Eledoisin (BioDeep_00000013212)

   

Marine Natural Products


代谢物信息卡片


Eledoisin acetate salt

化学式: C54H85N13O15S (1187.60085)
中文名称: 依来多新
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C2CCCN2C(=O)C3CCC(=O)N3
InChI: InChI=1S/C54H85N13O15S/c1-7-30(4)44(53(81)57-27-42(70)60-36(24-29(2)3)49(77)61-33(45(56)73)20-23-83-6)66-50(78)37(25-32-14-9-8-10-15-32)63-46(74)31(5)58-48(76)38(26-43(71)72)64-47(75)34(16-11-12-21-55)62-51(79)39(28-68)65-52(80)40-17-13-22-67(40)54(82)35-18-19-41(69)59-35/h8-10,14-15,29-31,33-40,44,68H,7,11-13,16-28,55H2,1-6H3,(H2,56,73)(H,57,81)(H,58,76)(H,59,69)(H,60,70)(H,61,77)(H,62,79)(H,63,74)(H,64,75)(H,65,80)(H,66,78)(H,71,72)/t30-,31-,33-,34-,35-,36-,37-,38-,39-,40-,44-/m0/s1

描述信息

D009676 - Noxae > D011042 - Poisons > D008978 - Mollusk Venoms
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
D018377 - Neurotransmitter Agents > D015320 - Tachykinins
D009676 - Noxae > D011042 - Poisons > D014688 - Venoms
Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.

同义名列表

5 个代谢物同义名

Eledoisin acetate salt; Eledoisin; Eledoisin Acetate; Eledoisinum; Eledone peptide



