DPDPE (BioDeep_00000013265)

   


代谢物信息卡片


DPDPE

化学式: C30H39N5O7S2 (645.2290784)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C(C(=O)NCC(=O)NC(C(=O)NC(C(SS1)(C)C)C(=O)O)CC2=CC=CC=C2)NC(=O)C(CC3=CC=C(C=C3)O)N)C
InChI: InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004745 - Enkephalins
DPDPE, an opioid peptide, is a selective δ-opioid receptor?(DOR) agonist?with anticonvulsant effects[1].
DPDPE, an opioid peptide, is a selective δ-opioid receptor?(DOR) agonist?with anticonvulsant effects[1].

同义名列表

2 个代谢物同义名

DPDPE; YXGFX



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Samuel Obeng, Shyam H Kamble, Morgan E Reeves, Luis F Restrepo, Avi Patel, Mira Behnke, Nelson J-Y Chear, Surash Ramanathan, Abhisheak Sharma, Francisco León, Takato Hiranita, Bonnie A Avery, Lance R McMahon, Christopher R McCurdy. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry. 2020 01; 63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. [PMID: 31834797]
  • Miriam Stoeber, Damien Jullié, Braden T Lobingier, Toon Laeremans, Jan Steyaert, Peter W Schiller, Aashish Manglik, Mark von Zastrow. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron. 2018 06; 98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. [PMID: 29754753]
  • Andrew C Kruegel, Madalee M Gassaway, Abhijeet Kapoor, András Váradi, Susruta Majumdar, Marta Filizola, Jonathan A Javitch, Dalibor Sames. Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators. Journal of the American Chemical Society. 2016 06; 138(21):6754-64. doi: 10.1021/jacs.6b00360. [PMID: 27192616]
  • Chunshan Gui, Bruno Hagenbuch. Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2010 Apr; 151(3):393-9. doi: 10.1016/j.cbpc.2010.01.005. [PMID: 20079461]
  • Atsushi Ose, Hiroyuki Kusuhara, Chihiro Endo, Kimio Tohyama, Mari Miyajima, Satoshi Kitamura, Yuichi Sugiyama. Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier. Drug metabolism and disposition: the biological fate of chemicals. 2010 Jan; 38(1):168-76. doi: 10.1124/dmd.109.029454. [PMID: 19833843]
  • Faye A Bradbury, Jennifer C Zelnik, John R Traynor. G protein independent phosphorylation and internalization of the delta-opioid receptor. Journal of neurochemistry. 2009 Jun; 109(5):1526-35. doi: 10.1111/j.1471-4159.2009.06082.x. [PMID: 19344370]
  • Min-Hua Hong, Chi Xu, Yu-Jun Wang, Jing-Li Ji, Yi-Min Tao, Xue-Jun Xu, Jie Chen, Xin Xie, Zhi-Qiang Chi, Jing-Gen Liu. Role of Src in ligand-specific regulation of delta-opioid receptor desensitization and internalization. Journal of neurochemistry. 2009 Jan; 108(1):102-14. doi: 10.1111/j.1471-4159.2008.05740.x. [PMID: 19014372]
  • Sara M Thomasy, Khursheed R Mama, Scott D Stanley. Comparison of liquid chromatography-mass spectrometry and radioimmunoassay for measurement of fentanyl and determination of pharmacokinetics in equine plasma. Journal of analytical toxicology. 2008 Nov; 32(9):754-9. doi: 10.1093/jat/32.9.754. [PMID: 19021930]
  • Ahmed Hasbi, Tuan Nguyen, Theresa Fan, Regina Cheng, Asim Rashid, Mohammad Alijaniaram, Mark M Rasenick, Brian F O'Dowd, Susan R George. Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists. Biochemistry. 2007 Nov; 46(45):12997-3009. doi: 10.1021/bi701436w. [PMID: 17941650]
  • Danxin Wang, Xiaochun Sun, Wolfgang Sadee. Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment. The Journal of pharmacology and experimental therapeutics. 2007 May; 321(2):544-52. doi: 10.1124/jpet.106.118810. [PMID: 17267582]
  • Peng Huang, Wei Xu, Su-In Yoon, Chongguang Chen, Parkson Lee-Gau Chong, Lee-Yuan Liu-Chen. Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Biochemical pharmacology. 2007 Feb; 73(4):534-49. doi: 10.1016/j.bcp.2006.10.032. [PMID: 17141202]
  • Thierry Clerbaux, Bruno Detry, Andre Geubel, Claude Veriter, Giuseppe Liistro, Yves Horsmans, Albert Frans. The oxyhemoglobin dissociation curve in liver cirrhosis. Chest. 2006 Feb; 129(2):438-445. doi: 10.1378/chest.129.2.438. [PMID: 16478864]
  • Natalia Jiménez, Margarita M Puig, Olga Pol. Antiexudative effects of opioids and expression of kappa- and delta-opioid receptors during intestinal inflammation in mice: involvement of nitric oxide. The Journal of pharmacology and experimental therapeutics. 2006 Jan; 316(1):261-70. doi: 10.1124/jpet.105.091991. [PMID: 16183704]
