Iminodiacetate (IDA) (BioDeep_00000013126)

 

Secondary id: BioDeep_00001868205

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


Iminodiacetic acid, calcium salt (1:1)

化学式: C4H7NO4 (133.0375062)
中文名称: 亚氨基二乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.12%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Iminodiacetate (IDA). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/iminodiacetate_(ida) (retrieved 2024-11-08) (BioDeep RN: BioDeep_00000013126). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(=O)O)NCC(=O)O
InChI: InChI=1S/C4H7NO4/c6-3(7)1-5-2-4(8)9/h5H,1-2H2,(H,6,7)(H,8,9)

描述信息

Iminodiacetic acid (IDA) is a dicarboxylic acid amine. It is a strongly acidic compound that is very water soluble. It naturally exists as a white powder. IDA is food by-product or intermediate produced via the reaction of glycine with acrylamide through the heating, baking or frying of carbohydrate-rich foods such as potatoes (PMID: 25212154). Acrylamide is typically produced through a Maillard reaction (a heating reaction) of asparagine and various reducing sugars in plant-derived foods (PMID: 12368844). Concentrations of IDA are reduced in the plasma of individuals with autism (PMID: 33087514) and elevated in individuals with acute respiratory distress syndrome (ARDS) (PMID: 30779905). In addition to its role in metabolism, IDA has many industrial applications or roles. For instance, it is an important intermediate in the manufacture the herbicide glyphosate. IDA is also used in capillary electrophoresis for modulating peptide mobility and can be used as a precursor for the manufacture of the indicator xylenol orange. The iminodiacetate anion can act as a tridentate ligand to form a metal complex with two, fused, five membered chelate rings. The proton on the nitrogen atom can be replaced by a carbon atom of a polymer to create an ion-exchange resin, such as chelex 100. Iminodiacetic acid is used in HIDA (hepatobiliary iminodiacetic acid) scans or cholescintigraphy scans, that employ the radionuclide Technetium 99m, to diagnose several diseases in the liver, gallbladder and bile duct.
Iminodiacetic acid (IDA) is an polyamino carboxylic acid. The iminodiacetate anion can act as a tridentate ligand to form a metal complex with two, fused, five membered chelate rings. The proton on the nitrogen atom can be replaced by a carbon atom of a polymer to create an ion-exchange resin, such as chelex 100.
D064449 - Sequestering Agents > D002614 - Chelating Agents
Iminodiacetic acid (IDA) is a chelating agent that strongly binds transition metals[1]. Iminodiacetic acid can be used for removal of toxic metal ions from water[2]. Iminodiacetic acid can serve as a biomarker to potentially predict the severity of ARDS (acute respiratory distress syndrome)[3].

同义名列表

25 个代谢物同义名

Iminodiacetic acid, calcium salt (1:1); 2-[(Carboxymethyl)amino]acetic acid; Iminodiacetic acid, disodium salt; Iminodiacetic acid, sodium salt; 2-[(Carboxymethyl)amino]acetate; N-(Carboxymethyl)- glycine; 2,2-Azanediyldiacetic acid; N-(Carboxymethyl)glycine; Bis(carboxymethyl)amine; 2,2-Iminodiacetic acid; 2,2-Azanediyldiacetate; Iminobis(acetic acid); Iminodiethanoic acid; IMINODIACETIC ACID; 2,2-Iminodiacetate; Aminodiacetic acid; Imidodiacetic acid; Iminobis(acetate); Iminodiethanoate; Aminodiacetate; Iminodiacetate; Diglycocoll; Diglykokoll; Diglycine; IDA



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ashish Khaparde, S Lokesh Kumar, M A Vijayalakshmi, Kishore K R Tetala. A conjoint multi metal-ion iminodiacetic acid monolith microfluidic chip for structural-based protein pre-fractionation. Electrophoresis. 2021 12; 42(24):2647-2655. doi: 10.1002/elps.202100288. [PMID: 34687221]
  • Muhammad Salman Sajid, Shafaq Saleem, Fahmida Jabeen, Batool Fatima, M Zulfikar, Muhammad Naeem Ashiq, Habtom W Ressom, Tara Louise Pukala, Muhammad Najam-Ul-Haq. Iminodiacetic acid (IDA)-generated mesoporous nanopolymer: a template to relate surface area, hydrophilicity, and glycopeptides enrichment. Mikrochimica acta. 2021 11; 188(12):417. doi: 10.1007/s00604-021-05074-8. [PMID: 34762162]
  • Meng Wang, Huifang Ma, Quan Chi, Qin Li, Ming Li, Huijuan Zhang, Chunya Li, Huaifang Fang. A monolithic copolymer prepared from N-(4-vinyl)-benzyl iminodiacetic acid, divinylbenzene and N,N'-methylene bisacrylamide for preconcentration of cadmium(II) and cobalt(II) from biological samples prior to their determination by ICP-MS. Mikrochimica acta. 2019 07; 186(8):537. doi: 10.1007/s00604-019-3656-6. [PMID: 31317277]
  • Magdalena Markowicz-Piasecka, Agata Skupień, Elżbieta Mikiciuk-Olasik, Joanna Sikora. Biocompatibility Studies of Gadolinium Complexes with Iminodiacetic Acid Derivatives. Biological trace element research. 2019 Jun; 189(2):426-436. doi: 10.1007/s12011-018-1496-6. [PMID: 30215189]
  • Wenjuan Zhang, Liyan Jiang, Li Fu, Qiong Jia. Selective enrichment of glycopeptides based on copper tetra(N-carbonylacrylic) aminephthalocyanine and iminodiacetic acid functionalized polymer monolith. Journal of separation science. 2019 Mar; 42(5):1037-1044. doi: 10.1002/jssc.201801030. [PMID: 30593720]
  • Haizhu Lin, Xi Shao, Yan Lu, Chunhui Deng. Preparation of iminodiacetic acid functionalized silica capillary trap column for on-column selective enrichment of N-linked glycopeptides. Talanta. 2018 Oct; 188(?):499-506. doi: 10.1016/j.talanta.2018.06.031. [PMID: 30029404]
  • Mengfan Zhai, Feng Ma, Junying Li, Binbin Wan, Ning Yu. Preparation and properties of cryogel based on poly(hydroxypropyl methacrylate). Journal of biomaterials science. Polymer edition. 2018 08; 29(12):1401-1425. doi: 10.1080/09205063.2018.1464263. [PMID: 29667520]
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  • Shasha Yao, Yanqin Huang, Yanbao Zhao, Yu Zhang, Xueyan Zou, Chunpeng Song. Iminodiacetic acid functionalized porous hydroxyapatite nanoparticles for capturing histidine-tagged proteins. Materials science & engineering. C, Materials for biological applications. 2014 Jun; 39(?):1-5. doi: 10.1016/j.msec.2014.02.034. [PMID: 24863189]
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