Diethyldithiocarbamic acid (BioDeep_00000012646)
Secondary id: BioDeep_00001868464
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
Diethyl[sulphanyl(carbonothioyl)]amine
化学式: C5H11NS2 (149.0332886)
中文名称: 二乙基二硫代氨基甲酸
谱图信息:
最多检出来源 Homo sapiens(blood) 14.41%
分子结构信息
SMILES: CCN(CC)C(=S)S
InChI: InChI=1S/C5H11NS2/c1-3-6(4-2)5(7)8/h3-4H2,1-2H3,(H,7,8)
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D064449 - Sequestering Agents > D002614 - Chelating Agents
C308 - Immunotherapeutic Agent > C2139 - Immunostimulant
D007155 - Immunologic Factors
同义名列表
33 个代谢物同义名
Diethyl[sulphanyl(carbonothioyl)]amine; diethyl[sulfanyl(carbonothioyl)]amine; Ditiocarb, sodium salt, trihydrate; Diethyldithiocarbamate, sodium; Sodium diethyldithiocarbamate; Diethyldithiocarbamate, zinc; Diethyldithiocarbamate (DDC); zinc diethyldithiocarbamate; Diethylcarbamodithioic acid; Diethyldithiocarbamic acid; Ditiocarb, potassium salt; Ditiocarb, ammonium salt; Potassium salt ditiocarb; Ammonium salt ditiocarb; Ditiocarb, tin(4+) salt; Diethylcarbamodithioate; Ditiocarb, bismuth salt; Diethyldithiocarbamate; Bismuth salt ditiocarb; Ditiocarb, sodium salt; Sodium salt ditiocarb; Ditiocarb, lead salt; Ditiocarb, zinc salt; Zinc salt ditiocarb; Lead salt ditiocarb; Sodium, ditiocarb; Ditiocarb sodium; Dithiocarb; Ditiocarb; Thiocarb; Imuthiol; Diethyldithiocarbamic acid; Diethyldithiocarbamic acid
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:144353
- KEGG: C19150
- PubChem: 8987
- HMDB: HMDB0251244
- Metlin: METLIN2346
- DrugBank: DB02520
- ChEMBL: CHEMBL961
- MeSH: Ditiocarb
- CAS: 147-84-2
- PMhub: MS000026971
- PubChem: 124489822
- PDB-CCD: DCD
- KNApSAcK: 144353
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
21 个相关的代谢反应过程信息。
Reactome(21)
- Programmed Cell Death:
E1BKA8 + UDP-GlcNAc ⟶ E1BKA8 + UDP - Regulated Necrosis:
E1BKA8 + UDP-GlcNAc ⟶ E1BKA8 + UDP - Programmed Cell Death:
A0A5F4C4F2 + UDP-GlcNAc ⟶ A0A5F4C4F2 + UDP - Regulated Necrosis:
A0A5F4C4F2 + UDP-GlcNAc ⟶ A0A5F4C4F2 + UDP - Programmed Cell Death:
A0A1L1RUM0 + Antabuse ⟶ A0A1L1RUM0 + diethyldithiocarbamic acid - Regulated Necrosis:
A0A1L1RUM0 + Antabuse ⟶ A0A1L1RUM0 + diethyldithiocarbamic acid - Programmed Cell Death:
RIP3 + UDP-GlcNAc ⟶ OGlcNAc-T467-RIP3 + UDP - Regulated Necrosis:
RIP3 + UDP-GlcNAc ⟶ OGlcNAc-T467-RIP3 + UDP - Programmed Cell Death:
Q9QZL0 + UDP-GlcNAc ⟶ Q9QZL0 + UDP - Regulated Necrosis:
Q9QZL0 + UDP-GlcNAc ⟶ Q9QZL0 + UDP - Programmed Cell Death:
Q9Z2P5 + UDP-GlcNAc ⟶ Q9Z2P5 + UDP - Regulated Necrosis:
Q9Z2P5 + UDP-GlcNAc ⟶ Q9Z2P5 + UDP - Programmed Cell Death:
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL + I(1,3,4,5,6)P5 + I(1,3,4,6)P4 + myo-inositol hexakisphosphate ⟶ p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 - Regulated Necrosis:
(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL + I(1,3,4,5,6)P5 + I(1,3,4,6)P4 + myo-inositol hexakisphosphate ⟶ p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 - Pyroptosis:
Antabuse + GSDMD ⟶ GSDMD + diethyldithiocarbamic acid - Pyroptosis:
A0A1L1RUM0 + Antabuse ⟶ A0A1L1RUM0 + diethyldithiocarbamic acid - Pyroptosis:
