Aminocaproic acid (BioDeep_00000001271)

 

Secondary id: BioDeep_00000400276, BioDeep_00000402946, BioDeep_00000405481

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


Sanofi winthrop brand OF aminocaproic acid

化学式: C6H13NO2 (131.0946238)
中文名称: 氨基己酸, 6-氨基己酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.03%

分子结构信息

SMILES: C(CCC(=O)O)CCN
InChI: InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

描述信息

Aminocaproic acid (marketed as Amicar) is a drug used to treat bleeding disorders. It is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. [HMDB]
Aminocaproic acid (marketed as Amicar) is a drug used to treat bleeding disorders. It is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin.
B - Blood and blood forming organs > B02 - Antihemorrhagics > B02A - Antifibrinolytics > B02AA - Amino acids
Acquisition and generation of the data is financially supported in part by CREST/JST.
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
C78275 - Agent Affecting Blood or Body Fluid > C78311 - Hemostatic Agent
D050299 - Fibrin Modulating Agents > D000933 - Antifibrinolytic Agents
IPB_RECORD: 266; CONFIDENCE confident structure
KEIO_ID A053
6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

同义名列表

95 个代谢物同义名

Sanofi winthrop brand OF aminocaproic acid; Epsillon-aminocaproic acid epsilcapramin; Pharmachemie brand OF aminocaproic acid; Delagrange brand OF aminocaproic acid; Rottapharm brand OF aminocaproic acid; Leurquin brand OF aminocaproic acid; epsilon-Amino-N-hexanoic acid; epsilon-Aminocaproic acid usp; Epsillon-aminocaproic acid; epsilon-Aminohexanoic acid; epsilon-Aminocaproic acid; epsilon Aminocaproic acid; epsilon-Amino-N-hexanoate; Omega-aminohexanoic acid; e-amino-N-Hexanoic acid; 6-amino-N-Hexanoic acid; e-Aminocaproic acid usp; Omega-aminocaproic acid; epsilon-Aminohexanoate; Epsillon-aminocaproate; epsilon-Aminocaproate; 6-amino-hexanoic acid; Acidum aminocaproicum; e-Aminohexanoic acid; 6 Aminohexanoic acid; 6-Aminohexanoic acid; Omega-aminohexanoate; W-Aminohexanoic acid; e-amino-N-Hexanoate; W-Aminocaproic acid; e-Aminocaproic acid; 6-Aminocaproic acid; Omega-aminocaproate; Acido aminocaproico; 6 Aminocaproic acid; Acide aminocaproque; 6-amino-N-Hexanoate; Aminohexanoic acid; epsilon-Norleucine; Aminocaproic acid; 6-amino-Hexanoate; e-Aminohexanoate; 6-Aminohexanoate; H-epsilon-Acp-OH; W-Aminohexanoate; W-Aminocaproate; 6-Aminocaproate; e-Aminocaproate; epsilon-Leucine; Aminohexanoate; Epsilcapramine; Epsilcapramin; Aminocaproate; e-Norleucine; AMINOCAPROIC; epsilon-Ahx; Aminokapron; Caprolisin; Acepramine; Hemocaprol; Epsicaprom; Epsikapron; H-6-Ahx-OH; Capralense; Epsicapron; H-EAhx-OH; e-Leucine; Caproamin; Epsilon S; Acikaprin; Hexalense; Acepramin; Respramin; epsilon-S; Caprolest; Capracid; Caprocid; Capramol; Capranol; Caplamin; Epsamon; Atsemin; Afibrin; Hemopar; Ipsilon; Amikar; Amicar; Hepin; EACA; Ahx; Z; Aminocaproic acid; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoate; Aminocaproic acid



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fasika A Woreta, Kristina B Lindsley, Almutez Gharaibeh, Sueko M Ng, Roberta W Scherer, Morton F Goldberg. Medical interventions for traumatic hyphema. The Cochrane database of systematic reviews. 2023 03; 3(?):CD005431. doi: 10.1002/14651858.cd005431.pub5. [PMID: 36912744]
  • Dong-Wan Kang, Bong Geun Cha, Jee Hoon Lee, Wookjin Yang, Seul Ki Ki, Ju Hee Han, Ha Yoon Cho, Eunchae Park, Sohyun Jeon, Seung-Hoon Lee. Ultrasmall polymer-coated cerium oxide nanoparticles as a traumatic brain injury therapy. Nanomedicine : nanotechnology, biology, and medicine. 2022 09; 45(?):102586. doi: 10.1016/j.nano.2022.102586. [PMID: 35868519]
  • Taylor E Wallen, Kathleen E Singer, Matthew R Baucom, Lisa G England, Rebecca M Schuster, Timothy A Pritts, Michael D Goodman. Effects of antifibrinolytics on systemic and cerebral inflammation after traumatic brain injury. The journal of trauma and acute care surgery. 2022 07; 93(1):30-37. doi: 10.1097/ta.0000000000003607. [PMID: 35319541]
