Ethyl acrylate (BioDeep_00000012705)
Secondary id: BioDeep_00001867716
human metabolite
代谢物信息卡片
化学式: C5H8O2 (100.0524)
中文名称: 丙烯酸乙酯
谱图信息:
最多检出来源 Mus musculus(not specific) 9.04%
分子结构信息
SMILES: C=CC(=O)OCC
InChI: InChI=1S/C5H8O2/c1-3-5(6)7-4-2/h3H,1,4H2,2H3
描述信息
Ethyl acrylate is an organic compound with the formula CH2CHCO2CH2CH3. It is the ethyl ester of acrylic acid. It is a colourless liquid with a characteristic acrid odor. Ethyl acrylate is found in pineapple. Ethyl acrylate is a flavouring ingredient Although there are some reports claiming that ethyl acrylate is a carcinogen, major respected bodies regard the evidence of human carcinogenicity as weak and/or inconsistent. The International Agency for Research on Cancer stated, "Overall evaluation, Ethyl acrylate is possibly carcinogenic to humans (Group 2B)." The United States Environmental Protection Agency (EPA) states, "Human studies on occupational exposure to ethyl acrylate have suggested a relationship between exposure to the chemical(s) and colorectal cancer, but the evidence is conflicting and inconclusive. In a study by the National Toxicology Program (NTP), increased incidences of squamous cell papillomas and carcinomas of the forestomach were observed in rats and mice exposed via gavage (experimentally placing the chemical in the stomach). However, the NTP recently determined that these data were not relevant to human carcinogenicity and removed ethyl acrylate from its list of carcinogens." (Occupational exposure generally involves exposure that occurs regularly, over an extended period of time). Ethyl acrylate is an organic compound primarily used in the preparation of various polymers. It is a clear liquid with an acrid penetrating odor. The human nose is capable of detecting this odor at a thousand times lower concentration then is considered harmful if continuously exposed for some period of time.
D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens
Flavouring ingredient
同义名列表
38 个代谢物同义名
Propenoic acid,ethyl ester (ethylacrylate); 2-Propenoic acid, ethyl ester, homopolymer; Acrylic acid, ethyl ester (inhibited); Poly(acrylic acid, ethyl ester); Ethyl ester OF 2-propenoic acid; Ethyl 2-propenoate, homopolymer; 2-Propenoic acid, ethyl ester; 2-Propenoic acid ethyl ester; Ethyl acrylate TOP1 supplier; Ethylester kyseliny akrylove; Ethyl propenoate, inhibited; Ethyl acrylate (inhibited); Ethyl acrylate homopolymer; Etilacrilatului(roumanian); Ethyl acrylate, inhibited; Acrylic acid, ethyl ester; Acrylic acid ethyl ester; Ethyl 2E-propenoic acid; Ethyl acrylate polymer; Ethoxycarbonylethylene; poly(ethyl acrylate); ethyl prop-2-enoate; Ethyl acrylic acid; Ethyl 2-propenoate; Polyethylacrylate; Ethyl propenoate; Akrylanem etylu; Etilacrilatului; ETHYL ACRYLATE; Etil acrilato; CH2=chcooc2h5; Aethylacrylat; Ethylacrylaat; Ethylakrylat; Carboset 511; FEMA 2418; Ethyl acrylate; Ethyl acrylate
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:82327
- KEGG: C19238
- PubChem: 8821
- HMDB: HMDB0033978
- Metlin: METLIN72961
- ChEMBL: CHEMBL52084
- Wikipedia: Ethyl acrylate
- foodb: FDB012210
- chemspider: 8490
- CAS: 35717-06-7
- CAS: 9003-32-1
- CAS: 140-88-5
- PMhub: MS000027030
- PubChem: 124489910
- LipidMAPS: LMFA07010505
- KNApSAcK: 82327
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Narimane Lammari, Francesca Froiio, Mehdi Louaer, Maria Chiara Cristiano, Chawki Bensouici, Donatella Paolino, Ouahida Louaer, Abdeslam Hassen Meniai, Abdelhamid Elaissari. Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent.
Biomacromolecules.
2020 11; 21(11):4442-4456. doi:
10.1021/acs.biomac.0c00255
. [PMID: 32286798] - Erika Parkinson, Maja Aleksic, Rachael Arthur, Sergio Regufe Da Mota, Richard Cubberley, Paul J Skipp. Proteomic analysis of haptenation by skin sensitisers: Diphencyprone and ethyl acrylate.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Feb; 62(?):104697. doi:
10.1016/j.tiv.2019.104697
. [PMID: 31669365] - Vandana Singh, Angela Singh, Sneha Joshi, Tulika Malviya. Grafting of vinyl acetate-ethylacrylate binary monomer mixture onto guar gum.
