1,1-Dimethylhydrazine (BioDeep_00000012700)

 

Secondary id: BioDeep_00001868279

human metabolite blood metabolite


代谢物信息卡片


Unsymmetrical dimethylhydrazine

化学式: C2H8N2 (60.068744800000005)
中文名称: 偏二甲肼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)N
InChI: InChI=1S/C2H8N2/c1-4(2)3/h3H2,1-2H3

描述信息

D009676 - Noxae > D002273 - Carcinogens > D004127 - Dimethylhydrazines

同义名列表

9 个代谢物同义名

Unsymmetrical dimethylhydrazine; Dimazine dihydrochloride; Dimazine hydrochloride; Gem-dimethylhydrazine; 1,1-DIMETHYLHYDRAZINE; N,N-Dimethylhydrazine; 1,1-Dimethyhydrazine; 1,1-Dimethylhydrazin; Dimazine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Iryna Herasymets, Liudmyla Fira, Ihor Medvid, Dmytro Fira, Oleh Yasinovskyi, Liliia Grytsyshyn. EFFECT OF DRY EXTRACT FROM REISHI MUSHROOMS ON THE STATE OF ANTIOXIDANT SYSTEM IN RATS WITH DMH-INDUCED COLON CARCINOGENESIS. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2023; 76(12):2632-2640. doi: 10.36740/wlek202312112. [PMID: 38290027]
  • Rentong Hu, Weerachai Chantana, Pornsiri Pitchakarn, Subhawat Subhawa, Bhanumas Chantarasuwan, Piya Temviriyanukul, Teera Chewonarin. Ficus dubia latex extract prevent DMH-induced rat early colorectal carcinogenesis through the regulation of xenobiotic metabolism, inflammation, cell proliferation and apoptosis. Scientific reports. 2022 09; 12(1):15472. doi: 10.1038/s41598-022-19843-9. [PMID: 36104433]
  • Anastasiia E Karnaeva, Aleksey L Milyushkin, Zoya B Khesina, Alexey K Buryak. 1-Methyl-1H-1,2,4-triazole as the main marker of 1,1-dimethylhydrazine exposure in plants. Environmental science and pollution research international. 2022 Sep; 29(42):64225-64231. doi: 10.1007/s11356-022-22157-y. [PMID: 35896873]
  • Xiaogang Mu, Xuanjun Wang, Yue Zhang, Bo Liu, Jingjing Yang. Major products and their formation and transformation mechanism through degrading UDMH wastewater via DBD low temperature plasma. Environmental technology. 2021 Jul; 42(17):2709-2720. doi: 10.1080/09593330.2019.1710573. [PMID: 31903864]
  • Qiuyu Wang, Peng Wang, Zhigang Xiao. Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway. International journal of molecular medicine. 2018 Apr; 41(4):1887-1898. doi: 10.3892/ijmm.2018.3423. [PMID: 29393371]
  • Heng Xu, Wen-Bo Yu, Yuan Gao, Mei-Jun Zhang, Anshoo Malhotra, Wen-Hui Yu. Modulatory Potential of Curcumin and Resveratrol on p53 Post-Translational Modifications during Gastric Cancer. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2018; 37(2):93-101. doi: 10.1615/jenvironpatholtoxicoloncol.2018025547. [PMID: 30055545]
  • Marize de Lourdes Marzo Solano, Noeme Souza Rocha, Luis Fernando Barbisan, Carla Adriene da Silva Franchi, Ana Lúcia Tozzi Spinardi-Barbisan, Maria Luiza Cotrim Sartor de Oliveira, Daisy Maria Fávero Salvadori, Lúcia Regina Ribeiro, João Lauro Viana de Camargo. Alternative Multiorgan Initiation-Promotion Assay for Chemical Carcinogenesis in the Wistar Rat. Toxicologic pathology. 2016 12; 44(8):1146-1159. doi: 10.1177/0192623316678931. [PMID: 28245158]
  • Wei Li, Mengzhou Zhou, Ning Xu, Yong Hu, Chao Wang, Deyuan Li, Liegang Liu, Dongsheng Li. Comparative analysis of protective effects of curcumin, curcumin-β-cyclodextrin nanoparticle and nanoliposomal curcumin on unsymmetrical dimethyl hydrazine poisoning in mice. Bioengineered. 2016 Sep; 7(5):334-341. doi: 10.1080/21655979.2016.1197029. [PMID: 27710431]