  • Xiao-Long Fan. Comment on article by Zhong et al.: Local administration of epsilon-aminocaproic acid reduces post-operative blood loss from surgery for closed, Sanders III-IV calcaneal fractures. International orthopaedics. 2022 06; 46(6):1427-1428. doi: 10.1007/s00264-022-05355-8. [PMID: 35262758]
  • Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Bassem M Mohammed, Rabia Shaban, Ashoka Maddur, Ingrid M Verhamme, Owen J T McCarty, Ruby H P Law, David Gailani. Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains. Blood advances. 2022 05; 6(10):3142-3154. doi: 10.1182/bloodadvances.2021005976. [PMID: 35086137]
  • Philip C Spinella, Julie C Leonard, Barbara A Gaines, James F Luther, Stephen R Wisniewski, Cassandra D Josephson, Christine M Leeper. Use of Antifibrinolytics in Pediatric Life-Threatening Hemorrhage: A Prospective Observational Multicenter Study. Critical care medicine. 2022 04; 50(4):e382-e392. doi: 10.1097/ccm.0000000000005383. [PMID: 34661553]
  • Ebtehal F Anwer, Deena A M Nour El-Deen, Sayed M Derayea, Mahmoud A Omar. Benzofurazan -based fluorophore for the spectrofluorimetric determination of 6-Aminocaproic acid: Application to spiked human plasma and urine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Mar; 268(?):120723. doi: 10.1016/j.saa.2021.120723. [PMID: 34915229]
  • Ruchi Sharma, Aman George, Malika Nimmagadda, Davide Ortolan, Barbosa-Sabanero Karla, Zoya Qureshy, Devika Bose, Roba Dejene, Genqing Liang, Qin Wan, Justin Chang, Balendu Shekhar Jha, Omar Memon, Kiyoharu Joshua Miyagishima, Aaron Rising, Madhu Lal, Eric Hanson, Rebecca King, Mercedes Maria Campos, Marc Ferrer, Juan Amaral, David McGaughey, Kapil Bharti. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nature communications. 2021 12; 12(1):7293. doi: 10.1038/s41467-021-27488-x. [PMID: 34911940]
  • Ebtehal F Anwer, Deena A M Nour El-Deen, Mahmoud A Omar. An innovational validated spectrofluorimetric technique for determination of 6-Aminocaproic acid in pure form and its tablet: Application to spiked human plasma and urine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Nov; 261(?):119984. doi: 10.1016/j.saa.2021.119984. [PMID: 34087772]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Madison Coleman, Joel Davis, Kevin O Maher, Shriprasad R Deshpande. Clinical and Hematological Outcomes of Aminocaproic Acid Use During Pediatric Cardiac ECMO. The journal of extra-corporeal technology. 2021 Mar; 53(1):40-45. doi: 10.1182/ject-2000032. [PMID: 33814604]
  • Erik R Strauss, Elyes Dahmane, Miranda Judd, Dong Guo, Brittney Williams, Michael Meyer, James S Gammie, Bradley Taylor, Michael A Mazzeffi, Jogarao V S Gobburu, Kenichi A Tanaka. A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass. Journal of cardiothoracic and vascular anesthesia. 2021 Feb; 35(2):406-417. doi: 10.1053/j.jvca.2020.07.048. [PMID: 32811752]
  • Raffi Tachdjian, Karin E Johnson, Deborah Casso, Susan A Oliveria, Giovanna Devercelli, Gagan Jain. Real-world cohort study of adult and pediatric patients treated for hereditary angioedema in the United States. Allergy and asthma proceedings. 2020 05; 41(3):172-182. doi: 10.2500/aap.2020.41.200011. [PMID: 32375961]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Keita Hayashi, Kazutoshi Morimoto, Toshiyuki Kamei, Eiko Mieda, Sosaku Ichikawa, Takashi Kuroiwa, Sakiko Fujita, Hidemi Nakamura, Hiroshi Umakoshi. Effect of dehydrocholic acid conjugated with a hydrocarbon on a lipid bilayer composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine. Colloids and surfaces. B, Biointerfaces. 2019 Sep; 181(?):58-65. doi: 10.1016/j.colsurfb.2019.05.009. [PMID: 31121382]
  • Nadia Sabbah, Stéphane Jaisson, Roselyne Garnotel, Eduardo Anglés-Cano, Philippe Gillery. Small size apolipoprotein(a) isoforms enhance inflammatory and proteolytic potential of collagen-primed monocytes. Lipids in health and disease. 2019 Aug; 18(1):166. doi: 10.1186/s12944-019-1106-4. [PMID: 31470857]
  • Shana A Shaya, Dhulfiha Muzafar Gani, Jeffrey I Weitz, Paul Y Kim, Peter L Gross. Factor XIII Prevents Pulmonary Emboli in Mice by Stabilizing Deep Vein Thrombi. Thrombosis and haemostasis. 2019 Jun; 119(6):992-999. doi: 10.1055/s-0039-1685141. [PMID: 31005064]