  • Emily A Smith, Jason W Coym, Scott M Cowell, Takahira Tokimoto, Victor J Hruby, Henry I Yamamura, Mary J Wirth. Lipid bilayers on polyacrylamide brushes for inclusion of membrane proteins. Langmuir : the ACS journal of surfaces and colloids. 2005 Oct; 21(21):9644-50. doi: 10.1021/la051116h. [PMID: 16207048]
  • Eddy H T Wu, Yung H Wong. Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells. Biochemical and biophysical research communications. 2005 Sep; 334(3):838-44. doi: 10.1016/j.bbrc.2005.06.184. [PMID: 16053916]
  • Isabel D Alves, Zdzislaw Salamon, Victor J Hruby, Gordon Tollin. Ligand modulation of lateral segregation of a G-protein-coupled receptor into lipid microdomains in sphingomyelin/phosphatidylcholine solid-supported bilayers. Biochemistry. 2005 Jun; 44(25):9168-78. doi: 10.1021/bi050207a. [PMID: 15966741]
  • Maria Waldhoer, Jamie Fong, Robert M Jones, Mary M Lunzer, Shiv K Sharma, Evi Kostenis, Philip S Portoghese, Jennifer L Whistler. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proceedings of the National Academy of Sciences of the United States of America. 2005 Jun; 102(25):9050-5. doi: 10.1073/pnas.0501112102. [PMID: 15932946]
  • Asunción Romero, Eulalia Planas, Raquel Poveda, Silvia Sánchez, Olga Pol, Margarita M Puig. Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw. European journal of pharmacology. 2005 Mar; 511(2-3):207-17. doi: 10.1016/j.ejphar.2005.02.004. [PMID: 15792790]
  • Wooin Lee, Hartmut Glaeser, L Harris Smith, Richard L Roberts, Gilbert W Moeckel, Guillermo Gervasini, Brenda F Leake, Richard B Kim. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. The Journal of biological chemistry. 2005 Mar; 280(10):9610-7. doi: 10.1074/jbc.m411092200. [PMID: 15632119]
  • Rico K H Lo, Yung H Wong. Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates. Molecular pharmacology. 2004 Jun; 65(6):1427-39. doi: 10.1124/mol.65.6.1427. [PMID: 15155836]
  • M Soaje, R P Deis. Involvement of opioid receptor subtypes in both stimulatory and inhibitory effects of the opioid peptides on prolactin secretion during pregnancy. Cellular and molecular neurobiology. 2004 Apr; 24(2):193-204. doi: 10.1023/b:cemn.0000018616.00018.98. [PMID: 15176435]
  • V Boguslavsky, V J Hruby, D F O'Brien, A Misicka, A W Lipkowski. Effect of peptide conformation on membrane permeability. The journal of peptide research : official journal of the American Peptide Society. 2003 Jun; 61(6):287-97. doi: 10.1034/j.1399-3011.2003.00047.x. [PMID: 12753376]
  • Parham Gharagozlou, Hasan Demirci, J David Clark, Jelveh Lameh. Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors. BMC neuroscience. 2002 Nov; 3(?):19. doi: 10.1186/1471-2202-3-19. [PMID: 12437765]
  • Marek Romanowski, Xiaoyun Zhu, Kathy Kim, Victor J Hruby, David F O'Brien. Interaction of enkephalin peptides with anionic model membranes. Biochimica et biophysica acta. 2002 Jan; 1558(1):45-53. doi: 10.1016/s0005-2736(01)00421-7. [PMID: 11750263]
  • M Narita, O Ohnishi, M Nemoto, Y Yajima, T Suzuki. Implications of phosphoinositide 3-kinase in the mu- and delta-opioid receptor-mediated supraspinal antinociception in the mouse. Neuroscience. 2002; 113(3):647-52. doi: 10.1016/s0306-4522(02)00197-5. [PMID: 12150784]
  • A Alt, M J Clark, J H Woods, J R Traynor. Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells. British journal of pharmacology. 2002 Jan; 135(1):217-25. doi: 10.1038/sj.bjp.0704430. [PMID: 11786497]
  • M Toselli, V Taglietti, V Parente, S Flati, A Pavan, F Guzzi, M Parenti. Attenuation of G protein-mediated inhibition of N-type calcium currents by expression of caveolins in mammalian NG108-15 cells. The Journal of physiology. 2001 Oct; 536(Pt 2):361-73. doi: 10.1111/j.1469-7793.2001.0361c.xd. [PMID: 11600672]
  • K A Witt, J D Huber, R D Egleton, M J Roberts, M D Bentley, L Guo, H Wei, H I Yamamura, T P Davis. Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen2, D-Pen5]-enkephalin (DPDPE). The Journal of pharmacology and experimental therapeutics. 2001 Aug; 298(2):848-56. doi: . [PMID: 11454951]