  • Léa Payen, Mylène Honorat, Charlotte Bouard, Guy Jacob, Raphael Terreux, Henri Delalu, Emilie Labarthe, Jérôme Guitton. Quantification and kinetic study in plasma and tissues of (E)-1,1,4,4-tetramethyl-2-tetrazene, a liquid propellant and a transformation product of 1,1-dimethyl hydrazine. Analytical and bioanalytical chemistry. 2015 Sep; 407(22):6721-9. doi: 10.1007/s00216-015-8829-5. [PMID: 26082396]
  • Julie Triolet, Ahmad Ali Shaik, Daniel D Gallaher, Michael G O'Sullivan, Chengguo Xing. Reduction in colon cancer risk by consumption of kava or kava fractions in carcinogen-treated rats. Nutrition and cancer. 2012 Aug; 64(6):838-46. doi: 10.1080/01635581.2012.689917. [PMID: 22693990]
  • Yuhua Li, Li Liu, Yinbo Niu, Juan Feng, Yang Sun, Xianghe Kong, Yongchun Chen, Xiaoyan Chen, Hongquan Gan, Shousong Cao, Qibing Mei. Modified apple polysaccharide prevents against tumorigenesis in a mouse model of colitis-associated colon cancer: role of galectin-3 and apoptosis in cancer prevention. European journal of nutrition. 2012 Feb; 51(1):107-17. doi: 10.1007/s00394-011-0194-3. [PMID: 21516492]
  • Emília Hijová, Alojz Bomba, Izabela Bertková, Ladislav Strojný, Viktória Szabadosová, Alena Šoltésová. Prebiotics and bioactive natural substances induce changes of composition and metabolic activities of the colonic microflora in cancerous rats. Acta biochimica Polonica. 2012; 59(2):271-4. doi: 10.18388/abp.2012_2150. [PMID: 22540114]
  • Xiaofang Quan, Yi Wang, Xiaofeng Ma, Yan Liang, Weixi Tian, Qingyun Ma, Hezhong Jiang, Youxing Zhao. α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase. PloS one. 2012; 7(3):e33376. doi: 10.1371/journal.pone.0033376. [PMID: 22428036]
  • Pamela Christudoss, R Selvakumar, Anna B Pulimood, Jude Joseph Fleming, George Mathew. Zinc and zinc related enzymes in precancerous and cancerous tissue in the colon of dimethyl hydrazine treated rats. Asian Pacific journal of cancer prevention : APJCP. 2012; 13(2):487-92. doi: 10.7314/apjcp.2012.13.2.487. [PMID: 22524812]
  • K Stecker, M Vieth, A Koschel, B Wiedenmann, C Röcken, M Anders. Impact of the coxsackievirus and adenovirus receptor on the adenoma-carcinoma sequence of colon cancer. British journal of cancer. 2011 Apr; 104(9):1426-33. doi: 10.1038/bjc.2011.116. [PMID: 21468049]
  • Mei Jing Piao, Eun Sook Yoo, Young Sang Koh, Hee Kyoung Kang, Junoh Kim, Yong Jin Kim, Hak Hee Kang, Jin Won Hyun. Antioxidant effects of the ethanol extract from flower of Camellia japonica via scavenging of reactive oxygen species and induction of antioxidant enzymes. International journal of molecular sciences. 2011; 12(4):2618-30. doi: 10.3390/ijms12042618. [PMID: 21731461]
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  • Vijayta Dani Chadha, Davinder Dhawan. 65Zn kinetics as a biomarker of DMH induced colon carcinogenesis. Hellenic journal of nuclear medicine. 2010 Sep; 13(3):257-60. doi: NULL. [PMID: 21193881]
  • M Kaur Saini, S Nath Sanyal. Evaluation of chemopreventive response of two cycloxygenase-2 inhibitors, etoricoxib and diclofenac in rat colon cancer using FTIR and NMR spectroscopic techniques. Nutricion hospitalaria. 2010 Jul; 25(4):577-85. doi: ". [PMID: 20694294]
  • Albert A Baskar, Savarimuthu Ignacimuthu, Gabriel M Paulraj, Khalid S Al Numair. Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study. BMC complementary and alternative medicine. 2010 Jun; 10(?):24. doi: 10.1186/1472-6882-10-24. [PMID: 20525330]
