ERASTIN (BioDeep_00000014069)
代谢物信息卡片
ERASTIN
化学式: C30H31ClN4O4 (546.2034)
中文名称: 爱拉斯汀
谱图信息:
最多检出来源 Homo sapiens(not specific) 16.18%
分子结构信息
SMILES: CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
InChI: InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:94287
- KEGG: C21478
- PubChem: 11214940
- ChEMBL: CHEMBL401989
- CAS: 571203-78-6
- PMhub: MS000028678
- PubChem: 329970430
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Xiongbo Liu, Jiali Zhu, Qiangsheng Zhang, Hao Hu, Wei Zhang, Hui Xu, Yan Huang, Jialin Xie, Hongtao Liu, Yan Feng, Jianwei Li, Chunman Jia. Multifunctional fluorescent probe for simultaneous revealing Cys and ONOO- dynamic correlation in the ferroptosis.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2024 Jul; 315(?):124248. doi:
10.1016/j.saa.2024.124248. [PMID: 38599026] - Julia María Torres-Velarde, Kaitlin N Allen, Andrea Salvador-Pascual, Roberto G Leija, Diamond Luong, Diana Daniela Moreno-Santillán, David C Ensminger, José Pablo Vázquez-Medina. Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells.
Free radical biology & medicine.
2024 Jun; 218(?):82-93. doi:
10.1016/j.freeradbiomed.2024.04.208. [PMID: 38579937] - Jiaojiao Li, Junlan Ma, Rui Zhang, Yan Zhai, Wei Zhang, Rong Fu. A new therapeutic perspective: Erastin inhibits tumor progression by driving ferroptosis in myelodysplastic syndromes.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
2024 Jun; 72(5):414-424. doi:
10.1177/10815589241246541. [PMID: 38557364] - Caiyou Song, Zhili Chu, Jingyi Dai, Danni Xie, Tao Qin, Linjiang Xie, Zhenwei Zhai, Sha Huang, Ying Xu, Tao Sun. Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1/Nrf2 pathway in HT22 cells.
Journal of ethnopharmacology.
2024 May; 326(?):117937. doi:
10.1016/j.jep.2024.117937. [PMID: 38423409] - Ziyue Kou, Franklin Tran, Tania Colon, Yvette Shteynfeld, Suwon Noh, Fei Chen, Byeong Hyeok Choi, Wei Dai. AhR signaling modulates Ferroptosis by regulating SLC7A11 expression.
Toxicology and applied pharmacology.
2024 May; 486(?):116936. doi:
10.1016/j.taap.2024.116936. [PMID: 38641223] - Jiaqi Bao, Xufei Yu, Yuting Yang, Weilian Sun, Zhongxiu Wang, Lili Chen. Effects of the ferroptosis inducer erastin on osteogenic differentiation and biological pathways of primary osteoblasts.
Connective tissue research.
2024 May; 65(3):202-213. doi:
10.1080/03008207.2024.2338348. [PMID: 38578221] - Liqing Guo, Zhi Wang, Yanpeng Fu, Shuhong Wu, Yaqiong Zhu, Jiasheng Yuan, Yuehui Liu. MiR-122-5p regulates erastin-induced ferroptosis via CS in nasopharyngeal carcinoma.
Scientific reports.
2024 05; 14(1):10019. doi:
10.1038/s41598-024-59080-w. [PMID: 38693171] - Hongge Wang, Ming-Jie Hou, Lixi Liao, Peng Li, Tongxiang Chen, Pan Wang, Bao Ting Zhu. Strong Protection by 4-Hydroxyestrone against Erastin-Induced Ferroptotic Cell Death in Estrogen Receptor-Negative Human Breast Cancer Cells: Evidence for Protein Disulfide Isomerase as a Mechanistic Target for Protection.
Biochemistry.
2024 Apr; 63(8):984-999. doi:
10.1021/acs.biochem.3c00261. [PMID: 38569593] - Upasana Ganguly, Sukhpal Singh, Aritri Bir, Arindam Ghosh, Sankha Shubhra Chakrabarti, Reena V Saini, Luciano Saso, Marco Bisaglia, Sasanka Chakrabarti. Alpha-synuclein interaction with mitochondria is the final mechanism of ferroptotic death induced by erastin in SH-SY5Y cells.
Free radical research.
2024 Mar; 58(3):217-228. doi:
10.1080/10715762.2024.2336563. [PMID: 38572725] - Takahiro Horinouchi, Yuichi Mazaki, Soichi Miwa. Mechanism of cytotoxicity induced by the cigarette smoke extract (CSE) of heated tobacco products in vascular smooth muscle cells: A comparative study of the cytotoxic effects of CSE and the ferroptosis inducer, erastin.
