N-Acetylgalactosamine 4-sulphate (BioDeep_00000014377)

 

Secondary id: BioDeep_00001032374

human metabolite Endogenous


代谢物信息卡片


N-[(2R,3R,4R,5R,6R)-2,4-Dihydroxy-6-(hydroxymethyl)-5-(sulphooxy)oxan-3-yl]ethanimidic acid

化学式: C8H15NO9S (301.04675000000003)
中文名称:
谱图信息: 最多检出来源 Bos taurus(endogenous) 5.88%

分子结构信息

SMILES: CC(=O)NC1C(C(C(OC1O)CO)OS(=O)(=O)O)O
InChI: InChI=1S/C8H15NO9S/c1-3(11)9-5-6(12)7(18-19(14,15)16)4(2-10)17-8(5)13/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H,14,15,16)/t4-,5-,6-,7+,8-/m1/s1

描述信息

Also known as GalNAc4S, this molecule is a key component of dermatan, keratan and chondroitin sulfate. It is also a substrate for the enzyme N-acteylgalactosamine-4-sulphate transferase. This molecule is found in elevated concentrations in the urine of patients suffering from muchopolysaccharidosis type III, IV and VI. Levels are typically 300-400 times normal values. GalNAc4S is thought to be derived from the action of beta-N-acetylhexosaminidase on sulphated GlcNAc or GalNAc residues at the non-reducing end of keratan sulphate, dermatan sulphate or chondroitin sulphate. [HMDB]
Also known as GalNAc4S, this molecule is a key component of dermatan, keratan and chondroitin sulfate. It is also a substrate for the enzyme N-acteylgalactosamine-4-sulphate transferase. This molecule is found in elevated concentrations in the urine of patients suffering from muchopolysaccharidosis type III, IV and VI. Levels are typically 300-400 times normal values. GalNAc4S is thought to be derived from the action of beta-N-acetylhexosaminidase on sulphated GlcNAc or GalNAc residues at the non-reducing end of keratan sulphate, dermatan sulphate or chondroitin sulphate.

同义名列表

49 个代谢物同义名

N-[(2R,3R,4R,5R,6R)-2,4-Dihydroxy-6-(hydroxymethyl)-5-(sulphooxy)oxan-3-yl]ethanimidic acid; [(2R,3R,4R,5R,6R)-5-acetamido-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxidanesulfonic acid; N-[(2R,3R,4R,5R,6R)-2,4-Dihydroxy-6-(hydroxymethyl)-5-(sulphooxy)oxan-3-yl]ethanimidate; N-[(2R,3R,4R,5R,6R)-2,4-Dihydroxy-6-(hydroxymethyl)-5-(sulfooxy)oxan-3-yl]ethanimidate; 2-(Acetylamino)-2-deoxy-4-O-sulphO-beta-D-galactopyranose; 2-(Acetylamino)-2-deoxy-D-galactose 4-(hydrogen sulphate); 2-(Acetylamino)-2-deoxy-4-O-sulfO-beta-D-galactopyranose; 2-(Acetylamino)-2-deoxy-D-galactose 4-(hydrogen sulfate); 2-(Acetylamino)-2-deoxy-4-O-sulphO-b-D-galactopyranose; 2-(Acetylamino)-2-deoxy-4-O-sulphO-β-D-galactopyranose; 2-(Acetylamino)-2-deoxy-4-O-sulfO-β-D-galactopyranose; 2-(Acetylamino)-2-deoxy-4-O-sulfO-b-D-galactopyranose; 2-Deoxy-2-acetamido-beta-D-galactose-4-sulphuric acid; 2-Deoxy-2-acetamido-beta-D-galactose-4-sulfuric acid; 2-Deoxy-2-acetamido-b-D-galactose-4-sulphuric acid; 2-Deoxy-2-acetamido-β-D-galactose-4-sulphuric acid; 2-Deoxy-2-acetamido-β-D-galactose-4-sulfuric acid; 2-Deoxy-2-acetamido-b-D-galactose-4-sulfuric acid; 2-Deoxy-2-acetamido-beta-D-galactose-4-sulphate; N-Acetyl-beta-D-galactosamine 4-sulphuric acid; 2-Deoxy-2-acetamido-beta-D-galactose-4-sulfate; N-Acetyl-beta-D-galactosamine 4-sulfuric acid; 2-Deoxy-2-acetamido-b-D-galactose-4-sulphate; 2-Deoxy-2-acetamido-β-D-galactose-4-sulphate; N-Acetyl-β-D-galactosamine 4-sulphuric acid; N-Acetyl-b-D-galactosamine 4-sulphuric acid; 2-Deoxy-2-acetamido-β-D-galactose-4-sulfate; 2-Deoxy-2-acetamido-b-D-galactose-4-sulfate; N-Acetyl-b-D-galactosamine 4-sulfuric acid; N-Acetyl-β-D-galactosamine 4-sulfuric acid; N-Acetyl-beta-D-galactosamine 4-sulphate; N-Acetyl-beta-D-galactosamine 4-sulfate; N-Acetylgalactosamine 4-sulphuric acid; N-Acetylgalactosamine 4-sulfuric acid; N-Acetyl-b-D-galactosamine 4-sulphate; N-Acetyl-β-D-galactosamine 4-sulphate; N-Acetyl-β-D-galactosamine 4-sulfate; N-Acetyl-b-D-galactosamine 4-sulfate; N-Acetyl-D-galactosamine 4-sulphate; N-Acetyl-D-galactosamine 4-sulfate; N-Acetylgalactosamine 4-sulphate; N-Acetylgalactosamine-4-sulphate; N-Acetylgalactosamine-4-sulfate; N-Acetylgalactosamine 4-sulfate; beta-D-GalpNAc4S; b-D-GalpNAc4S; Β-D-galpnac4S; GalNAc4S; NAG-4-S



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16 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • D S Roseman, J U Baenziger. The mannose/N-acetylgalactosamine-4-SO4 receptor displays greater specificity for multivalent than monovalent ligands. The Journal of biological chemistry. 2001 May; 276(20):17052-7. doi: 10.1074/jbc.m101027200. [PMID: 11279168]
  • C Leteux, W Chai, R W Loveless, C T Yuen, L Uhlin-Hansen, Y Combarnous, M Jankovic, S C Maric, Z Misulovin, M C Nussenzweig, T Feizi. The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin. The Journal of experimental medicine. 2000 Apr; 191(7):1117-26. doi: 10.1084/jem.191.7.1117. [PMID: 10748230]
  • J E Christner. Biosynthesis of chondroitin sulfate proteoglycan by P388D1 macrophage-like cell line. Arteriosclerosis (Dallas, Tex.). 1988 Sep; 8(5):535-43. doi: 10.1161/01.atv.8.5.535. [PMID: 3142452]
  • G Constantopoulos. Multiple sulfatase deficiency with a novel biochemical presentation. European journal of pediatrics. 1988 Aug; 147(6):634-8. doi: 10.1007/bf00442480. [PMID: 2903054]
  • J J Hopwood, H Elliott. Urinary excretion of sulphated N-acetylhexosamines in patients with various mucopolysaccharidoses. The Biochemical journal. 1985 Aug; 229(3):579-86. doi: 10.1042/bj2290579. [PMID: 3931626]