  • Nagarajan Sangeetha, Selvaraj Aranganathan, Namasivayam Nalini. Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer. Investigational new drugs. 2010 Jun; 28(3):225-33. doi: 10.1007/s10637-009-9237-5. [PMID: 19274440]
  • K R Anilakumar, Farhath Khanum, A S Bawa. Effect of coriander seed powder (CSP) on 1, 2-dimethyl hydrazine-induced changes in antioxidant enzyme system and lipid peroxide formation in rats. Journal of dietary supplements. 2010 Mar; 7(1):9-20. doi: 10.3109/19390210903534970. [PMID: 22435570]
  • I Bertkova, E Hijova, A Chmelarova, G Mojzisova, D Petrasova, L Strojny, A Bomba, R Zitnan. The effect of probiotic microorganisms and bioactive compounds on chemically induced carcinogenesis in rats. Neoplasma. 2010; 57(5):422-8. doi: 10.4149/neo_2010_05_422. [PMID: 20568896]
  • Abdollah Ramzanighara, Fereshteh Ezzatighadi, D V Rai, Davinder K Dhawan. Effect of Neem (Azadirchta indica) on serum glycoprotein contents of rats administered 1,2 dimethylhydrazine. Toxicology mechanisms and methods. 2009 May; 19(4):298-301. doi: 10.1080/15376510802646523. [PMID: 19778220]
  • Vennila Sreedharan, Karthik Kumar Venkatachalam, Nalini Namasivayam. Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Investigational new drugs. 2009 Feb; 27(1):21-30. doi: 10.1007/s10637-008-9136-1. [PMID: 18496650]
  • E Hijova, A Chmelarova, A Bomba, R Zitnan. Prebiotic foodstuffs and their health benefits in experiment. Bratislavske lekarske listy. 2009; 110(9):523-5. doi: NULL. [PMID: 19827333]
  • I R Kulmagambetov, L E Muravleva, V V Koĭkov. [Oxidative modification of serum proteins in rats exposed to nonsymmetric dimethylhydrazine poisoning]. Meditsina truda i promyshlennaia ekologiia. 2009; ?(9):45-8. doi: NULL. [PMID: 19877443]
  • Anshoo Malhotra, Vijayta Dani Chadha, Praveen Nair, Devinder K Dhawan. Role of zinc in modulating histo-architectural and biochemical alterations during dimethylhydrazine (DMH)-induced rat colon carcinogenesis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2009; 28(4):351-9. doi: 10.1615/jenvironpatholtoxicoloncol.v28.i4.90. [PMID: 20102331]
  • Yin-ping Qiu, Ming-ming Su, Da-zheng Wu, Ai-hua Zhao, Yu-min Liu, Wei Jia. [Effect of jinfu kang to experimental precancerous colon lesions and urinary metabolites in rat]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Nov; 33(22):2653-7. doi: NULL. [PMID: 19216165]
  • N Mittal, S Singh Kanwar, S Nath Sanyal. Effect of non-steroidal anti-inflammatory drugs and the pro-carcinogen 1,2 dimethylhydrazine on the rat intestinal membrane structure and function. Nutricion hospitalaria. 2008 Sep; 23(5):439-48. doi: . [PMID: 19160894]
  • I R Kulmagambetov, L E Muravleva, Iu E Abdrakhmanova, V V Koĭkov, O A Ponamareva, V S Triték, A K Eshmanova. [Effects of asymmetric dimethyl hydrazine on physical and chemical properties of blood plasma if experimental animals]. Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine. 2008 Jan; 42(1):32-5. doi: NULL. [PMID: 18564567]
  • Janice E Drew, Andrew J Farquharson, Sara Padidar, Garry G Duthie, Julian G Mercer, John R Arthur, Philip C Morrice, Lawrence N Barrera. Insulin, leptin, and adiponectin receptors in colon: regulation relative to differing body adiposity independent of diet and in response to dimethylhydrazine. American journal of physiology. Gastrointestinal and liver physiology. 2007 Oct; 293(4):G682-91. doi: 10.1152/ajpgi.00231.2007. [PMID: 17656443]