  • Jian Jing, Zhenhuan Du, Songyang Ji, Keqiang Han. Urinary proteome analysis of acute hypercoagulable state in rat model induced by ε-aminocaproic acid. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Feb; 110(?):275-284. doi: 10.1016/j.biopha.2018.11.148. [PMID: 30513505]
  • Almutez Gharaibeh, Howard I Savage, Roberta W Scherer, Morton F Goldberg, Kristina Lindsley. Medical interventions for traumatic hyphema. The Cochrane database of systematic reviews. 2019 01; 1(?):CD005431. doi: 10.1002/14651858.cd005431.pub4. [PMID: 30640411]
  • Vance G Nielsen, Paul M Ford. The ratio of concentrations of aminocaproic acid and tranexamic acid that prevent plasmin activation of platelets does not provide equivalent inhibition of plasmatic fibrinolysis. Journal of thrombosis and thrombolysis. 2018 Oct; 46(3):365-370. doi: 10.1007/s11239-018-1705-3. [PMID: 29926296]
  • Ranran Zhao, Xiaolong Liang, Bo Zhao, Min Chen, Renfa Liu, Sujuan Sun, Xiuli Yue, Shumin Wang. Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer. Biomaterials. 2018 08; 173(?):58-70. doi: 10.1016/j.biomaterials.2018.04.054. [PMID: 29758547]
  • Alexandre Le Joncour, Laurent Mesnard, Alexandre Hertig, Thomas Robert. Red urine, updated for the nephrologist: a case report. BMC nephrology. 2018 06; 19(1):133. doi: 10.1186/s12882-018-0939-9. [PMID: 29884120]
  • Rustam Al-Shahi Salman, Zhe Kang Law, Philip M Bath, Thorsten Steiner, Nikola Sprigg. Haemostatic therapies for acute spontaneous intracerebral haemorrhage. The Cochrane database of systematic reviews. 2018 04; 4(?):CD005951. doi: 10.1002/14651858.cd005951.pub4. [PMID: 29664991]
  • Michael G Fitzsimons, Rebecca Karp Leaf, Johnathan Mack, Pavan K Bendapudi, Tao Shen, Duke E Cameron. Perioperative management of a redo aortic root replacement in a patient with severe factor XI deficiency. Journal of cardiac surgery. 2018 Feb; 33(2):86-89. doi: 10.1111/jocs.13526. [PMID: 29399875]
  • Clifford Kent Boese, Leslie Centeno, Ryan W Walters. Blood Conservation Using Tranexamic Acid Is Not Superior to Epsilon-Aminocaproic Acid After Total Knee Arthroplasty. The Journal of bone and joint surgery. American volume. 2017 Oct; 99(19):1621-1628. doi: 10.2106/jbjs.16.00738. [PMID: 28976426]
  • Huiyoung Kwon, In Ho Jung, Ji Hyun Yi, Jae Hoon Kim, Jung Hoon Park, Seungheon Lee, Ji Wook Jung, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim. The Seed of Zizyphus jujuba var. spinosa Attenuates Alzheimer's Disease-Associated Hippocampal Synaptic Deficits through BDNF/TrkB Signaling. Biological & pharmaceutical bulletin. 2017; 40(12):2096-2104. doi: 10.1248/bpb.b17-00378. [PMID: 29199234]
  • Steven de Maat, Jenny Björkqvist, Chiara Suffritti, Chantal P Wiesenekker, Willem Nagtegaal, Arnold Koekman, Sanne van Dooremalen, Gerard Pasterkamp, Philip G de Groot, Marco Cicardi, Thomas Renné, Coen Maas. Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations. The Journal of allergy and clinical immunology. 2016 11; 138(5):1414-1423.e9. doi: 10.1016/j.jaci.2016.02.021. [PMID: 27130860]
  • Jamie C Brown, Benjamin M Brainard, Daniel J Fletcher, Ben Nie, Robert D Arnold, Chad W Schmiedt. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. American journal of veterinary research. 2016 Nov; 77(11):1258-1265. doi: 10.2460/ajvr.77.11.1258. [PMID: 27805439]
  • Seung H Yoo, Emilee Venn, Lauren A Sullivan, Christine S Olver. Thromboelastographic evidence of inhibition of fibrinolysis after ε-aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2016 Sep; 26(5):737-42. doi: 10.1111/vec.12467. [PMID: 26990227]
  • Ramona Nicolau-Raducu, Timothy C Ku, Donald R Ganier, Brian M Evans, Joseph Koveleskie, William J Daly, Brian Fish, Ari J Cohen, Trevor W Reichman, Humberto E Bohorquez, David S Bruce, Ian C Carmody, George E Loss, Marina Gitman, Thomas Marshall, Bobby D Nossaman. Epsilon-Aminocaproic Acid Has No Association With Thromboembolic Complications, Renal Failure, or Mortality After Liver Transplantation. Journal of cardiothoracic and vascular anesthesia. 2016 Aug; 30(4):917-23. doi: 10.1053/j.jvca.2015.12.003. [PMID: 27020101]