Antabuse + Gsdmd ⟶ Gsdmd + diethyldithiocarbamic acid - Pyroptosis:
Antabuse + GSDMD ⟶ GSDMD + diethyldithiocarbamic acid - Pyroptosis:
Antabuse + GSDMD ⟶ GSDMD + diethyldithiocarbamic acid - Pyroptosis:
Antabuse + Gsdmd ⟶ Gsdmd + diethyldithiocarbamic acid - Pyroptosis:
Antabuse + GSDMD_HUMAN ⟶ GSDMD_HUMAN + diethyldithiocarbamic acid
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rui Wang, Wenqin Song, Jie Zhu, Xinyue Shao, Chenxiao Yang, Wei Xiong, Bing Wang, Pengfei Zhao, Meiwan Chen, Yongzhuo Huang. Biomimetic nano-chelate diethyldithiocarbamate Cu/Fe for enhanced metalloimmunity and ferroptosis activation in glioma therapy.
Journal of controlled release : official journal of the Controlled Release Society.
2024 Apr; 368(?):84-96. doi:
10.1016/j.jconrel.2024.02.004. [PMID: 38331004] - Marwa M Abu-Serie, Eisayeda Zeinab A Abdelfattah. Anti-metastatic breast cancer potential of novel nanocomplexes of diethyldithiocarbamate and green chemically synthesized iron oxide nanoparticles.
International journal of pharmaceutics.
2022 Nov; 627(?):122208. doi:
10.1016/j.ijpharm.2022.122208. [PMID: 36122615] - Lixun Zhang, Fangxin He, Yuntao Guan. Immobilization of hexavalent chromium in contaminated soil by nano-sized layered double hydroxide intercalated with diethyldithiocarbamate: Fraction distribution, plant growth, and microbial evolution.
Journal of hazardous materials.
2022 05; 430(?):128382. doi:
10.1016/j.jhazmat.2022.128382. [PMID: 35739652] - Marwa M Abu-Serie, Marwa Eltarahony. Novel nanoformulated diethyldithiocarbamate complexes with biosynthesized or green chemosynthesized copper oxide nanoparticles: An in vitro comparative anticancer study.
International journal of pharmaceutics.
2021 Nov; 609(?):121149. doi:
10.1016/j.ijpharm.2021.121149. [PMID: 34601057] - Vitaly D Samuilov, Dmitry B Kiselevsky, Elena V Dzyubinskaya, Olga Yu Frolova. Effects of Superoxide Dismutase Inhibitors and Glucose on Cell Death and Generation of Reactive Oxygen Species in Pea Leaves.
Biochemistry. Biokhimiia.
2021 Jul; 86(7):878-886. doi:
10.1134/s0006297921070087. [PMID: 34284711] - Cuiping Li, Yongli Li, Liying Lou, Xinyi Han, Huihui Wang, Tengfei Huang, Changzheng Li. The interaction between lipocalin 2 and dipyridine ketone hydrazone dithiocarbamte may influence respective function in proliferation and metastasis-related gene expressions in HepG2 cell.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2021 02; 26(1):123-133. doi:
10.1007/s00775-020-01842-8. [PMID: 33449164] - João Paulo Assolini, Fernanda Tomiotto-Pellissier, Bruna Taciane da Silva Bortoleti, Manoela Daiele Gonçalves, Claudia Stoeglehner Sahd, Amanda Cristina Machado Carloto, Paulo Emilio Feuser, Arthur Poester Cordeiro, Sergio Marques Borghi, Waldiceu Aparecido Verri, Claudia Sayer, Pedro Henrique Hermes de Araújo, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Wander Rogério Pavanelli. Diethyldithiocarbamate encapsulation reduces toxicity and promotes leishmanicidal effect through apoptosis-like mechanism in promastigote and ROS production by macrophage.