  • S Zh Kolumbaeva, T M Shalakhmetova, D A Begimbetova, R I Bersimbaev, A M Kalimagambetov. [Mutagenic effect of the rocket fuel component asymmetric dimethylhydrazine on rats of various ages]. Genetika. 2007 Jun; 43(6):742-6. doi: ". [PMID: 17853800]
  • I R Kulmagametov, L E Muravleva, V V Koĭkov, Iu E Abrakhmanova. [Oxidative metabolism and crystal-forming properties of blood of the experimental animals subjected to nonsymmetrical dimethylhydrazine]. Biomeditsinskaia khimiia. 2007 May; 53(3):276-83. doi: NULL. [PMID: 17722577]
  • V Manju, N Nalini. Protective role of luteolin in 1,2-dimethylhydrazine induced experimental colon carcinogenesis. Cell biochemistry and function. 2007 Mar; 25(2):189-94. doi: 10.1002/cbf.1305. [PMID: 16850523]
  • S Pérez-Holanda, L Rodrigo, J Viñas-Salas, C Piñol-Felis, C Ildefonso. Effect of defunctionalization on colon carcinogenesis in the rat. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 2006 Sep; 98(9):644-54. doi: 10.4321/s1130-01082006000900002. [PMID: 17092196]
  • Oren Tirosh, Michal Pardo, Betty Schwartz, Ruth Miskin. Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine. Mechanisms of ageing and development. 2005 Dec; 126(12):1262-73. doi: 10.1016/j.mad.2005.07.003. [PMID: 16139868]
  • Kai Li, Jiechun Gao, Xianmin Xiao, Lian Chen, Liang Zhang. The enhancing role of vitamin A deficiency on chemically induced nephroblastoma in rats. Journal of pediatric surgery. 2005 Dec; 40(12):1951-6. doi: 10.1016/j.jpedsurg.2005.08.015. [PMID: 16338327]
  • Aniele R Agner, Ana P Bazo, Lúcia R Ribeiro, Daisy M F Salvadori. DNA damage and aberrant crypt foci as putative biomarkers to evaluate the chemopreventive effect of annatto (Bixa orellana L.) in rat colon carcinogenesis. Mutation research. 2005 Apr; 582(1-2):146-54. doi: 10.1016/j.mrgentox.2005.01.009. [PMID: 15781219]
  • Connie Cheung, Ai-Ming Yu, Jerrold M Ward, Kristopher W Krausz, Taro E Akiyama, Lionel Feigenbaum, Frank J Gonzalez. The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug metabolism and disposition: the biological fate of chemicals. 2005 Mar; 33(3):449-57. doi: 10.1124/dmd.104.002402. [PMID: 15576447]
  • Mao-xing Yue, Rui-yun Peng, Zheng-guo Wang, De-wen Wang, Zhi-huan Yang, He-ming Yang, Qun Su, Ya-dong Xia, Ya-bing Gao, Xue-mei Cui, Jian-zhong Li, Yan Li. [Intoxication induced by unsymmetrical dimethylhydrazine: characteristics and mechanism of its acute and chronic injuries]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. 2004 Dec; 16(12):740-2. doi: NULL. [PMID: 15585150]
  • Viengvansay Nabandith, Masumi Suzui, Takamitsu Morioka, Tatsuya Kaneshiro, Tatsuya Kinjo, Kenji Matsumoto, Yukihiro Akao, Munekazu Iinuma, Naoki Yoshimi. Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat. Asian Pacific journal of cancer prevention : APJCP. 2004 Oct; 5(4):433-8. doi: . [PMID: 15546251]
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  • K R Anilakumar, Farhath Khanum, K R Sudarshanakrishna, K Santhanam. Effect of amaranth leaves on dimethylhydrazine-induced changes in multicomponent antioxidant system of rat liver. Indian journal of experimental biology. 2004 Jun; 42(6):595-600. doi: ". [PMID: 15260111]
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