D-Arabitol (BioDeep_00000014352)

 

Secondary id: BioDeep_00000405288, BioDeep_00000410641, BioDeep_00001868250

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


D-Arabinitol - L-arabinitol (1:1)

化学式: C5H12O5 (152.0684702)
中文名称: D(+)-阿拉伯糖醇, DL-阿拉伯糖醇, D-阿拉伯糖醇, 阿拉伯糖醇
谱图信息: 最多检出来源 Homo sapiens(blood) 0.92%

Reviewed

Last reviewed on 2024-07-16.

Cite this Page

D-Arabitol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/d-arabitol (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000014352). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(C(CO)O)O)O)O
InChI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2

描述信息

D-Arabitol is a polyol. Polyols are sugar alcohols linked to the pentose phosphate pathway (PPP). They are classified on the basis of the number of carbon atoms. Polyols occur in body fluids. A patient with leukoencephalopathy and peripheral neuropathy has been identified as suffering from ribose-5-phosphate isomerase (RPI) deficiency, a defect in the PPP. In this disorder, highly elevated concentrations of the C5 polyols such as D-arabitol are found in body fluids. In addition, transaldolase deficiency, another defect in the PPP, has been diagnosed in a patient with mainly liver problems among others. This patient had increased concentrations of polyols, mainly D-arabitol. So far, the pathophysiological role of polyols is relatively unknown. It is thought that D-arabitol is a metabolic end-product in humans. The strong brain-CSF-plasma gradient of polyols in the patient with RPI deficiency suggested a primary metabolic disorder. The mechanisms of brain and neuronal damage in RPI deficiency remain to be elucidated. A neurotoxic effect due to the accumulation of the polyols may play a role. D-Arabitol is a product of the enzyme D-arabinitol 4-dehydrogenase (EC 1.1.1.11) in the pentose and glucuronate interconversion pathway (PMID: 16435225, J Inherit Metab Dis. 2005;28(6):1181-3). D-Arabitol has also been found to be a fungal metabolite, urinary D-Arabinitol is a marker for invasive candidiasis or infection by Candida fungal species (PMID: 15183861; PMID: 10647119). It can also a metabolite in Debaryomyces, Pichia and Zygosaccharomyces (PMID: 25809659).
D-Arabitol is a polyol. Polyols are sugar alcohols linked to the pentose phosphate pathway (PPP). They are classified on the basis of the number of carbon atoms. Polyols occur in body fluids. A patient with leukoencephalopathy and peripheral neuropathy has been identified as suffering from ribose-5-phosphate isomerase (RPI) deficiency, a defect in the PPP. In this disorder, highly elevated concentrations of the C5 polyols such as D-arabitol are found in body fluids. In addition, transaldolase deficiency, another defect in the PPP, has been diagnosed in a patient with mainly liver problems among others had increased concentrations of polyols, mainly D-arabitol. So far, the pathophysiological role of polyols is relatively unknown. It is thought that D-arabitol is a metabolic end-product in humans. The strong brain-CSF-plasma gradient of polyols in the patient with RPI deficiency suggested a primary metabolic disorder. The mechanisms of brain and neuronal damage in RPI deficiency remain to be elucidated. A neurotoxic effect due to accumulation of the polyols may play a role. D-Arabitol is a product of the enzyme D-arabinitol 4-dehydrogenase (EC 1.1.1.11) in the Pentose and glucuronate interconversion pathway. (PMID: 16435225, J Inherit Metab Dis. 2005;28(6):1181-3).
D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.
D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.

同义名列表

14 个代谢物同义名

D-Arabinitol - L-arabinitol (1:1); (2R,4R)-pentane-1,2,3,4,5-pentol; Arabitol, (D)-isomer; Arabino-pentitol; D-(+)-Arabitol; (+--)-Arabitol; D-arabinitol; DL-Arabitol; D-Arabitol; D-Arabinol; arabinitol; D-Lyxitol; Arabitol; Lyxitol