International journal of biological macromolecules.
2016 Mar; 84(?):442-7. doi:
10.1016/j.ijbiomac.2015.12.039
. [PMID: 26708437] - Xin Zheng, Rui Yang, Yu Zhang, Zhijun Wang, Xing Tang, Liangyuan Zheng. Part II: bioavailability in beagle dogs of nimodipine solid dispersions prepared by hot-melt extrusion.
Drug development and industrial pharmacy.
2007 Jul; 33(7):783-9. doi:
10.1080/03639040601050205
. [PMID: 17654027] - Marie-Andrée Yessine, Michel Lafleur, Christian Meier, Hans-Ulrich Petereit, Jean-Christophe Leroux. Characterization of the membrane-destabilizing properties of different pH-sensitive methacrylic acid copolymers.
Biochimica et biophysica acta.
2003 Jun; 1613(1-2):28-38. doi:
10.1016/s0005-2736(03)00137-8
. [PMID: 12832084] - M Tucek, J Tenglerová, B Kollárová, M Kvasnicková, K Maxa, I Mohyluk, E Svandová, O Topolcan, Z Vlasák, M Cikrt. Effect of acrylate chemistry on human health.
International archives of occupational and environmental health.
2002 Oct; 75 Suppl(?):S67-72. doi:
10.1007/s00420-002-0381-x
. [PMID: 12397413] - John B Morris. Sensory nerve-mediated nasal vasodilatory response to inspired ethyl acrylate.
Inhalation toxicology.
2002 Jun; 14(6):585-97. doi:
10.1080/08958370290084511
. [PMID: 12119070] - S Fujisawa, T Atsumi, Y Kadoma. Cytotoxicity of methyl methacrylate (MMA) and related compounds and their interaction with dipalmitoylphosphatidylcholine (DPPC) liposomes as a model for biomembranes.
Oral diseases.
2000 Jul; 6(4):215-21. doi:
10.1111/j.1601-0825.2000.tb00116.x
. [PMID: 10918558] - I Linhart, M Vosmanská, J Smejkal. Biotransformation of acrylates. Excretion of mercapturic acids and changes in urinary carboxylic acid profile in rat dosed with ethyl and 1-butyl acrylate.
Xenobiotica; the fate of foreign compounds in biological systems.
1994 Oct; 24(10):1043-52. doi:
10.3109/00498259409043301
. [PMID: 7900410] - D B Clayson, F Iverson, E A Nera, E Lok. Early indicators of potential neoplasia produced in the rat forestomach by non-genotoxic agents: the importance of induced cellular proliferation.
Mutation research.
1991 Jun; 248(2):321-31. doi:
10.1016/0027-5107(91)90065-v
. [PMID: 2046688] - B I Ghanayem, R R Maronpot, H B Matthews. Effects of sulfhydryl modulation on ethyl acrylate-induced forestomach toxicity.
Toxicology letters.
1991 Feb; 55(2):215-21. doi:
10.1016/0378-4274(91)90136-t
. [PMID: 1998209] - B I Ghanayem, L T Burka, H B Matthews. Ethyl acrylate distribution, macromolecular binding, excretion, and metabolism in male Fisher 344 rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1987 Oct; 9(3):389-97. doi:
10.1016/0272-0590(87)90021-2
. [PMID: 3691998] - J D deBethizy, J R Udinsky, H E Scribner, C B Frederick. The disposition and metabolism of acrylic acid and ethyl acrylate in male Sprague-Dawley rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1987 May; 8(4):549-61. doi:
10.1016/0272-0590(87)90140-0
. [PMID: 3609541] - B Samimi, L Falbo. Monitoring of workers exposure to low levels of airborne monomers in a polystyrene production plant.
American Industrial Hygiene Association journal.
1982 Nov; 43(11):858-62. doi:
10.1080/15298668291410693
. [PMID: 7168443] - U C POZZANI, C S WEIL, C P CARPENTER. Subacute vapor toxicity and range-finding data for ethyl acrylate.
The Journal of industrial hygiene and toxicology.
1949 Nov; 31(6):311-6. doi:
"
. [PMID: 15393973] - J F TREON, H SIGMON. The toxicity of methyl and ethyl acrylate.
The Journal of industrial hygiene and toxicology.
1949 Nov; 31(6):317-26. doi:
"
. [PMID: 15393974]