohydrate electrophoresis for the study of the dolichol pyrophosphate-linked oligosaccharides pathway in cell cultures and animal tissues. Methods in molecular biology (Clifton, N.J.). 2006; 347(?):1-12. doi: 10.1385/1-59745-167-3:1. [PMID: 17072000]
  • Ningguo Gao. Fluorophore-assisted carbohydrate electrophoresis: a sensitive and accurate method for the direct analysis of dolichol pyrophosphate-linked oligosaccharides in cell cultures and tissues. Methods (San Diego, Calif.). 2005 Apr; 35(4):323-7. doi: 10.1016/j.ymeth.2004.10.003. [PMID: 15804603]
  • Ningguo Gao, Mark A Lehrman. Analyses of dolichol pyrophosphate-linked oligosaccharides in cell cultures and tissues by fluorophore-assisted carbohydrate electrophoresis. Glycobiology. 2002 May; 12(5):353-60. doi: 10.1093/glycob/12.5.353. [PMID: 12070078]
  • M Konrad, W E Merz. Regulation of N-glycosylation. Long term effect of cyclic AMP mediates enhanced synthesis of the dolichol pyrophosphate core oligosaccharide. The Journal of biological chemistry. 1994 Mar; 269(12):8659-66. doi: 10.1016/s0021-9258(17)37018-7. [PMID: 8132594]
  • M J Wolf, J S Rush, C J Waechter. Golgi-enriched membrane fractions from rat brain and liver contain long-chain polyisoprenyl pyrophosphate phosphatase activity. Glycobiology. 1991 Sep; 1(4):405-10. doi: 10.1093/glycob/1.4.405. [PMID: 1668143]
  • N A Hall, B D Lake, A D Patrick. Recent biochemical and genetic advances in our understanding of Batten's disease (ceroid-lipofuscinosis). Developmental neuroscience. 1991; 13(4-5):339-44. doi: 10.1159/000112183. [PMID: 1840101]
  • R K Pullarkat, P S Pullarkat, G N Morris. Phosphorylated dolichols in aging. The Biochemical journal. 1990 Feb; 265(3):891-4. doi: 10.1042/bj2650891. [PMID: 2306221]
  • M A Lehrman, Y Zeng. Pleiotropic resistance to glycoprotein processing inhibitors in Chinese hamster ovary cells. The role of a novel mutation in the asparagine-linked glycosylation pathway. The Journal of biological chemistry. 1989 Jan; 264(3):1584-93. doi: . [PMID: 2521484]
  • P A Romero, A Herscovics. Transfer of nonglucosylated oligosaccharide from lipid to protein in a mammalian cell. The Journal of biological chemistry. 1986 Dec; 261(34):15936-40. doi: 10.1016/s0021-9258(18)66656-6. [PMID: 3782099]