2-Chloropropanoic acid (BioDeep_00000013561)
Secondary id: BioDeep_00001868922
Volatile Flavor Compounds
代谢物信息卡片
化学式: C3H5ClO2 (107.99780600000001)
中文名称: (S)-(-)-2-氯代丙酸, (S)-2-氯丙酸, 2-氯丙酸, （S） -2-氯丙酸
谱图信息:
最多检出来源 Homo sapiens(blood) 4.17%
分子结构信息
SMILES: CC(C(=O)O)Cl
InChI: InChI=1S/C3H5ClO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:73956
- KEGG: C20608
- PubChem: 107915
- PubChem: 11734
- ChEMBL: CHEMBL1743205
- CAS: 28554-00-9
- CAS: 29617-66-1
- CAS: 598-78-7
- PMhub: MS000028047
- PubChem: 172232335
- PDB-CCD: CNR
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- E A Lock, A Gyte, S Duffell, I Wyatt. The absence of cerebellar granule cell necrosis in the mouse following L-2-chloropropionic acid administration.
Archives of toxicology.
2000 Nov; 74(9):547-54. doi:
10.1007/s002040000160. [PMID: 11131035] - P S Widdowson, A Gyte, R Upton, J Foster, C T Coutts, I Wyatt. Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis.
Toxicology and applied pharmacology.
1997 Feb; 142(2):248-55. doi:
10.1006/taap.1996.7940. [PMID: 9070346] - I Wyatt, M Farnworth, A J Gyte, E A Lock. L-2-Chloropropionic acid metabolism and disposition in male rats: relevance to cerebellar injury.
Archives of toxicology.
1997; 71(11):668-76. doi:
10.1007/s002040050443. [PMID: 9363839] - I Wyatt, A Gyte, M G Simpson, P S Widdowson, E A Lock. The role of glutathione in L-2-chloropropionic acid induced cerebellar granule cell necrosis in the rat.
Archives of toxicology.
1996; 70(11):724-35. doi:
10.1007/s002040050333. [PMID: 8896718] - I Wyatt, A Gyte, G Mainwaring, P S Widdowson, E A Lock. Glutathione depletion in the liver and brain produced by 2-chloropropionic acid: relevance to cerebellar granule cell necrosis.
Archives of toxicology.
1996; 70(6):380-9. doi:
10.1007/s002040050289. [PMID: 8975638] - E A Lock, A Gyte, P Widdowson, M Simpson, I Wyatt. Chloropropionic acid-induced alterations in glucose metabolic status: possible relevance to cerebellar granule cell necrosis.
Archives of toxicology.
1995; 69(9):640-3. doi:
10.1007/s002040050225. [PMID: 8660142] - B Mercier, P Granier, J Mercier, F Anselme, G Ribes, C Préfaut. Effects of 2-chloropropionate on venous plasma lactate concentration and anaerobic power during periods of incremental intensive exercise in humans.
European journal of applied physiology and occupational physiology.
1994; 68(5):425-9. doi:
10.1007/bf00843740. [PMID: 8076623] - G Ribes, G Valette, J M Dalstein, M M Loubatieres-Mariani. Effect of sodium 2-chloropropionate on glucagon secretion in the rat.
Diabetes.
1985 Jun; 34(6):536-40. doi:
10.2337/diab.34.6.536. [PMID: 4007281] - E A Yount, S Y Felten, B L O'Connor, R G Peterson, R S Powell, M N Yum, R A Harris. Comparison of the metabolic and toxic effects of 2-chloropropionate and dichloroacetate.
The Journal of pharmacology and experimental therapeutics.
1982 Aug; 222(2):501-8. doi:
. [PMID: 7097569] - G Ribes, G Valette, J F Valette, M M Loubatieres-Mariani. Effects of chronic administration of sodium 2 chloropropionate in normal and diabetic dogs.
Diabetes.
1982 Jun; 31(6 Pt 1):484-8. doi:
10.2337/diab.31.6.484. [PMID: 7152136] - D W Crabb, R A Harris. Mechanism responsible for the hypoglycemic actions of dichloroacetate and 2-chloropropionate.
Archives of biochemistry and biophysics.
1979 Nov; 198(1):145-52. doi:
10.1016/0003-9861(79)90405-3. [PMID: 507835]