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(4)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Elena A Ianutsevich, Olga A Danilova, Olga A Grum-Grzhimaylo, Vera M Tereshina. Membrane Lipids and Osmolytes in the Response of the Acidophilic Basidiomycete Phlebiopsis gigantea to Heat, Cold, and Osmotic Shocks. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063380. [PMID: 38542352]
  • Paul A Adamczyk, Samuel T Coradetti, John M Gladden. Non-canonical D-xylose and L-arabinose metabolism via D-arabitol in the oleaginous yeast Rhodosporidium toruloides. Microbial cell factories. 2023 Aug; 22(1):145. doi: 10.1186/s12934-023-02126-x. [PMID: 37537595]
  • Zhong-Duo Yang, Xu-Dong Zhang, Xing Yang, Xiao-Jun Yao, Zong-Mei Shu. A norbisabolane and an arabitol benzoate from Talaromyces marneffei, an endophytic fungus of Epilobium angustifolium. Fitoterapia. 2021 Sep; 153(?):104948. doi: 10.1016/j.fitote.2021.104948. [PMID: 34087409]
  • Simeng Zheng, Bo Jiang, Tao Zhang, Jingjing Chen. Combined mutagenesis and metabolic regulation to enhance D-arabitol production from Candida parapsilosis. Journal of industrial microbiology & biotechnology. 2020 May; 47(4-5):425-435. doi: 10.1007/s10295-020-02278-4. [PMID: 32361796]
  • Chen Cui, Hui Xu, Hua Yang, Rui Wang, Yu Xiang, Bingxuan Li, Xuedong Zhou, Ruijie Huang, Shujie Cheng. Antibacterial Activity of Fruiting Body Extracts from Culinary-Medicinal Winter Mushroom, Flammulina velutipes (Agaricomycetes) against Oral Pathogen Streptococcus mutans. International journal of medicinal mushrooms. 2020; 22(2):115-124. doi: 10.1615/intjmedmushrooms.2020033335. [PMID: 32479000]
  • Liam E Broughton-Neiswanger, Sol M Rivera-Velez, Martin A Suarez, Jennifer E Slovak, Pablo E Piñeyro, Julianne K Hwang, Nicolas F Villarino. Urinary chemical fingerprint left behind by repeated NSAID administration: Discovery of putative biomarkers using artificial intelligence. PloS one. 2020; 15(2):e0228989. doi: 10.1371/journal.pone.0228989. [PMID: 32053695]
  • Parneet Kaur, Mirjam M C Wamelink, Marjo S van der Knaap, Katta Mohan Girisha, Anju Shukla. Confirmation of a Rare Genetic Leukoencephalopathy due to a Novel Bi-allelic Variant in RPIA. European journal of medical genetics. 2019 Aug; 62(8):103708. doi: 10.1016/j.ejmg.2019.103708. [PMID: 31247379]
  • Helena Hammarström, Anna Stjärne Aspelund, Bertil Christensson, Claus Peter Heußel, Jenny Isaksson, Nahid Kondori, Lennart Larsson, Pawel Markowicz, Johan Richter, Christine Wennerås, Vanda Friman. Prospective evaluation of a combination of fungal biomarkers for the diagnosis of invasive fungal disease in high-risk haematology patients. Mycoses. 2018 Sep; 61(9):623-632. doi: 10.1111/myc.12773. [PMID: 29577474]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Patryk Lipiński, Teresa Stradomska, Anna Tylki-Szymańska. [Transaldolase deficiency - clinical outcome, pathogenesis, diagnostic process]. Developmental period medicine. 2018 ; 22(2):187-196. doi: NULL. [PMID: 30056406]
  • Sujit Sadashiv Jagtap, Christopher V Rao. Production of D-arabitol from D-xylose by the oleaginous yeast Rhodosporidium toruloides IFO0880. Applied microbiology and biotechnology. 2018 Jan; 102(1):143-151. doi: 10.1007/s00253-017-8581-1. [PMID: 29127468]
  • Monika Kordowska-Wiater, Adam Kuzdraliński, Tomasz Czernecki, Zdzisław Targoński, Magdalena Frąc, Karolina Oszust. The Ability of a Novel Strain Scheffersomyces (Syn. Candida) shehatae Isolated from Rotten Wood to Produce Arabitol. Polish journal of microbiology. 2017 Sep; 66(3):335-343. doi: 10.5604/01.3001.0010.4863. [PMID: 29319532]
  • Michail Michailidis, Evangelos Karagiannis, Georgia Tanou, Katerina Karamanoli, Athina Lazaridou, Theodora Matsi, Athanassios Molassiotis. Metabolomic and physico-chemical approach unravel dynamic regulation of calcium in sweet cherry fruit physiology. Plant physiology and biochemistry : PPB. 2017 Jul; 116(?):68-79. doi: 10.1016/j.plaphy.2017.05.005. [PMID: 28551418]
  • Yeo Ul Cho, Deokjong Lee, Jung-Eun Lee, Kyoung Heon Kim, Do Yup Lee, Young-Chul Jung. Exploratory metabolomics of biomarker identification for the internet gaming disorder in young Korean males. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jul; 1057(?):24-31. doi: 10.1016/j.jchromb.2017.04.046. [PMID: 28482325]
