Cylindrospermopsin (BioDeep_00000013184)

   


代谢物信息卡片


2,4(1h,3h)-pyrimidinedione, 6-((R)-hydroxy((2AS,3R,4S,5AS,7R)-2,2A,3,4,5,5A,6,7-octahydro-3-methyl-4-(sulfooxy)-1h-1,8,8B-triazaacenaphthylen-7-yl)methyl)-

化学式: C15H21N5O7S (415.11616360000005)
中文名称: 柱孢藻毒素
谱图信息: 最多检出来源 Homo sapiens(blood) 7.81%

分子结构信息

SMILES: CC1C(CC2CC(N=C3N2C1CN3)C(C4=CC(=O)NC(=O)N4)O)OS(=O)(=O)O
InChI: InChI=1S/C15H21N5O7S/c1-6-10-5-16-14-17-8(13(22)9-4-12(21)19-15(23)18-9)2-7(20(10)14)3-11(6)27-28(24,25)26/h4,6-8,10-11,13,22H,2-3,5H2,1H3,(H,16,17)(H,24,25,26)(H2,18,19,21,23)/t6-,7+,8-,10-,11+,13-/m1/s1

描述信息

A triazaacenaphthylene that is 2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylene which is substituted at positions 3, 4, and 7 by methyl, sulfooxy, and (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl groups, respectively (the 2aS,3R,4S,5aS,7R stereoisomer in which the carbon bearing the hydroxy group has R configuration). It is a cyanotoxin produced by several species of freshwater cyanobacteria, such as Aphanizomenon ovalisporum.

