Dslet (BioDeep_00000013266)

   


代谢物信息卡片


(D-Ser2)-Leu-Enkephalin-Thr

化学式: C33H46N6O10 (686.3275256000001)
中文名称: (D-SER2)-LEU-ENKEPHALIN-THR
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)C(CO)NC(=O)C(CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C33H46N6O10/c1-18(2)13-24(32(47)39-28(19(3)41)33(48)49)37-31(46)25(15-20-7-5-4-6-8-20)36-27(43)16-35-30(45)26(17-40)38-29(44)23(34)14-21-9-11-22(42)12-10-21/h4-12,18-19,23-26,28,40-42H,13-17,34H2,1-3H3,(H,35,45)(H,36,43)(H,37,46)(H,38,44)(H,39,47)(H,48,49)

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004745 - Enkephalins

同义名列表

3 个代谢物同义名

(D-Ser2)-Leu-Enkephalin-Thr; Dslet; YSGFLT



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A V Solin, A Yu Lyashev, Yu D Lyashev. Effects of Opioid Peptides on Changes in Lipid Metabolism in Rats Subjected to Swimming Stress. Bulletin of experimental biology and medicine. 2017 Jan; 162(3):313-315. doi: 10.1007/s10517-017-3603-7. [PMID: 28091903]
  • A V Solin, Yu D Lyashev. [THE INFLUENCE OF OPIOID PEPTIDES DSLET AND DAGO ON LIPID PEROXIDATION AND THE ACTIVITY OF ANTIOXIDANT ENZYMES IN THE LIVER TISSUE OF RATS IN THE STRESS OF DIFFERENT DURATION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2016 Sep; 102(9):1066-73. doi: ". [PMID: 30193423]
  • A V Solin, Yu D Lyashev. [THE INFLUENCE OF OPIOID PEPTIDES ON LIPID PEROXIDATION AND ANTIOXIDANT ENZYME ACTIVITY IN RATS AFTER SWIMMING STRESS]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2015 Aug; 101(8):929-35. doi: NULL. [PMID: 26591588]
  • A V Solin, Yu D Lyashev. Effect of opioid peptides on the content of LPO products and antioxidant enzyme activity in the liver of rats after restraint stress. Bulletin of experimental biology and medicine. 2012 Oct; 153(6):827-9. doi: 10.1007/s10517-012-1836-z. [PMID: 23113295]
  • H Kenneth Kramer, Irma Onoprishvili, Matthew L Andria, Kayane Hanna, Karina Sheinkman, Lisa B Haddad, Eric J Simon. Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinases. BMC pharmacology. 2002; 2(?):5. doi: 10.1186/1471-2210-2-5. [PMID: 11897012]
  • T Iu Rebrova, L N Maslov, Iu B Lishmanov, S V Tam. [The role of mu- and delta-opiate receptors in resistance of the myocardium to free radical damage]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2001 May; 87(5):628-41. doi: ". [PMID: 11452797]
  • S D Mikhailova, N V Glushchenko, T M Semushkina, G I Storozhakov. Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists. Bulletin of experimental biology and medicine. 2000 May; 129(5):423-4. doi: 10.1007/bf02439790. [PMID: 10977939]
  • E Dermitzaki, E Chatzaki, A Gravanis, A N Margioris. Opioids transiently prevent activation of apoptotic mechanisms following short periods of serum withdrawal. Journal of neurochemistry. 2000 Mar; 74(3):960-9. doi: 10.1046/j.1471-4159.2000.0740960.x. [PMID: 10693926]
  • H K Kramer, E J Simon. Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists. Journal of neurochemistry. 1999 Feb; 72(2):585-93. doi: 10.1046/j.1471-4159.1999.0720585.x. [PMID: 9930730]
  • H K Kramer, E J Simon. Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC. Journal of neurochemistry. 1999 Feb; 72(2):594-604. doi: 10.1046/j.1471-4159.1999.0720594.x. [PMID: 9930731]