Journal of pharmacological sciences.
2024 Feb; 154(2):86-96. doi:
10.1016/j.jphs.2023.12.010. [PMID: 38246732] - Rui Bi, Rui Hu, Lianyong Jiang, Bohan Wen, Zhaolei Jiang, Hongtao Liu, Ju Mei. Butyrate enhances erastin-induced ferroptosis of lung cancer cells via modulating the ATF3/SLC7A11 pathway.
Environmental toxicology.
2024 Feb; 39(2):529-538. doi:
10.1002/tox.23857. [PMID: 37341073] - Zehua Li, Dongyang Liu, Yankun Wang, Chu Wang. Chemoproteomic Profiling of Erastin-Interacting Proteins.
Chemical research in toxicology.
2024 01; 37(1):109-116. doi:
10.1021/acs.chemrestox.3c00347. [PMID: 38173279] - Yichen Li, Xing Wang, Yong-Hua Chen, Qing-Quan Tan, Xu-Bao Liu, Chunlu Tan. Clusterin is upregulated by erastin, a ferroptosis inducer and exerts cytoprotective effects in pancreatic adenocarcinoma cells.
Anti-cancer drugs.
2023 Dec; ?(?):. doi:
10.1097/cad.0000000000001561. [PMID: 38085677] - Shun-Hong Luo, Jia-Ming Tian, Yi Chu, Hong-Yi Zhu, Jiang-Dong Ni, Jun Huang. The BRD4-SRPK2-SRSF2 signal modulates the splicing efficiency of ACSL3 pre-mRNA and influences erastin-induced ferroptosis in osteosarcoma cells.
Cell death & disease.
2023 11; 14(11):760. doi:
10.1038/s41419-023-06273-2. [PMID: 37993451] - Yunwen Zhang, Xinghai Wu, Jiyong Zhu, Ruibin Lu, Yian Ouyang. Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression.
BMC cancer.
2023 Nov; 23(1):1120. doi:
10.1186/s12885-023-11637-0. [PMID: 37978473] - Filiz Bakar-Ates, Erva Ozkan. Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation.
Toxicology in vitro : an international journal published in association with BIBRA.
2023 Nov; ?(?):105732. doi:
10.1016/j.tiv.2023.105732. [PMID: 37956772] - Deeksha Rajput, Paramasivam Mahalingavelar, Virupakshi Soppina, Sriram Kanvah. Improved lipophilic probe for visualizing lipid droplets in erastin-induced ferroptosis.
Organic & biomolecular chemistry.
2023 11; 21(42):8554-8562. doi:
10.1039/d3ob01545a. [PMID: 37853800] - Huifang Li, Ni Deng, Tess Puopolo, Xian Jiang, Navindra P Seeram, Chang Liu, Hang Ma. Cannflavins A and B with Anti-Ferroptosis, Anti-Glycation, and Antioxidant Activities Protect Human Keratinocytes in a Cell Death Model with Erastin and Reactive Carbonyl Species.
Nutrients.
2023 Oct; 15(21):. doi:
10.3390/nu15214565. [PMID: 37960218] - Xinxin Guo, Yubo Guo, Jiahuan Li, Qian Liu, Hao Wu. Arginine Expedites Erastin-Induced Ferroptosis through Fumarate.
International journal of molecular sciences.
2023 Sep; 24(19):. doi:
10.3390/ijms241914595. [PMID: 37834044] - Deqian Kong, Yue Liu, Li Li, Huajun Wang, Ke Li, Guangying Zheng. Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating GPX4 and ferroptosis.
Chemico-biological interactions.
2023 Sep; 383(?):110684. doi:
10.1016/j.cbi.2023.110684. [PMID: 37648051] - Yinli Zheng, Leyan Li, Haipeng Chen, Yuting Zheng, Xuanjing Tan, Guiyu Zhang, Ruidi Jiang, Hong Yu, Senyi Lin, Yijie Wei, Ying Wang, Rong Zhang, Zhongqiu Liu, Jinjun Wu. Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression.
Free radical biology & medicine.
2023 Sep; ?(?):. doi:
10.1016/j.freeradbiomed.2023.09.014. [PMID: 37717793] - Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He. Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway.
European journal of pharmacology.
2023 Aug; ?(?):176009. doi:
10.1016/j.ejphar.2023.176009. [PMID: 37619784] - Wei Xue, Wengang Jian, Yuyang Meng, Tengda Wang, Licheng Cai, Yongchun Yu, Yipeng Yu, Zhinan Xia, Cheng Zhang. Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC.
Cell death & disease.
