Trehalose-6,6-dibehenate (BioDeep_00000012675)

   


代谢物信息卡片


Trehalose-6,6-dibehenate

化学式: C56H106O13 (986.7633026)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCCCCC(=O)OCC1C(C(C(C(O1)OC2C(C(C(C(O2)COC(=O)CCCCCCCCCCCCCCCCCCCCC)O)O)O)O)O)O
InChI: InChI=1S/C56H106O13/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39-41-47(57)65-43-45-49(59)51(61)53(63)55(67-45)69-56-54(64)52(62)50(60)46(68-56)44-66-48(58)42-40-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h45-46,49-56,59-64H,3-44H2,1-2H3/t45-,46-,49-,50-,51+,52+,53-,54-,55-,56-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

Trehalose-6,6-dibehenate



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ling Hao, Yaqi Wu, Yandi Zhang, Zijie Zhou, Qing Lei, Nadeem Ullah, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Xionglin Fan. Combinational PRR Agonists in Liposomal Adjuvant Enhances Immunogenicity and Protective Efficacy in a Tuberculosis Subunit Vaccine. Frontiers in immunology. 2020; 11(?):575504. doi: 10.3389/fimmu.2020.575504. [PMID: 33117374]
  • Alexander Wilkinson, Eric Lattmann, Carla B Roces, Gabriel K Pedersen, Dennis Christensen, Yvonne Perrie. Lipid conjugation of TLR7 agonist Resiquimod ensures co-delivery with the liposomal Cationic Adjuvant Formulation 01 (CAF01) but does not enhance immunopotentiation compared to non-conjugated Resiquimod+CAF01. Journal of controlled release : official journal of the Controlled Release Society. 2018 12; 291(?):1-10. doi: 10.1016/j.jconrel.2018.10.002. [PMID: 30291987]
  • Gabriel Kristian Pedersen, Peter Andersen, Dennis Christensen. Immunocorrelates of CAF family adjuvants. Seminars in immunology. 2018 10; 39(?):4-13. doi: 10.1016/j.smim.2018.10.003. [PMID: 30396811]
  • Fabrice Rose, Jeanette Erbo Wern, Francesca Gavins, Peter Andersen, Frank Follmann, Camilla Foged. A strong adjuvant based on glycol-chitosan-coated lipid-polymer hybrid nanoparticles potentiates mucosal immune responses against the recombinant Chlamydia trachomatis fusion antigen CTH522. Journal of controlled release : official journal of the Controlled Release Society. 2018 02; 271(?):88-97. doi: 10.1016/j.jconrel.2017.12.003. [PMID: 29217176]
  • Maria Vono, Christiane Sigrid Eberhardt, Elodie Mohr, Floriane Auderset, Dennis Christensen, Mirco Schmolke, Rhea Coler, Andreas Meinke, Peter Andersen, Paul-Henri Lambert, Beatris Mastelic-Gavillet, Claire-Anne Siegrist. Overcoming the Neonatal Limitations of Inducing Germinal Centers through Liposome-Based Adjuvants Including C-Type Lectin Agonists Trehalose Dibehenate or Curdlan. Frontiers in immunology. 2018; 9(?):381. doi: 10.3389/fimmu.2018.00381. [PMID: 29541075]
  • Rie S Kallerup, Henrik Franzyk, Mikkel L Schiøth, Sarah Justesen, Birte Martin-Bertelsen, Fabrice Rose, Cecilie M Madsen, Dennis Christensen, Karen S Korsholm, Anan Yaghmur, Camilla Foged. Adjuvants Based on Synthetic Mycobacterial Cord Factor Analogues: Biophysical Properties of Neat Glycolipids and Nanoself-Assemblies with DDA. Molecular pharmaceutics. 2017 07; 14(7):2294-2306. doi: 10.1021/acs.molpharmaceut.7b00170. [PMID: 28497975]
  • Fabrice Rose, Jeanette Erbo Wern, Pall Thor Ingvarsson, Marco van de Weert, Peter Andersen, Frank Follmann, Camilla Foged. Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach. Journal of controlled release : official journal of the Controlled Release Society. 2015 Jul; 210(?):48-57. doi: 10.1016/j.jconrel.2015.05.004. [PMID: 25957906]
  • Elisabeth Kastner, M Jubair Hussain, Vincent W Bramwell, Dennis Christensen, Yvonne Perrie. Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study. The Journal of pharmacy and pharmacology. 2015 Mar; 67(3):450-63. doi: 10.1111/jphp.12390. [PMID: 25677402]
  • Pall Thor Ingvarsson, Ida Svahn Rasmussen, Michelle Viaene, Przemyslaw Jedrzej Irlik, Hanne Mørck Nielsen, Camilla Foged. The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2014 Aug; 87(3):480-8. doi: 10.1016/j.ejpb.2014.04.001. [PMID: 24726978]
  • Mohammed Jubair Hussain, Alexander Wilkinson, Vincent W Bramwell, Dennis Christensen, Yvonne Perrie. Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants. The Journal of pharmacy and pharmacology. 2014 Mar; 66(3):358-66. doi: 10.1111/jphp.12173. [PMID: 24251796]
  • Randip Kaur, Malou Henriksen-Lacey, Jitinder Wilkhu, Andrew Devitt, Dennis Christensen, Yvonne Perrie. Effect of incorporating cholesterol into DDA:TDB liposomal adjuvants on bilayer properties, biodistribution, and immune responses. Molecular pharmaceutics. 2014 Jan; 11(1):197-207. doi: 10.1021/mp400372j. [PMID: 24171445]