  • Alex Soroceanu, Jonathan H Oren, Justin S Smith, Richard Hostin, Christopher I Shaffrey, Gregory M Mundis, Christopher P Ames, Douglas C Burton, Shay Bess, Munish C Gupta, Vedat Deviren, Frank J Schwab, Virginie Lafage, Thomas J Errico. Effect of Antifibrinolytic Therapy on Complications, Thromboembolic Events, Blood Product Utilization, and Fusion in Adult Spinal Deformity Surgery. Spine. 2016 Jul; 41(14):E879-E886. doi: 10.1097/brs.0000000000001454. [PMID: 27398796]
  • Ning Wan, Yi-Yang Jia, Yi-Lin Hou, Xi-Xi Ma, Yong-Sheng He, Chen Li, Si-Yuan Zhou, Bang-Le Zhang. Preparation, Physicochemical Properties, and Transfection Activities of Tartaric Acid-Based Cationic Lipids as Effective Nonviral Gene Delivery Vectors. Biological & pharmaceutical bulletin. 2016 Jul; 39(7):1112-20. doi: 10.1248/bpb.b16-00007. [PMID: 27118165]
  • Sarrah Kaye, Noha Abou-Madi, Daniel J Fletcher. EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2016 Jun; 47(2):397-404. doi: 10.1638/2015-0255.1. [PMID: 27468009]
  • Sarrah Kaye, Shawn Johnson, Robert D Arnold, Ben Nie, Joshua T Davis, Frances Gulland, Noha Abou-Madi, Daniel J Fletcher. PHARMACOKINETIC STUDY OF ORAL ε-AMINOCAPROIC ACID IN THE NORTHERN ELEPHANT SEAL (MIROUNGA ANGUSTIROSTRIS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2016 Jun; 47(2):438-46. doi: 10.1638/2015-0138.1. [PMID: 27468014]
  • Patricia A Ford, Shakira J Grant, Rosemarie Mick, Gina Keck. Autologous Stem-Cell Transplantation Without Hematopoietic Support for the Treatment of Hematologic Malignancies in Jehovah's Witnesses. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 May; 33(15):1674-9. doi: 10.1200/jco.2014.57.9912. [PMID: 25870085]
  • Michael P Eaton, George M Alfieris, Dawn M Sweeney, Ronald E Angona, Jill M Cholette, Charles Venuto, Brian Anderson. Pharmacokinetics of ε-Aminocaproic Acid in Neonates Undergoing Cardiac Surgery with Cardiopulmonary Bypass. Anesthesiology. 2015 May; 122(5):1002-9. doi: 10.1097/aln.0000000000000616. [PMID: 25723765]
  • P A Stricker, M R Gastonguay, D Singh, J E Fiadjoe, E M Sussman, E Y Pruitt, T K Goebel, A F Zuppa. Population pharmacokinetics of ϵ-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery. British journal of anaesthesia. 2015 Apr; 114(4):689-99. doi: 10.1093/bja/aeu459. [PMID: 25586726]
  • M Stalnaker, P Esquivel. Managing menorrhagia in a familial case of factor V deficiency. Journal of pediatric and adolescent gynecology. 2015 Feb; 28(1):e9-e12. doi: 10.1016/j.jpag.2014.03.007. [PMID: 25256869]
  • Jun Lu, Haoyu Meng, Zhaoyi Meng, Ying Sun, John P Pribis, Chunyan Zhu, Quan Li. Epsilon aminocaproic acid reduces blood transfusion and improves the coagulation test after pediatric open-heart surgery: a meta-analysis of 5 clinical trials. International journal of clinical and experimental pathology. 2015; 8(7):7978-87. doi: . [PMID: 26339364]
  • Daniel J Fletcher, Kelly J Blackstock, Kira Epstein, Benjamin M Brainard. Evaluation of tranexamic acid and ε-aminocaproic acid concentrations required to inhibit fibrinolysis in plasma of dogs and humans. American journal of veterinary research. 2014 Aug; 75(8):731-8. doi: 10.2460/ajvr.75.8.731. [PMID: 25061704]
  • R S Mangus, S B Kinsella, J A Fridell, C A Kubal, P Lahsaei, L O Mark, A J Tector. Aminocaproic Acid (amicar) as an alternative to aprotinin (trasylol) in liver transplantation. Transplantation proceedings. 2014 Jun; 46(5):1393-9. doi: 10.1016/j.transproceed.2014.04.006. [PMID: 24935303]
  • Leifeng Cheng, Daniel Pettersen, Bengt Ohlsson, Peter Schell, Michael Karle, Emma Evertsson, Sara Pahlén, Maria Jonforsen, Alleyn T Plowright, Jonas Boström, Tomas Fex, Anders Thelin, Constanze Hilgendorf, Yafeng Xue, Göran Wahlund, Walter Lindberg, Lars-Olof Larsson, David Gustafsson. Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. ACS medicinal chemistry letters. 2014 May; 5(5):538-43. doi: 10.1021/ml400526d. [PMID: 24900876]
  • Ellen Scepansky, Maha Othman, Hedy Smith. Acquired von Willebrand syndrome with a type 2B phenotype: diagnostic and therapeutic dilemmas. Acta haematologica. 2014; 131(4):213-7. doi: 10.1159/000353525. [PMID: 24296552]