同义名列表

4 个代谢物同义名

2,4(1h,3h)-pyrimidinedione, 6-((R)-hydroxy((2AS,3R,4S,5AS,7R)-2,2A,3,4,5,5A,6,7-octahydro-3-methyl-4-(sulfooxy)-1h-1,8,8B-triazaacenaphthylen-7-yl)methyl)-; Cylindrospermopsin; 7-epi-Cylindrospermopsin; epicylindrospermopsin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Barbara Pawlik-Skowrońska, Adam Bownik, Magdalena Pogorzelec, Justyna Kulczycka, Aleksandra Sumińska. First report on adverse effects of cyanobacterial anabaenopeptins, aeruginosins, microginin and their mixtures with microcystin and cylindrospermopsin on aquatic plant physiology: An experimental approach. Toxicon : official journal of the International Society on Toxinology. 2023 Dec; 236(?):107333. doi: 10.1016/j.toxicon.2023.107333. [PMID: 37951248]
  • Adam Bownik, Małgorzata Adamczuk, Barbara Pawlik Skowrońska. Effects of cyanobacterial metabolites: Aeruginosin 98A, microginin-FR1, anabaenopeptin-A, cylindrospermopsin in binary and quadruple mixtures on the survival and oxidative stress biomarkers of Daphnia magna. Toxicon : official journal of the International Society on Toxinology. 2023 Jun; 229(?):107137. doi: 10.1016/j.toxicon.2023.107137. [PMID: 37121403]
  • Zhongshi He, Youxin Chen, Da Huo, Jin Gao, Yewei Xu, Rui Yang, Yiming Yang, Gongliang Yu. Combined-methods elucidate the multi-organ toxicity of cylindrospermopsin (CYN) on Daphnia magna. Environmental pollution (Barking, Essex : 1987). 2023 Feb; ?(?):121250. doi: 10.1016/j.envpol.2023.121250. [PMID: 36813104]
  • Leticia Diez-Quijada, María Puerto, Daniel Gutiérrez-Praena, Maria V Turkina, Alexandre Campos, Vitor Vasconcelos, Ana M Cameán, Ángeles Jos. In Vitro Toxicity Evaluation of Cyanotoxins Cylindrospermopsin and Microcystin-LR on Human Kidney HEK293 Cells. Toxins. 2022 06; 14(7):. doi: 10.3390/toxins14070429. [PMID: 35878167]
  • Yanyan Zhang, Sung Vo Duy, Gabriel Munoz, Sébastien Sauvé. Phytotoxic effects of microcystins, anatoxin-a and cylindrospermopsin to aquatic plants: A meta-analysis. The Science of the total environment. 2022 Mar; 810(?):152104. doi: 10.1016/j.scitotenv.2021.152104. [PMID: 34863769]
  • Marcel Schneider, Marina F Grossi, Darshak Gadara, Zdeněk Spáčil, Pavel Babica, Luděk Bláha. Treatment of cylindrospermopsin by hydroxyl and sulfate radicals: Does degradation equal detoxification?. Journal of hazardous materials. 2022 02; 424(Pt B):127447. doi: 10.1016/j.jhazmat.2021.127447. [PMID: 34688008]
  • A C N Moraes, D S Freire, H Habibi, J Lowe, V F Magalhães. Cylindrospermopsin impairs tubular transport function in kidney cells LLC-PK1. Toxicology letters. 2021 Jun; 344(?):26-33. doi: 10.1016/j.toxlet.2021.03.002. [PMID: 33689780]
  • Leticia Díez-Quijada, Rosario Moyano, Verónica Molina-Hernández, Ana M Cameán, Ángeles Jos. Evaluation of toxic effects induced by repeated exposure to Cylindrospermopsin in rats using a 28-day feeding study. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 May; 151(?):112108. doi: 10.1016/j.fct.2021.112108. [PMID: 33741479]
  • Michal Adamski, Eliza Zimolag, Ariel Kaminski, Justyna Drukała, Jan Bialczyk. Effects of cylindrospermopsin, its decomposition products, and anatoxin-a on human keratinocytes. The Science of the total environment. 2021 Apr; 765(?):142670. doi: 10.1016/j.scitotenv.2020.142670. [PMID: 33069473]
  • Kornelia Duchnik, Jan Bialczyk, Ewelina Chrapusta-Srebrny, Beata Bober. Inhibition of growth rate and cylindrospermopsin synthesis by Raphidiopsis raciborskii upon exposure to macrophyte Lemna trisulca (L). Ecotoxicology (London, England). 2021 Apr; 30(3):470-477. doi: 10.1007/s10646-021-02377-7. [PMID: 33710451]
  • Małgorzata Kucała, Michał Saładyga, Ariel Kaminski. Phytoremediation of CYN, MC-LR and ANTX-a from Water by the Submerged Macrophyte Lemna trisulca. Cells. 2021 03; 10(3):. doi: 10.3390/cells10030699. [PMID: 33801135]
