1-Ethyl-1-nitrosourea (BioDeep_00000012669)

 

Secondary id: BioDeep_00001868143

human metabolite blood metabolite


代谢物信息卡片


N-(C-hydroxycarbonimidoyl)-N-nitrosoethan-1-amine

化学式: C3H7N3O2 (117.0538)
中文名称: 1-乙基-1-亚硝基脲
谱图信息: 最多检出来源 Homo sapiens(blood) 68.29%

分子结构信息

SMILES: CCN(C(=O)N)N=O
InChI: InChI=1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)

描述信息

D009676 - Noxae > D000477 - Alkylating Agents

同义名列表

17 个代谢物同义名

N-(C-hydroxycarbonimidoyl)-N-nitrosoethan-1-amine; 1-(Aminocarbonyl)-1-ethyl-2-oxohydrazine; N-Ethyl-N-nitroso carbamide; Aethylnitroso-harnstoff; N-Ethyl-N-nitroso-urea; N-NITROSO-N-ETHYLUREA; N Ethyl N nitrosourea; N-Ethyl-N-nitrosourea; 1-Ethyl-1-nitrosourea; N-Ethylnitrosourea; Ethyl nitrosourea; Ethylnitrosourea; Nitrosoethylurea; ENU; NEU; N-Nitroso-N-ethylurea; 1-Ethyl-1-nitrosourea



