N,N-Dimethyl-4-nitrosoaniline (BioDeep_00000012996)

 

Secondary id: BioDeep_00001868111

human metabolite blood metabolite


代谢物信息卡片


4-Nitrosodimethylaniline monohydrochloride

  化学式: C8H10N2O (150.0793)
中文名称: N,N-二甲基-4-亚硝基苯胺
  谱图信息: 最多检出来源 Homo sapiens(blood) 44.23%

分子结构信息

SMILES: CN(C)C1=CC=C(C=C1)N=O
InChI: InChI=1S/C8H10N2O/c1-10(2)8-5-3-7(9-11)4-6-8/h3-6H,1-2H3


描述信息

CONFIDENCE standard compound; INTERNAL_ID 907; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2330; ORIGINAL_PRECURSOR_SCAN_NO 2329
CONFIDENCE standard compound; INTERNAL_ID 907; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2326; ORIGINAL_PRECURSOR_SCAN_NO 2324
CONFIDENCE standard compound; INTERNAL_ID 907; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2328; ORIGINAL_PRECURSOR_SCAN_NO 2327
CONFIDENCE standard compound; INTERNAL_ID 907; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2338; ORIGINAL_PRECURSOR_SCAN_NO 2337
CONFIDENCE standard compound; INTERNAL_ID 907; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2335; ORIGINAL_PRECURSOR_SCAN_NO 2331
CONFIDENCE standard compound; INTERNAL_ID 907; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2337; ORIGINAL_PRECURSOR_SCAN_NO 2335

同义名列表

65 个代谢物同义名

4-Nitrosodimethylaniline monohydrochloride; p-(N,N-Dimethylamino)nitrosobenzene; 4-(Dimethylamino)nitrosobenzene; p-(Dimethylamino)nitrosobenzene; Dimethyl(p-nitrosophenyl)amine; 4-Nitroso-N,N-dimethylaniline; N,N-Dimethyl-4-nitrosoaniline; N,N-Dimethyl-p-nitrosoaniline; p-Nitroso-N,N-dimethylaniline; NDMA nitrosodimethylaniline; Para-nitrosodimethylaniline; Paranitrosodimethylanilide; Dimethyl-p-nitrosoaniline; p-Nitroso dimethylaniline; p-Nitrosodimethylaniline; 4-Nitrosodimethylaniline; p-Nitrosodimethylanilide; Accelerine; NDMA; WLN: ONR DN1 & 1; N,N-Dimethyl-4-nitrosoaniline; 1-(Dimethylamino)-4-nitrosobenzene; 4-12-00-01558 (Beilstein Handbook Reference); 4-NITROSO-N,N-DIMETHYLAMINOBENZENE; 4(Dimethylamino)nitrosobenzene; 4Nitrosodimethylaniline; 4NitrosoN,Ndimethylaniline; Accelerene; AI3-15393; Aniline, 4-nitrosodimethyl; aniline, N,N-dimethyl-4-nitroso-; Aniline, N,N-dimethyl-p-nitroso-; Aniline, N,Ndimethylpnitroso; Aniline,N-dimethyl-p-nitroso-; Benzen-2,6-d2-amine, N,N-dimethyl-4-nitroso-; Benzenamine, N,N-dimethyl-4-nitroso-; Benzenamine, N,Ndimethyl4nitroso; Benzenamine,N-dimethyl-4-nitroso-; dimethyl-(4-nitroso-phenyl)-amine; DIMETHYL-P-NITROSOANILINE, N,N-; Dimethyl(pnitrosophenyl)amine; N,N-dimethyl-4-nitroso-aniline; N,N-Dimethyl-4-nitrosoaniline, 97%; N,N-Dimethyl-4-nitrosobenzenamine; N,N-dimethyl-N-(4-nitrosophenyl)amine; N,N-DIMETHYL-P-NITROSO ANILINE; N,N-DIMETHYL-P-NITROSOANILINE [HSDB]; n,n-dimethyl-para-nitrosoaniline; N,N'-dimethyl-4-nitrosoaniline; N,NDimethyl4nitrosoaniline; N,NDimethyl4nitrosobenzenamine; NDMA (Substrate 4); NITROSOANILINE, N,N-DIMETHYL-P-; P-NDMA; P-NITROSO-N,N-DIMETHYLANILINE [MI]; p-nitrosodimethylanilin; p(Dimethylamino)nitrosobenzene; p(N,NDimethylamino)nitrosobenzene; pNitrosodimethylanilide; pNitrosodimethylaniline; pNitrosoN,Ndimethylaniline; Tox21_202129; Tox21_303049; Ultra Brilliant Blue P; Vulcaniline