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bingxia Chen, Huqing Yang. 6-Benzylaminopurine alleviates chilling injury of postharvest cucumber fruit through modulating antioxidant system and energy status. Journal of the science of food and agriculture. 2013 Jun; 93(8):1915-21. doi: 10.1002/jsfa.5990. [PMID: 23258766]
  • Jason M Elliott, Robert W Carling, Gary G Chicchi, James Crawforth, Peter H Hutson, A Brian Jones, Sarah Kelly, Rose Marwood, Georgina Meneses-Lorente, Elena Mezzogori, Fraser Murray, Michael Rigby, Inmaculada Royo, Michael G N Russell, Duncan Shaw, Bindi Sohal, Kwei Lan Tsao, Brian Williams. N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II. Bioorganic & medicinal chemistry letters. 2006 Nov; 16(22):5752-6. doi: 10.1016/j.bmcl.2006.08.085. [PMID: 16950617]
  • Jason M Elliott, Robert W Carling, Mark Chambers, Gary G Chicchi, Peter H Hutson, A Brian Jones, Angus MacLeod, Rose Marwood, Georgina Meneses-Lorente, Elena Mezzogori, Fraser Murray, Michael Rigby, Inmaculada Royo, Michael G N Russell, Bindi Sohal, Kwei Lan Tsao, Brian Williams. N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists. Bioorganic & medicinal chemistry letters. 2006 Nov; 16(22):5748-51. doi: 10.1016/j.bmcl.2006.08.086. [PMID: 16950620]
  • R Christy Rani Grace, Indu R Chandrashekar, Sudha M Cowsik. Solution structure of the tachykinin peptide eledoisin. Biophysical journal. 2003 Jan; 84(1):655-64. doi: 10.1016/s0006-3495(03)74885-1. [PMID: 12524318]
  • M Bergstrom, E Theodorsson, I Norheim, K Oberg. Immunoreactive tachykinins in 24-h collections of urine from patients with carcinoid tumours: characterization and correlation with plasma concentrations. Scandinavian journal of clinical and laboratory investigation. 1995 Dec; 55(8):679-89. doi: 10.3109/00365519509075398. [PMID: 8903838]
  • R J Naukam, W C Parris, J R Kambam, J B Kruskal. The effects of neurokinin A, neurokinin B, and eledoisin on substance P analysis. Journal of clinical monitoring. 1991 Apr; 7(2):181-5. doi: 10.1007/bf01618120. [PMID: 1712834]
  • P Zanoli, M Baraldi. Evidence that bremazocine prevents urine retention induced by intraspinal cord injection of colchicine in rats. Journal of the autonomic nervous system. 1990 Jul; 30 Suppl(?):S191-3. doi: 10.1016/0165-1838(90)90129-7. [PMID: 2170490]
  • C A Maggi, R Patacchini, P Baroldi, E Theodorsson, A Meli. Immunoblockade by a specific tachykinin antiserum of the non-cholinergic contractile responses in the guinea-pig isolated bronchus. Journal of autonomic pharmacology. 1990 Jun; 10(3):173-9. doi: 10.1111/j.1474-8673.1990.tb00016.x. [PMID: 1696261]
  • E Tarjan, J R Blair-West, G de Caro, D A Denton, M I McBurnie, M Massi, J Szmydynger-Chodobska, R S Weisinger. Sodium and water intake of sheep, rabbits and cattle during ICV infusion of eledoisin. Pharmacology, biochemistry, and behavior. 1990 Apr; 35(4):823-8. doi: 10.1016/0091-3057(90)90365-o. [PMID: 2345760]
  • P V Andrews, R D Helme, K L Thomas. NK-1 receptor mediation of neurogenic plasma extravasation in rat skin. British journal of pharmacology. 1989 Aug; 97(4):1232-8. doi: 10.1111/j.1476-5381.1989.tb12583.x. [PMID: 2477105]
  • A Saija, C Polidori, M Massi, M Perfumi, G De Caro, G Costa. Label distribution after injection of labelled tachykinins into the rat lateral cerebroventricle. Research communications in chemical pathology and pharmacology. 1989 Apr; 64(1):99-110. doi: NULL. [PMID: 2473501]
  • M C Perfumi, C Polidori, E Caraffa, M Cucculelli, M Fede, A Fiorelli. [Effects of eledoisin on water intake induced by subcutaneous injection of hypertonic NaCl in the rat]. Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma. 1989; 60(1-2):103-11. doi: NULL. [PMID: 2535090]
  • M Perfumi, A Sajia, G Costa, M Massi, C Polidori. Vasopressin release induced by intracranial injection of eledoisin is mediated by central angiotensin II. Pharmacological research communications. 1988 Sep; 20(9):811-26. doi: 10.1016/s0031-6989(88)80719-7. [PMID: 3051054]
  • A C Foster, R Tridgett. Comparison of the binding of radiolabelled neurokinin A and eledoisin in rat cortex synaptic membranes. British journal of pharmacology. 1988 Jun; 94(2):602-8. doi: 10.1111/j.1476-5381.1988.tb11566.x. [PMID: 2840165]
