Chlorozotocin (BioDeep_00000012662)

 

Secondary id: BioDeep_00001868889


代谢物信息卡片


D-Glucose, 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-2-deoxy-

化学式: C9H16ClN3O7 (313.0677)
中文名称: L-氯霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCl)N(C(=O)NC(C=O)C(C(C(CO)O)O)O)N=O
InChI: InChI=1S/C9H16ClN3O7/c10-1-2-13(12-20)9(19)11-5(3-14)7(17)8(18)6(16)4-15/h3,5-8,15-18H,1-2,4H2,(H,11,19)

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D002273 - Carcinogens
D000970 - Antineoplastic Agents

同义名列表

6 个代谢物同义名

D-Glucose, 2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-2-deoxy-; L-Chlorozotocin; Chlorozotocin; DCNU; Chlorozotocin; L-Chlorozotocin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Gianlorenzo Dionigi, Sam Van Slycke, Stefano Rausei, Luigi Boni, Renzo Dionigi. Parathyroid function after open thyroidectomy: A prospective randomized study for ligasure precise versus harmonic FOCUS. Head & neck. 2013 Apr; 35(4):562-7. doi: 10.1002/hed.23005. [PMID: 22715020]
  • R M Bukowski, C Tangen, R Lee, J S Macdonald, A B Einstein, R Peterson, T R Fleming. Phase II trial of chlorozotocin and fluorouracil in islet cell carcinoma: a Southwest Oncology Group study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1992 Dec; 10(12):1914-8. doi: 10.1200/jco.1992.10.12.1914. [PMID: 1333517]
  • K H Wong, K T Wheeler. Ability of the alpha and beta anomers of chlorozotocin to kill rat 9L tumor cells in vitro. Cancer research. 1989 Nov; 49(22):6169-73. doi: NULL. [PMID: 2529961]
  • C Pauwels-Vergely, M F Poupon. Chlorozotocin-induced selection of autocrine and multidrug resistant variants from a rat rhabdomyosarcoma. Anticancer research. 1988 Jan; 8(1):137-43. doi: NULL. [PMID: 2965863]
  • M Leeman, P Lejeune, R Naeije. Inhibition of angiotensin-converting enzyme by perindopril diacid in canine oleic acid pulmonary edema. Critical care medicine. 1987 Jun; 15(6):567-73. doi: 10.1097/00003246-198706000-00005. [PMID: 3032515]
  • R A Kramer, M R Boyd, J H Dees. Comparative nephrotoxicity of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU) and chlorozotocin: functional-structural correlations in the Fischer 344 rat. Toxicology and applied pharmacology. 1986 Mar; 82(3):540-50. doi: 10.1016/0041-008x(86)90289-9. [PMID: 2937179]
  • J H Dees, R A Kramer. Sequential morphologic analysis of the nephrotoxicity produced in rats by single doses of chlorozotocin. Toxicologic pathology. 1986; 14(2):213-31. doi: 10.1177/019262338601400211. [PMID: 2945250]
  • W J Moriconi, S Taylor, M Slavik, R J Belt, C D Haas, B Hoogstraten. Phase I evaluation of chlorozotocin (NSC-178248): weekly schedule. Investigational new drugs. 1985; 3(1):57-62. doi: 10.1007/bf00176825. [PMID: 3157661]
  • S E Tuttle, H M Sharma, W H Bay, L A Hebert. Glomerular basement membrane splitting and microaneurysm formation associated with nitrosourea therapy. American journal of nephrology. 1985; 5(5):388-94. doi: 10.1159/000166969. [PMID: 2998189]
  • F Y Lee, P Workman. Nitroimidazoles as modifiers of nitrosourea pharmacokinetics. International journal of radiation oncology, biology, physics. 1984 Sep; 10(9):1627-30. doi: 10.1016/0360-3016(84)90516-9. [PMID: 6237080]
  • K Edanami, K Komiyama, T Kuroda, I Umezawa. Antitumor activity of a nitrosourea derivative, CNUA, on murine tumors. Cancer chemotherapy and pharmacology. 1984; 13(1):22-6. doi: 10.1007/bf00401441. [PMID: 6234104]
  • W J Suling, L S Rice, W M Shannon. Increased mutagenicity of chloroethylnitrosoureas in the presence of a rat liver S9 microsome mixture. Journal of the National Cancer Institute. 1983 Apr; 70(4):767-9. doi: NULL. [PMID: 6220173]
  • A Wakui. [Cancer chemotherapy with special reference to pharmacokinetics of nitrosoureas]. Gan to kagaku ryoho. Cancer & chemotherapy. 1982 Aug; 9(8):1327-38. doi: ". [PMID: 6223595]
  • M K Samson, L H Baker, G Cummings, R W Talley, B McDonald, D B Bhathena. Clinical trial of chlorozotocin, DTIC, and dactinomycin in metastatic malignant melanoma. Cancer treatment reports. 1982 Feb; 66(2):371-3. doi: NULL. [PMID: 6459845]
  • L Panasci, R Comis, S Ginsberg, L Kohn, A Fitzpatrick, M Rubert, T Scalzo. Phase I trial of chlorozotocin: attempted amelioration of myelotoxicity by glucose administration. Cancer treatment reports. 1981 Jul; 65(7-8):647-50. doi: NULL. [PMID: 6454483]
  • K Komiyama, K Edanami, T Kuroda, I Umezawa. Antitumor effect of 3-[3-(2-chloroethyl)-3-nitrosoureido]-3-deoxy-D-glucopyranose on murine tumors. Gan. 1981 Feb; 72(1):53-9. doi: NULL. [PMID: 6456168]
  • J J Baker, J L Lokey, N A Price, S H Winokur, M Chang. Renal-failure anemia and nitrosourea therapy. The New England journal of medicine. 1979 Sep; 301(12):662. doi: 10.1056/nejm197909203011214. [PMID: 157434]
  • R L McQuinn, J Feola, G A Digenis. The effect of vitamin a on the uptake of a water soluble and lipid soluble nitrosourea by the EMT6 mouse mammary tumor. International journal of radiation oncology, biology, physics. 1979 Sep; 5(9):1577-80. doi: 10.1016/0360-3016(79)90775-2. [PMID: 161303]
  • J S Kovach, C G Moertel, A J Schutt, S Frytak, M J O'Connell, J Rubin, J N Ingle. A phase I study of chlorozotocin (NSC 178248). Cancer. 1979 Jun; 43(6):2189-96. doi: 10.1002/1097-0142(197906)43:6<2189::aid-cncr2820430605>3.0.co;2-#. [PMID: 156580]
  • R M Mhatre, D Green, L C Panasci, P V Woolley, P S Schein. Pharmacologic disposition of chlorozotocin in mice. Cancer treatment reports. 1978 Aug; 62(8):1145-51. doi: NULL. [PMID: 150943]
  • D Hoth, P Woolley, D Green, J Macdonald, P Schein. Phase I studies on chlorozotocin. Clinical pharmacology and therapeutics. 1978 Jun; 23(6):712-22. doi: 10.1002/cpt1978236712. [PMID: 148344]