2023 08; 14(8):539. doi:
10.1038/s41419-023-06057-8. [PMID: 37604811] - Ziying Ye, Chuna Li, Shuqiong Liu, Hongbin Liang, Jialiang Feng, Danyu Lin, Ying Chen, Sudan Peng, Lulu Bu, Enxiang Tao, Xiuna Jing, Yanran Liang. Dl-3-n-butylphthalide activates Nrf2, inhibits ferritinophagy, and protects MES23.5 dopaminergic neurons from ferroptosis.
Chemico-biological interactions.
2023 Jun; ?(?):110604. doi:
10.1016/j.cbi.2023.110604. [PMID: 37315914] - Lei Huang, Mengxuan Bian, Shunyi Lu, Jiayi Wang, Jieqin Yu, Libo Jiang, Jian Zhang. Engeletin alleviates erastin-induced oxidative stress and protects against ferroptosis via Nrf2/Keap1 pathway in bone marrow mesenchymal stem cells.
Tissue & cell.
2023 Jun; 82(?):102040. doi:
10.1016/j.tice.2023.102040. [PMID: 36857798] - Nana Liu, Ge Liu, Haihong Jiang, Jing Yu, Yunqin Jin, Hong Wang. Effect of the Mitogen-Activated Protein Kinase Pathway on the Erastin-Induced Ferroptosis of Molt-4 Cells.
DNA and cell biology.
2023 Jun; 42(6):348-356. doi:
10.1089/dna.2022.0661. [PMID: 37140570] - Ming-Jie Hou, Pan Wang, Bao Ting Zhu. Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells.
Acta biochimica et biophysica Sinica.
2023 May; 55(5):853-865. doi:
10.3724/abbs.2023058. [PMID: 37249331] - Yeyang Wang, Wenjun Li, Mingsen Wang, Hongdong Chen, Yongsheng Li, Wei Wei, Xuhua Liu, Yuelin Wu, Sidong Luo, Xinfang Liu, Man Xiong. Quercetin prevents the ferroptosis of OPCs by inhibiting the Id2/transferrin pathway.
Chemico-biological interactions.
2023 May; ?(?):110556. doi:
10.1016/j.cbi.2023.110556. [PMID: 37230155] - Jia Ma, Jiaqi Wang, Chenjie Ma, Qian Cai, Shuang Wu, Wenfeng Hu, Jiali Yang, Jing Xue, Juan Chen, Xiaoming Liu. Wnt5a/Ca2+ signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance.
Toxicology.
2023 05; 490(?):153514. doi:
10.1016/j.tox.2023.153514. [PMID: 37075931] - Gang Wei, Yan Wang, Ping Yang, Shujia Peng, Sensen Duan, Xi'e Hu, Lijuan Yuan, Guoqiang Bao. Enhancing vulnerability of Afatinib using Erastin via xCT-mediated ROS/P38MAPK signaling feedback loop in gastric cancer cells.
Gene.
2023 May; 873(?):147468. doi:
10.1016/j.gene.2023.147468. [PMID: 37169154] - Leilei Wang, Chuan Wang, Xuan Li, Zhuoying Tao, Wangyong Zhu, Yuxiong Su, Wing Shan Choi. Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS.
Cellular & molecular biology letters.
2023 May; 28(1):36. doi:
10.1186/s11658-023-00449-6. [PMID: 37131152] - Annamarie E Allen, Yudong Sun, Fangchao Wei, Michael A Reid, Jason W Locasale. Nucleotide metabolism is linked to cysteine availability during ferroptosis.
The Journal of biological chemistry.
2023 Feb; ?(?):103039. doi:
10.1016/j.jbc.2023.103039. [PMID: 36803962] - Dragana Savic, Teresa Bernadette Steinbichler, Julia Ingruber, Giulia Negro, Bertram Aschenbrenner, Herbert Riechelmann, Ute Ganswindt, Sergej Skvortsov, József Dudás, Ira-Ida Skvortsova. Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis.
Cells.
2023 01; 12(2):. doi:
10.3390/cells12020336. [PMID: 36672272] - Shengjie Liao, Mi Huang, Yanli Liao, Chao Yuan. HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe2+ Production.
Current eye research.
2023 01; 48(1):25-33. doi:
10.1080/02713683.2022.2138450. [PMID: 36300537] - Erva Ozkan, Filiz Bakar-Ates. Etoposide in combination with erastin synergistically altered iron homeostasis and induced ferroptotic cell death through regulating IREB2/FPN1 expression in estrogen receptor positive-breast cancer cells.
Life sciences.
2023 Jan; 312(?):121222. doi:
10.1016/j.lfs.2022.121222. [PMID: 36442526] - Linzhou Yin, Pengyu Liu, Yue Jin, Zunxi Ning, Yiren Yang, Huiyuan Gao. Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications.
European journal of medicinal chemistry.