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Wojciech Jelski, Magdalena Laniewska-Dunaj, Jacek Niklinski, Miroslaw Kozłowski, Jerzy Laudanski, Maciej Szmitkowski. The alcohol dehydrogenase isoenzyme (ADH IV) as a candidate tumour marker of esophageal cancer. Acta biochimica Polonica. 2013; 60(3):489-93. doi: 10.18388/abp.2013_2012. [PMID: 24051444]
  • Wojciech Jelski, Emilia Kutylowska, Magdalena Laniewska-Dunaj, Karolina Orywal, Wiktor Laszewicz, Maciej Szmitkowski. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with acute and chronic pancreatitis. Experimental and molecular pathology. 2011 Oct; 91(2):631-5. doi: 10.1016/j.yexmp.2011.06.008. [PMID: 21798257]
  • Gopal K Pattanayak, Baishnab C Tripathy. Overexpression of protochlorophyllide oxidoreductase C regulates oxidative stress in Arabidopsis. PloS one. 2011; 6(10):e26532. doi: 10.1371/journal.pone.0026532. [PMID: 22031838]
  • Wojciech Jelski, Miroslaw Kozlowski, Jerzy Laudanski, Jacek Niklinski, Maciej Szmitkowski. Alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in the sera of patients with esophageal cancer. Clinical and experimental medicine. 2009 Jun; 9(2):131-7. doi: 10.1007/s10238-008-0028-7. [PMID: 19184326]
  • Biplab Bose, Alok Dube. Photodynamic efficacy of chlorin p6: a pH dependent study in aqueous and lipid environment. Journal of photochemistry and photobiology. B, Biology. 2008 Oct; 93(1):32-5. doi: 10.1016/j.jphotobiol.2008.06.007. [PMID: 18682329]
  • Wojciech Jelski, Bogdan Zalewski, Maciej Szmitkowski. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with pancreatic cancer. Digestive diseases and sciences. 2008 Aug; 53(8):2276-80. doi: 10.1007/s10620-007-0144-3. [PMID: 18095160]
  • Wojciech Jelski, Bogdan Zalewski, Maciej Szmitkowski. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer. Journal of clinical laboratory analysis. 2008; 22(3):204-9. doi: 10.1002/jcla.20241. [PMID: 18484658]
  • W Jelski, B Zalewski, L Chrostek, M Szmitkowski. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with colorectal cancer. Clinical and experimental medicine. 2007 Dec; 7(4):154-7. doi: 10.1007/s10238-007-0140-0. [PMID: 18188528]
  • Wojciech Jelski, Lech Chrostek, Wiktor Laszewicz, Maciej Szmitkowski. Alcohol dehydrogenase (ADH) isoenzyme activity in the sera of patients with Helicobacter pylori infection. Digestive diseases and sciences. 2007 Jun; 52(6):1513-6. doi: 10.1007/s10620-006-9566-6. [PMID: 17404875]
  • Dawit D Yifru, Valentine A Nzengung. Uptake of N-nitrosodimethylamine (NDMA) from water by phreatophytes in the absence and presence of perchlorate as a co-contaminant. Environmental science & technology. 2006 Dec; 40(23):7374-80. doi: 10.1021/es060449d. [PMID: 17180991]
  • W Jelski, L Chrostek, M Szmitkowski, W Markiewicz. The activity of class I, II, III and IV alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in breast cancer. Clinical and experimental medicine. 2006 Jun; 6(2):89-93. doi: 10.1007/s10238-006-0101-z. [PMID: 16820997]