  • Marcel Schneider, Raphael Rataj, Juergen F Kolb, Luděk Bláha. Cylindrospermopsin is effectively degraded in water by pulsed corona-like and dielectric barrier discharges. Environmental pollution (Barking, Essex : 1987). 2020 Nov; 266(Pt 2):115423. doi: 10.1016/j.envpol.2020.115423. [PMID: 32829127]
  • Michal Adamski, Konrad Wołowski, Ariel Kaminski, Alica Hindáková. Cyanotoxin cylindrospermopsin producers and the catalytic decomposition process: A review. Harmful algae. 2020 09; 98(?):101894. doi: 10.1016/j.hal.2020.101894. [PMID: 33129452]
  • Wanda Czyżewska, Marlena Piontek, Katarzyna Łuszczyńska. The Occurrence of Potential Harmful Cyanobacteria and Cyanotoxins in the Obrzyca River (Poland), a Source of Drinking Water. Toxins. 2020 04; 12(5):. doi: 10.3390/toxins12050284. [PMID: 32354080]
  • Nataliia Khomutovska, Małgorzata Sandzewicz, Łukasz Łach, Małgorzata Suska-Malawska, Monika Chmielewska, Hanna Mazur-Marzec, Marta Cegłowska, Toirbek Niyatbekov, Susanna A Wood, Jonathan Puddick, Jan Kwiatowski, Iwona Jasser. Limited Microcystin, Anatoxin and Cylindrospermopsin Production by Cyanobacteria from Microbial Mats in Cold Deserts. Toxins. 2020 04; 12(4):. doi: 10.3390/toxins12040244. [PMID: 32290390]
  • Nelida Cecilia Flores-Rojas, Maranda Esterhuizen-Londt, Stephan Pflugmacher. Uptake, Growth, and Pigment Changes in Lemna minor L. Exposed to Environmental Concentrations of Cylindrospermopsin. Toxins. 2019 11; 11(11):. doi: 10.3390/toxins11110650. [PMID: 31703455]
  • Daniel M Evans, Jack Hughes, Leigh F Jones, Patrick J Murphy, Halina Falfushynska, Oksana Horyn, Inna M Sokolova, Jeppe Christensen, Simon J Coles, Piotr Rzymski. Elucidating cylindrospermopsin toxicity via synthetic analogues: An in vitro approach. Chemosphere. 2019 Nov; 234(?):139-147. doi: 10.1016/j.chemosphere.2019.06.021. [PMID: 31207420]
  • Tereza Vanova, Jan Raska, Pavel Babica, Iva Sovadinova, Michaela Kunova Bosakova, Petr Dvorak, Ludek Blaha, Vladimir Rotrekl. Freshwater Cyanotoxin Cylindrospermopsin Has Detrimental Stage-specific Effects on Hepatic Differentiation From Human Embryonic Stem Cells. Toxicological sciences : an official journal of the Society of Toxicology. 2019 03; 168(1):241-251. doi: 10.1093/toxsci/kfy293. [PMID: 30500929]
  • Leticia Díez-Quijada, Remedios Guzmán-Guillén, Ana I Prieto Ortega, María Llana-Ruíz-Cabello, Alexandre Campos, Vítor Vasconcelos, Ángeles Jos, Ana M Cameán. New Method for Simultaneous Determination of Microcystins and Cylindrospermopsin in Vegetable Matrices by SPE-UPLC-MS/MS. Toxins. 2018 Oct; 10(10):. doi: 10.3390/toxins10100406. [PMID: 30297653]
  • Evanthia Mantzouki, Miquel Lürling, Jutta Fastner, Lisette de Senerpont Domis, Elżbieta Wilk-Woźniak, Judita Koreivienė, Laura Seelen, Sven Teurlincx, Yvon Verstijnen, Wojciech Krztoń, Edward Walusiak, Jūratė Karosienė, Jūratė Kasperovičienė, Ksenija Savadova, Irma Vitonytė, Carmen Cillero-Castro, Agnieszka Budzyńska, Ryszard Goldyn, Anna Kozak, Joanna Rosińska, Elżbieta Szeląg-Wasielewska, Piotr Domek, Natalia Jakubowska-Krepska, Kinga Kwasizur, Beata Messyasz, Aleksandra Pełechaty, Mariusz Pełechaty, Mikolaj Kokocinski, Ana García-Murcia, Monserrat Real, Elvira Romans, Jordi Noguero-Ribes, David Parreño Duque, Elísabeth Fernández-Morán, Nusret Karakaya, Kerstin Häggqvist, Nilsun Demir, Meryem Beklioğlu, Nur Filiz, Eti E. Levi, Uğur Iskin, Gizem Bezirci, Ülkü Nihan Tavşanoğlu, Koray Özhan, Spyros Gkelis, Manthos Panou, Özden Fakioglu, Christos Avagianos, Triantafyllos Kaloudis, Kemal Çelik, Mete Yilmaz, Rafael Marcé, Nuria Catalán, Andrea G. Bravo, Moritz Buck, William Colom-Montero, Kristiina