Journal of drug targeting.
2020 12; 28(10):1110-1123. doi:
10.1080/1061186x.2020.1783669. [PMID: 32546016] - Seyyed Alireza Hashemi, Seyyed Mojtaba Mousavi, Sonia Bahrani, Seeram Ramakrishna, Seyyed Hamid Hashemi. Picomolar-level detection of mercury within non-biological/biological aqueous media using ultra-sensitive polyaniline-Fe3O4-silver diethyldithiocarbamate nanostructure.
Analytical and bioanalytical chemistry.
2020 Sep; 412(22):5353-5365. doi:
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International journal of molecular sciences.
2020 Aug; 21(17):. doi:
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Neuroscience bulletin.
2020 May; 36(5):463-474. doi:
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Colloids and surfaces. B, Biointerfaces.
2019 Apr; 176(?):507-512. doi:
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2018 Dec; 10(48):41118-41128. doi:
10.1021/acsami.8b14940. [PMID: 30444340] - Tianhui Liu, Ping Wang, Min Cong, Xinyan Zhao, Dong Zhang, Hufeng Xu, Lin Liu, Jidong Jia, Hong You. Diethyldithiocarbamate, an anti-abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress.
British journal of pharmacology.
2018 12; 175(24):4480-4495. doi:
10.1111/bph.14503. [PMID: 30266038] - Gurpreet Singh, Harkamal Kaur Sahota. Impact of benzimidazole and dithiocarbamate fungicides on the photosynthetic machinery, sugar content and various antioxidative enzymes in chickpea.
Plant physiology and biochemistry : PPB.
2018 Nov; 132(?):166-173. doi:
10.1016/j.plaphy.2018.09.001. [PMID: 30195856] - Linpei Zhang, Yuqiu Li, Youhe Gao. Early changes in the urine proteome in a diethyldithiocarbamate-induced chronic pancreatitis rat model.
Journal of proteomics.
2018 08; 186(?):8-14. doi:
10.1016/j.jprot.2018.07.015. [PMID: 30044967] - A F Ahmeda, M G Rae, L M Anweigi, M F Al Otaibi, A A Al-Masri, E J Johns. The effect of superoxide dismutase enzyme inhibition on renal microcirculation of spontaneously hypertensive-stroke prone and Wistar rats.
Physiological research.
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10.33549/physiolres.933655. [PMID: 29750873] - Vaibhav G Sheth, Umashanker Navik, Krishna Prahlad Maremanda, Gopabandhu Jena. Effect of diethyldithiocarbamate in cyclophosphamide-induced nephrotoxicity: Immunohistochemical study of superoxide dismutase 1 in rat.
Indian journal of pharmacology.
2018 Jan; 50(1):4-11. doi:
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Free radical biology & medicine.
2017 12; 113(?):143-156. doi:
10.1016/j.freeradbiomed.2017.09.027. [PMID: 28974447] - Ardeshir Shokrollahi, Foroogh Ebrahimi. Supramolecular-Based Ultrasonic-Assisted Dispersion Solidification Liquid-Liquid Microextraction of Copper and Cobalt Prior to Their Flame Atomic Absorption Spectrometry Determination.
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Journal of microbiology and biotechnology.
2017 Jun; 27(6):1090-1097. doi:
10.4014/jmb.1612.12018. [PMID: 28376611] - Lingmei Sun, Kai Liao, Chengcheng Hang, Dayong Wang. Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction.
PloS one.