  • Marcin Dabrowski, Piyush Sindhu Sharma, Zofia Iskierko, Krzysztof Noworyta, Maciej Cieplak, Wojciech Lisowski, Sylwia Oborska, Alexander Kuhn, Wlodzimierz Kutner. Early diagnosis of fungal infections using piezomicrogravimetric and electric chemosensors based on polymers molecularly imprinted with d-arabitol. Biosensors & bioelectronics. 2016 May; 79(?):627-35. doi: 10.1016/j.bios.2015.12.088. [PMID: 26761618]
  • Tomotake Morita, Tokuma Fukuoka, Ayana Kosaka, Tomohiro Imura, Hideki Sakai, Masahiko Abe, Dai Kitamoto. Selective formation of mannosyl-L-arabitol lipid by Pseudozyma tsukubaensis JCM16987. Applied microbiology and biotechnology. 2015 Jul; 99(14):5833-41. doi: 10.1007/s00253-015-6575-4. [PMID: 25957491]
  • V Stone, K Y Kudo, P M August, T B Marcelino, C Matté. Polyols accumulated in ribose-5-phosphate isomerase deficiency increase mitochondrial superoxide production and improve antioxidant defenses in rats' prefrontal cortex. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2014 Oct; 37(?):21-5. doi: 10.1016/j.ijdevneu.2014.06.009. [PMID: 24970317]
  • Makiko Kosugi, Hirohisa Miyake, Hisanori Yamakawa, Yutaka Shibata, Atsuo Miyazawa, Takashi Sugimura, Kazuhiko Satoh, Shigeru Itoh, Yasuhiro Kashino. Arabitol provided by lichenous fungi enhances ability to dissipate excess light energy in a symbiotic green alga under desiccation. Plant & cell physiology. 2013 Aug; 54(8):1316-25. doi: 10.1093/pcp/pct079. [PMID: 23737501]
  • Martha Malapi-Wight, Jonathon Smith, Jacquelyn Campbell, Burton H Bluhm, Won-Bo Shim. Sda1, a Cys2-His2 zinc finger transcription factor, is involved in polyol metabolism and fumonisin B1 production in Fusarium verticillioides. PloS one. 2013; 8(7):e67656. doi: 10.1371/journal.pone.0067656. [PMID: 23844049]
  • Tomotake Morita, Tokuma Fukuoka, Tomohiro Imura, Dai Kitamoto. Formation of the two novel glycolipid biosurfactants, mannosylribitol lipid and mannosylarabitol lipid, by Pseudozyma parantarctica JCM 11752T. Applied microbiology and biotechnology. 2012 Nov; 96(4):931-8. doi: 10.1007/s00253-012-4230-x. [PMID: 22722912]
  • Joanna Kałużna-Czaplińska, Sylwia Błaszczyk. The level of arabinitol in autistic children after probiotic therapy. Nutrition (Burbank, Los Angeles County, Calif.). 2012 Feb; 28(2):124-6. doi: 10.1016/j.nut.2011.08.002. [PMID: 22079796]
  • Bo Zhu, Miao-Miao Lou, Guan-Lin Xie, Guo-Fen Wang, Qin Zhou, Fang Wang, Yuan Fang, Ting Su, Bin Li, Yong-Pin Duan. Enterobacter mori sp. nov., associated with bacterial wilt on Morus alba L. International journal of systematic and evolutionary microbiology. 2011 Nov; 61(Pt 11):2769-2774. doi: 10.1099/ijs.0.028613-0. [PMID: 21216919]
  • Chiaraluce Moretti, Taha Hosni, Katrien Vandemeulebroecke, Carrie Brady, Paul De Vos, Roberto Buonaurio, Ilse Cleenwerck. Erwinia oleae sp. nov., isolated from olive knots caused by Pseudomonas savastanoi pv. savastanoi. International journal of systematic and evolutionary microbiology. 2011 Nov; 61(Pt 11):2745-2752. doi: 10.1099/ijs.0.026336-0. [PMID: 21186287]
  • Suzanne Joneson, Daniele Armaleo, François Lutzoni. Fungal and algal gene expression in early developmental stages of lichen-symbiosis. Mycologia. 2011 Mar; 103(2):291-306. doi: 10.3852/10-064. [PMID: 20943535]
  • Tatjana Mitrović, Slaviša Stamenković, Vladimir Cvetković, Svetlana Tošić, Milan Stanković, Ivana Radojević, Olgica Stefanović, Ljiljana Comić, Dragana Dačić, Milena Curčić, Snežana Marković. Antioxidant, antimicrobial and antiproliferative activities of five lichen species. International journal of molecular sciences. 2011; 12(8):5428-48. doi: 10.3390/ijms12085428. [PMID: 21954369]
  • Teresa J Stradomska, Dorota Sobielarska, Zbigniew Mielniczuk, Dorota Jagiełłowicz, Małgorzata Syczewska, Danuta Dzierżanowska. Determination of urinary D-/L-arabinitol ratios as a biomarker for invasive candidiasis in children with cardiac diseases. Journal of medical microbiology. 2010 Dec; 59(Pt 12):1490-1496. doi: 10.1099/jmm.0.018135-0. [PMID: 20724507]