Mustonen, Don Pierson, Yang Yang, Pedro M. Raposeiro, Vítor Gonçalves, Maria G. Antoniou, Nikoletta Tsiarta, Valerie McCarthy, Victor C. Perello, Tõnu Feldmann, Alo Laas, Kristel Panksep, Lea Tuvikene, Ilona Gagala, Joana Mankiewicz-Boczek, Meral Apaydın Yağcı, Şakir Çınar, Kadir Çapkın, Abdulkadir Yağcı, Mehmet Cesur, Fuat Bilgin, Cafer Bulut, Rahmi Uysal, Ulrike Obertegger, Adriano Boscaini, Giovanna Flaim, Nico Salmaso, Leonardo Cerasino, Jessica Richardson, Petra M. Visser, Jolanda M. H. Verspagen, Tünay Karan, Elif Neyran Soylu, Faruk Maraşlıoğlu, Agnieszka Napiórkowska-Krzebietke, Agnieszka Ochocka, Agnieszka Pasztaleniec, Ana M. Antão-Geraldes, Vitor Vasconcelos, João Morais, Micaela Vale, Latife Köker, Reyhan Akçaalan, Meriç Albay, Dubravka Špoljarić Maronić, Filip Stević, Tanja Žuna Pfeiffer, Jeremy Fonvielle, Dietmar Straile, Karl-Otto Rothhaupt, Lars-Anders Hansson, Pablo Urrutia-Cordero, Luděk Bláha, Rodan Geriš, Markéta Fránková, Mehmet Ali Turan Koçer, Mehmet Tahir Alp, Spela Remec-Rekar, Tina Elersek, Theodoros Triantis, Sevasti-Kiriaki Zervou, Anastasia Hiskia, Sigrid Haande, Birger Skjelbred, Beata Madrecka, Hana Nemova, Iveta Drastichova, Lucia Chomova, Christine Edwards, Tuğba Ongun Sevindik, Hatice Tunca, Burçin Önem, Boris Aleksovski, Svetislav Krstić, Itana Bokan Vucelić, Lidia Nawrocka, Pauliina Salmi, Danielle Machado-Vieira, Alinne Gurjão de Oliveira, Jordi Delgado-Martín, David García, Jose Luís Cereijo, Joan Gomà, Mari Carmen Trapote, Teresa Vegas-Vilarrúbia, Biel Obrador, Magdalena Grabowska, Maciej Karpowicz, Damian Chmura, Bárbara Úbeda, José Ángel Gálvez, Arda Özen, Kirsten Seestern Christoffersen, Trine Perlt Warming, Justyna Kobos, Hanna Mazur-Marzec, Carmen Pérez-Martínez, Eloísa Ramos-Rodríguez, Lauri Arvola, Pablo Alcaraz-Párraga, Magdalena Toporowska, Barbara Pawlik-Skowronska, Michał Niedźwiecki, Wojciech Pęczuła, Manel Leira, Armand Hernández, Enrique Moreno-Ostos, José María Blanco, Valeriano Rodríguez, Jorge Juan Montes-Pérez, Roberto L. Palomino, Estela Rodríguez-Pérez, Rafael Carballeira, Antonio Camacho, Antonio Picazo, Carlos Rochera, Anna C. Santamans, Carmen Ferriol, Susana Romo, Juan Miguel Soria, Julita Dunalska, Justyna Sieńska, Daniel Szymański, Marek Kruk, Iwona Kostrzewska-Szlakowska, Iwona Jasser, Petar Žutinić, Marija Gligora Udovič, Anđelka Plenković-Moraj, Magdalena Frąk, Agnieszka Bańkowska-Sobczak, Michał Wasilewicz, Korhan Özkan, Valentini Maliaka, Kersti Kangro, Hans-Peter Grossart, Hans W. Paerl, Cayelan C. Carey, Bas W. Ibelings. Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins. Toxins. 2018 04; 10(4):. doi: 10.3390/toxins10040156. [PMID: 29652856]
  • A C N Moraes, V F Magalhães. Renal tubular damage caused by cylindrospermopsin (cyanotoxin) in mice. Toxicology letters. 2018 Apr; 286(?):89-95. doi: 10.1016/j.toxlet.2017.12.028. [PMID: 29305327]
  • Ana I Prieto, Remedios Guzmán-Guillén, Leticia Díez-Quijada, Alexandre Campos, Vitor Vasconcelos, Ángeles Jos, Ana M Cameán. Validation of a Method for Cylindrospermopsin Determination in Vegetables: Application to Real Samples Such as Lettuce (Lactuca sativa L.). Toxins. 2018 Feb; 10(2):. doi: 10.3390/toxins10020063. [PMID: 29389882]
  • Rodrigo de Cássio da Silva, Sonia Regina Grötzner, Daniele Dietrich Moura Costa, Juan Ramón Esquivel Garcia, Juan Muelbert, Valéria Freitas de Magalhães, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro. Comparative bioaccumulation and effects of purified and cellular extract of cylindrospermopsin to freshwater fish Hoplias malabaricus. Journal of toxicology and environmental health. Part A. 2018; 81(14):620-632. doi: 10.1080/15287394.2018.1469101. [PMID: 29764335]
