Tabtoxin (BioDeep_00000013730)

   


代谢物信息卡片


Tabtoxin

化学式: C11H19N3O6 (289.1274)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 34.24%

分子结构信息

SMILES: CC(C(C(=O)O)NC(=O)C(CCC1(CNC1=O)O)N)O
InChI: InChI=1S/C11H19N3O6/c1-5(15)7(9(17)18)14-8(16)6(12)2-3-11(20)4-13-10(11)19/h5-7,15,20H,2-4,12H2,1H3,(H,13,19)(H,14,16)(H,17,18)/t5-,6+,7+,11+/m1/s1

描述信息

A monobactam phytotoxic dipeptide produced by Pseudomonas syringae, that causes wildfire disease in tobacco.

同义名列表

1 个代谢物同义名

Tabtoxin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jiaqi Lyu, Richiro Ushimaru, Ikuro Abe. Characterization of Enzymes Catalyzing the Initial Steps of the β-Lactam Tabtoxin Biosynthesis. Organic letters. 2022 05; 24(18):3337-3341. doi: 10.1021/acs.orglett.2c00878. [PMID: 35510837]
  • M E Carezzano, J P Sotelo, E Primo, E B Reinoso, M F Paletti Rovey, M S Demo, W F Giordano, M de Las M Oliva. Inhibitory effect of Thymus vulgaris and Origanum vulgare essential oils on virulence factors of phytopathogenic Pseudomonas syringae strains. Plant biology (Stuttgart, Germany). 2017 Jul; 19(4):599-607. doi: 10.1111/plb.12572. [PMID: 28403565]
  • Timothy A Wencewicz, Christopher T Walsh. Pseudomonas syringae self-protection from tabtoxinine-β-lactam by ligase TblF and acetylase Ttr. Biochemistry. 2012 Oct; 51(39):7712-25. doi: 10.1021/bi3011384. [PMID: 22994681]
  • Hye Suk Kong, Daniel P Roberts, Cheryl D Patterson, Sarah A Kuehne, Stephan Heeb, Dilip K Lakshman, John Lydon. Effect of overexpressing rsmA from Pseudomonas aeruginosa on virulence of select phytotoxin-producing strains of P. syringae. Phytopathology. 2012 Jun; 102(6):575-87. doi: 10.1094/phyto-09-11-0267. [PMID: 22568815]
  • Eva Arrebola, Víctor J Carrión, Francisco M Cazorla, Alejandro Pérez-García, Jesús Murillo, Antonio de Vicente. Characterisation of the mgo operon in Pseudomonas syringae pv. syringae UMAF0158 that is required for mangotoxin production. BMC microbiology. 2012 Jan; 12(?):10. doi: 10.1186/1471-2180-12-10. [PMID: 22251433]
  • Eva Arrebola, Francisco M Cazorla, Alejandro Perez-García, Antonio de Vicente. Chemical and metabolic aspects of antimetabolite toxins produced by Pseudomonas syringae pathovars. Toxins. 2011 09; 3(9):1089-110. doi: 10.3390/toxins3091089. [PMID: 22069758]
  • David A Baltrus, Marc T Nishimura, Artur Romanchuk, Jeff H Chang, M Shahid Mukhtar, Karen Cherkis, Jeff Roach, Sarah R Grant, Corbin D Jones, Jeffery L Dangl. Dynamic evolution of pathogenicity revealed by sequencing and comparative genomics of 19 Pseudomonas syringae isolates. PLoS pathogens. 2011 Jul; 7(7):e1002132. doi: 10.1371/journal.ppat.1002132. [PMID: 21799664]
  • Mingsheng Qi, Dongping Wang, Carl A Bradley, Youfu Zhao. Genome sequence analyses of Pseudomonas savastanoi pv. glycinea and subtractive hybridization-based comparative genomics with nine pseudomonads. PloS one. 2011 Jan; 6(1):e16451. doi: 10.1371/journal.pone.0016451. [PMID: 21304594]
