Aminocaproic acid (BioDeep_00000001271)

 

Secondary id: BioDeep_00000400276, BioDeep_00000402946, BioDeep_00000405481

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs


Metabolite Card


Sanofi winthrop brand OF aminocaproic acid

Formula: C6H13NO2 (131.0946238)
Chinese Names: 6-氨基己酸, 氨基己酸
Spectrum Hits: Top Source Homo sapiens(blood) 0.03%

Molecular Structure

SMILES: C(CCC(=O)O)CCN
InChI: InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

Description

Aminocaproic acid (marketed as Amicar) is a drug used to treat bleeding disorders. It is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. [HMDB]
Aminocaproic acid (marketed as Amicar) is a drug used to treat bleeding disorders. It is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin.
B - Blood and blood forming organs > B02 - Antihemorrhagics > B02A - Antifibrinolytics > B02AA - Amino acids
Acquisition and generation of the data is financially supported in part by CREST/JST.
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
C78275 - Agent Affecting Blood or Body Fluid > C78311 - Hemostatic Agent
D050299 - Fibrin Modulating Agents > D000933 - Antifibrinolytic Agents
IPB_RECORD: 266; CONFIDENCE confident structure
KEIO_ID A053
6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

Synonyms

93 synonym names

Sanofi winthrop brand OF aminocaproic acid; Epsillon-aminocaproic acid epsilcapramin; Pharmachemie brand OF aminocaproic acid; Delagrange brand OF aminocaproic acid; Rottapharm brand OF aminocaproic acid; Leurquin brand OF aminocaproic acid; epsilon-Amino-N-hexanoic acid; epsilon-Aminocaproic acid usp; Epsillon-aminocaproic acid; epsilon-Aminohexanoic acid; epsilon-Aminocaproic acid; epsilon Aminocaproic acid; epsilon-Amino-N-hexanoate; Omega-aminohexanoic acid; e-amino-N-Hexanoic acid; 6-amino-N-Hexanoic acid; e-Aminocaproic acid usp; Omega-aminocaproic acid; epsilon-Aminohexanoate; Epsillon-aminocaproate; epsilon-Aminocaproate; 6-amino-hexanoic acid; Acidum aminocaproicum; e-Aminohexanoic acid; 6 Aminohexanoic acid; 6-Aminohexanoic acid; Omega-aminohexanoate; W-Aminohexanoic acid; e-amino-N-Hexanoate; W-Aminocaproic acid; e-Aminocaproic acid; 6-Aminocaproic acid; Omega-aminocaproate; Acido aminocaproico; 6 Aminocaproic acid; Acide aminocaproque; 6-amino-N-Hexanoate; Aminohexanoic acid; epsilon-Norleucine; Aminocaproic acid; 6-amino-Hexanoate; e-Aminohexanoate; 6-Aminohexanoate; H-epsilon-Acp-OH; W-Aminohexanoate; W-Aminocaproate; 6-Aminocaproate; e-Aminocaproate; epsilon-Leucine; Aminohexanoate; Epsilcapramine; Epsilcapramin; Aminocaproate; e-Norleucine; AMINOCAPROIC; epsilon-Ahx; Aminokapron; Caprolisin; Acepramine; Hemocaprol; Epsicaprom; Epsikapron; H-6-Ahx-OH; Capralense; Epsicapron; H-EAhx-OH; e-Leucine; Caproamin; Epsilon S; Acikaprin; Hexalense; Acepramin; Respramin; epsilon-S; Caprolest; Capracid; Caprocid; Capramol; Capranol; Caplamin; Epsamon; Atsemin; Afibrin; Hemopar; Ipsilon; Amikar; Amicar; Hepin; EACA; Ahx; Z; Aminocaproic acid; Epsilon-Amino-n-caproic Acid



Cross Reference

43 cross reference id

Classification Terms

Related Pathways

Reactome(0)

BioCyc(0)

PlantCyc(0)

Biological Process

1 related biological process reactions.

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



Literature Reference

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