  • Udo F H Engelke, Fokje S M Zijlstra, Fanny Mochel, Vassili Valayannopoulos, Daniel Rabier, Leo A J Kluijtmans, András Perl, Nanda M Verhoeven-Duif, Pascale de Lonlay, Mirjam M C Wamelink, Cornelis Jakobs, Eva Morava, Ron A Wevers. Mitochondrial involvement and erythronic acid as a novel biomarker in transaldolase deficiency. Biochimica et biophysica acta. 2010 Nov; 1802(11):1028-35. doi: 10.1016/j.bbadis.2010.06.007. [PMID: 20600873]
  • Kristin Baumann, Marc Carnicer, Martin Dragosits, Alexandra B Graf, Johannes Stadlmann, Paula Jouhten, Hannu Maaheimo, Brigitte Gasser, Joan Albiol, Diethard Mattanovich, Pau Ferrer. A multi-level study of recombinant Pichia pastoris in different oxygen conditions. BMC systems biology. 2010 Oct; 4(?):141. doi: 10.1186/1752-0509-4-141. [PMID: 20969759]
  • Eda Akel, Benjamin Metz, Bernhard Seiboth, Christian P Kubicek. Molecular regulation of arabinan and L-arabinose metabolism in Hypocrea jecorina (Trichoderma reesei). Eukaryotic cell. 2009 Dec; 8(12):1837-44. doi: 10.1128/ec.00162-09. [PMID: 19801419]
  • Robert Hanczko, David R Fernandez, Edward Doherty, Yueming Qian, Gyorgy Vas, Brian Niland, Tiffany Telarico, Adinoyi Garba, Sanjay Banerjee, Frank A Middleton, Donna Barrett, Maureen Barcza, Katalin Banki, Steve K Landas, Andras Perl. Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. The Journal of clinical investigation. 2009 Jun; 119(6):1546-57. doi: 10.1172/jci35722. [PMID: 19436114]
  • Gerald Kayingo, António Martins, Rachael Andrie, Luisa Neves, Cândida Lucas, Brian Wong. A permease encoded by STL1 is required for active glycerol uptake by Candida albicans. Microbiology (Reading, England). 2009 May; 155(Pt 5):1547-1557. doi: 10.1099/mic.0.023457-0. [PMID: 19383674]
  • Yayoi Sakiyama, Nguyen K N Thao, Nguyen M Giang, Shinji Miyadoh, Duong V Hop, Katsuhiko Ando. Kineosporia babensis sp. nov., isolated from plant litter in Vietnam. International journal of systematic and evolutionary microbiology. 2009 Mar; 59(Pt 3):550-4. doi: 10.1099/ijs.0.002907-0. [PMID: 19244439]
  • Anne Koy, Anne Waldhaus, Hans-Werner Hammen, Udo Wendel, Ertan Mayatepek, Peter Schadewaldt. Urinary excretion of pentose phosphate pathway-associated polyols in early postnatal life. Neonatology. 2009; 95(3):256-61. doi: 10.1159/000167789. [PMID: 18987485]
  • Richard S Lord, J Alexander Bralley. Clinical applications of urinary organic acids. Part 2. Dysbiosis markers. Alternative medicine review : a journal of clinical therapeutic. 2008 Dec; 13(4):292-306. doi: . [PMID: 19152477]
  • Bertil Christensson, Lennart Larsson. [Arabinitol ratio in urine for early diagnosis of Candidiasis infection]. Lakartidningen. 2008 Nov; 105(48-49):3537-8. doi: NULL. [PMID: 19133581]
  • Rohan G T Lowe, Maryn Lord, Kasia Rybak, Robert D Trengove, Richard P Oliver, Peter S Solomon. A metabolomic approach to dissecting osmotic stress in the wheat pathogen Stagonospora nodorum. Fungal genetics and biology : FG & B. 2008 Nov; 45(11):1479-86. doi: 10.1016/j.fgb.2008.08.006. [PMID: 18796335]
  • Jang W Yoon, Carolyn J Hovde. All blood, no stool: enterohemorrhagic Escherichia coli O157:H7 infection. Journal of veterinary science. 2008 Sep; 9(3):219-31. doi: 10.4142/jvs.2008.9.3.219. [PMID: 18716441]
  • Emilie Duquesnoy, Vincent Castola, Joseph Casanova. Identification and quantitative determination of carbohydrates in ethanolic extracts of two conifers using 13C NMR spectroscopy. Carbohydrate research. 2008 Apr; 343(5):893-902. doi: 10.1016/j.carres.2008.01.001. [PMID: 18299126]
  • Atanas Kamburov, Leon Goldovsky, Shiri Freilich, Aliki Kapazoglou, Victor Kunin, Anton J Enright, Athanasios Tsaftaris, Christos A Ouzounis. Denoising inferred functional association networks obtained by gene fusion analysis. BMC genomics. 2007 Dec; 8(?):460. doi: 10.1186/1471-2164-8-460. [PMID: 18081932]
  • Fasahat F Alam, Abu S Mustafa, Zia U Khan. Comparative evaluation of (1, 3)-beta-D-glucan, mannan and anti-mannan antibodies, and Candida species-specific snPCR in patients with candidemia. BMC infectious diseases. 2007 Sep; 7(?):103. doi: 10.1186/1471-2334-7-103. [PMID: 17784947]
  • Gudrun Sigmundsdottir, Lennart Larsson, Thomas Wiebe, Lars J Björklund, Bertil Christensson. Clinical experience of urine D-arabinitol/L-arabinitol ratio in the early diagnosis of invasive candidiasis in paediatric high risk populations. Scandinavian journal of infectious diseases. 2007; 39(2):146-51. doi: 10.1080/00365540600951267. [PMID: 17366032]
