Fludarabine (BioDeep_00000014105)
代谢物信息卡片
化学式: C10H12FN5O4 (285.08732840000005)
中文名称: 氟达拉滨
谱图信息:
最多检出来源 Astragalus membranaceus(plant) 80%
分子结构信息
SMILES: C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N
InChI: InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BB - Purine analogues
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2150 - Ribonucleotide Reductase Inhibitor
D000970 - Antineoplastic Agents
Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes[1][2][3][4].
同义名列表
4 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:94701
- KEGG: C21550
- KEGGdrug: D07966
- PubChem: 657237
- Metlin: METLIN566
- DrugBank: DB01073
- ChEMBL: CHEMBL1568
- CAS: 21679-14-1
- PMhub: MS000028721
- PubChem: 336445188
- medchemexpress: HY-B0069
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Jade L Kutzke, Julianna A Merten, Amanda G Pawlenty, Erin F Barreto, Gabe T Bartoo, Kristin C Mara, Mark R Litzow, William J Hogan, Mithun V Shah, Abhishek A Mangaonkar, Nelson Leung, Hassan B Alkhateeb. Relationship of iothalamate clearance and NRM in patients receiving fludarabine and melphalan reduced-intensity conditioning.
Blood advances.
2022 07; 6(13):3844-3849. doi:
10.1182/bloodadvances.2021006395
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Antiviral research.
2022 02; 198(?):105254. doi:
10.1016/j.antiviral.2022.105254
. [PMID: 35101534] - Guoxing Zhao, Runhong Wei, Lei Feng, Yi Wu, Feng He, Mingxing Xiao, Zhi Cheng. Lenalidomide enhances the efficacy of anti-BCMA CAR-T treatment in relapsed/refractory multiple myeloma: a case report and revies of the literature.
Cancer immunology, immunotherapy : CII.
2022 Jan; 71(1):39-44. doi:
10.1007/s00262-021-02959-8
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Cellular & molecular immunology.
2021 07; 18(7):1829-1831. doi:
10.1038/s41423-021-00698-5
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Blood reviews.
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Journal for immunotherapy of cancer.
2021 05; 9(5):. doi:
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FEBS open bio.
2021 03; 11(3):880-889. doi:
10.1002/2211-5463.13081
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2021 Feb; 15(1):90. doi:
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International journal of hematology.
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International journal of biological macromolecules.
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Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
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Leukemia.
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Blood.
2020 07; 136(4):480-488. doi:
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British journal of cancer.
2020 07; 123(2):240-251. doi:
10.1038/s41416-020-0887-6
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Jun; 233(?):118170. doi:
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Annals of hematology.
2020 Apr; 99(4):855-866. doi:
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American journal of hematology.
2020 03; 95(3):251-257. doi:
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Transplantation proceedings.
2020 Mar; 52(2):647-652. doi:
10.1016/j.transproceed.2019.11.033
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Pharmacotherapy.
2020 01; 40(1):26-32. doi:
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Blood.
2019 11; 134(22):1951-1959. doi:
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Stem cells and development.
2019 10; 28(20):1376-1383. doi:
10.1089/scd.2019.0139
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Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2019 08; 25(8):1592-1596. doi:
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Blood advances.
2019 07; 3(14):2179-2187. doi:
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. [PMID: 31324638] - Karen Sweiss, Gregory S Calip, Annie L Oh, Damiano Rondelli, Pritesh R Patel. Renal dysfunction within 90 days of FluBu4 predicts early and late mortality.
Bone marrow transplantation.
2019 07; 54(7):980-986. doi:
10.1038/s41409-018-0361-8
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International journal of radiation oncology, biology, physics.
2019 05; 104(1):137-143. doi:
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Blood.
2019 04; 133(17):1876-1887. doi:
10.1182/blood-2018-11-887067
. [PMID: 30782611] - Mohamad Fekredeen Ayas, Amal Al-Seraihi, Amal Al-Agil, Ali Al-Ahmari, Ibrahim Ghemlas, Mouhab Ayas. Successful hematopoietic cell transplantation in Fanconi anemia patients with renal impairment using ultra-reduced doses of cyclophosphamide and fludarabine.
Pediatric blood & cancer.
2018 12; 65(12):e27371. doi:
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. [PMID: 30070008] - Can Boga, Mahmut Yeral, Ciğdem Gereklioglu, Suheyl Asma, Erkan Maytalman, Pelin Aytan, Ilknur Kozanoglu, Cagla Sariturk, Hakan Ozdogu. Effects of two doses of anti-T lymphocyte globulin-Fresenius given after full-match sibling stem cell transplantation in acute myeloblastic leukemia patients who underwent myeloablative fludarabine/busulfan conditioning.
Hematology/oncology and stem cell therapy.
2018 Sep; 11(3):149-157. doi:
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Journal of pediatric hematology/oncology.
2018 08; 40(6):e350-e354. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2018 08; 36(22):2267-2280. doi:
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British journal of haematology.
2018 08; 182(4):554-558. doi:
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Transplantation.
2018 04; 102(4):593-600. doi:
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American journal of hematology.
2018 03; 93(3):E77-E79. doi:
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Bulletin du cancer.
2017 Dec; 104(12S):S99-S105. doi:
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Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2017 Dec; 23(12):2088-2095. doi:
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Transplantation.
2017 11; 101(11):2695-2704. doi:
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Cancer immunology, immunotherapy : CII.
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Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2017 Oct; 23(10):1701-1713. doi:
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Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
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Bone marrow transplantation.
2017 Jul; 52(7):977-983. doi:
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Blood.
2017 06; 129(25):3396. doi:
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