  • G Bot, A D Blake, S Li, T Reisine. Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells. Molecular pharmacology. 1997 Aug; 52(2):272-81. doi: 10.1124/mol.52.2.272. [PMID: 9271350]
  • C D Márquez, S T Weintraub, P C Smith. Quantitative analysis of two opioid peptides in plasma by liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jun; 694(1):21-30. doi: 10.1016/s0378-4347(97)00029-7. [PMID: 9234844]
  • X Zhu, C Wang, Z Cheng, Y Wu, D Zhou, G Pei. The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activation. Biochemical and biophysical research communications. 1997 Mar; 232(2):513-6. doi: 10.1006/bbrc.1997.6324. [PMID: 9125212]
  • M Shahrestanifar, W W Wang, R D Howells. Studies on inhibition of mu and delta opioid receptor binding by dithiothreitol and N-ethylmaleimide. His223 is critical for mu opioid receptor binding and inactivation by N-ethylmaleimide. The Journal of biological chemistry. 1996 Mar; 271(10):5505-12. doi: 10.1074/jbc.271.10.5505. [PMID: 8621408]
  • W W Wang, M Shahrestanifar, J Jin, R D Howells. Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors. Proceedings of the National Academy of Sciences of the United States of America. 1995 Dec; 92(26):12436-40. doi: 10.1073/pnas.92.26.12436. [PMID: 8618916]
  • C Hayashi, H Ueda, N Fukushima, T Katayama, Y Misu. Protein kinase C inhibitor potentiates the agonist-induced GTPase activity in COS cell membranes expressing delta-opioid receptor. Brain research. Molecular brain research. 1995 Nov; 33(2):347-50. doi: 10.1016/0169-328x(95)00155-l. [PMID: 8750896]
  • A Petit, N Gallo-Payet, D Bellabarba, J G Lehoux, S Bélisle. The modulation of placental lactogen release by opioids: a role for extracellular calcium. Molecular and cellular endocrinology. 1993 Jan; 90(2):165-70. doi: 10.1016/0303-7207(93)90148-d. [PMID: 7684340]
  • Z Khalil, R D Helme. Modulation of a peripheral inflammatory response to substance P by locally administered opioid receptor agonists. Neuropeptides. 1990 Sep; 17(1):45-53. doi: 10.1016/0143-4179(90)90140-t. [PMID: 1703284]
  • H N Bhargava, P Ramarao, A Gulati. Changes in multiple opioid receptors in regions of the brain in rats treated chronically with thyroxine. Neuropharmacology. 1989 Sep; 28(9):955-60. doi: 10.1016/0028-3908(89)90195-0. [PMID: 2554187]
  • D R Oleson, D R Johnson. Regulation of human natural cytotoxicity by enkephalins and selective opiate agonists. Brain, behavior, and immunity. 1988 Sep; 2(3):171-86. doi: 10.1016/0889-1591(88)90020-7. [PMID: 2907409]
  • H N Bhargava, P Ramarao, A Gulati. Effect of methimazole-induced hypothyroidism on multiple opioid receptors in rat brain regions. Pharmacology. 1988; 37(6):356-64. doi: 10.1159/000138489. [PMID: 2854273]
  • S Khatami, P L Hoffman, T Shibuya, B Salafsky. Selective effects of ethanol on opiate receptor subtypes in brain. Neuropharmacology. 1987 Oct; 26(10):1503-7. doi: 10.1016/0028-3908(87)90170-5. [PMID: 2825059]
  • E Castanas, N Bourhim, P Giraud, F Boudouresque, P Cantau, C Oliver. Interaction of opiates with opioid binding sites in the bovine adrenal medulla: II. Interaction with kappa sites. Journal of neurochemistry. 1985 Sep; 45(3):688-99. doi: 10.1111/j.1471-4159.1985.tb04047.x. [PMID: 2993510]