2,5-Furandicarboxylic acid (BioDeep_00000013454)

 

Secondary id: BioDeep_00000405591, BioDeep_00000603888

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Furane-alpha,alpha-dicarboxylic acid

化学式: C6H4O5 (156.00587339999998)
中文名称: 2,5-呋喃二羧酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.8%

分子结构信息

SMILES: C1=C(OC(=C1)C(=O)O)C(=O)O
InChI: InChI=1S/C6H4O5/c7-5(8)3-1-2-4(11-3)6(9)10/h1-2H,(H,7,8)(H,9,10)

描述信息

2,5-Furandicarboxylic acid is a normal urinary metabolite in humans. (PMID:14708889, 8087979, 2338430, 3711221). Dietary studies show that the furan derivatives or their precursors are of exogenous origin. They are originated from furan derivatives found in food prepared by strong heating. This may explain the absence of 2,5-furandicarboxylic acid in urine of breastfed children, and the absence of these acids in the urine of rats, pigs, cows, oxs, rabbits, and monkeys (PMID 4630229). 2,5-Furandicarboxylic acid is also a microbial metabolite, a product of the oxidation of hydroxymethylfurfural (HMF) by the enzyme furfural/HMF oxidoreductase which is found in the bacterium Cupriavidus basilensis. Cupriavidus basilensis is a gram-negative soil bacterium of the genus Cupriavidus and the family Burkholderiaceae. 2,5-Furandicarboxylic acid increases with the level of fructose consumed (PMID:20194784).
2,5-Furandicarboxylic acid is a normal urinary metabolite in humans. (PMIDs 14708889, 8087979, 2338430, 3711221)
2,5-Furandicarboxylic acid, detected in human urine, is an important renewable biotechnological building block because it serves as an environmentally friendly substitute for terephthalic acid in the production of polyesters[1].

同义名列表

21 个代谢物同义名

Furane-alpha,alpha-dicarboxylic acid; Furane-alpha,alpha-dicarboxylate; Furane-a,alpha-dicarboxylic acid; Furane-α,alpha-dicarboxylic acid; Furane-α,alpha-dicarboxylate; (1,5-Dimethylhexyl)hydrazine; Furane-a,alpha-dicarboxylate; Furane-a,a-dicarboxylic acid; Furan-2,5-dicarboxylic acid; Furan 2,5-dicarboxylic acid; 2,5-Furandicarboxylic acid; Furane-a,a-dicarboxylate; Furan-2,5-dicarbonsaeure; Furan 2,5-dicarboxylate; Furan-2,5-dicarboxylate; 2,5-Furandicarboxylate; Dehydroschleimsaeure; 2,5-Dicarboxyfuran; Dehydromucic acid; Dehydromucate; FDCA CPD



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jae Bok Heo, Yong-Suk Lee, Chung-Han Chung. Marine plant-based biorefinery for sustainable 2,5-furandicarboxylic acid production: A review. Bioresource technology. 2023 Dec; 390(?):129817. doi: 10.1016/j.biortech.2023.129817. [PMID: 37839644]
  • Rajendran Omana Rajesh, Nalinakshan Sreevidya Shruthy, Santhamma Akhila, Tharangattumana Krishnan Godan, Nair R Dileep, Júlio César de Carvalho, Luciana Porto de Souza Vandenberghe, Carlos Ricardo Soccol, Raveendran Sindhu, Parameswaran Binod. Whole-cell synthesis of 2,5-furandicarboxylic acid from pineapple waste under various fermentation strategies. Bioresource technology. 2023 Jul; 386(?):129545. doi: 10.1016/j.biortech.2023.129545. [PMID: 37488015]
  • Grazia Totaro, Laura Sisti, Paola Marchese, Martino Colonna, Angela Romano, Claudio Gioia, Micaela Vannini, Annamaria Celli. Current Advances in the Sustainable Conversion of 5-Hydroxymethylfurfural into 2,5-Furandicarboxylic Acid. ChemSusChem. 2022 Jul; 15(13):e202200501. doi: 10.1002/cssc.202200501. [PMID: 35438242]
  • Jae Bok Heo, Yong-Suk Lee, Chung-Han Chung. Conversion of inulin-rich raw plant biomass to 2,5-furandicarboxylic acid (FDCA): Progress and challenge towards biorenewable plastics. Biotechnology advances. 2021 12; 53(?):107838. doi: 10.1016/j.biotechadv.2021.107838. [PMID: 34571195]
  • María Isabel Sánchez-Ruiz, Angel T Martínez, Ana Serrano. Optimizing operational parameters for the enzymatic production of furandicarboxylic acid building block. Microbial cell factories. 2021 Sep; 20(1):180. doi: 10.1186/s12934-021-01669-1. [PMID: 34503517]