  • Vassili Valayannopoulos, Nanda M Verhoeven, Karine Mention, Gajja S Salomons, Danièle Sommelet, Marie Gonzales, Guy Touati, Pascale de Lonlay, Cornelis Jakobs, Jean-Marie Saudubray. Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease. The Journal of pediatrics. 2006 Nov; 149(5):713-7. doi: 10.1016/j.jpeds.2006.08.016. [PMID: 17095351]
  • Siew Fah Yeo, Sharon Huie, Andre N Sofair, Sheldon Campbell, Amanda Durante, Brian Wong. Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. Journal of clinical microbiology. 2006 Nov; 44(11):3894-9. doi: 10.1128/jcm.01045-06. [PMID: 16957030]
  • György Vas, Karina Conkrite, Wendy Amidon, Yueming Qian, Katalin Bánki, András Perl. Study of transaldolase deficiency in urine samples by capillary LC-MS/MS. Journal of mass spectrometry : JMS. 2006 Apr; 41(4):463-9. doi: 10.1002/jms.1004. [PMID: 16470722]
  • Teresa Goszczynska, Stephanus N Venter, Teresa A Coutinho. PA 20, a semi-selective medium for isolation and enumeration of Pantoea ananatis. Journal of microbiological methods. 2006 Feb; 64(2):225-31. doi: 10.1016/j.mimet.2005.05.004. [PMID: 15979177]
  • P R LaFayette, P M Kane, B H Phan, W A Parrott. Arabitol dehydrogenase as a selectable marker for rice. Plant cell reports. 2005 Dec; 24(10):596-602. doi: 10.1007/s00299-005-0015-3. [PMID: 16151815]
  • Teresa J Stradomska, Bogumila Bobula-Milewska, Anna Bauer, Zbigniew Mielniczuk, Maria Dabkowska, Malgorzata Syczewska, Danuta Dzierzanowska. Urinary D-arabinitol/L-arabinitol levels in infants undergoing long-term antibiotic therapy. Journal of clinical microbiology. 2005 Oct; 43(10):5351-4. doi: 10.1128/jcm.43.10.5351-5354.2005. [PMID: 16208016]
  • Tobias Link, Gertrud Lohaus, Ingrid Heiser, Kurt Mendgen, Matthias Hahn, Ralf T Voegele. Characterization of a novel NADP(+)-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae. The Biochemical journal. 2005 Jul; 389(Pt 2):289-95. doi: 10.1042/bj20050301. [PMID: 15796718]
  • J J Christensen, M Kilian, V Fussing, K Andresen, J Blom, B Korner, A G Steigerwalt. Aerococcus urinae: polyphasic characterization of the species. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2005 Jul; 113(7-8):517-25. doi: 10.1111/j.1600-0463.2005.apm_183.x. [PMID: 16086822]
  • Gisela Gaio-Oliveira, Lena Dahlman, Kristin Palmqvist, Maria Amélia Martins-Loução, Cristina Máguas. Nitrogen uptake in relation to excess supply and its effects on the lichens Evernia prunastri (L.) Ach and Xanthoria parietina (L.) Th. Fr. Planta. 2005 Mar; 220(5):794-803. doi: 10.1007/s00425-004-1396-1. [PMID: 15503128]
  • M M C Wamelink, D E C Smith, C Jakobs, N M Verhoeven. Analysis of polyols in urine by liquid chromatography-tandem mass spectrometry: a useful tool for recognition of inborn errors affecting polyol metabolism. Journal of inherited metabolic disease. 2005; 28(6):951-63. doi: 10.1007/s10545-005-0233-4. [PMID: 16435188]
  • Mamie Hui, Siu-Wai Cheung, Miu-Ling Chin, Kai-Cheong Chu, Raphael Chiu-Yeung Chan, Augustine Fun-Bun Cheng. Development and application of a rapid diagnostic method for invasive Candidiasis by the detection of D-/L-arabinitol using gas chromatography/mass spectrometry. Diagnostic microbiology and infectious disease. 2004 Jun; 49(2):117-23. doi: 10.1016/j.diagmicrobio.2004.02.006. [PMID: 15183861]
  • M W Shehee, M D Sobsey. Development of a L-rhamnose and D-arabitol supplemented MacConkey agar to identify pathogenic Yersinia enterocolitica among environmental Yersinias in swine production wastes. Journal of microbiological methods. 2004 May; 57(2):289-92. doi: 10.1016/j.mimet.2004.01.014. [PMID: 15063070]
  • W Bär, B Beyreiss, G Rebentisch, T Juretzek. [Diagnosis of systemic Candida infections. Evaluation of serology, molecular biology and D-arabinitol detection]. Mycoses. 2004; 47 Suppl 1(?):32-6. doi: 10.1111/j.1439-0507.2004.01034.x. [PMID: 15667362]
  • Lin Zhang, Helen Meakin, Matt Dickinson. Isolation of genes expressed during compatible interactions between leaf rust (Puccinia triticina) and wheat using cDNA-AFLP. Molecular plant pathology. 2003 Nov; 4(6):469-77. doi: 10.1046/j.1364-3703.2003.00192.x. [PMID: 20569406]