  • H Y Kong, X H Wen, S Q Huang, S M Zhu. Epsilon-aminocaproic acid improves postrecirculation hemodynamics by reducing intraliver activated protein C consumption in orthotopic liver transplantation. World journal of surgery. 2014 Jan; 38(1):177-85. doi: 10.1007/s00268-013-2282-4. [PMID: 24142329]
  • Almutez Gharaibeh, Howard I Savage, Roberta W Scherer, Morton F Goldberg, Kristina Lindsley. Medical interventions for traumatic hyphema. The Cochrane database of systematic reviews. 2013 Dec; ?(12):CD005431. doi: 10.1002/14651858.cd005431.pub3. [PMID: 24302299]
  • D J Fletcher, B M Brainard, K Epstein, R Radcliffe, T Divers. Therapeutic plasma concentrations of epsilon aminocaproic acid and tranexamic acid in horses. Journal of veterinary internal medicine. 2013 Nov; 27(6):1589-95. doi: 10.1111/jvim.12202. [PMID: 24118238]
  • Michael M Frank. Update on preventive therapy (prophylaxis) for hereditary angioedema. Immunology and allergy clinics of North America. 2013 Nov; 33(4):495-503. doi: 10.1016/j.iac.2013.07.005. [PMID: 24176214]
  • Hildo J K Ananias, Zilin Yu, Hilde D Hoving, Stefano Rosati, Rudi A Dierckx, Fan Wang, Yongjun Yan, Xiaoyuan Chen, Jan Pruim, Marjolijn N Lub-de Hooge, Wijnand Helfrich, Philip H Elsinga, Igle J de Jong. Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients: a first-in-man study. Nuclear medicine and biology. 2013 Oct; 40(7):933-8. doi: 10.1016/j.nucmedbio.2013.05.009. [PMID: 23891351]
  • Vadim Kostousov, Yao-Wei W Wang, Bryan A Cotton, Charles E Wade, John B Holcomb, Nena Matijevic. Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2013 Jul; 24(5):489-97. doi: 10.1097/mbc.0b013e32835e4246. [PMID: 23406662]
  • P A Stricker, A F Zuppa, J E Fiadjoe, L G Maxwell, E M Sussman, E Y Pruitt, T K Goebel, M R Gastonguay, J A Taylor, S P Bartlett, M S Schreiner. Population pharmacokinetics of epsilon-aminocaproic acid in infants undergoing craniofacial reconstruction surgery. British journal of anaesthesia. 2013 May; 110(5):788-99. doi: 10.1093/bja/aes507. [PMID: 23353035]
  • Anju Sarupria, Neeti Makhija, Ramakrishnan Lakshmy, Usha Kiran. Comparison of different doses of ε-aminocaproic acid in children for tetralogy of Fallot surgery: clinical efficacy and safety. Journal of cardiothoracic and vascular anesthesia. 2013 Feb; 27(1):23-9. doi: 10.1053/j.jvca.2012.07.001. [PMID: 22995453]
  • Tulsidas G Shrivastav, Shail K Chaube, Kiran P Kariya, Pramod K V Prasad, Dinesh Kumar. Influence of different length spacers containing enzyme conjugate on functional parameters of progesterone ELISA. Journal of immunoassay & immunochemistry. 2013; 34(1):94-108. doi: 10.1080/15321819.2012.686470. [PMID: 23323985]
  • Chengfei Lu, Susmita Das, Paul K S Magut, Min Li, Bilal El-Zahab, Isiah M Warner. Irradiation induced fluorescence enhancement in PEGylated cyanine-based NIR nano- and mesoscale GUMBOS. Langmuir : the ACS journal of surfaces and colloids. 2012 Oct; 28(40):14415-23. doi: 10.1021/la302428a. [PMID: 22957476]
  • Seung Yon Han, Si Hyung Yang, Insoo Yoon, Myung Gull Lee, Young Hee Choi. Reduced clearance of ε-acetamidocaproic acid in rats with acute renal failure induced by uranyl nitrate. The Journal of pharmacy and pharmacology. 2012 Oct; 64(10):1452-60. doi: 10.1111/j.2042-7158.2012.01517.x. [PMID: 22943176]
  • K F French, Jacob White, R E Hoesch. Treatment of intracerebral hemorrhage with tranexamic acid after thrombolysis with tissue plasminogen activator. Neurocritical care. 2012 Aug; 17(1):107-11. doi: 10.1007/s12028-012-9681-5. [PMID: 22311234]
  • Tianjun Chang, Xiangjun Liu, Xiaohong Cheng, Cui Qi, Hongcheng Mei, Dihua Shangguan. Selective isolation of G-quadruplexes by affinity chromatography. Journal of chromatography. A. 2012 Jul; 1246(?):62-8. doi: 10.1016/j.chroma.2012.02.026. [PMID: 22398385]
  • Karen Kim, Christian Schuetz, Nahel Elias, Gregory R Veillette, Isaac Wamala, Manish Varma, R Neal Smith, Simon C Robson, A Benedict Cosimi, David H Sachs, Martin Hertl. Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons. Xenotransplantation. 2012 Jul; 19(4):256-64. doi: 10.1111/j.1399-3089.2012.00717.x. [PMID: 22909139]