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Subhashree Bhattacharyya, Sujata Law. Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by Eclipta alba in murine model. International journal of environmental health research. 2022 Nov; 32(11):2435-2449. doi: 10.1080/09603123.2021.1969341. [PMID: 34420458]
  • Priyatosh Nath, Debabrata Majumder, Rahul Debnath, Mousumi Debnath, Surinder Singh Sekhawat, Debasish Maiti. Immunotherapeutic potential of ethanolic olive leaves extract (EOLE) and IL-28B combination therapy in ENU induced animal model of leukemia. Cytokine. 2022 Aug; 156(?):155913. doi: 10.1016/j.cyto.2022.155913. [PMID: 35640418]
  • Subhashree Bhattacharyya, Sujata Law. Environmental pollutant N-N'ethylnitrosourea-induced leukemic NLRP3 inflammasome activation and its amelioration by Eclipta prostrata and its active compound wedelolactone. Environmental toxicology. 2022 Feb; 37(2):322-334. doi: 10.1002/tox.23400. [PMID: 34726823]
  • Zhu-Xiang Jiang, Meher Un Nissa, Zao-Zao Guo, Ya-Bing Zhang, Guo-Dong Zheng, Shu-Ming Zou. An SNP at the target site of cid-miR-nov-1043 in the TOLLIP 3' UTR decreases mortality rate in grass carp subjected to ENU-induced mutagenesis following grass carp reovirus infection. Fish & shellfish immunology. 2022 Jan; 120(?):451-457. doi: 10.1016/j.fsi.2021.12.010. [PMID: 34902502]
  • Ricardo Pereira, José M Leitão. A Non-Rogue Mutant Line Induced by ENU Mutagenesis in Paramutated Rogue Peas (Pisum sativum L.) Is Still Sensitive to the Rogue Paramutation. Genes. 2021 Oct; 12(11):. doi: 10.3390/genes12111680. [PMID: 34828288]
  • Xiaohua Su, Zhidong Li, Bayaer Nashun, Juncheng Deng, Min Yue, Ming Lv, Weiwang Gu. Establishment of a diabetes susceptible family in the Bama minipig (BMP) by N-ethyl-N-nitrosourea (ENU) induction. Neuro endocrinology letters. 2021 Jul; 42(3):177-184. doi: NULL. [PMID: 34279861]
  • M J Ramírez-Expósito, M P Carrera-González, J M Martínez-Martos. Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas. Brain research bulletin. 2021 03; 168(?):1-7. doi: 10.1016/j.brainresbull.2020.12.008. [PMID: 33359638]
  • Caroline M Gorvin, Bushra N Ahmad, Michael J Stechman, Nellie Y Loh, Tertius A Hough, Paul Leo, Mhairi Marshall, Siddharth Sethi, Liz Bentley, Sian E Piret, Anita Reed, Jeshmi Jeyabalan, Paul T Christie, Sara Wells, Michelle M Simon, Ann-Marie Mallon, Herbert Schulz, Norbert Huebner, Matthew A Brown, Roger D Cox, Steve D Brown, Rajesh V Thakker. An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2019 03; 34(3):497-507. doi: 10.1002/jbmr.3624. [PMID: 30395686]
  • Meirong Qin, Runhua Chen, Zeyu Huang, Jinping Wang, Suowen Xu, Ruiqi Jiang, Junpeng Li, Jingwen Xian, Xiaowei Wang, Yi Lu, Liang Xu, Ning Chen, Xiangfu Chen, Ping Wang, Tiejie Wang. Application of the in vivo Pig-a gene mutation assay to test the potential genotoxicity of p-phenylenediamine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Jan; 123(?):424-430. doi: 10.1016/j.fct.2018.10.061. [PMID: 30439388]
  • María Jesús Ramírez-Expósito, María Dolores Mayas, María Pilar Carrera-González, José Manuel Martínez-Martos. Gender Differences in the Antioxidant Response to Oxidative Stress in Experimental Brain Tumors. Current cancer drug targets. 2019; 19(8):641-654. doi: 10.2174/1568009618666181018162549. [PMID: 30338739]
  • Keiichi Itoh, Shoji Masumori, Daisuke Mukai, Hiroyuki Sakakibara, Michiko Yasuda, Kayoko Shimoi. Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin. The Journal of toxicological sciences. 2019; 44(4):273-282. doi: 10.2131/jts.44.273. [PMID: 30944280]
  • Aarifa Nazmeen, Smarajit Maiti. Oxidant stress induction and signalling in xenografted (human breast cancer-tissues) plus estradiol treated or N-ethyl-N-nitrosourea treated female rats via altered estrogen sulfotransferase (rSULT1E1) expressions and SOD1/catalase regulations. Molecular biology reports. 2018 Dec; 45(6):2571-2584. doi: 10.1007/s11033-018-4425-z. [PMID: 30315444]
  • Hiroyuki Oka, Koichi Masuno, Takeki Uehara, Toru Okamoto, Yoshiharu Matsuura, Toru Nakano, Shinpei Yamaguchi. Novel miRNA biomarkers for genotoxicity screening in mouse. Toxicology. 2018 07; 404-405(?):68-75. doi: 10.1016/j.tox.2018.05.009. [PMID: 29777724]
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  • Tae Woo Oh, Hyun Ju Do, Kwang-Youn Kim, Kwang Il Park, Jin Yeul Ma. Leaves of Acer palmatum thumb. Rescues N-ethyl-N-nitrosourea (ENU)-Induced retinal degeneration in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Mar; 42(?):51-55. doi: 10.1016/j.phymed.2018.03.026. [PMID: 29655697]
  • Tao Wang, Chun Hui Bu, Sara Hildebrand, Gaoxiang Jia, Owen M Siggs, Stephen Lyon, David Pratt, Lindsay Scott, Jamie Russell, Sara Ludwig, Anne R Murray, Eva Marie Y Moresco, Bruce Beutler. Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database. Nature communications. 2018 01; 9(1):441. doi: 10.1038/s41467-017-02806-4. [PMID: 29382827]