2022 Dec; 244(?):114861. doi:
10.1016/j.ejmech.2022.114861. [PMID: 36332549] - Tugba Kose, Paul A Sharp, Gladys O Latunde-Dada. Upregulation of Nrf2 Signalling and the Inhibition of Erastin-Induced Ferroptosis by Ferulic Acid in MIN6 Cells.
International journal of molecular sciences.
2022 Dec; 23(24):. doi:
10.3390/ijms232415886. [PMID: 36555529] - Asmaa Oun, Ahmed Soliman, Marina Trombetta-Lima, Afroditi Tzepapadaki, Dikaia Tsagkari, Arjan Kortholt, Amalia M Dolga. LRRK2 protects immune cells against erastin-induced ferroptosis.
Neurobiology of disease.
2022 12; 175(?):105917. doi:
10.1016/j.nbd.2022.105917. [PMID: 36336242] - Meijie Chen, Xuena Li, Bulin Du, Song Chen, Yaming Li. Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2.
Biochemical pharmacology.
2022 11; 205(?):115255. doi:
10.1016/j.bcp.2022.115255. [PMID: 36210578] - Wenting Xuan, Xinyi Lu, Zeyong Yang, Jun Li, Weilin Jin, Yuanhai Li. Propofol Protects Against Erastin-Induced Ferroptosis in HT-22 Cells.
Journal of molecular neuroscience : MN.
2022 Sep; 72(9):1797-1808. doi:
10.1007/s12031-022-02017-7. [PMID: 35727524] - Mehdi Rabiee Valashedi, Amaneh Mohammadi Roushandeh, Kazuo Tomita, Yoshikazu Kuwahara, Zahra Pourmohammadi-Bejarpasi, Pouya Safarzadeh Kozani, Tomoaki Sato, Mehryar Habibi Roudkenar. CRISPR/Cas9-mediated knockout of Lcn2 in human breast cancer cell line MDA-MB-231 ameliorates erastin-mediated ferroptosis and increases cisplatin vulnerability.
Life sciences.
2022 Sep; 304(?):120704. doi:
10.1016/j.lfs.2022.120704. [PMID: 35714703] - Hongge Wang, Pan Wang, Bao Ting Zhu. Mechanism of Erastin-Induced Ferroptosis in MDA-MB-231 Human Breast Cancer Cells: Evidence for a Critical Role of Protein Disulfide Isomerase.
Molecular and cellular biology.
2022 06; 42(6):e0052221. doi:
10.1128/mcb.00522-21. [PMID: 35499331] - Lv Yang, Tang WenTao, Zhang ZhiYuan, Lin Qi, Luo YuXiang, Zheng Peng, Li Ke, Jia XiaoNa, Pang YuZhi, Ji MeiLing, Feng QingYang, He GuoDong, Wang YueXiang, Xu JianMin. Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by MDM2 inhibition in colorectal cancer.
Oncogene.
2022 06; 41(23):3210-3221. doi:
10.1038/s41388-022-02284-z. [PMID: 35505093] - Ziming Xia, Yongzhong Li, Ruihong Li, Xuanhui He, Li Chen, Bin Li, Shijun Liu, Guangjie Zhang, Junxing Dong, Min Li, Ying Tian. Supercritical CO2 extraction of fermented soybean lipids against erastin-induced ferroptosis in rat pheochromocytoma cells.
Food chemistry.
2022 May; 377(?):132051. doi:
10.1016/j.foodchem.2022.132051. [PMID: 35008017] - Saurabh Joshi, Saloni Agarwal, Apurva Panjla, Suresh Valiyaveettil, Subramaniam Ganesh, Sandeep Verma. Inhibiting Erastin-Induced Ferroptotic Cell Death by Purine-Based Chelators.
Chembiochem : a European journal of chemical biology.
2022 05; 23(9):e202100654. doi:
10.1002/cbic.202100654. [PMID: 35188704] - Shuo Li, Wenhui Xu, Huajing Wang, Tian Tang, Ji Ma, Zhao Cui, Hang Shi, Ting Qin, Hongying Zhou, Lanfang Li, Tingliang Jiang, Canghai Li. Ferroptosis plays an essential role in the antimalarial mechanism of low-dose dihydroartemisinin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Apr; 148(?):112742. doi:
10.1016/j.biopha.2022.112742. [PMID: 35228063] - Kai Sun, Wenhao Ren, Shaoming Li, Jingjing Zheng, Yichuan Huang, Keqian Zhi, Ling Gao. MiR-34c-3p upregulates erastin-induced ferroptosis to inhibit proliferation in oral squamous cell carcinomas by targeting SLC7A11.
Pathology, research and practice.