  • Lena Dahlman, Jörgen Persson, Torgny Näsholm, Kristin Palmqvist. Carbon and nitrogen distribution in the green algal lichens Hypogymnia physodes and Platismatia glauca in relation to nutrient supply. Planta. 2003 May; 217(1):41-8. doi: 10.1007/s00425-003-0977-8. [PMID: 12721847]
  • Anthony J Clark, Kerry J Blissett, Richard P Oliver. Investigating the role of polyols in Cladosporium fulvum during growth under hyper-osmotic stress and in planta. Planta. 2003 Feb; 216(4):614-9. doi: 10.1007/s00425-002-0833-2. [PMID: 12569403]
  • Susana Pascual, Paloma Melgarejo, Naresh Magan. Water availability affects the growth, accumulation of compatible solutes and the viability of the biocontrol agent Epicoccum nigrum. Mycopathologia. 2003; 156(2):93-100. doi: 10.1023/a:1022991025675. [PMID: 12733630]
  • W Onkenhout, J E M Groener, N M Verhoeven, C Yin, L A E M Laan. L-Arabinosuria: a new defect in human pentose metabolism. Molecular genetics and metabolism. 2002 Sep; 77(1-2):80-5. doi: 10.1016/s1096-7192(02)00125-7. [PMID: 12359133]
  • Teresa J Stradomska, Zbigniew Mielniczuk. Gas chromatographic determination of D-/L-arabinitol ratio in healthy Polish children. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Jun; 773(2):175-81. doi: 10.1016/s1570-0232(02)00180-0. [PMID: 12031844]
  • E V Morozova, V P Kozlov, V M Tereshina, A S Memorskaia, E P Feofilova. [Changes in lipid composition and carbohydrate composition of Aspergillus niger conidia during germination]. Prikladnaia biokhimiia i mikrobiologiia. 2002 Mar; 38(2):149-54. doi: ". [PMID: 11962211]
  • Christine Oesterhelt, Wolfgang Gross. Different sugar kinases are involved in the sugar sensing of Galdieria sulphuraria. Plant physiology. 2002 Jan; 128(1):291-9. doi: . [PMID: 11788774]
  • Damon P Eisen, Paul B Bartley, William Hope, Gudrun Sigmundsdottir, Christina Pehrson, Lennart Larsson, Bertil Christensson. Urine D-arabinitol/L-arabinitol ratio in diagnosing Candida infection in patients with haematological malignancy and HIV infection. Diagnostic microbiology and infectious disease. 2002 Jan; 42(1):39-42. doi: 10.1016/s0732-8893(01)00310-8. [PMID: 11821170]
  • S H Moolenaar, M S van der Knaap, U F Engelke, P J Pouwels, F S Janssen-Zijlstra, N M Verhoeven, C Jakobs, R A Wevers. In vivo and in vitro NMR spectroscopy reveal a putative novel inborn error involving polyol metabolism. NMR in biomedicine. 2001 May; 14(3):167-76. doi: 10.1002/nbm.690. [PMID: 11357181]
  • J H Salonen, M Rimpiläinen, L Lehtonen, O P Lehtonen, J Nikoskelainen. Measurement of the D-arabinitol/L-arabinitol ratio in urine of neutropenic patients treated empirically with amphotericin B. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2001 Mar; 20(3):179-84. doi: 10.1007/s100960100472. [PMID: 11347667]
  • G Sigmundsdóttir, B Christensson, L J Björklund, K Håkansson, C Pehrson, L Larsson. Urine D-arabinitol/L-arabinitol ratio in diagnosis of invasive candidiasis in newborn infants. Journal of clinical microbiology. 2000 Aug; 38(8):3039-42. doi: 10.1128/jcm.38.8.3039-3042.2000. [PMID: 10921974]
  • S F Yeo, Y Zhang, D Schafer, S Campbell, B Wong. A rapid, automated enzymatic fluorometric assay for determination of D-arabinitol in serum. Journal of clinical microbiology. 2000 Apr; 38(4):1439-43. doi: 10.1128/jcm.38.4.1439-1443.2000. [PMID: 10747122]
  • Y Matsuda, Y Ohta, Y Tsukada, H Nishikiori, T Sakai, S Yuasa, N Fujita, M Yoshimura. [Interference by D-mannitol on serum D-arabinitol determination by enzymatic assay]. Rinsho byori. The Japanese journal of clinical pathology. 2000 Apr; 48(4):337-41. doi: NULL. [PMID: 10810879]
  • D P Eisen, R MacGinley, B Christensson, L Larsson, M L Woods. Candida tropicalis vertebral osteomyelitis complicating epidural catheterisation with disease paralleled by elevated D-arabinitol/L-arabinitol ratios. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2000 Jan; 19(1):61-3. doi: 10.1007/s100960050013. [PMID: 10706184]
  • M S van der Knaap, R A Wevers, E A Struys, N M Verhoeven, P J Pouwels, U F Engelke, W Feikema, J Valk, C Jakobs. Leukoencephalopathy associated with a disturbance in the metabolism of polyols. Annals of neurology. 1999 Dec; 46(6):925-8. doi: 10.1002/1531-8249(199912)46:6<925::aid-ana18>3.0.co;2-j. [PMID: 10589548]