  • N Chernoff, D J Hill, I Chorus, D L Diggs, H Huang, D King, J R Lang, T-T Le, J E Schmid, G S Travlos, E M Whitley, R E Wilson, C R Wood. Cylindrospermopsin toxicity in mice following a 90-d oral exposure. Journal of toxicology and environmental health. Part A. 2018; 81(13):549-566. doi: 10.1080/15287394.2018.1460787. [PMID: 29693504]
  • R C Silva, S Liebel, H H P de Oliveira, W A Ramsdorf, J R E Garcia, S M F O Azevedo, V F Magalhães, C A Oliveira Ribeiro, F Filipak Neto. Cylindrospermopsin effects on cell viability and redox milieu of Neotropical fish Hoplias malabaricus hepatocytes. Fish physiology and biochemistry. 2017 Oct; 43(5):1237-1244. doi: 10.1007/s10695-017-0367-y. [PMID: 28389904]
  • Christopher Cartmell, Daniel M Evans, Jessica M L Elwood, Hisham S Fituri, Patrick J Murphy, Thomas Caspari, Barbara Poniedziałek, Piotr Rzymski. Synthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Oct; 44(?):172-181. doi: 10.1016/j.tiv.2017.07.007. [PMID: 28705760]
  • Remedios Guzmán-Guillén, Ana I Prieto Ortega, Isabel M Moreno, Victoria Ríos, Rosario Moyano, Alfonso Blanco, Vitor Vasconcelos, Ana M Cameán. Effects of depuration on histopathological changes in tilapia (Oreochromis niloticus) after exposure to cylindrospermopsin. Environmental toxicology. 2017 Apr; 32(4):1318-1332. doi: 10.1002/tox.22326. [PMID: 27463828]
  • Márta M-Hamvas, Kitti Ajtay, Dániel Beyer, Katalin Jámbrik, Gábor Vasas, Gyula Surányi, Csaba Máthé. Cylindrospermopsin induces biochemical changes leading to programmed cell death in plants. Apoptosis : an international journal on programmed cell death. 2017 Feb; 22(2):254-264. doi: 10.1007/s10495-016-1322-6. [PMID: 27787653]
  • J Machado, A Campos, V Vasconcelos, M Freitas. Effects of microcystin-LR and cylindrospermopsin on plant-soil systems: A review of their relevance for agricultural plant quality and public health. Environmental research. 2017 Feb; 153(?):191-204. doi: 10.1016/j.envres.2016.09.015. [PMID: 27702441]
  • Csaba Mathe, Márta M-Hamvas, Tamas Garda, Daniel Beyer, Gabor Vasas. Cellular Effects of Cylindrospermopsin (Cyanobacterial Alkaloid Toxin) and its Potential Medical Consequences. Current medicinal chemistry. 2017; 24(1):91-109. doi: 10.2174/0929867323666161028153814. [PMID: 27804882]
  • Remedios Guzmán-Guillén, Ana I Prieto Ortega, Rosario Moyano, Alfonso Blanco, Vitor Vasconcelos, Ana M Cameán. Dietary l-carnitine prevents histopathological changes in tilapia (Oreochromis Niloticus) exposed to cylindrospermopsin. Environmental toxicology. 2017 Jan; 32(1):241-254. doi: 10.1002/tox.22229. [PMID: 26714798]
  • Remedios Guzmán-Guillén, Alexandre Campos, Joana Machado, Marisa Freitas, Joana Azevedo, Edgar Pinto, Agostinho Almeida, Ana M Cameán, Vitor Vasconcelos. Effects of Chrysosporum (Aphanizomenon) ovalisporum extracts containing cylindrospermopsin on growth, photosynthetic capacity, and mineral content of carrots (Daucus carota). Ecotoxicology (London, England). 2017 Jan; 26(1):22-31. doi: 10.1007/s10646-016-1737-4. [PMID: 27770233]
  • Maranda Esterhuizen-Londt, Stephan Pflugmacher. Inability to detect free cylindrospermopsin in spiked aquatic organism extracts plausibly suggests protein binding. Toxicon : official journal of the International Society on Toxinology. 2016 Nov; 122(?):89-93. doi: 10.1016/j.toxicon.2016.09.020. [PMID: 27693305]
  • Remedios Guzmán-Guillén, Ana I Prieto Ortega, Daniel Gutiérrez-Praena, Isabel M Moreno, Rosario Moyano, Alfonso Blanco, Ana M Cameán. Vitamin E pretreatment prevents histopathological effects in tilapia (Oreochromis niloticus) acutely exposed to cylindrospermopsin. Environmental toxicology. 2016 Nov; 31(11):1469-1485. doi: 10.1002/tox.22152. [PMID: 26011011]