2022 Mar; 231(?):153778. doi:
10.1016/j.prp.2022.153778. [PMID: 35093695] - Cong Chen, Bojian Xie, Zhaoqing Li, Lini Chen, Yongxia Chen, Jichun Zhou, Siwei Ju, Yulu Zhou, Xun Zhang, Wenying Zhuo, Jingjing Yang, Misha Mao, Ling Xu, Linbo Wang. Fascin enhances the vulnerability of breast cancer to erastin-induced ferroptosis.
Cell death & disease.
2022 02; 13(2):150. doi:
10.1038/s41419-022-04579-1. [PMID: 35165254] - Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Alexia Belavgeni, Wulf Tonnus, Claudia Meyer, Kristina Beer, Monica T Hannani, Arthur Lau, Mirko Peitzsch, Paul Hoppenz, Sophie Locke, Triantafyllos Chavakis, Rafael Kramann, Daniel A Muruve, Christian Hugo, Stefan R Bornstein, Andreas Linkermann. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion.
Science advances.
2022 02; 8(5):eabl8920. doi:
10.1126/sciadv.abl8920. [PMID: 35108055] - Jia Xia, Xiaoying Song, Jing Meng, Danfei Lou. Endothelial progenitor cells-derived exosomes transfer microRNA-30e-5p to regulate Erastin-induced ferroptosis in human umbilical vein endothelial cells via the specificity protein 1/adenosine monophosphate-activated protein kinase axis.
Bioengineered.
2022 02; 13(2):3566-3580. doi:
10.1080/21655979.2022.2025519. [PMID: 35068337] - Wang Yangyun, Shi Guowei, Shi Shufen, Yao Jie, Yu Rui, Ren Yu. Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma.
Gene.
2022 Jan; 809(?):145992. doi:
10.1016/j.gene.2021.145992. [PMID: 34648917] - Chao Xu, Su Ni, Nanwei Xu, Guangrong Yin, Yunyuan Yu, Baojun Zhou, Gongyin Zhao, Liangliang Wang, Ruixia Zhu, Shijie Jiang, Yuji Wang. Theaflavin-3,3'-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis.
Oxidative medicine and cellular longevity.
2022; 2022(?):3531995. doi:
10.1155/2022/3531995. [PMID: 36439689] - Deng Guan, Wei Zhou, Huiping Wei, Ting Wang, Kangwei Zheng, Chunjie Yang, Rui Feng, Ruifang Xu, Yun Fu, Cuiping Li, Yongli Li, Changzheng Li. Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester.
Oxidative medicine and cellular longevity.
2022; 2022(?):3920664. doi:
10.1155/2022/3920664. [PMID: 35237380] - Meiling Yu, Zhuoheng Lin, Xiaoxue Tian, Shiyu Chen, Xinling Liang, Min Qin, Qian Zhu, Yuanyuan Wu, Shilong Zhong. Downregulation of Cx43 reduces cisplatin-induced acute renal injury by inhibiting ferroptosis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Dec; 158(?):112672. doi:
10.1016/j.fct.2021.112672. [PMID: 34785303] - Zhongyuan Bao, Lingyang Hua, Yangfan Ye, Daijun Wang, Chong Li, Qing Xie, Hiroaki Wakimoto, Ye Gong, Jing Ji. MEF2C silencing downregulates NF2 and E-cadherin and enhances Erastin-induced ferroptosis in meningioma.
Neuro-oncology.
2021 12; 23(12):2014-2027. doi:
10.1093/neuonc/noab114. [PMID: 33984142] - Xiaoqin Zhang, Linda Xiaoyan Li, Hao Ding, Vicente E Torres, Chen Yu, Xiaogang Li. Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models.
Journal of the American Society of Nephrology : JASN.
2021 11; 32(11):2759-2776. doi:
10.1681/asn.2021040460. [PMID: 34716241] - Lena Hoffmann, Marcel S Waclawczyk, Stephan Tang, Eva-Maria Hanschmann, Manuela Gellert, Marco B Rust, Carsten Culmsee. Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death.
Cell death & disease.
2021 10; 12(11):953. doi:
10.1038/s41419-021-04242-1. [PMID: 34657120] - Jing Zhao, Ben Xu, Qingqing Xiong, Yunfei Feng, Huahua Du. Erastin‑induced ferroptosis causes physiological and pathological changes in healthy tissues of mice.
Molecular medicine reports.
2021 Oct; 24(4):. doi:
10.3892/mmr.2021.12352. [PMID: 34396451] - Yanchun Li, Xin Wang, Zhihui Huang, Yi Zhou, Jun Xia, Wanye Hu, Xu Wang, Jing Du, Xiangmin Tong, Ying Wang. CISD3 inhibition drives cystine-deprivation induced ferroptosis.