  • B Christensson, G Sigmundsdottir, L Larsson. D-arabinitol--a marker for invasive candidiasis. Medical mycology. 1999 Dec; 37(6):391-6. doi: 10.1046/j.1365-280x.1999.00249.x. [PMID: 10647119]
  • T Abe. [Evaluation of serum D-arabinitol as a diagnostic test for invasive candidiasis in the urinary tract]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. 1999 Aug; 90(8):697-705. doi: 10.5980/jpnjurol1989.90.697. [PMID: 10487045]
  • E Chryssanthou, L Klingspor, J Tollemar, B Petrini, L Larsson, B Christensson, O Ringdén. PCR and other non-culture methods for diagnosis of invasive Candida infections in allogeneic bone marrow and solid organ transplant recipients. Mycoses. 1999; 42(4):239-47. doi: 10.1046/j.1439-0507.1999.00451.x. [PMID: 10424090]
  • N V Beloborodova, V A Kurchavov, V V Pozdorovkina, N B Boĭko, E A Rogatina, A M Demina. [Gas chromatography in express diagnosis of candidiasis and monitoring of antifungal therapy efficacy by D-arabinitol and mannose levels in pediatric patients]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1998; 43(4):24-9. doi: NULL. [PMID: 9606501]
  • B Christensson, T Wiebe, C Pehrson, L Larsson. Diagnosis of invasive candidiasis in neutropenic children with cancer by determination of D-arabinitol/L-arabinitol ratios in urine. Journal of clinical microbiology. 1997 Mar; 35(3):636-40. doi: 10.1128/jcm.35.3.636-640.1997. [PMID: 9041403]
  • L Lehtonen, V J Anttila, T Ruutu, J Salonen, J Nikoskelainen, E Eerola, P Ruutu. Diagnosis of disseminated candidiasis by measurement of urine D-arabinitol/L-arabinitol ratio. Journal of clinical microbiology. 1996 Sep; 34(9):2175-9. doi: 10.1128/jcm.34.9.2175-2179.1996. [PMID: 8862580]
  • T J Walsh, W G Merz, J W Lee, R Schaufele, T Sein, P O Whitcomb, M Ruddel, W Burns, J R Wingard, A C Switchenko. Diagnosis and therapeutic monitoring of invasive candidiasis by rapid enzymatic detection of serum D-arabinitol. The American journal of medicine. 1995 Aug; 99(2):164-72. doi: 10.1016/s0002-9343(99)80136-3. [PMID: 7625421]
  • J S Murray, M L Wong, C G Miyada, A C Switchenko, T C Goodman, B Wong. Isolation, characterization and expression of the gene that encodes D-arabinitol dehydrogenase in Candida tropicalis. Gene. 1995 Mar; 155(1):123-8. doi: 10.1016/0378-1119(94)00900-d. [PMID: 7698655]
  • S Tokunaga, M Ohkawa, M Takashima, C Seto, S Nakamura. D-arabinitol versus mannan antigen and candidal protein antigen as a serum marker for Candida pyelonephritis. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 1995 Feb; 14(2):118-21. doi: 10.1007/bf02111869. [PMID: 7758476]
  • H U Shetty, H W Holloway, S I Rapoport. Capillary gas chromatography combined with ion trap detection for quantitative profiling of polyols in cerebrospinal fluid and plasma. Analytical biochemistry. 1995 Jan; 224(1):279-85. doi: 10.1006/abio.1995.1041. [PMID: 7710082]
  • R P de Vries, M J Flipphi, C F Witteveen, J Visser. Characterization of an Aspergillus nidulans L-arabitol dehydrogenase mutant. FEMS microbiology letters. 1994 Oct; 123(1-2):83-90. doi: 10.1111/j.1574-6968.1994.tb07205.x. [PMID: 7988903]
  • M J Flipphi, J Visser, P van der Veen, L H de Graaff. Arabinase gene expression in Aspergillus niger: indications for coordinated regulation. Microbiology (Reading, England). 1994 Oct; 140 ( Pt 10)(?):2673-82. doi: 10.1099/00221287-140-10-2673. [PMID: 8000538]
  • L Larsson, C Pehrson, T Wiebe, B Christensson. Gas chromatographic determination of D-arabinitol/L-arabinitol ratios in urine: a potential method for diagnosis of disseminated candidiasis. Journal of clinical microbiology. 1994 Aug; 32(8):1855-9. doi: 10.1128/jcm.32.8.1855-1859.1994. [PMID: 7989532]
  • S Morimoto, C Shimazaki, H Goto, Y Hirata, T Tasumi, N Yamagata, T Hirata, E Ashihara, T Inaba, N Fujita. Trichosporon cutaneum fungemia in patients with acute myeloblastic leukemia and measurement of serum D-arabinitol, Candida antigen (CAND-TEC), and beta-D-glucan. Annals of hematology. 1994 Mar; 68(3):159-61. doi: 10.1007/bf01727422. [PMID: 8167183]