  • C Vergés Roger, D Pita Salorio, L Rodríguez Alvarez. [Comparative study with physiologic serum, eledoisin and bromhexine in the treatment of dry eye syndromes]. Medicina clinica. 1985 Sep; 85(9):347-9. doi: NULL. [PMID: 4079572]
  • T Mitsuma, T Nogimori, D H Sun, M Chaya. Effects of eledoisin on thyrotrophin secretion in rats. Acta endocrinologica. 1985 Sep; 110(1):90-4. doi: 10.1530/acta.0.1100090. [PMID: 3929520]
  • E Theodorsson-Norheim, I Norheim, K Oberg, E Brodin, J M Lundberg, K Tatemoto, P G Lindgren. Neuropeptide K: a major tachykinin in plasma and tumor tissues from carcinoid patients. Biochemical and biophysical research communications. 1985 Aug; 131(1):77-83. doi: 10.1016/0006-291x(85)91772-3. [PMID: 2412557]
  • X Hua, J M Lundberg, E Theodorsson-Norheim, E Brodin. Comparison of cardiovascular and bronchoconstrictor effects of substance P, substance K and other tachykinins. Naunyn-Schmiedeberg's archives of pharmacology. 1984 Dec; 328(2):196-201. doi: 10.1007/bf00512072. [PMID: 6084817]
  • I Norheim, E Theodorsson-Norheim, E Brodin, K Oberg, G Lundqvist, S Rosell. Antisera raised against eledoisin and kassinin detect elevated levels of immunoreactive material in plasma and tumor tissues from patients with carcinoid tumors. Regulatory peptides. 1984 Nov; 9(4):245-57. doi: 10.1016/0167-0115(84)90076-4. [PMID: 6084259]
  • F Cantalamessa, G De Caro, M Massi, M Perfumi. Possible influence of tachykinins on body fluid homeostasis in the rat. Journal de physiologie. 1984; 79(6):524-30. doi: NULL. [PMID: 6085638]
  • J T Fitzsimons, M Massi, S N Thornton. The effects of changes in osmolality and sodium concentration on angiotensin-induced drinking and excretion in the pigeon. The Journal of physiology. 1982 Sep; 330(?):1-15. doi: 10.1113/jphysiol.1982.sp014325. [PMID: 7175737]
  • R T Jensen, J D Gardner. Interaction of physalaemin, substance P, and eledoisin with specific membrane receptors on pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America. 1979 Nov; 76(11):5679-83. doi: 10.1073/pnas.76.11.5679. [PMID: 230488]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]
  • I H Mills, P A Newport, L F Obika. Interaction between arterial pressure and vasoactive hormones in the release of renal kallikrein. Advances in experimental medicine and biology. 1979; 120B(?):561-70. doi: NULL. [PMID: 517250]
  • J L Osborn, B Noordewier, J B Hook, M D Bailie. Mechanism of prostaglandin E(2) stimulation of renin secretion. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1978 Nov; 159(2):249-52. doi: 10.3181/00379727-159-40325. [PMID: 714953]
  • I H Mills, L F Obika. Urinary kallikrein excretion during bradykinin and eledoisin infusions and its relationship to urinary osmolality [proceedings]. The Journal of physiology. 1977 Jul; 269(1):72P-73P. doi: NULL. [PMID: 894582]
  • H D Itskovitz, W B Campbell. Vasodilators, intrarenal distribution of blood flow, and renal function in isolated perfused canine kidneys. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1976 Oct; 153(1):161-5. doi: 10.3181/00379727-153-39502. [PMID: 995938]
  • J C McGiff, H D Itskovitz, A Terragno, P Y Wong. Modulation and mediation of the action of the renal kallikrein-kinin system by prostaglandins. Federation proceedings. 1976 Feb; 35(2):175-80. doi: NULL. [PMID: 765161]
  • N A Terragno, K U Malik, A Nasjletti, D A Terragno, J C McGiff. Renal prostaglandins. Advances in prostaglandin and thromboxane research. 1976; 2(?):561-71. doi: NULL. [PMID: 824936]
  • J C McGiff, H D Itskovitz, N A Terragno. The actions of bradykinin and eledoisin in the canine isolated kidney: relationships to prostaglandins. Clinical science and molecular medicine. 1975 Aug; 49(2):125-31. doi: 10.1042/cs0490125. [PMID: 1149403]
  • L J De Asua, D Clingan, P S Rudland. Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha. Proceedings of the National Academy of Sciences of the United States of America. 1975 Jul; 72(7):2724-8. doi: 10.1073/pnas.72.7.2724. [PMID: 170616]
  • A W Mondorf. [Evidence of urinary tubular proteins in inflammatory and toxic kidney damage]. Wiener medizinische Wochenschrift. Supplement. 1975; 27(?):20-3. doi: NULL. [PMID: 5816]
  • J C McGiff, K Crowshaw, H D Itskovitz. Prostaglandins and renal function. Federation proceedings. 1974 Jan; 33(1):39-47. doi: NULL. [PMID: 4359037]
  • P Oehme, S Katzwinkel, W E Vogt, H Niedrich. Retarded enzymatic degradation of heterologous eledoisin sequences. Experientia. 1973 Aug; 29(8):947-8. doi: 10.1007/bf01930392. [PMID: 4733308]