  • Anna M Ledgerwood, William Blaisdell. Coagulation challenges after severe injury with hemorrhagic shock. The journal of trauma and acute care surgery. 2012 Jun; 72(6):1714-8. doi: 10.1097/ta.0b013e318245225c. [PMID: 22695446]
  • Liliana M Marín, M Cristina Iazbik, Sara Zaldivar-Lopez, Linda K Lord, Nicole Stingle, Paulo Vilar, Ana Lara-Garcia, Francisco Alvarez, Kenji Hosoya, Laura Nelson, Antonio Pozzi, Edward Cooper, Mary A McLoughlin, Rebecca Ball, William C Kisseberth, Cheryl A London, Robert Dudley, Jonathan Dyce, Melanie McMahon, Phillip Lerche, Richard Bednarski, C Guillermo Couto. Retrospective evaluation of the effectiveness of epsilon aminocaproic acid for the prevention of postamputation bleeding in retired racing Greyhounds with appendicular bone tumors: 46 cases (2003-2008). Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2012 Jun; 22(3):332-40. doi: 10.1111/j.1476-4431.2012.00735.x. [PMID: 22612729]
  • Yanting Song, Takashi Funatsu, Makoto Tsunoda. Rapid determination of amino acids in biological samples using a monolithic silica column. Amino acids. 2012 May; 42(5):1897-902. doi: 10.1007/s00726-011-0914-2. [PMID: 21505823]
  • Jonathan A Bernstein, Joseph J Moellman. Progress in the emergency management of hereditary angioedema: focus on new treatment options in the United States. Postgraduate medicine. 2012 May; 124(3):91-100. doi: 10.3810/pgm.2012.05.2552. [PMID: 22691903]
  • Lajos Gera, Caroline Roy, Marie-Thérèse Bawolak, Xavier Charest-Morin, François Marceau. N-terminal extended conjugates of the agonists and antagonists of both bradykinin receptor subtypes: structure-activity relationship, cell imaging using ligands conjugated with fluorophores and prospect for functionally active cargoes. Peptides. 2012 Apr; 34(2):433-46. doi: 10.1016/j.peptides.2012.02.007. [PMID: 22349904]
  • Chul Min Ahn, Håkan Sandler, Tom Saldeen. Decreased lung hyaluronan in a model of ARDS in the rat: effect of an inhibitor of leukocyte elastase. Upsala journal of medical sciences. 2012 Mar; 117(1):1-9. doi: 10.3109/03009734.2011.622812. [PMID: 22283425]
  • Theodore A Pasquali, Milap P Mehta, Julian D Perry. Conjunctival bleeding after ectropion repair due to paraneoplastic primary fibrinolysis. Ophthalmic plastic and reconstructive surgery. 2012 Mar; 28(2):e44-5. doi: 10.1097/iop.0b013e31821de7ff. [PMID: 21743371]
  • Andrea J Bixby-Brosi, Daniel A Potter. Can a chitin-synthesis-inhibiting turfgrass fungicide enhance black cutworm susceptibility to a baculovirus?. Pest management science. 2012 Mar; 68(3):324-9. doi: 10.1002/ps.2252. [PMID: 21815243]
  • U Lee, Y H Choi, Y G Kim, B K Lee, E Oh, M G Lee. ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation. Xenobiotica; the fate of foreign compounds in biological systems. 2012 Mar; 42(3):310-5. doi: 10.3109/00498254.2011.619014. [PMID: 21992030]
  • Ya-Hsueh Wu, Ming-Ling Wu, Chun-Chi Lin, Wei-Lan Chu, Chen-Chang Yang, Robert Tate Lin, Jou-Fang Deng. Determination of caprolactam and 6-aminocaproic acid in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Feb; 885-886(?):61-5. doi: 10.1016/j.jchromb.2011.12.014. [PMID: 22237132]
  • Jessica Schmitz, Mark Aurel Schöttler, Stephan Krueger, Stefan Geimer, Anja Schneider, Tatjana Kleine, Dario Leister, Kirsten Bell, Ulf-Ingo Flügge, Rainer E Häusler. Defects in leaf carbohydrate metabolism compromise acclimation to high light and lead to a high chlorophyll fluorescence phenotype in Arabidopsis thaliana. BMC plant biology. 2012 Jan; 12(?):8. doi: 10.1186/1471-2229-12-8. [PMID: 22248311]
  • Weimin Hu, Ritsuko Narasaki, Naoko Nishimura, Keiji Hasumi. SMTP (Stachybotrys microspora triprenyl phenol) enhances clot clearance in a pulmonary embolism model in rats. Thrombosis journal. 2012 Jan; 10(1):2. doi: 10.1186/1477-9560-10-2. [PMID: 22230042]
  • Zachary P Weiner, Anne E Boyer, Maribel Gallegos-Candela, Amber N Cardani, John R Barr, Ian J Glomski. Debridement increases survival in a mouse model of subcutaneous anthrax. PloS one. 2012; 7(2):e30201. doi: 10.1371/journal.pone.0030201. [PMID: 22393351]