  • Chuanping Feng, Norio Sugiura, Satoru Shimada, Takaaki Maekawa. Development of a high performance electrochemical wastewater treatment system. Journal of hazardous materials. 2003 Oct; 103(1-2):65-78. doi: 10.1016/s0304-3894(03)00222-x. [PMID: 14568697]
  • William A Mitch, Andreas C Gerecke, David L Sedlak. A N-Nitrosodimethylamine (NDMA) precursor analysis for chlorination of water and wastewater. Water research. 2003 Sep; 37(15):3733-41. doi: 10.1016/s0043-1354(03)00289-6. [PMID: 12867341]
  • Wojciech Lesniak, Wesley R Harris, Joslyn Yudenfreund Kravitz, Jochen Schacht, Vincent L Pecoraro. Solution chemistry of copper(II)-gentamicin complexes: relevance to metal-related aminoglycoside toxicity. Inorganic chemistry. 2003 Mar; 42(5):1420-9. doi: 10.1021/ic025965t. [PMID: 12611506]
  • Kun Lin, Wenying Shen, Zhongying Shen, Yongning Wu, Shihhsin Lu. Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China. International journal of cancer. 2002 Nov; 102(3):207-11. doi: 10.1002/ijc.10698. [PMID: 12397637]
  • P Navasumrit, T H Ward, P J O'Connor, J Nair, N Frank, H Bartsch. Ethanol enhances the formation of endogenously and exogenously derived adducts in rat hepatic DNA. Mutation research. 2001 Aug; 479(1-2):81-94. doi: 10.1016/s0027-5107(01)00156-7. [PMID: 11470483]
  • S K Chhabra, L M Anderson, C Perella, D Desai, S Amin, S A Kyrtopoulos, V L Souliotis. Coexposure to ethanol with N-nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone during lactation of rats: marked increase in O(6)-methylguanine-DNA adducts in maternal mammary gland and in suckling lung and kidney. Toxicology and applied pharmacology. 2000 Dec; 169(2):191-200. doi: 10.1006/taap.2000.9068. [PMID: 11097872]
  • E Arinç, O Adali, A M Gençler-Ozkan. Stimulation of aniline, p-nitrophenol and N-nitrosodimethylamine metabolism in kidney by pyridine pretreatment of rabbits. Archives of toxicology. 2000 Nov; 74(9):527-32. doi: 10.1007/s002040000164. [PMID: 11131032]
  • T Fujioka, Y Suzuki, T Okamoto, N Mastushita, M Hasegawa, S Omori. Prevention of renal cell carcinoma by active vitamin D3. World journal of surgery. 2000 Oct; 24(10):1205-10. doi: 10.1007/s002680010206. [PMID: 11071463]
  • M Sawamura, S H Sun, K Ozaki, J Ishikawa, H Ukeda. Inhibitory effects of citrus essential oils and their components on the formation of N-nitrosodimethylamine. Journal of agricultural and food chemistry. 1999 Dec; 47(12):4868-72. doi: 10.1021/jf9903206. [PMID: 10606544]
  • M Taniguchi, A Yasutake, K Takedomi, K Inoue. Effects of N-nitrosodimethylamine (NDMA) on the oxidative status of rat liver. Archives of toxicology. 1999 Apr; 73(3):141-6. doi: 10.1007/s002040050598. [PMID: 10401679]
  • L L de Zwart, N P Vermeulen, R C Hermanns, J N Commandeur, P J Salemink, J H Meerman. Urinary excretion of biomarkers for radical-induced damage in rats treated with NDMA or diquat and the effects of calcium carbimide co-administration. Chemico-biological interactions. 1999 Jan; 117(2):151-72. doi: 10.1016/s0009-2797(98)00106-9. [PMID: 10190574]
