trans-Dodec-2-enoic acid (BioDeep_00000013907)

 

Secondary id: BioDeep_00001869179

human metabolite Endogenous


代谢物信息卡片


trans-Dodec-2-enoic acid

化学式: C12H22O2 (198.1619712)
中文名称: 顺-2-十二碳烯酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCC=CC(=O)O
InChI: InChI=1S/C12H22O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h10-11H,2-9H2,1H3,(H,13,14)/b11-10+

描述信息

In humans fatty acids are predominantly formed in the liver and adipose tissue, and mammary glands during lactation. trans-Dodec-2-enoic acid is an intermediate in fatty acid biosynthesis. Specifically, trans-Dodec-2-enoic acid is converted from (R)-3-Hydroxydodecanoic acid via two enzymes; fatty-acid Synthase and 3-Hydroxypalmitoyl- [acyl-carrier-protein] dehydratase (EC: 2.3.1.85 and EC: 4.2.1.61) [HMDB]
In humans fatty acids are predominantly formed in the liver and adipose tissue, and mammary glands during lactation. trans-Dodec-2-enoic acid is an intermediate in fatty acid biosynthesis. Specifically, trans-Dodec-2-enoic acid is converted from (R)-3-Hydroxydodecanoic acid via two enzymes; fatty-acid Synthase and 3-Hydroxypalmitoyl- [acyl-carrier-protein] dehydratase (EC: 2.3.1.85 and EC: 4.2.1.61).

同义名列表

17 个代谢物同义名

trans-Dodec-2-enoic acid; TRANS-2-DODECENOIC ACID; (2E)-dodec-2-enoic acid; (Z)-dodec-2-enoic acid; trans-2-Lauroleic acid; cis-2-Dodecenoic acid; (e)-2-Dodecenoic acid; trans-Dodec-2-enoate; Dodecen-(2t)-saeure; trans-2-Lauroleate; 2-dodecenoic acid; (e)-2-Dodecenoate; C12:1, N-10 trans; 2t-Dodecensaeure; 2-lauroleic acid; 12:1, N-10 trans; 2-Lauroleate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xia Li, Shihao Song, Xiaohan Kong, Xiayu Chen, Zhuoxian Zhao, Zizi Lin, Yantao Jia, Yong Zhang, Hai-Bin Luo, Qiao-Ping Wang, Lian-Hui Zhang, Wei Qian, Yinyue Deng. Regulation of Burkholderia cenocepacia virulence by the fatty acyl-CoA ligase DsfR as a response regulator of quorum sensing signal. Cell reports. 2024 May; 43(5):114223. doi: 10.1016/j.celrep.2024.114223. [PMID: 38748879]
  • Yilei Liu, Gabriella Pessi, Katharina Riedel, Leo Eberl. Identification of AHL- and BDSF-Controlled Proteins in Burkholderia cenocepacia by Proteomics. Methods in molecular biology (Clifton, N.J.). 2018; 1673(?):193-202. doi: 10.1007/978-1-4939-7309-5_15. [PMID: 29130174]
  • Chunxi Yang, Chaoyu Cui, Qiumian Ye, Jinhong Kan, Shuna Fu, Shihao Song, Yutong Huang, Fei He, Lian-Hui Zhang, Yantao Jia, Yong-Gui Gao, Caroline S Harwood, Yinyue Deng. Burkholderia cenocepacia integrates cis-2-dodecenoic acid and cyclic dimeric guanosine monophosphate signals to control virulence. Proceedings of the National Academy of Sciences of the United States of America. 2017 12; 114(49):13006-13011. doi: 10.1073/pnas.1709048114. [PMID: 29158389]
  • Nadine Schmid, Angela Suppiger, Elisabeth Steiner, Gabriella Pessi, Volkhard Kaever, Mustafa Fazli, Tim Tolker-Nielsen, Urs Jenal, Leo Eberl. High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111. Microbiology (Reading, England). 2017 05; 163(5):754-764. doi: 10.1099/mic.0.000452. [PMID: 28463102]
  • N Nasiri, H Shamkhani, Z Ghelichpour, M A Mohammadi, A Sonboli. Essential oil constituents of the aerial parts and root of Cymbocarpum anethoides (Apiaceae) from Iran. Natural product research. 2017 Apr; 31(8):980-983. doi: 10.1080/14786419.2016.1255884. [PMID: 27834096]
  • Yvonne McCarthy, Liang Yang, Kate B Twomey, Andrea Sass, Tim Tolker-Nielsen, Eshwar Mahenthiralingam, J Maxwell Dow, Robert P Ryan. A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia. Molecular microbiology. 2010 Sep; 77(5):1220-36. doi: 10.1111/j.1365-2958.2010.07285.x. [PMID: 20624216]