  • T J Walsh, J W Lee, T Sien, R Schaufele, J Bacher, A C Switchenko, T C Goodman, P A Pizzo. Serum D-arabinitol measured by automated quantitative enzymatic assay for detection and therapeutic monitoring of experimental disseminated candidiasis: correlation with tissue concentrations of Candida albicans. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology. 1994; 32(3):205-15. doi: 10.1080/02681219480000271. [PMID: 7965491]
  • J Roboz. Diagnosis and monitoring of disseminated candidiasis based on serum/urine D/L-arabinitol ratios. Chirality. 1994; 6(2):51-7. doi: 10.1002/chir.530060203. [PMID: 8204415]
  • A C Switchenko, C G Miyada, T C Goodman, T J Walsh, B Wong, M J Becker, E F Ullman. An automated enzymatic method for measurement of D-arabinitol, a metabolite of pathogenic Candida species. Journal of clinical microbiology. 1994 Jan; 32(1):92-7. doi: 10.1128/jcm.32.1.92-97.1994. [PMID: 8126210]
  • E Reiss, C J Morrison. Nonculture methods for diagnosis of disseminated candidiasis. Clinical microbiology reviews. 1993 Oct; 6(4):311-23. doi: 10.1128/cmr.6.4.311. [PMID: 8269389]
  • C McSharry, C Lewis, G Cruickshank, M D Richardson. Measurement of serum arabinitol by gas-liquid chromatography: limitations for detection of systemic candida infections. Journal of clinical pathology. 1993 May; 46(5):475-6. doi: 10.1136/jcp.46.5.475. [PMID: 8320332]
  • L Lehtonen, A Rantala, P Oksman, E Eerola, O P Lehtonen. Determination of serum arabinitol levels by mass spectrometry in patients with postoperative candidiasis. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 1993 May; 12(5):330-5. doi: 10.1007/bf01964428. [PMID: 8354298]
  • J Roboz, R N Katz. Diagnosis of disseminated candidiasis based on serum D/L-arabinitol ratios using negative chemical ionization mass spectrometry. Journal of chromatography. 1992 Mar; 575(2):281-6. doi: 10.1016/0378-4347(92)80157-l. [PMID: 1629305]
  • S Tokunaga, M Ohkawa, M Takashima, H Hisazumi. Clinical significance of measurement of serum D-arabinitol levels in candiduria patients. Urologia internationalis. 1992; 48(2):195-9. doi: 10.1159/000282330. [PMID: 1585514]
  • B Christensson, J Roboz. Arabinitol enantiomers in cerebrospinal fluid. Journal of the neurological sciences. 1991 Oct; 105(2):234-9. doi: 10.1016/0022-510x(91)90150-6. [PMID: 1757799]
  • N Fujita, K Hamada, H Takahashi, M Yoshimura, S Nakanishi, H Gotoh, N Oku, T Inaba, S Muragashira, K Ito. [Differentiation of intestinal candidial colonization from invasive candidiasis by measuring serum level of D-arabinitol in combination with oral administration of low dose amphotericin B]. Rinsho byori. The Japanese journal of clinical pathology. 1991 Aug; 39(8):895-7. doi: NULL. [PMID: 1920890]
  • S Hayasaka, S Noda, T Setogawa. Endogenous Candida species endophthalmitis associated with increased levels of D-arabinitol in serum and vitreous. American journal of ophthalmology. 1991 Mar; 111(3):379-80. doi: 10.1016/s0002-9394(14)72333-5. [PMID: 2000915]
  • K Maeno, S Hirota, K Kubota, S Takata, T Ikeda, K Kobayachi, S Fujita, F Matsubara. [A case of candida endocarditis with consecutive measurement of serum mannan and D-arabinitol concentrations]. Kokyu to junkan. Respiration & circulation. 1990 Jun; 38(6):605-8. doi: NULL. [PMID: 2377834]
  • M E Bougnoux, C Hill, D Moissenet, M Feuilhade de Chauvin, M Bonnay, I Vicens-Sprauel, F Pietri, M McNeil, L Kaufman, J Dupouy-Camet. Comparison of antibody, antigen, and metabolite assays for hospitalized patients with disseminated or peripheral candidiasis. Journal of clinical microbiology. 1990 May; 28(5):905-9. doi: 10.1128/jcm.28.5.905-909.1990. [PMID: 2351733]
  • T Miyazaki, S Kohno, A Yasuoka, K Sasayama, H Yamada, Y Dohtsu, K Yamaguchi, M Hirota, K Hara. [Comparison of D-arabinitol, candida antigen, and beta-glucan, measured by the chromogenic limulus assay, in the rabbit model of systemic candidiasis]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 1990 Apr; 64(4):474-8. doi: 10.11150/kansenshogakuzasshi1970.64.474. [PMID: 2205670]
  • J Roboz, E Nieves, J F Holland. Separation and quantification by gas chromatography-mass spectrometry of arabinitol enantiomers to aid the differential diagnosis of disseminated candidiasis. Journal of chromatography. 1990 Feb; 500(?):413-26. doi: 10.1016/s0021-9673(00)96082-5. [PMID: 2329144]