  • Shvetank Agarwal, Beth Ullom, Yasser Al-Baghdadi, Michael Okumura. Challenges encountered with argatroban anticoagulation during cardiopulmonary bypass. Journal of anaesthesiology, clinical pharmacology. 2012 Jan; 28(1):106-10. doi: 10.4103/0970-9185.92458. [PMID: 22345956]
  • Hai-Dong Yu, Xiao-Fei Yang, Si-Ting Chen, Yu-Ting Wang, Ji-Kai Li, Qi Shen, Xun-Liang Liu, Fang-Qing Guo. Downregulation of chloroplast RPS1 negatively modulates nuclear heat-responsive expression of HsfA2 and its target genes in Arabidopsis. PLoS genetics. 2012; 8(5):e1002669. doi: 10.1371/journal.pgen.1002669. [PMID: 22570631]
  • Jamal Stie, Deborah Fox. Blood-brain barrier invasion by Cryptococcus neoformans is enhanced by functional interactions with plasmin. Microbiology (Reading, England). 2012 Jan; 158(Pt 1):240-258. doi: 10.1099/mic.0.051524-0. [PMID: 21998162]
  • Alejandro Malbrán, Diego S Fernández Romero, Alejandra Menéndez. [Hereditary angioedema. A therapeutic guide]. Medicina. 2012; 72(2):119-23. doi: NULL. [PMID: 22522852]
  • Anton G Kutikhin, Elena B Brusina, Arseniy E Yuzhalin. The role of calcifying nanoparticles in biology and medicine. International journal of nanomedicine. 2012; 7(?):339-50. doi: 10.2147/ijn.s28069. [PMID: 22287843]
  • Bluma Linkowski Faintuch, Erica A Oliveira, Eutimio G F Nunez, Ana M Moro, P K Nanda, Charles J Smith. Comparison of two peptide radiotracers for prostate carcinoma targeting. Clinics (Sao Paulo, Brazil). 2012; 67(2):163-70. doi: 10.6061/clinics/2012(02)12. [PMID: 22358242]
  • John W Avery, Geoffrey M Smith, Simon O Owino, Demba Sarr, Tamas Nagy, Stephen Mwalimu, James Matthias, Lauren F Kelly, Jayakumar S Poovassery, Joab D Middii, Carlos Abramowsky, Julie M Moore. Maternal malaria induces a procoagulant and antifibrinolytic state that is embryotoxic but responsive to anticoagulant therapy. PloS one. 2012; 7(2):e31090. doi: 10.1371/journal.pone.0031090. [PMID: 22347435]
  • Santiago J Ramírez-Aguilar, Mandy Keuthe, Marcio Rocha, Vadim V Fedyaev, Katharina Kramp, Kapuganti J Gupta, Allan G Rasmusson, Waltraud X Schulze, Joost T van Dongen. The composition of plant mitochondrial supercomplexes changes with oxygen availability. The Journal of biological chemistry. 2011 Dec; 286(50):43045-53. doi: 10.1074/jbc.m111.252544. [PMID: 22009743]
  • Jeremiah R Brown, Robert S Kramer, Steven G Coca, Chirag R Parikh. The prognostic value of using the duration of acute kidney injury in cardiac surgery: an example using two antifibrinolytics. The journal of extra-corporeal technology. 2011 Dec; 43(4):227-31. doi: NULL. [PMID: 22416602]
  • Sham Sunder Goyal, D Vimal Bhardwaj, Uk Shenoy, Bhavya Reddy. Anaesthetic management of a child with congenital afibrinogenemia - A rare inherited coagulation disorder. Indian journal of anaesthesia. 2011 Nov; 55(6):605-7. doi: 10.4103/0019-5049.90617. [PMID: 22223906]
  • Juan J Jiménez, José L Iribarren, Maitane Brouard, Domingo Hernández, Salomé Palmero, Alejandro Jiménez, Leonardo Lorente, Patricia Machado, Juan M Borreguero, José M Raya, Beatriz Martín, Rosalía Pérez, Rafael Martínez, María L Mora. Safety and effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: a randomized double-blind, dose-dependent, phase IV clinical trial. Journal of cardiothoracic surgery. 2011 Oct; 6(?):138. doi: 10.1186/1749-8090-6-138. [PMID: 21999189]
  • Erika Kovács-Bogdán, J Philipp Benz, Jürgen Soll, Bettina Bölter. Tic20 forms a channel independent of Tic110 in chloroplasts. BMC plant biology. 2011 Sep; 11(?):133. doi: 10.1186/1471-2229-11-133. [PMID: 21961525]
  • Ulyana Lalo, Jonathan A Roberts, Richard J Evans. Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation. The Journal of biological chemistry. 2011 Sep; 286(35):30591-30599. doi: 10.1074/jbc.m111.253153. [PMID: 21757694]
  • Roman M Sniecinski, Jerrold H Levy. Bleeding and management of coagulopathy. The Journal of thoracic and cardiovascular surgery. 2011 Sep; 142(3):662-7. doi: 10.1016/j.jtcvs.2011.03.015. [PMID: 21549397]