  • A M Lefer, T F Inge. Differentiation of a myocardial depressant factor present in shock plasma from known plasma peptides and salts. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1973 Feb; 142(2):429-33. doi: 10.3181/00379727-142-37039. [PMID: 4347607]
  • P Oehme, W E Vogt, H Niedrich, S Katzwinkel, J Bergmann, F Jung. [Pharmacology of hydrazino carbonic acids, hydrazino peptides and other hydrazine derivatives. X. Enzymatic breakdown of heterologous eledoisin sequences]. Acta biologica et medica Germanica. 1973; 30(3):415-22. doi: NULL. [PMID: 4762326]
  • E Winter, F Jung, R Winter. [Effect of eledoisin peptides on artificial lipid membranes]. Acta biologica et medica Germanica. 1973; 31(1):149-52. doi: ". [PMID: 4774668]
  • J C McGiff, N A Terragno, K U Malik, A J Lonigro. Release of a prostaglandin E-like substance from canine kidney by bradykinin. Circulation research. 1972 Jul; 31(1):36-43. doi: 10.1161/01.res.31.1.36. [PMID: 5038736]
  • D P Mertz, W Poppe, G Poser. [The effect of kinin hormones on gastric juice secretion. 3. Effect of synthetic eledoisin]. Medizinische Klinik. 1970 Mar; 65(12):548-52. doi: NULL. [PMID: 5519234]
  • G Finardi, E Molinari, A Regazzini. [Serum non-esterified fatty acid changes after infusion of eledoisin in men. Changes in normal and essential hypertensive subjects]. Il Farmaco; edizione pratica. 1969 Nov; 24(11):690-9. doi: NULL. [PMID: 5361897]
  • A L Gascon. Influence of rat plasma and of various cations on the anti-eledoisin activity of morin. British journal of pharmacology. 1969 Jan; 35(1):187-96. doi: 10.1111/j.1476-5381.1969.tb07979.x. [PMID: 5762039]
  • J D Horowitz, M L Mashford. A perfused vein preparation sensitive to plasma kinins. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie. 1969; 263(2):332-9. doi: 10.1007/bf00537607. [PMID: 4305806]
  • U Hamberg, M L Savolainen. Effect of bradykinin on the urokinase excretion in rabbits. Scandinavian journal of clinical and laboratory investigation. Supplementum. 1969; 107(?):105-12. doi: NULL. [PMID: 5375719]
  • S H Ferreira, J R Vane. The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat. British journal of pharmacology and chemotherapy. 1967 Jun; 30(2):417-24. doi: 10.1111/j.1476-5381.1967.tb02148.x. [PMID: 6036419]
  • D P Mertz. [On the effect of kinin-hormones on the mechanism of urine dilution and urine concentration. II. Studies during hydropenia and eliguria as well as during osmotic diuresis with hypertonic mannitol solutions]. Arzneimittel-Forschung. 1967 Apr; 17(4):440-6. doi: NULL. [PMID: 4300998]
  • D P Mertz. [The effect of kinin hormones on urine dilution and urine concentration. 1. Studies on diuresis]. Arzneimittel-Forschung. 1967 Mar; 17(3):376-82. doi: NULL. [PMID: 4296810]
  • T Kusakari, J Nakano. Effects of synthetic eledoisin on plasma free fatty acid and blood glucose levels in dogs. Japanese journal of pharmacology. 1966 Sep; 16(3):324-5. doi: 10.1254/jjp.16.324. [PMID: 5298312]
  • T Furuyama, C Suzuki, H Saito, Y Onozawa, R Shioji, S Rikimaru, K Abe, K Yoshinaga. Effect of bradykinin and eledoisin on renal function in the dog. The Tohoku journal of experimental medicine. 1966 May; 89(1):69-76. doi: 10.1620/tjem.89.69. [PMID: 5914093]
  • M B Nobili. [On the inactivation of eledoisin and physalaemin by whole blood and tissue homogenates of several vertebrates]. Archives internationales de pharmacodynamie et de therapie. 1965 Nov; 158(1):187-201. doi: NULL. [PMID: 5854046]
  • F S Feruglio, B Migheli, S Campus, G Pandolfo, P Dessy, C Gagna, E Uslenghi, L Chiandussi, G Bert, P G Colongo, F Greco, I Mathis, A Ruschena. [Study of the action of eledoisin on general and regional circulation in dogs]. Archives internationales de pharmacodynamie et de therapie. 1965 Oct; 157(2):400-23. doi: NULL. [PMID: 5868742]
  • O Heidenreich, L Baumeister, G Fülgraff, P Keller, Y Kook. [The effect of eledoisin on kidney function in dogs]. Archives internationales de pharmacodynamie et de therapie. 1965 Aug; 156(2):348-57. doi: NULL. [PMID: 5868942]
  • D P MERTZ. [ON THE EFFECT OF SYNTHETIC ELEDOISIN ON KIDNEY FUNCTION, WATER AND ELECTROLYTE BALANCE IN MAN]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie. 1964 Jan; 246(?):338-54. doi: 10.1007/bf00247396. [PMID: 14137059]