  • Y H Shiao, J M Rice, L M Anderson, B A Diwan, G C Hard. von Hippel-Lindau gene mutations in N-nitrosodimethylamine-induced rat renal epithelial tumors. Journal of the National Cancer Institute. 1998 Nov; 90(22):1720-3. doi: 10.1093/jnci/90.22.1720. [PMID: 9827526]
  • J R Gnarra. von Hippel-Lindau gene mutations in human and rodent renal tumors--association with clear cell phenotype. Journal of the National Cancer Institute. 1998 Nov; 90(22):1685-7. doi: 10.1093/jnci/90.22.1685. [PMID: 9827515]
  • T Daussmann, A Aivasidis, C Wandrey. Purification and characterization of an alcohol:N,N-dimethyl-4-nitrosoaniline oxidoreductase from the methanogen Methanosarcina barkeri DSM 804 strain Fusaro. European journal of biochemistry. 1997 Sep; 248(3):889-96. doi: 10.1111/j.1432-1033.1997.00889.x. [PMID: 9342243]
  • L Chrostek, M Szmitkowski. Activity of class I and II isoenzymes of alcohol dehydrogenase measured by a fluorometric method in the sera of patients with obstructive jaundice. Clinica chimica acta; international journal of clinical chemistry. 1997 Jul; 263(1):117-22. doi: 10.1016/s0009-8981(97)00056-9. [PMID: 9247733]
  • L B Fay, C D Leaf, E Gremaud, J M Aeschlimann, C Steen, D E Shuker, R J Turesky. Urinary excretion of 3-methyladenine after consumption of fish containing high levels of dimethylamine. Carcinogenesis. 1997 May; 18(5):1039-44. doi: 10.1093/carcin/18.5.1039. [PMID: 9163693]
  • B Hasséus, M Wallström, B G Osterdahl, J M Hirsch, M Jontell. Immunotoxic effects of smokeless tobacco on the accessory cell function of rat oral epithelium. European journal of oral sciences. 1997 Feb; 105(1):45-51. doi: 10.1111/j.1600-0722.1997.tb00179.x. [PMID: 9085028]
  • L Chrostek, M Szmitkowski, A Panasiuk. Alcohol dehydrogenase (ADH) activity in the sera of patients during the course of viral hepatitis. Roczniki Akademii Medycznej w Bialymstoku (1995). 1997; 42(1):107-13. doi: NULL. [PMID: 9581470]
  • P Widlak, X Zheng, B G Osterdahl, B Drettner, B Christensson, R Kumar, K Hemminki. N-nitrosodimethylamine and 7-methylguanine DNA adducts in tissues of rats fed Chinese salted fish. Cancer letters. 1995 Jul; 94(1):85-90. doi: 10.1016/0304-3835(95)03828-k. [PMID: 7621449]
  • E Mereto, L Robbiano, M Ghia, A Allavena, A Martelli, G Brambilla. Evaluation of DNA-damaging, clastogenic, and promoting activities of metoclopramide and procainamide in rats. Toxicology and applied pharmacology. 1995 Apr; 131(2):192-7. doi: 10.1006/taap.1995.1061. [PMID: 7716761]
  • D G Robertson, G A Epling, J S Kiely, D L Bailey, B Song. Mechanistic studies of the phototoxic potential of PD 117596, a quinolone antibacterial compound. Toxicology and applied pharmacology. 1991 Nov; 111(2):221-32. doi: 10.1016/0041-008x(91)90026-b. [PMID: 1659755]
  • E B Leahey, J A Reiffel, R H Heissenbuttel, R E Drusin, W P Lovejoy, J T Bigger. Enhanced cardiac effect of digoxin during quinidine treatment. Archives of internal medicine. 1979 May; 139(5):519-21. doi: NULL. [PMID: 443945]
  • C M Goodall, W Lijinsky. Oncogenicity tests of p-nitroso-N,N-dimethylaniline and p-nitroso-N,N-diethylaniline in NZR rats and NZO mice. Pathology. 1976 Apr; 8(2):143-9. doi: 10.3109/00313027609094440. [PMID: 972772]