  • Chi-Hsien Liu, Wei-Chi Wu, Hsuan-Yu Lai, Hau-Yaun Hou. Magnetic purification of plasminogen from human plasma by specific lysine affinity. Journal of bioscience and bioengineering. 2011 Sep; 112(3):219-24. doi: 10.1016/j.jbiosc.2011.05.004. [PMID: 21632285]
  • Brian Schloss, Parul Gulati, Lianbo Yu, Mahmoud Abdel-Rasoul, William O'Brien, Jon Von Visger, Hamdy Awad. Impact of aprotinin and renal function on mortality: a retrospective single center analysis. Journal of cardiothoracic surgery. 2011 Aug; 6(?):103. doi: 10.1186/1749-8090-6-103. [PMID: 21878108]
  • Kanjaksha Ghosh, Shrimati Shetty. Epidemiology, diagnosis, and management of von Willebrand disease in India. Seminars in thrombosis and hemostasis. 2011 Jul; 37(5):595-601. doi: 10.1055/s-0031-1281048. [PMID: 22102205]
  • Lars Baltzer. Crossing borders to bind proteins--a new concept in protein recognition based on the conjugation of small organic molecules or short peptides to polypeptides from a designed set. Analytical and bioanalytical chemistry. 2011 Jun; 400(6):1653-64. doi: 10.1007/s00216-011-4905-7. [PMID: 21461620]
  • Galina Leyvi, Olivia Nelson, Adam Yedlin, Michelle Pasamba, Peter F Belamarich, Singh Nair, Hillel W Cohen. A comparison of the effect of aprotinin and ε-aminocaproic acid on renal function in children undergoing cardiac surgery. Journal of cardiothoracic and vascular anesthesia. 2011 Jun; 25(3):402-6. doi: 10.1053/j.jvca.2011.01.015. [PMID: 21419653]
  • Silke Hack, Babette Wörlein, Georg Höfner, Jörg Pabel, Klaus T Wanner. Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. European journal of medicinal chemistry. 2011 May; 46(5):1483-98. doi: 10.1016/j.ejmech.2011.01.042. [PMID: 21353350]
  • Y H Choi, U Lee, J H Suh, Y G Kim, M Lee, E Oh, M G Lee. Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. Xenobiotica; the fate of foreign compounds in biological systems. 2011 May; 41(5):409-15. doi: 10.3109/00498254.2010.549250. [PMID: 21250786]
  • Zeyad D Nassar, Abdalrahim Fa Aisha, Mohamed Bk Ahamed, Zhari Ismail, Khalid M Abu-Salah, Salman A Alrokayan, Amin Malik Shah Abdul Majid. Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr. Cancer cell international. 2011 Apr; 11(1):12. doi: 10.1186/1475-2867-11-12. [PMID: 21524294]
  • Dagmar Hosiner, Gerhard Sponder, Anton Graschopf, Siegfried Reipert, Rudolf J Schweyen, Christoph Schüller, Markus Aleschko. Pun1p is a metal ion-inducible, calcineurin/Crz1p-regulated plasma membrane protein required for cell wall integrity. Biochimica et biophysica acta. 2011 Apr; 1808(4):1108-19. doi: 10.1016/j.bbamem.2011.01.002. [PMID: 21223946]
  • Mindy L Simpson, Neil A Goldenberg, Linda J Jacobson, Christopher G Bombardier, William E Hathaway, Marilyn J Manco-Johnson. Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in children and adults. Thrombosis research. 2011 Apr; 127(4):317-23. doi: 10.1016/j.thromres.2010.12.011. [PMID: 21316746]
  • Vance G Nielsen. Epsilon-aminocaproic acid, neonates, and cardiopulmonary bypass. Anesthesia and analgesia. 2011 Mar; 112(3):735. doi: 10.1213/ane.0b013e31820547e6. [PMID: 21350231]
  • Christoph A Reichel, Max Lerchenberger, Bernd Uhl, Markus Rehberg, Nina Berberich, Stefan Zahler, Matthias P Wymann, Fritz Krombach. Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. PloS one. 2011 Feb; 6(2):e17229. doi: 10.1371/journal.pone.0017229. [PMID: 21364954]
  • Wagner L Araújo, Adriano Nunes-Nesi, Sonia Osorio, Björn Usadel, Daniela Fuentes, Réka Nagy, Ilse Balbo, Martin Lehmann, Claudia Studart-Witkowski, Takayuki Tohge, Enrico Martinoia, Xavier Jordana, Fábio M Damatta, Alisdair R Fernie. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. The Plant cell. 2011 Feb; 23(2):600-27. doi: 10.1105/tpc.110.081224. [PMID: 21307286]
  • Pooja D Amarapurkar, Deepak N Amarapurkar. Management of coagulopathy in patients with decompensated liver cirrhosis. International journal of hepatology. 2011; 2011(?):695470. doi: 10.4061/2011/695470. [PMID: 22164337]
  • Turki Alameel, Michael West. Tranexamic Acid treatment of life-threatening hematuria in polycystic kidney disease. International journal of nephrology. 2011; 2011(?):203579. doi: 10.4061/2011/203579. [PMID: 21716688]