Cell death & disease.
2021 09; 12(9):839. doi:
10.1038/s41419-021-04128-2. [PMID: 34497268] - Wen-Juan Wang, Xia Jiang, Chang-Chun Gao, Zhi-Wei Chen. Salusin‑β participates in high glucose‑induced HK‑2 cell ferroptosis in a Nrf‑2‑dependent manner.
Molecular medicine reports.
2021 Sep; 24(3):. doi:
10.3892/mmr.2021.12313. [PMID: 34296310] - Jing Wang, Tao Wang, Yang Zhang, Jiaqi Liu, Jie Song, Yanlong Han, Lihong Wang, Shuang Yang, Lili Zhu, Rui Geng, Weimin Li, Xiaoguang Yu. CPEB1 enhances erastin-induced ferroptosis in gastric cancer cells by suppressing twist1 expression.
IUBMB life.
2021 09; 73(9):1180-1190. doi:
10.1002/iub.2525. [PMID: 34184391] - Ruiqing Lu, Yinan Jiang, Xianxin Lai, Shujie Liu, Litao Sun, Zhong-Wei Zhou. A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168898. [PMID: 34445601] - Pranavi Koppula, Li Zhuang, Boyi Gan. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Protein & cell.
2021 08; 12(8):599-620. doi:
10.1007/s13238-020-00789-5. [PMID: 33000412] - Seiya Nagai, Masaki Yoshida, Yuta Takigawa, Seiji Torii, Ichiro Koshiishi. Botanical sulfane sulfur donors inhibit ferroptotic cell death caused by the depletion of cysteine.
Food chemistry.
2021 May; 343(?):128511. doi:
10.1016/j.foodchem.2020.128511. [PMID: 33168263] - Rui Wang, Qi Su, Hongzhuan Yin, Di Wu, Chi Lv, Zhaopeng Yan. Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression.
The international journal of biochemistry & cell biology.
2021 05; 134(?):105948. doi:
10.1016/j.biocel.2021.105948. [PMID: 33609745] - Xin Chen, Rui Kang, Guido Kroemer, Daolin Tang. Broadening horizons: the role of ferroptosis in cancer.
Nature reviews. Clinical oncology.
2021 05; 18(5):280-296. doi:
10.1038/s41571-020-00462-0. [PMID: 33514910] - Yanrong Yang, Taiyuan Liu, Cheng Hu, Hongyan Xia, Wei Liu, Junyu Chen, Shan Wu, Yu Jiang, Yang Xu, Wanxia Liu, Lijing Zhao. Ferroptosis inducer erastin downregulates androgen receptor and its splice variants in castration‑resistant prostate cancer.
Oncology reports.
2021 04; 45(4):. doi:
10.3892/or.2021.7976. [PMID: 33649848] - Shazhou Ye, Mingjun Xu, Tingwei Zhu, Jiayi Chen, Shanping Shi, Haizhong Jiang, Qingfang Zheng, Qi Liao, Xiaoyun Ding, Yang Xi. Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells.
Journal of cellular and molecular medicine.
2021 04; 25(7):3300-3311. doi:
10.1111/jcmm.16400. [PMID: 33611811] - Yajie Li, Xinliu Zeng, Dingheng Lu, Minuo Yin, Meirong Shan, Ying Gao. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis.
Human reproduction (Oxford, England).
2021 03; 36(4):951-964. doi:
10.1093/humrep/deaa363. [PMID: 33378529] - Ali Ghoochani, En-Chi Hsu, Merve Aslan, Meghan A Rice, Holly M Nguyen, James D Brooks, Eva Corey, Ramasamy Paulmurugan, Tanya Stoyanova. Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer.
Cancer research.
2021 03; 81(6):1583-1594. doi:
10.1158/0008-5472.can-20-3477. [PMID: 33483372] - Lulu Sun, Hongliang Dong, Weiqun Zhang, Nan Wang, Na Ni, Xuelian Bai, Naiguo Liu. Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition Are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms.
DNA and cell biology.
2021 Feb; 40(2):172-183. doi:
10.1089/dna.2020.5730. [PMID: 33351681] - Magdalena Gryzik, Michela Asperti, Andrea Denardo, Paolo Arosio, Maura Poli. NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells.
Biochimica et biophysica acta. Molecular cell research.
2021 02; 1868(2):118913. doi:
10.1016/j.bbamcr.2020.118913. [PMID: 33245979] - Bo Yan, Youwei Ai, Qi Sun, Yan Ma, Yang Cao, Jiawen Wang, Zhiyuan Zhang, Xiaodong Wang. Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.
Molecular cell.
