LY404039 (BioDeep_00000014127)

   


代谢物信息卡片


(1R,4S,5S,6S)-4-amino-2,2-dioxo-2$l^{6}-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

化学式: C7H9NO6S (235.01505740000002)
中文名称: (1R,4S,5S,6S)-4-氨基-2-硫杂双环[3.1.0]己烷-4,6-二甲酸 2,2-二氧化物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C2C(C2S1(=O)=O)C(=O)O)(C(=O)O)N
InChI: InChI=1S/C7H9NO6S/c8-7(6(11)12)1-15(13,14)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1

描述信息

LY404039 is a potent, selective and orally active mGluR2 and mGluR3 agonist with Kis of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects[1].

同义名列表

4 个代谢物同义名

(1R,4S,5S,6S)-4-amino-2,2-dioxo-2$l^{6}-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; (1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide; LY404039; SCHEMBL5973199



数据库引用编号

11 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Cameron S Metcalf, Brian D Klein, Misty D Smith, Tim Pruess, Marc Ceusters, Hilde Lavreysen, Stefan Pype, Nancy Van Osselaer, Roy Twyman, H Steve White. Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures. Epilepsia. 2017 03; 58(3):484-493. doi: 10.1111/epi.13659. [PMID: 28166368]
  • Y Anne Pak, Amanda J Long, William F Annes, Jennifer W Witcher, Mary Pat Knadler, Mosun A Ayan-Oshodi, Malcolm I Mitchell, Phillip Leese, Kathleen M Hillgren. In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1. Drug metabolism and disposition: the biological fate of chemicals. 2017 02; 45(2):137-144. doi: 10.1124/dmd.116.071118. [PMID: 27895114]
  • Richard D Moulton, Kenneth J Ruterbories, David W Bedwell, Michael A Mohutsky. In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug. Drug metabolism and disposition: the biological fate of chemicals. 2015 May; 43(5):756-61. doi: 10.1124/dmd.114.062893. [PMID: 25755052]
  • William F Annes, Amanda Long, Jennifer W Witcher, Mosun A Ayan-Oshodi, Mary Pat Knadler, Wei Zhang, Malcolm I Mitchell, Karen Cornelissen, Stephen D Hall. Relative contributions of presystemic and systemic peptidases to oral exposure of a novel metabotropic glutamate 2/3 receptor agonist (LY404039) after oral administration of prodrug pomaglumetad methionil (LY2140023). Journal of pharmaceutical sciences. 2015 Jan; 104(1):207-14. doi: 10.1002/jps.24226. [PMID: 25382826]
  • Linda M Rorick-Kehn, Bryan G Johnson, Jennifer L Burkey, Rebecca A Wright, David O Calligaro, Gerard J Marek, Eric S Nisenbaum, John T Catlow, Ann E Kingston, Deborah D Giera, Marc F Herin, James A Monn, David L McKinzie, Darryle D Schoepp. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039). The Journal of pharmacology and experimental therapeutics. 2007 Apr; 321(1):308-17. doi: 10.1124/jpet.106.110809. [PMID: 17204749]