  • David J Studholme, Selena Gimenez Ibanez, Daniel MacLean, Jeffery L Dangl, Jeff H Chang, John P Rathjen. A draft genome sequence and functional screen reveals the repertoire of type III secreted proteins of Pseudomonas syringae pathovar tabaci 11528. BMC genomics. 2009 Aug; 10(?):395. doi: 10.1186/1471-2164-10-395. [PMID: 19703286]
  • Ji Young Cha, Jun Seung Lee, Jeong-Il Oh, Jang Won Choi, Hyung Suk Baik. Functional analysis of the role of Fur in the virulence of Pseudomonas syringae pv. tabaci 11528: Fur controls expression of genes involved in quorum-sensing. Biochemical and biophysical research communications. 2008 Feb; 366(2):281-7. doi: 10.1016/j.bbrc.2007.11.021. [PMID: 18023417]
  • Thomas G Kinscherf, David K Willis. The biosynthetic gene cluster for the beta-lactam antibiotic tabtoxin in Pseudomonas syringae. The Journal of antibiotics. 2005 Dec; 58(12):817-21. doi: 10.1038/ja.2005.109. [PMID: 16506699]
  • J Lydon, C D Patterson. Detection of tabtoxin-producing strains of Pseudomonas syringae by PCR. Letters in applied microbiology. 2001 Mar; 32(3):166-70. doi: 10.1046/j.1472-765x.2001.00882.x. [PMID: 11264746]
  • C L Bender, F Alarcón-Chaidez, D C Gross. Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases. Microbiology and molecular biology reviews : MMBR. 1999 Jun; 63(2):266-92. doi: 10.1128/mmbr.63.2.266-292.1999. [PMID: 10357851]
  • B K Scholz, J L Jakobek, P B Lindgren. Restriction fragment length polymorphism evidence for genetic homology within a pathovar of Pseudomonas syringae. Applied and environmental microbiology. 1994 Apr; 60(4):1093-1100. doi: 10.1128/aem.60.4.1093-1100.1994. [PMID: 7912500]
  • D K Willis, J J Rich, T G Kinscherf, T Kitten. Genetic regulation in plant pathogenic pseudomonads. Genetic engineering. 1994; 16(?):167-93. doi: ". [PMID: 7765196]
  • T M Barta, T G Kinscherf, T F Uchytil, D K Willis. DNA sequence and transcriptional analysis of the tblA gene required for tabtoxin biosynthesis by Pseudomonas syringae. Applied and environmental microbiology. 1993 Feb; 59(2):458-66. doi: 10.1128/aem.59.2.458-466.1993. [PMID: 7679566]
  • K Engst, P D Shaw. Identification of a lysA-like gene required for tabtoxin biosynthesis and pathogenicity in Pseudomonas syringae pv. tabaci strain PTBR2.024. Molecular plant-microbe interactions : MPMI. 1992 Jul; 5(4):322-9. doi: 10.1094/mpmi-5-322. [PMID: 1515668]
  • T M Barta, T G Kinscherf, D K Willis. Regulation of tabtoxin production by the lemA gene in Pseudomonas syringae. Journal of bacteriology. 1992 May; 174(9):3021-9. doi: 10.1128/jb.174.9.3021-3029.1992. [PMID: 1314808]
  • T G Kinscherf, R H Coleman, T M Barta, D K Willis. Cloning and expression of the tabtoxin biosynthetic region from Pseudomonas syringae. Journal of bacteriology. 1991 Jul; 173(13):4124-32. doi: 10.1128/jb.173.13.4124-4132.1991. [PMID: 1648077]
  • D L Palmquist. A kinetic concepto of lipid transport in ruminants. Journal of dairy science. 1976 Mar; 59(3):355-63. doi: 10.3168/jds.s0022-0302(76)84212-9. [PMID: 4477]