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  • Christopher T Esapa, Sian E Piret, M Andrew Nesbit, Nellie Y Loh, Gethin Thomas, Peter I Croucher, Matthew A Brown, Steve D M Brown, Roger D Cox, Rajesh V Thakker. Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway. PloS one. 2016; 11(12):e0167916. doi: 10.1371/journal.pone.0167916. [PMID: 27959934]
  • Satoshi Tsuji, Yusuke Kuwahara, Hironori Takagi, Masayuki Sugiura, Yutaka Nakanishi, Masaki Wakamatsu, Katsuki Tsuritani, Yasushi Sato. Gene expression analysis in the lung of the rasH2 transgenic mouse at week 4 prior to induction of malignant tumor formation by urethane and N-methylolacrylamide. The Journal of toxicological sciences. 2015 Dec; 40(6):685-700. doi: 10.2131/jts.40.685. [PMID: 26558449]
  • Birgit Rathkolb, Martina Klempt, Sibylle Sabrautzki, Dian Michel, Matthias Klaften, Jürgen Laufs, Reinhard Sedlmeier, Wolfgang Hans, Helmut Fuchs, Martina U Muckenthaler, Marion Horsch, Dean R Campagna, Mark Fleming, Martin Hrabé de Angelis, Eckhard Wolf, Bernhard Aigner. Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2015 Apr; 28(2):293-306. doi: 10.1007/s10534-015-9824-1. [PMID: 25636453]
  • A Sen, K K Goswami, A Mallick, A K Saxena, U Sanyal, R Baral. In vitro and in vivo evaluation of 2-chloroethylnitrosourea derivatives as antitumor agents. Experimental oncology. 2015 Mar; 37(1):23-9. doi: 10.31768/2312-8852.2015.37(1):23-29. [PMID: 25804227]
  • Keiyu Oshida, Naresh Vasani, Russell S Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M Aleksunes, Curtis Klaassen, J Christopher Corton. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. PloS one. 2015; 10(2):e0112655. doi: 10.1371/journal.pone.0112655. [PMID: 25689681]
  • Christopher T Esapa, Fadil M Hannan, Valerie N Babinsky, Paul Potter, Gethin P Thomas, Peter I Croucher, Matthew A Brown, Steve D M Brown, Roger D Cox, Rajesh V Thakker. N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. PloS one. 2015; 10(4):e0122650. doi: 10.1371/journal.pone.0122650. [PMID: 25860694]
  • Mariko Matsumoto, Shoji Masumori, Mutsuko Hirata-Koizumi, Atsushi Ono, Masamitsu Honma, Kazuhito Yokoyama, Akihiko Hirose. Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice. Mutation research. Genetic toxicology and environmental mutagenesis. 2014 Dec; 775-776(?):94-8. doi: 10.1016/j.mrgentox.2014.10.009. [PMID: 25435360]
  • Youming Zhang, Charlotte Dean, Lauren Chessum, Dao Nguyen, Michelle Stewart, Martin Taylor, William O Cookson, Miriam F Moffatt. Functional analysis of a novel ENU-induced PHD finger 11 (Phf11) mouse mutant. Mammalian genome : official journal of the International Mammalian Genome Society. 2014 Dec; 25(11-12):573-82. doi: 10.1007/s00335-014-9535-x. [PMID: 25091723]
  • Katherine R Bull, Thomas Mason, Andrew J Rimmer, Tanya L Crockford, Karlee L Silver, Tiphaine Bouriez-Jones, Tertius A Hough, Shirine Chaudhry, Ian S D Roberts, Christopher C Goodnow, Richard J Cornall. Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome. The Journal of pathology. 2014 May; 233(1):18-26. doi: 10.1002/path.4308. [PMID: 24293254]
  • Liz Bentley, Christopher T Esapa, M Andrew Nesbit, Rosie A Head, Holly Evans, Darren Lath, Cheryl L Scudamore, Tertius A Hough, Christine Podrini, Fadil M Hannan, William D Fraser, Peter I Croucher, Matthew A Brown, Steve D M Brown, Roger D Cox, Rajesh V Thakker. An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess. Endocrinology. 2014 Mar; 155(3):908-22. doi: 10.1210/en.2013-1247. [PMID: 24302625]
  • Megumi Aizawa-Abe, Ken Ebihara, Chihiro Ebihara, Tomoji Mashimo, Akiko Takizawa, Tsutomu Tomita, Toru Kusakabe, Yuji Yamamoto, Daisuke Aotani, Sachiko Yamamoto-Kataoka, Takeru Sakai, Kiminori Hosoda, Tadao Serikawa, Kazuwa Nakao. Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Physiological genomics. 2013 Sep; 45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. [PMID: 23800849]
  • V Gadjeva, B Grigorov, G Nikolova, A Tolekova, A Zheleva, M Vasileva. Protective effect of spin-labeled 1-ethyl-1-nitrosourea against oxidative stress in liver induced by antitumor drugs and radiation. BioMed research international. 2013; 2013(?):924870. doi: 10.1155/2013/924870. [PMID: 24175309]
  • Bum Jun Kim, Hitisha P Zaveri, Oleg A Shchelochkov, Zhiyin Yu, Andrés Hernández-García, Michelle L Seymour, John S Oghalai, Fred A Pereira, David W Stockton, Monica J Justice, Brendan Lee, Daryl A Scott. An allelic series of mice reveals a role for RERE in the development of multiple organs affected in chromosome 1p36 deletions. PloS one. 2013; 8(2):e57460. doi: 10.1371/journal.pone.0057460. [PMID: 23451234]
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