2021 01; 81(2):355-369.e10. doi:
10.1016/j.molcel.2020.11.024. [PMID: 33321093] - Jianbing Du, Zhuo Wan, Cong Wang, Fan Lu, Mengying Wei, Desheng Wang, Qiang Hao. Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy.
Theranostics.
2021; 11(17):8185-8196. doi:
10.7150/thno.59121. [PMID: 34373736] - Ruiran Wei, Yueqin Zhao, Juan Wang, Xu Yang, Shunlin Li, Yinyuan Wang, Xingzhi Yang, Jimin Fei, Xiaojiang Hao, Yuhan Zhao, Liming Gui, Xiao Ding. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells.
International journal of biological sciences.
2021; 17(11):2703-2717. doi:
10.7150/ijbs.59404. [PMID: 34345202] - Mariluz Soula, Ross A Weber, Omkar Zilka, Hanan Alwaseem, Konnor La, Frederick Yen, Henrik Molina, Javier Garcia-Bermudez, Derek A Pratt, Kıvanç Birsoy. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers.
Nature chemical biology.
2020 12; 16(12):1351-1360. doi:
10.1038/s41589-020-0613-y. [PMID: 32778843] - Jingjing Liu, Hui He, Jing Wang, Xiaoping Guo, Hongkun Lin, Huimin Chen, Chunjie Jiang, Li Chen, Ping Yao, Yuhan Tang. Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis.
Toxicology.
2020 12; 445(?):152584. doi:
10.1016/j.tox.2020.152584. [PMID: 33017621] - Zixuan Liu, Xuying Lv, Erqun Song, Yang Song. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis.
Toxicology and applied pharmacology.
2020 11; 407(?):115241. doi:
10.1016/j.taap.2020.115241. [PMID: 32937103] - Yanping Wu, Haixia Chen, Nanxia Xuan, Lingren Zhou, Yinfang Wu, Chen Zhu, Miao Li, Qingyu Weng, Jiaxin Shen, Hao Zhang, Bin Zhang, Fen Lan, Lixia Xia, Xuefang Xiong, Zhouyang Li, Yun Zhao, Mindan Wu, Songmin Ying, Wen Li, Huahao Shen, Zhihua Chen. Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation.
Thorax.
2020 11; 75(11):918-927. doi:
10.1136/thoraxjnl-2020-214764. [PMID: 32759385] - Yingwei Sun, Rongrong Deng, Cuiwei Zhang. Erastin induces apoptotic and ferroptotic cell death by inducing ROS accumulation by causing mitochondrial dysfunction in gastric cancer cell HGC‑27.
Molecular medicine reports.
2020 10; 22(4):2826-2832. doi:
10.3892/mmr.2020.11376. [PMID: 32945484] - Xinghan Wu, Chuanliang Liu, Zihaoran Li, Chengcheng Gai, Dejun Ding, Weijuan Chen, Fengyun Hao, Wentong Li. Regulation of GSK3β/Nrf2 signaling pathway modulated erastin-induced ferroptosis in breast cancer.
Molecular and cellular biochemistry.
2020 Oct; 473(1-2):217-228. doi:
10.1007/s11010-020-03821-8. [PMID: 32642794] - Chengcheng Gai, Chuanliang Liu, Xinghan Wu, Mengyu Yu, Jie Zheng, Weifen Zhang, Shijun Lv, Wentong Li. MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells.
Cell death & disease.
2020 09; 11(9):751. doi:
10.1038/s41419-020-02939-3. [PMID: 32929075] - Shuai Hu, Mario Sechi, Pankaj Kumar Singh, Lipeng Dai, Sean McCann, Duxin Sun, Mats Ljungman, Nouri Neamati. A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species.
Journal of medicinal chemistry.
2020 09; 63(17):9838-9855. doi:
10.1021/acs.jmedchem.0c01016. [PMID: 32809827] - Huimin Mao, Yunhe Zhao, Houxuan Li, Lang Lei. Ferroptosis as an emerging target in inflammatory diseases.
Progress in biophysics and molecular biology.
2020 09; 155(?):20-28. doi:
10.1016/j.pbiomolbio.2020.04.001. [PMID: 32311424] - Tomonori Hoshino, Hodaka Yamakado, Ryosuke Takahashi, Shu-Ichi Matsuzawa. Susceptibility to erastin-induced ferroptosis decreases during maturation in a human oligodendrocyte cell line.
FEBS open bio.
2020 09; 10(9):1758-1764. doi:
10.1002/2211-5463.12923. [PMID: 32608563] - Yuxue Shang, Meiying Luo, Fengping Yao, Shukun Wang, Zengqiang Yuan, Yongfei Yang. Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells.
Cellular signalling.
