zofenoprilat (BioDeep_00000014126)
代谢物信息卡片
化学式: C15H19NO3S2 (325.08063039999996)
中文名称: Zofenoprilat 钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CS)C(=O)N1CC(CC1C(=O)O)SC2=CC=CC=C2
InChI: InChI=1S/C15H19NO3S2/c1-10(9-20)14(17)16-8-12(7-13(16)15(18)19)21-11-5-3-2-4-6-11/h2-6,10,12-13,20H,7-9H2,1H3,(H,18,19)
描述信息
A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-2-methyl-3-sulfanylpropanoyl group. The active metabolite of zofenopril.
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:82602
- KEGG: C21576
- PubChem: 3034048
- PubChem: 3086142
- DrugBank: DB08766
- ChEMBL: CHEMBL16332
- CAS: 75176-37-3
- CAS: 1217716-12-5
- PMhub: MS000028743
- MetaboLights: MTBLC82602
- PubChem: 340076557
- PDB-CCD: ZED
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Yuan Jiang, Fang Yan, Bin Di, Fang Feng, Linjun You, Lili Huang, Juan Lu. Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of zofenopril and its active metabolite zofenoprilat in human plasma.
Journal of pharmaceutical and biomedical analysis.
2011 Jun; 55(3):527-32. doi:
10.1016/j.jpba.2011.02.010. [PMID: 21377823] - Sandra Donnini, Erika Terzuoli, Marina Ziche, Lucia Morbidelli. Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talk.
The Journal of pharmacology and experimental therapeutics.
2010 Mar; 332(3):776-84. doi:
10.1124/jpet.109.159178. [PMID: 19959747] - Bart Westendorp, Regien G Schoemaker, Wiek H van Gilst, Dirk J van Veldhuisen, Hendrik Buikema. Hydrochlorothiazide increases plasma or tissue angiotensin-converting enzyme-inhibitor drug levels in rats with myocardial infarction: differential effects on lisinopril and zofenopril.
European journal of pharmacology.
2005 Dec; 527(1-3):141-9. doi:
10.1016/j.ejphar.2005.10.019. [PMID: 16310764] - Mario Matarrese, Aldo Salimbeni, Elia Anna Turolla, Damiano Turozzi, Rosa Maria Moresco, Davide Poma, Fulvio Magni, Sergio Todde, Claudio Rossetti, Maria Teresa Sciarrone, Giuseppe Bianchi, Marzia Galli Kienle, Ferruccio Fazio. 11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat.
Bioorganic & medicinal chemistry.
2004 Feb; 12(3):603-11. doi:
10.1016/j.bmc.2003.10.054. [PMID: 14738971] - L Dal Bo, P Mazzucchelli, A Marzo. Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications.
2000 Dec; 749(2):287-94. doi:
10.1016/s0378-4347(00)00419-9. [PMID: 11145066]