  • Yvonne Perrie, Elisabeth Kastner, Randip Kaur, Alexander Wilkinson, Andrew J Ingham. A case-study investigating the physicochemical characteristics that dictate the function of a liposomal adjuvant. Human vaccines & immunotherapeutics. 2013 Jun; 9(6):1374-81. doi: 10.4161/hv.24694. [PMID: 23584249]
  • Pall Thor Ingvarsson, Signe Tandrup Schmidt, Dennis Christensen, Niels Bent Larsen, Wouter Leonardus Joseph Hinrichs, Peter Andersen, Jukka Rantanen, Hanne Mørck Nielsen, Mingshi Yang, Camilla Foged. Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01. Journal of controlled release : official journal of the Controlled Release Society. 2013 May; 167(3):256-64. doi: 10.1016/j.jconrel.2013.01.031. [PMID: 23415813]
  • Mette Hamborg, Lene Jorgensen, Anders Riber Bojsen, Dennis Christensen, Camilla Foged. Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics. Pharmaceutical research. 2013 Jan; 30(1):140-55. doi: 10.1007/s11095-012-0856-8. [PMID: 22956169]
  • Dennis Christensen, Malou Henriksen-Lacey, Arun T Kamath, Thomas Lindenstrøm, Karen S Korsholm, Jan P Christensen, Anne-Francoise Rochat, Paul-Henri Lambert, Peter Andersen, Claire-Anne Siegrist, Yvonne Perrie, Else Marie Agger. A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog. Journal of controlled release : official journal of the Controlled Release Society. 2012 Jun; 160(3):468-76. doi: 10.1016/j.jconrel.2012.03.016. [PMID: 22709414]
  • Anita Milicic, Randip Kaur, Arturo Reyes-Sandoval, Choon-Kit Tang, Jared Honeycutt, Yvonne Perrie, Adrian V S Hill. Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. PloS one. 2012; 7(3):e34255. doi: 10.1371/journal.pone.0034255. [PMID: 22470545]
  • Sarah E McNeil, Ida Rosenkrands, Else Marie Agger, Peter Andersen, Yvonne Perrie. Subunit vaccines: distearoylphosphatidylcholine-based liposomes entrapping antigen offer a neutral alternative to dimethyldioctadecylammonium-based cationic liposomes as an adjuvant delivery system. Journal of pharmaceutical sciences. 2011 May; 100(5):1856-65. doi: 10.1002/jps.22427. [PMID: 21374619]
  • Pernille Nordly, Fabrice Rose, Dennis Christensen, Hanne Mørck Nielsen, Peter Andersen, Else Marie Agger, Camilla Foged. Immunity by formulation design: induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method. Journal of controlled release : official journal of the Controlled Release Society. 2011 Mar; 150(3):307-17. doi: 10.1016/j.jconrel.2010.11.021. [PMID: 21111765]
  • Pernille Nordly, Else Marie Agger, Peter Andersen, Hanne Mørck Nielsen, Camilla Foged. Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/TDB liposomes: physico-chemical characterization and induction of CD8+ T-cell responses in vivo. Pharmaceutical research. 2011 Mar; 28(3):553-62. doi: 10.1007/s11095-010-0301-9. [PMID: 21042837]
  • Lene Jorgensen, Grith Krøyer Wood, Ida Rosenkrands, Charlotte Petersen, Dennis Christensen. Protein adsorption and displacement at lipid layers determined by total internal reflection fluorescence (TIRF). Journal of liposome research. 2009; 19(2):99-104. doi: 10.1080/08982100902805475. [PMID: 19514999]
  • Dennis Christensen, Morten Allesø, Ida Rosenkrands, Jukka Rantanen, Camilla Foged, Else Marie Agger, Peter Andersen, Hanne Mørck Nielsen. NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2008 Nov; 70(3):914-20. doi: 10.1016/j.ejpb.2008.07.007. [PMID: 18694823]
  • Else Marie Agger, Ida Rosenkrands, Jon Hansen, Karima Brahimi, Brian S Vandahl, Claus Aagaard, Kerstin Werninghaus, Carsten Kirschning, Roland Lang, Dennis Christensen, Michael Theisen, Frank Follmann, Peter Andersen. Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. PloS one. 2008 Sep; 3(9):e3116. doi: 10.1371/journal.pone.0003116. [PMID: 18776936]
  • Dennis Christensen, Daniel Kirby, Camilla Foged, Else Marie Agger, Peter Andersen, Yvonne Perrie, Hanne Mørck Nielsen. alpha,alpha'-trehalose 6,6'-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying. Biochimica et biophysica acta. 2008 May; 1778(5):1365-73. doi: 10.1016/j.bbamem.2008.01.013. [PMID: 18261458]
  • Daniel J Kirby, Ida Rosenkrands, Else M Agger, Peter Andersen, Allan G A Coombes, Yvonne Perrie. PLGA microspheres for the delivery of a novel subunit TB vaccine. Journal of drug targeting. 2008 May; 16(4):282-93. doi: 10.1080/10611860801900462. [PMID: 18446607]
  • Jesper Davidsen, Ida Rosenkrands, Dennis Christensen, Anil Vangala, Daniel Kirby, Yvonne Perrie, Else Marie Agger, Peter Andersen. Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochimica et biophysica acta. 2005 Dec; 1718(1-2):22-31. doi: 10.1016/j.bbamem.2005.10.011. [PMID: 16321607]