Diazomethane (BioDeep_00000012804)

 

Secondary id: BioDeep_00000730222

human metabolite blood metabolite


代谢物信息卡片


Diazonium methylide

化学式: CH2N2 (42.0217972)
中文名称: 重氮甲烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=[N+]=[N-]
InChI: InChI=1S/CH2N2/c1-3-2/h1H2

描述信息

同义名列表

6 个代谢物同义名

Diazonium methylide; EINECS 206-382-7; Acomethylene; Azimethylene; DIAZOMETHANE; Diazirine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Samuel W J Shields, Carlos R Canez, Christian A Rosales, Joshua A Roberts, Hillary Bourgaize, Peter J Pallister, Jeffrey M Manthorpe, Jeffrey C Smith. Optimized 13C-TrEnDi Enhances the Sensitivity of Plasmenyl Ether Glycerophospholipids and Demonstrates Compatibility with Other Derivatization Strategies. Journal of the American Society for Mass Spectrometry. 2024 May; 35(5):972-981. doi: 10.1021/jasms.4c00015. [PMID: 38551491]
  • Liangming Zhang, Xiongfeng Chen, Jianwei Wang, Meihong Chen, Juan Chen, Wanzhen Zhuang, Yu Xia, Zhixin Huang, Yue Zheng, Yi Huang. Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer. Scientific reports. 2024 02; 14(1):4985. doi: 10.1038/s41598-024-55544-1. [PMID: 38424293]
  • Joshua A Roberts, Christian A Rosales, Karl V Wasslen, Angela S Radnoff, Elena Godbout, Jean-Simon Diallo, Jeffrey M Manthorpe, Jeffrey C Smith. An In Silico Database for Automated Feature Identification of High-Resolution Tandem Mass Spectrometry 13C-Trimethylation Enhancement Using Diazomethane (13C-TrEnDi)-Modified Lipid Data. Journal of the American Society for Mass Spectrometry. 2023 Dec; 34(12):2722-2730. doi: 10.1021/jasms.3c00273. [PMID: 37929927]
  • Yuta Murai, Makoto Hashimoto. Heteroaromatic Diazirines Are Essential Building Blocks for Material and Medicinal Chemistry. Molecules (Basel, Switzerland). 2023 Feb; 28(3):. doi: 10.3390/molecules28031408. [PMID: 36771073]
  • Patricia Korn, Christian Schwieger, Kai Gruhle, Vasil M Garamus, Annette Meister, Christian Ihling, Simon Drescher. Azide- and diazirine-modified membrane lipids: Physicochemistry and applicability to study peptide/lipid interactions via cross-linking/mass spectrometry. Biochimica et biophysica acta. Biomembranes. 2022 10; 1864(10):184004. doi: 10.1016/j.bbamem.2022.184004. [PMID: 35841926]
  • Weizhi Yu, Jeremy M Baskin. Photoaffinity labeling approaches to elucidate lipid-protein interactions. Current opinion in chemical biology. 2022 08; 69(?):102173. doi: 10.1016/j.cbpa.2022.102173. [PMID: 35724595]
  • Julia Dorner, Patricia Korn, Kai Gruhle, Daniel Ramsbeck, Vasil M Garamus, Hauke Lilie, Annette Meister, Christian Schwieger, Christian Ihling, Andrea Sinz, Simon Drescher. A Diazirine-Modified Membrane Lipid to Study Peptide/Lipid Interactions - Chances and Challenges. Chemistry (Weinheim an der Bergstrasse, Germany). 2021 Oct; 27(59):14586-14593. doi: 10.1002/chem.202102048. [PMID: 34406694]
  • T J Cuthbert, S Ennis, S F Musolino, H L Buckley, M Niikura, J E Wulff, C Menon. Covalent functionalization of polypropylene filters with diazirine-photosensitizer conjugates producing visible light driven virus inactivating materials. Scientific reports. 2021 09; 11(1):19029. doi: 10.1038/s41598-021-98280-6. [PMID: 34561486]
  • Craig Gutierrez, Leah J Salituro, Clinton Yu, Xiaorong Wang, Sadie F DePeter, Scott D Rychnovsky, Lan Huang. Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers. Molecular & cellular proteomics : MCP. 2021; 20(?):100084. doi: 10.1016/j.mcpro.2021.100084. [PMID: 33915260]
  • M Salah, M E Belghiti, A O Aitouna, A Zeroual, S Jorio, H El Alaoui Abdellaoui, H El Hadki, K Marakchi, N Komiha. MEDT study of the 1,3-DC reaction of diazomethane with Psilostachyin and investigation about the interactions of some pyrazoline derivatives with protease (Mpro) of nCoV-2. Journal of molecular graphics & modelling. 2021 01; 102(?):107763. doi: 10.1016/j.jmgm.2020.107763. [PMID: 33069124]
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  • Stella K Betancourt, Carlos R Canez, Samuel W J Shields, Jeffrey M Manthorpe, Jeffrey C Smith, Scott A McLuckey. Trimethylation Enhancement Using 13C-Diazomethane: Gas-Phase Charge Inversion of Modified Phospholipid Cations for Enhanced Structural Characterization. Analytical chemistry. 2017 09; 89(17):9452-9458. doi: 10.1021/acs.analchem.7b02271. [PMID: 28764333]
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  • Tanxi Cai, Qingbo Shu, Peibin Liu, Lili Niu, Xiaojing Guo, Xiang Ding, Peng Xue, Zhensheng Xie, Jifeng Wang, Nali Zhu, Peng Wu, Lili Niu, Fuquan Yang. Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling. Journal of lipid research. 2016 Mar; 57(3):388-97. doi: 10.1194/jlr.m063024. [PMID: 26733148]
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  • Karl V Wasslen, Carlos R Canez, Hyunmin Lee, Jeffrey M Manthorpe, Jeffrey C Smith. Trimethylation enhancement using diazomethane (TrEnDi) II: rapid in-solution concomitant quaternization of glycerophospholipid amino groups and methylation of phosphate groups via reaction with diazomethane significantly enhances sensitivity in mass spectrometry analyses via a fixed, permanent positive charge. Analytical chemistry. 2014 Oct; 86(19):9523-32. doi: 10.1021/ac501588y. [PMID: 25208053]
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  • Karl V Wasslen, Le Hoa Tan, Jeffrey M Manthorpe, Jeffrey C Smith. Trimethylation enhancement using diazomethane (TrEnDi): rapid on-column quaternization of peptide amino groups via reaction with diazomethane significantly enhances sensitivity in mass spectrometry analyses via a fixed, permanent positive charge. Analytical chemistry. 2014 Apr; 86(7):3291-9. doi: 10.1021/ac403349c. [PMID: 24555738]
  • Lucas Actis-Goretta, Antoine Lévèques, Francesca Giuffrida, Frédéric Destaillats, Kornél Nagy. Identification of O-methyl-(-)-epicatechin-O-sulphate metabolites by mass-spectrometry after O-methylation with trimethylsilyldiazomethane. Journal of chromatography. A. 2012 Jul; 1245(?):150-7. doi: 10.1016/j.chroma.2012.05.042. [PMID: 22663977]
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