Alamandine (BioDeep_00000013773)
代谢物信息卡片
化学式: C40H62N12O9 (854.4762)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 100%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)N
InChI: InChI=1S/C40H62N12O9/c1-6-22(4)32(37(58)49-29(18-25-19-44-20-46-25)38(59)52-16-8-10-30(52)39(60)61)51-35(56)28(17-24-11-13-26(53)14-12-24)48-36(57)31(21(2)3)50-34(55)27(47-33(54)23(5)41)9-7-15-45-40(42)43/h11-14,19-23,27-32,53H,6-10,15-18,41H2,1-5H3,(H,44,46)(H,47,54)(H,48,57)(H,49,58)(H,50,55)(H,51,56)(H,60,61)(H4,42,43,45)/t22-,23-,27-,28-,29-,30-,31-,32-/m0/s1
描述信息
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2].
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2].
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:190281
- KEGG: C20971
- PubChem: 44192273
- CAS: 1176306-10-7
- PMhub: MS000028310
- PubChem: 254741430
- medchemexpress: HY-P3108
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Wei Ding, Zhengyue Miao, Xiaoke Feng, Aishu Luo, Wenfeng Tan, Peng Li, Fang Wang. Alamandine, a new member of the renin-angiotensin system (RAS), attenuates collagen-induced arthritis in mice via inhibiting cytokine secretion in synovial fibroblasts.
Peptides.
2022 08; 154(?):170816. doi:
10.1016/j.peptides.2022.170816. [PMID: 35609788] - Wei Hu, Wenchuang Gao, Jiayi Miao, Ziheng Xu, Lei Sun. Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways.
Peptides.
2021 12; 146(?):170627. doi:
10.1016/j.peptides.2021.170627. [PMID: 34400214] - Jue Zhu, Jian-Guo Qiu, Wei-Tao Xu, Hong-Xiang Ma, Ke Jiang. Alamandine protects against renal ischaemia-reperfusion injury in rats via inhibiting oxidative stress.
The Journal of pharmacy and pharmacology.
2021 Oct; 73(11):1491-1502. doi:
10.1093/jpp/rgab091. [PMID: 34244746] - Fernanda Ribeiro Marins, Aline Cristina Oliveira, Fatimunnisa Qadri, Daisy Motta-Santos, Natalia Alenina, Michael Bader, Marco Antonio Peliky Fontes, Robson Augusto Souza Santos. Alamandine but not angiotensin-(1-7) produces cardiovascular effects at the rostral insular cortex.
American journal of physiology. Regulatory, integrative and comparative physiology.
2021 09; 321(3):R513-R521. doi:
10.1152/ajpregu.00308.2020. [PMID: 34346721] - Ava Soltani Hekmat, Ameneh Chenari, Hiva Alipanah, Kazem Javanmardi. Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats.
BMC pharmacology & toxicology.
2021 05; 22(1):31. doi:
10.1186/s40360-021-00494-x. [PMID: 34049594] - Renata Streck Fernandes, Henrique Bregolin Dias, Wynnie Amaral de Souza Jaques, Tiago Becker, Katya Rigatto. Assessment of Alamandine in Pulmonary Fibrosis and Respiratory Mechanics in Rodents.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2021; 2021(?):9975315. doi:
10.1155/2021/9975315. [PMID: 34285714] - Ava Soltani Hekmat, Kazem Javanmardi. Alamandine: Potential Protective Effects in SARS-CoV-2 Patients.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2021; 2021(?):6824259. doi:
10.1155/2021/6824259. [PMID: 34853605] - Thiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos. ACE2 in the renin-angiotensin system.
Clinical science (London, England : 1979).
2020 12; 134(23):3063-3078. doi:
10.1042/cs20200478. [PMID: 33264412] - Juexiao Gong, Yihui Shen, Peng Li, Kun Zhao, Xuguan Chen, Yong Li, Yanhui Sheng, Bin Zhou, Xiangqing Kong. Superoxide anions mediate the effects of angiotensin (1-7) analog, alamandine, on blood pressure and sympathetic activity in the paraventricular nucleus.
Peptides.
2019 08; 118(?):170101. doi:
10.1016/j.peptides.2019.170101. [PMID: 31199949] - Ava Soltani Hekmat, Nahid Zare, Ali Moravej, Mohammad Hassan Meshkibaf, Kazem Javanmardi. Effect of Prolonged Infusion of Alamandine on Cardiovascular Parameters and Cardiac ACE2 Expression in a Rat Model of Renovascular Hypertension.
Biological & pharmaceutical bulletin.
2019 Jun; 42(6):960-967. doi:
10.1248/bpb.b18-00985. [PMID: 30956259] - Byung Mun Park, Hoang Thi Ai Phuong, Lamei Yu, Suhn Hee Kim. Alamandine Protects the Heart Against Reperfusion Injury via the MrgD Receptor.
Circulation journal : official journal of the Japanese Circulation Society.
2018 09; 82(10):2584-2593. doi:
10.1253/circj.cj-17-1381. [PMID: 29998915] - Michaila Michalatou, Maria Eleni Androutsou, Markos Antonopoulos, Demetrios V Vlahakos, George Agelis, Anthony Zulli, Tawar Qaradakhi, Kathleen Mikkelsen, Vasso Apostolopoulos, John Matsoukas. Transdermal Delivery of AT1 Receptor Antagonists Reduce Blood Pressure and Reveal a Vasodilatory Effect on Kidney Blood Vessels.
Current molecular pharmacology.
2018; 11(3):226-236. doi:
10.2174/1874467211666180419152036. [PMID: 29676239] - Ava Soltani Hekmat, Kazem Javanmardi, Amin Kouhpayeh, Ehsan Baharamali, Mojtaba Farjam. Differences in Cardiovascular Responses to Alamandine in Two-Kidney, One Clip Hypertensive and Normotensive Rats.
Circulation journal : official journal of the Japanese Circulation Society.
2017 Feb; 81(3):405-412. doi:
10.1253/circj.cj-16-0958. [PMID: 28070059] - Analina R Da Silva, Sébastien Lenglet, Federico Carbone, Fabienne Burger, Aline Roth, Luca Liberale, Aldo Bonaventura, Franco Dallegri, Nikolaos Stergiopulos, Robson A S Santos, François Mach, Rodrigo A Fraga-Silva, Fabrizio Montecucco. Alamandine abrogates neutrophil degranulation in atherosclerotic mice.
European journal of clinical investigation.
2017 Feb; 47(2):117-128. doi:
10.1111/eci.12708. [PMID: 27930810] - Ana Cristina Simões E Silva, Mauro Martins Teixeira. ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosis.
Pharmacological research.
2016 05; 107(?):154-162. doi:
10.1016/j.phrs.2016.03.018. [PMID: 26995300] - Evelyn Mendoza-Torres, Alejandra Oyarzún, David Mondaca-Ruff, Andrés Azocar, Pablo F Castro, Jorge E Jalil, Mario Chiong, Sergio Lavandero, María Paz Ocaranza. ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension.
Therapeutic advances in cardiovascular disease.
2015 Aug; 9(4):217-37. doi:
10.1177/1753944715597623. [PMID: 26275770]
