Sumiki's acid (BioDeep_00000013452)

Secondary id: BioDeep_00000415950, BioDeep_00000860847

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite

代谢物信息卡片

5-(Hydroxymethyl)-2-furancarboxylic acid

化学式: C6H6O4 (142.0266076)
中文名称: 5-羟甲基-2-呋喃甲酸
谱图信息: 最多检出来源 Homo sapiens(blood) 1.63%

分子结构信息

SMILES: C1=C(OC(=C1)C(=O)O)CO
InChI: InChI=1S/C6H6O4/c7-3-4-1-2-5(10-4)6(8)9/h1-2,7H,3H2,(H,8,9)

描述信息

Sumikis acid is a naturally occurring human metabolite (PMID:949837). Sumikis acid was first identified in the urine of a leukemic patient who was excreting an abnormal amount of its glycine derivative (PMID:5043270). Sumikis acid was found to be excreted by normal subjects after a phenylalanine loading, while heterozygotes for phenylketonuria dont excrete it (instead, they excrete 2-hydroxybenzeneacetic acid) (PMID:4708049). Patients receiving furan-containing sugar solutions i.v. convert 50\\\\% of the 5-hydroxymethyl-2-furfural into Sumikis acid (PMID:4202014). Sumikis acid has been found to be a byproduct of the fungus Aspergillus and probably other species of fungi and yeast as well.
Sumikis acid is a naturally occurring human metabolite. (PMID: 949837) Sumikis acid was first identified in the urine of a leukemic patient who was excreting an abnormal amount of its glycine derivative. (PMID: 5043270)
5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural (HMF) in the body and eliminated renally.
5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural (HMF) in the body and eliminated renally.

同义名列表

24 个代谢物同义名

5-(Hydroxymethyl)-2-furancarboxylic acid; 5-(hydroxymethyl)furan-2-carboxylic acid; 2-(Hydroxymethyl)furan-5-carboxylic acid; 5-Hydroxymethyl-furan-2-carboxylic acid; 5-Hydroxymethyl-2-furancarboxylic acid; 5-Hydroxymethylfuran-2-carboxylic acid; 5-(Hydroxymethyl)- 2-furancarboxylate; 5-Hydroxymethyl-furan-2-carboxylate; 5-Hydroxymethyl-2-furancarboxylate; 5-Hydroxymethylfuran-2-carboxylate; 5-(Hydroxymethyl)-2-furoic acid; 5-Hydroxymethyl-2-furanoic acid; 5-Hydroxymethyl-2-furoic acid; 5-Hydroxymethylfuranoic acid; 5-(Hydroxymethyl)-2-furoate; 5-Hydroxymethyl-2-furanoate; 5-Hydroxymethylfuroic acid; 5-Hydroxymethyl-2-furoate; 5-Hydroxymethylfuranoate; 5-Hydroxymethylfuroate; Sumikis’ acid; HMFA compound; Sumiki’s acid; Sumikis acid

数据库引用编号

14 个数据库交叉引用编号

ChEBI: CHEBI:89118
KEGG: C20448
PubChem: 80642
HMDB: HMDB0002432
ChEMBL: CHEMBL468037
MetaCyc: CPD-14103
KNApSAcK: C00052414
foodb: FDB023004
chemspider: 72827
CAS: 6338-41-6
PMhub: MS000027916
PubChem: 163312185
RefMet: Sumiki's acid
medchemexpress: HY-W005241

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

29918 Cladosporium herbarum: 10.1021/NP000401S
186366 Wardomyces anomalus: 10.1021/NP020518B
5149 Chaetomium: 10.1016/J.TETLET.2008.08.064
99300 Rehmannia glutinosa: 10.1016/J.FOODCHEM.2013.07.026
29918 Cladosporium herbarum: 10.1021/NP000401S
186366 Wardomyces anomalus: 10.1021/NP020518B
5149 Chaetomium: 10.1016/J.TETLET.2008.08.064
99300 Rehmannia glutinosa: 10.1016/J.FOODCHEM.2013.07.026
9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Hansruedi Glatt, Heiko Schneider, Michael Murkovic, Bernhard H Monien, Walter Meinl. Hydroxymethyl-substituted furans: mutagenicity in Salmonella typhimurium strains engineered for expression of various human and rodent sulphotransferases. Mutagenesis. 2012 Jan; 27(1):41-8. doi: 10.1093/mutage/ger054. [PMID: 21825114]
T Husøy, M Haugen, M Murkovic, D Jöbstl, L H Stølen, T Bjellaas, C Rønningborg, H Glatt, J Alexander. Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008 Dec; 46(12):3697-702. doi: 10.1016/j.fct.2008.09.048. [PMID: 18929614]
Keisuke Kagami, Kenji Onda, Kitaro Oka, Toshihiko Hirano. Suppression of blood lipid concentrations by volatile Maillard reaction products. Nutrition (Burbank, Los Angeles County, Calif.). 2008 Nov; 24(11-12):1159-66. doi: 10.1016/j.nut.2008.05.010. [PMID: 18586457]
Yasuo Kimura, Satoko Tani, Asami Hayashi, Kouhei Ohtani, Shozo Fujioka, Tsuyoshi Kawano, Atsumi Shimada. Nematicidal activity of 5-hydroxymethyl-2-furoic acid against plant-parasitic nematodes. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2007 Mar; 62(3-4):234-8. doi: 10.1515/znc-2007-3-413. [PMID: 17542490]
Ronald L Prior, Xianli Wu, Liwei Gu. Identification and urinary excretion of metabolites of 5-(hydroxymethyl)-2-furfural in human subjects following consumption of dried plums or dried plum juice. Journal of agricultural and food chemistry. 2006 May; 54(10):3744-9. doi: 10.1021/jf0601113. [PMID: 19127754]
Ahmed Abdel-Lateff, Katja M Fisch, Anthony D Wright, Gabriele M König. A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp. Planta medica. 2003 Sep; 69(9):831-4. doi: 10.1055/s-2003-43209. [PMID: 14598209]