2020 08; 72(?):109633. doi:
10.1016/j.cellsig.2020.109633. [PMID: 32283255] - Martina Maria Capelletti, Hana Manceau, Hervé Puy, Katell Peoc'h. Ferroptosis in Liver Diseases: An Overview.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21144908. [PMID: 32664576] - Lingrong Wen, Dingding Shi, Ting Zhou, Jiaming Tu, Mingyang He, Yueming Jiang, Bao Yang. Identification of two novel prenylated flavonoids in mulberry leaf and their bioactivities.
Food chemistry.
2020 Jun; 315(?):126236. doi:
10.1016/j.foodchem.2020.126236. [PMID: 32000079] - Liang Chen, Linlin Qiao, Yue Bian, Xiuju Sun. GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression.
Biochemical and biophysical research communications.
2020 05; 526(2):293-299. doi:
10.1016/j.bbrc.2020.03.079. [PMID: 32209255] - Hyunjin Kim, Jin Hyup Lee, Jeen-Woo Park. Down-regulation of IDH2 sensitizes cancer cells to erastin-induced ferroptosis.
Biochemical and biophysical research communications.
2020 04; 525(2):366-371. doi:
10.1016/j.bbrc.2020.02.093. [PMID: 32089268] - Chengcheng Gai, Mengyu Yu, Zihaoran Li, Yonghong Wang, Dejun Ding, Jie Zheng, Shijun Lv, Weifen Zhang, Wentong Li. Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer.
Journal of cellular physiology.
2020 04; 235(4):3329-3339. doi:
10.1002/jcp.29221. [PMID: 31541463] - Yishu Wang, Yao Zhao, Haihua Wang, Chengliang Zhang, Meiqi Wang, Yong Yang, Xin Xu, Zhenbo Hu. Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11.
FEBS open bio.
2020 04; 10(4):637-643. doi:
10.1002/2211-5463.12823. [PMID: 32107878] - Ji Cao, Xiaobing Chen, Li Jiang, Bin Lu, Meng Yuan, Difeng Zhu, Hong Zhu, Qiaojun He, Bo Yang, Meidan Ying. DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase.
Nature communications.
2020 03; 11(1):1251. doi:
10.1038/s41467-020-15109-y. [PMID: 32144268] - Po-Han Chen, Jianli Wu, Chien-Kuang Cornelia Ding, Chao-Chieh Lin, Samuel Pan, Nathan Bossa, Yitong Xu, Wen-Hsuan Yang, Bernard Mathey-Prevot, Jen-Tsan Chi. Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism.
Cell death and differentiation.
2020 03; 27(3):1008-1022. doi:
10.1038/s41418-019-0393-7. [PMID: 31320750] - Hai Wang, Can Liu, Yongxin Zhao, Wenling Zhang, Keqian Xu, Dai Li, Yong Zhou, Hao Li, Guishan Xiao, Bin Lu, Ge Gao. Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells.
Biochemical and biophysical research communications.
2020 02; 522(4):1063-1068. doi:
10.1016/j.bbrc.2019.11.187. [PMID: 31822343] - Hyemin Lee, Fereshteh Zandkarimi, Yilei Zhang, Jitendra Kumar Meena, Jongchan Kim, Li Zhuang, Siddhartha Tyagi, Li Ma, Thomas F Westbrook, Gregory R Steinberg, Daisuke Nakada, Brent R Stockwell, Boyi Gan. Energy-stress-mediated AMPK activation inhibits ferroptosis.
Nature cell biology.
2020 02; 22(2):225-234. doi:
10.1038/s41556-020-0461-8. [PMID: 32029897] - Liyuan Wang, Yichen Liu, Tingting Du, Heng Yang, Lei Lei, Mengqi Guo, Han-Fei Ding, Junran Zhang, Hongbo Wang, Xiaoguang Chen, Chunhong Yan. ATF3 promotes erastin-induced ferroptosis by suppressing system Xc.
Cell death and differentiation.
2020 02; 27(2):662-675. doi:
10.1038/s41418-019-0380-z. [PMID: 31273299] - Zhaoxin Hu, Hao Zhang, Bin Yi, Shikun Yang, Jun Liu, Jing Hu, Jianwen Wang, Ke Cao, Wei Zhang. VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis.
Cell death & disease.
2020 01; 11(1):73. doi:
10.1038/s41419-020-2256-z. [PMID: 31996668] - Yongfei Yang, Meiying Luo, Kexin Zhang, Jun Zhang, Tongtong Gao, Douglas O' Connell, Fengping Yao, Changwen Mu, Bingyu Cai, Yuxue Shang, Wei Chen. Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.
Nature communications.
2020 01; 11(1):433. doi:
10.1038/s41467-020-14324-x. [PMID: 31974380]
