Trandolaprilat (BioDeep_00000014087)

 

Secondary id: BioDeep_00000593135

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2S,3aR,7aS)-1-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

化学式: C22H30N2O5 (402.215461)
中文名称: 群多普利拉
谱图信息: 最多检出来源 Homo sapiens(blood) 95.24%

分子结构信息

SMILES: CC(C(=O)N1C2CCCCC2CC1C(=O)O)NC(CCC3=CC=CC=C3)C(=O)O
InChI: InChI=1S/C22H30N2O5/c1-14(23-17(21(26)27)12-11-15-7-3-2-4-8-15)20(25)24-18-10-6-5-9-16(18)13-19(24)22(28)29/h2-4,7-8,14,16-19,23H,5-6,9-13H2,1H3,(H,26,27)(H,28,29)/t14-,16+,17-,18-,19-/m0/s1

描述信息

Trandolaprilat is a metabolite of trandolapril. Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions. It is marketed by Abbott Laboratories with the brand name Mavik. (Wikipedia)
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor

同义名列表

8 个代谢物同义名

(2S,3aR,7aS)-1-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid; (2S,3aR,7aS)-1-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-octahydroindole-2-carboxylic acid; 1-(2-((1-Carboxy-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic acid; Trandolaprilat, (2S-(1(s*(r*)),2alpha,3aalpha,7abeta))-isomer; Trandolaprilat, (2S-(1(r*(r*)),2alpha,3abeta,7abeta))-isomer; Trandolaprilat, (2S-(1R*(r*)),2alpha,3aalpha,7abeta)-isomer; Trandolaprilate; Trandolaprilat



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaojiao Li, Chang Liu, Min Wu, Hong Zhang, Yanfu Sun, Longmei Cheng, Hong Chen, Chengjiao Liu, Lizhi Yang, Qi Zhang, Yuchen Cao, Jingkai Gu, Yanhua Ding. Pharmacokinetics, Pharmacodynamics, and Tolerability of Single and Multiple Doses of Trandolapril, an Effective Angiotensin-Converting Enzyme Inhibitor, in Healthy Chinese Subjects. European journal of drug metabolism and pharmacokinetics. 2016 Aug; 41(4):373-84. doi: 10.1007/s13318-015-0277-2. [PMID: 25864194]
  • Ramakrishna V S Nirogi, Vishwottam N Kandikere, Wishu Shrivastava, Koteshwara Mudigonda. Quantification of trandolapril and its metabolite trandolaprilat in human plasma by liquid chromatography/tandem mass spectrometry using solid-phase extraction. Rapid communications in mass spectrometry : RCM. 2006; 20(24):3709-16. doi: 10.1002/rcm.2794. [PMID: 17117442]
  • Masayo Naito, Akira Kawashima, Takashi Akiba, Minoko Takanashi, Hiroshi Nihei. Effects of an angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitors on burst forming units-erythroid in chronic hemodialysis patients. American journal of nephrology. 2003 Sep; 23(5):287-93. doi: 10.1159/000072705. [PMID: 12897465]
  • H Berthold, K Münter, A Just, H R Kirchheim, H Ehmke. Contribution of endothelin to renal vascular tone and autoregulation in the conscious dog. The American journal of physiology. 1999 03; 276(3):F417-24. doi: 10.1152/ajprenal.1999.276.3.f417. [PMID: 10070165]
  • P M ter Wee, H G Forster, M Epstein. Video-microscopic assessment of the role of tissue angiotensin-converting enzyme in the control of the renal microcirculation. The Journal of pharmacology and experimental therapeutics. 1997 Apr; 281(1):434-9. doi: NULL. [PMID: 9103527]
  • M Hirayama, A Kurihara, T Manabe, Y Hasegawa. Pharmacokinetics of RU44403, an active form of newly developed angiotensin-converting enzyme inhibitor (RU44570) in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1994 Jul; 22(4):601-6. doi: NULL. [PMID: 7956736]
  • P Arner, A Wade, P Engfeldt, M Mouren, J P Stepniewski, E Sultan, T Bryce, B Lenfant. Pharmacokinetics and pharmacodynamics of trandolapril after repeated administration of 2 mg to young and elderly patients with mild-to-moderate hypertension. Journal of cardiovascular pharmacology. 1994; 23 Suppl 4(?):S44-9. doi: NULL. [PMID: 7527101]
  • B Danielson, S Querin, P LaRochelle, E Sultan, M Mouren, T Bryce, J P Stepniewski, B Lenfant. Pharmacokinetics and pharmacodynamics of trandolapril after repeated administration of 2 mg to patients with chronic renal failure and healthy control subjects. Journal of cardiovascular pharmacology. 1994; 23 Suppl 4(?):S50-9. doi: NULL. [PMID: 7527102]