  • N A Martin, M T Terruso, P L Prather. Agonist Activity of the delta-antagonists TIPP and TIPP-psi in cellular models expressing endogenous or transfected delta-opioid receptors. The Journal of pharmacology and experimental therapeutics. 2001 Jul; 298(1):240-8. doi: . [PMID: 11408548]
  • Z Salamon, S Cowell, E Varga, H I Yamamura, V J Hruby, G Tollin. Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions. Biophysical journal. 2000 Nov; 79(5):2463-74. doi: 10.1016/s0006-3495(00)76489-7. [PMID: 11053123]
  • G Bonner, F Meng, H Akil. Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop. European journal of pharmacology. 2000 Sep; 403(1-2):37-44. doi: 10.1016/s0014-2999(00)00578-1. [PMID: 10969141]
  • K A Witt, C A Slate, R D Egleton, J D Huber, H I Yamamura, V J Hruby, T P Davis. Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin. Journal of neurochemistry. 2000 Jul; 75(1):424-35. doi: 10.1046/j.1471-4159.2000.0750424.x. [PMID: 10854288]
  • P H Tso, L Y Yung, Y H Wong. Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor. Journal of neurochemistry. 2000 Apr; 74(4):1685-93. doi: 10.1046/j.1471-4159.2000.0741685.x. [PMID: 10737627]
  • J Garzón, M Rodríguez-Díaz, I DeAntonio, J DeFelipe, J R Rodríguez, P Sánchez-Blázquez. Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice. Neuropharmacology. 1999 Dec; 38(12):1861-73. doi: 10.1016/s0028-3908(99)00070-2. [PMID: 10608281]
  • L A Pohorecky, A Skiandos, X Zhang, K C Rice, D Benjamin. Effect of chronic social stress on delta-opioid receptor function in the rat. The Journal of pharmacology and experimental therapeutics. 1999 Jul; 290(1):196-206. doi: NULL. [PMID: 10381776]
  • R El Kouhen, O M Kouhen, P Y Law, H H Loh. The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation. The Journal of biological chemistry. 1999 Apr; 274(14):9207-15. doi: 10.1074/jbc.274.14.9207. [PMID: 10092593]
  • J Garzón, J DeFelipe, J R Rodríguez, I DeAntonio, A García-España, P Sánchez-Blázquez. Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity. Brain research. Molecular brain research. 1999 Mar; 65(2):151-66. doi: 10.1016/s0169-328x(98)00350-7. [PMID: 10064886]
  • C L Gentry, R D Egleton, T Gillespie, T J Abbruscato, H B Bechowski, V J Hruby, T P Davis. The effect of halogenation on blood-brain barrier permeability of a novel peptide drug. Peptides. 1999; 20(10):1229-38. doi: 10.1016/s0196-9781(99)00127-8. [PMID: 10573295]
  • B Yilmaz, D P Gilmore, C A Wilson. Effects of DPDPE (a specific delta-opioid receptor agonist) and naloxone on hypothalamic monoamine concentrations during the pre-ovulatory LH surge in the rat. European journal of endocrinology. 1998 Nov; 139(5):546-51. doi: 10.1530/eje.0.1390546. [PMID: 9849821]
  • Z J Cheng, Q M Yu, Y L Wu, L Ma, G Pei. Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling. The Journal of biological chemistry. 1998 Sep; 273(38):24328-33. doi: 10.1074/jbc.273.38.24328. [PMID: 9733719]
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  • M M Belcheva, Z Vogel, E Ignatova, T Avidor-Reiss, R Zippel, R Levy, E C Young, J Barg, C J Coscia. Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits. Journal of neurochemistry. 1998 Feb; 70(2):635-45. doi: 10.1046/j.1471-4159.1998.70020635.x. [PMID: 9453557]
  • T Thorlin, P S Eriksson, P A Persson, N D Aberg, E Hansson, L Rönnbäck. Delta-opioid receptors on astroglial cells in primary culture: mobilization of intracellular free calcium via a pertussis sensitive G protein. Neuropharmacology. 1998; 37(3):299-311. doi: 10.1016/s0028-3908(98)00026-4. [PMID: 9681928]
  • F Rinaldi, M Lin, M J Shapiro, M Petersheim. Delta-opiate DPDPE in magnetically oriented phospholipid micelles: binding and arrangement of aromatic pharmacophores. Biophysical journal. 1997 Dec; 73(6):3337-48. doi: 10.1016/s0006-3495(97)78358-9. [PMID: 9414244]
  • C Chen, D Jeffery, J W Jorgenson, M A Moseley, G M Pollack. Sensitive analysis of [D-Pen2,5]enkephalin in rat serum by capillary electrophoresis and laser-induced fluorescence detection. Journal of chromatography. B, Biomedical sciences and applications. 1997 Sep; 697(1-2):149-62. doi: 10.1016/s0378-4347(97)00062-5. [PMID: 9342665]
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