6-Nitrochrysene (BioDeep_00000012726)

 

Secondary id: BioDeep_00001868303

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


Chrysene, 6-nitro-

化学式: C18H11NO2 (273.0789746)
中文名称: 6-硝基联苯
谱图信息: 最多检出来源 Homo sapiens(blood) 26.09%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CC3=C2C=C(C4=CC=CC=C34)[N+](=O)[O-]
InChI: InChI=1S/C18H11NO2/c20-19(21)18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H

描述信息

同义名列表

4 个代谢物同义名

Chrysene, 6-nitro-; 6-nitro-Chrysene; 6-NITROCHRYSENE; 6-Nitrochrysene



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shu Zhang, Hailing Li, Rujian He, Weiqiang Deng, Shengtao Ma, Xin Zhang, Guiying Li, Taicheng An. Spatial distribution, source identification, and human health risk assessment of PAHs and their derivatives in soils nearby the coke plants. The Science of the total environment. 2023 Feb; 861(?):160588. doi: 10.1016/j.scitotenv.2022.160588. [PMID: 36470383]
  • Brent V Powell, Jan Henric T Bacurio, Ashis K Basu. Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells. DNA repair. 2020 11; 95(?):102935. doi: 10.1016/j.dnarep.2020.102935. [PMID: 32721818]
  • Yuan-Wan Sun, Joseph B Guttenplan, Timothy Cooper, Jacek Krzeminski, Ceaser Aliaga, Telih Boyiri, Wieslawa Kosinska, Zhong-Lin Zhao, Kun-Ming Chen, Arthur Berg, Shantu Amin, Karam El-Bayoumy. Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S]-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat. Chemical research in toxicology. 2013 Apr; 26(4):547-54. doi: 10.1021/tx300478z. [PMID: 23461617]
  • Donghui Li, Mianying Wang, Pervez Firoz Firozi, Ping Chang, Weiqing Zhang, Wanda Baer-Dubowska, Bhagavatula Moorthy, Suryanarayana V Vulimiri, Regine Goth-Goldstein, Eric H Weyand, John DiGiovanni. Characterization of a major aromatic DNA adduct detected in human breast tissues. Environmental and molecular mutagenesis. 2002; 39(2-3):193-200. doi: 10.1002/em.10063. [PMID: 11921189]
  • R M Chen, M W Chou, T H Ueng. Induction of cytochrome P450 1A in hamster liver and lung by 6-nitrochrysene. Archives of toxicology. 1998 Jun; 72(7):395-401. doi: 10.1007/s002040050519. [PMID: 9708878]
  • M W Chou, W Chen, M V Mikhailova, J Nichols, C Weis, C D Jackson, R W Hart, K T Chung. Dietary restriction modulated carcinogen-DNA adduct formation and the carcinogen-induced DNA strand breaks. Toxicology letters. 1997 Jun; 92(1):21-30. doi: 10.1016/s0378-4274(97)00029-5. [PMID: 9242354]
  • Y H Chae, K B Delclos, B Blaydes, K el-Bayoumy. Metabolism and DNA binding of the environmental colon carcinogen 6-nitrochrysene in rats. Cancer research. 1996 May; 56(9):2052-8. doi: NULL. [PMID: 8616850]
  • T E Gray, S J Zhu, P Nettesheim. Regulation of transformation frequency by exogenous and endogenous growth factors in rat tracheal epithelial cells. Carcinogenesis. 1994 Mar; 15(3):549-55. doi: 10.1093/carcin/15.3.549. [PMID: 8118942]
  • K B Delclos, C E Cerniglia, K L Dooley, W L Campbell, W Franklin, R P Walker. The role of intestinal microflora in the metabolic activation of 6-nitrochrysene to DNA-binding derivatives in mice. Toxicology. 1990 Jan; 60(1-2):137-50. doi: 10.1016/0300-483x(90)90168-g. [PMID: 2315936]
  • H Y Meltzer, R Belmaker, R J Wyatt, W Pollin, S Cohen. Serum creatine phosphokinase (CPK) activity in monozygotic twins discordant for schizophrenia: heritability of serum CPK activity. Comprehensive psychiatry. 1976 May; 17(3):469-75. doi: 10.1016/0010-440x(76)90051-1. [PMID: 6211]
  • J G Ljunggren, B Persson. Preoperative treatment of thyrotoxicosis with a beta-adrenergic blocking agent. Acta chirurgica Scandinavica. 1975; 141(8):715-8. doi: NULL. [PMID: 3081]