  • Maranda Esterhuizen-Londt, Marie von Schnehen, Sandra Kühn, Stephan Pflugmacher. Oxidative stress responses in the animal model, Daphnia pulex exposed to a natural bloom extract versus artificial cyanotoxin mixtures. Aquatic toxicology (Amsterdam, Netherlands). 2016 Oct; 179(?):151-7. doi: 10.1016/j.aquatox.2016.09.003. [PMID: 27614285]
  • Dariusz Dziga, Mikolaj Kokocinski, Anna Maksylewicz, Urszula Czaja-Prokop, Jakub Barylski. Cylindrospermopsin Biodegradation Abilities of Aeromonas sp. Isolated from Rusałka Lake. Toxins. 2016 Feb; 8(3):. doi: 10.3390/toxins8030055. [PMID: 26927173]
  • Ehsan Maghsoudi, Nathalie Fortin, Charles Greer, Sung Vo Duy, Paul Fayad, Sébastien Sauvé, Michèle Prévost, Sarah Dorner. Biodegradation of multiple microcystins and cylindrospermopsin in clarifier sludge and a drinking water source: Effects of particulate attached bacteria and phycocyanin. Ecotoxicology and environmental safety. 2015 Oct; 120(?):409-17. doi: 10.1016/j.ecoenv.2015.06.001. [PMID: 26122734]
  • Remedios Guzmán-Guillén, Ana I Prieto Ortega, Ana Martín-Caméan, Ana M Cameán. Beneficial effects of vitamin E supplementation against the oxidative stress on Cylindrospermopsin-exposed tilapia (Oreochromis niloticus). Toxicon : official journal of the International Society on Toxinology. 2015 Sep; 104(?):34-42. doi: 10.1016/j.toxicon.2015.07.336. [PMID: 26235908]
  • Barbara Poniedziałek, Piotr Rzymski, Jacek Karczewski. The role of the enzymatic antioxidant system in cylindrospermopsin-induced toxicity in human lymphocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2015 Aug; 29(5):926-32. doi: 10.1016/j.tiv.2015.03.023. [PMID: 25863213]
  • Marisa Freitas, Joana Azevedo, Edgar Pinto, Joana Neves, Alexandre Campos, Vitor Vasconcelos. Effects of microcystin-LR, cylindrospermopsin and a microcystin-LR/cylindrospermopsin mixture on growth, oxidative stress and mineral content in lettuce plants (Lactuca sativa L.). Ecotoxicology and environmental safety. 2015 Jun; 116(?):59-67. doi: 10.1016/j.ecoenv.2015.02.002. [PMID: 25768423]
  • Remedios Guzmán-Guillén, Inmaculada Lomares Manzano, Isabel M Moreno, Ana I Prieto Ortega, Rosario Moyano, Alfonso Blanco, Ana M Cameán. Cylindrospermopsin induces neurotoxicity in tilapia fish (Oreochromis niloticus) exposed to Aphanizomenon ovalisporum. Aquatic toxicology (Amsterdam, Netherlands). 2015 Apr; 161(?):17-24. doi: 10.1016/j.aquatox.2015.01.024. [PMID: 25661706]
  • Samuel Liebel, Ciro Alberto de Oliveira Ribeiro, Valéria Freitas de Magalhães, Rodrigo de Cássio da Silva, Stéfani Cibele Rossi, Marco Antônio Ferreira Randi, Francisco Filipak Neto. Low concentrations of cylindrospermopsin induce increases of reactive oxygen species levels, metabolism and proliferation in human hepatoma cells (HepG2). Toxicology in vitro : an international journal published in association with BIBRA. 2015 Apr; 29(3):479-88. doi: 10.1016/j.tiv.2014.12.022. [PMID: 25575781]
  • Remedios Guzmán-Guillén, Ana I Prieto, Isabel Moreno, Vitor M Vasconcelos, Rosario Moyano, Alfonso Blanco, Ana M Cameán Fernandez. Cyanobacterium producing cylindrospermopsin cause histopathological changes at environmentally relevant concentrations in subchronically exposed tilapia (Oreochromis niloticus). Environmental toxicology. 2015 Mar; 30(3):261-77. doi: 10.1002/tox.21904. [PMID: 24000190]
  • Marisa Freitas, Alexandre Campos, Joana Azevedo, Aldo Barreiro, Sébastien Planchon, Jenny Renaut, Vitor Vasconcelos. Lettuce (Lactuca sativa L.) leaf-proteome profiles after exposure to cylindrospermopsin and a microcystin-LR/cylindrospermopsin mixture: a concentration-dependent response. Phytochemistry. 2015 Feb; 110(?):91-103. doi: 10.1016/j.phytochem.2014.12.004. [PMID: 25553582]
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