2017; 12(2):e0172228. doi:
10.1371/journal.pone.0172228. [PMID: 28192489] - Mohamed Wehbe, Malathi Anantha, Minghan Shi, Ada Wai-Yin Leung, Wieslawa H Dragowska, Léon Sanche, Marcel B Bally. Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent.
International journal of nanomedicine.
2017; 12(?):4129-4146. doi:
10.2147/ijn.s137347. [PMID: 28615941] - Hadi Kahe, Mahmoud Chamsaz. A new supramolecular based liquid solid microextraction method for preconcentration and determination of trace bismuth in human blood serum and hair samples by electrothermal atomic absorption spectrometry.
Environmental monitoring and assessment.
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Behavioural brain research.
2016 Apr; 302(?):1-10. doi:
10.1016/j.bbr.2016.01.014. [PMID: 26778780] - Koukou Li, Min Yu, Yang Hu, Guangming Ren, Tingting Zang, Xiuhong Xu, Juanjuan Qu. Three kinds of Ganoderma lucidum polysaccharides attenuate DDC-induced chronic pancreatitis in mice.
Chemico-biological interactions.
2016 Mar; 247(?):30-8. doi:
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Journal of chromatographic science.
2016 Mar; 54(3):326-33. doi:
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Parasites & vectors.
2016 Jan; 9(?):32. doi:
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PloS one.
2016; 11(4):e0153416. doi:
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Redox biology.
2015 Dec; 6(?):100-105. doi:
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Talanta.
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Anticancer research.
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Molecular plant.
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Biochimica et biophysica acta.
2015 May; 1853(5):953-64. doi:
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Chemical research in toxicology.
2015 Apr; 28(4):682-90. doi:
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Journal of inorganic biochemistry.
2014 Jul; 136(?):67-72. doi:
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2014 Mar; 102(?):57-68. doi:
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Analytical and bioanalytical chemistry.
2014 Feb; 406(5):1331-8. doi:
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Biochimie.
2014 Feb; 97(?):181-93. doi:
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Talanta.
2013 Aug; 112(?):73-9. doi:
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Environmental toxicology.
2013 Jul; 28(7):372-9. doi:
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Oxidative medicine and cellular longevity.
2013; 2013(?):704654. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
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Archives of toxicology.
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2012 Nov; 84(6):131-8. doi:
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Psychopharmacology.
2012 Oct; 223(3):307-17. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2012 Aug; 38(2):207-15. doi:
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Talanta.
2012 May; 94(?):70-6. doi:
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Free radical biology & medicine.
2012 Apr; 52(8):1343-52. doi:
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2012 Mar; 204(3):443-50. doi:
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Laboratory investigation; a journal of technical methods and pathology.
2012 Mar; 92(3):396-410. doi:
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Planta.
2012 Jan; 235(1):217-23. doi:
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Journal of experimental botany.
2011 Nov; 62(15):5471-83. doi:
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Drug and chemical toxicology.
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Journal of hazardous materials.
2011 Sep; 192(3):1132-9. doi:
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Antimicrobial agents and chemotherapy.
2011 Sep; 55(9):4033-7. doi:
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Toxicology and applied pharmacology.
2011 Jun; 253(2):137-44. doi:
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Journal of applied physiology (Bethesda, Md. : 1985).
2011 Mar; 110(3):646-52. doi:
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Indian journal of biochemistry & biophysics.
2011 Feb; 48(1):42-6. doi:
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Journal of insect science (Online).
2011; 11(?):140. doi:
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2010 Nov; 1217(46):7198-207. doi:
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Analytical chemistry.
2010 Jul; 82(13):5534-40. doi:
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Fish & shellfish immunology.
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Current eye research.
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Fundamental & clinical pharmacology.
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Journal of microbiological methods.
2010 Mar; 80(3):262-6. doi:
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Oecologia.
2010 Feb; 162(2):393-404. doi:
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American journal of physiology. Renal physiology.
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Acta physiologica (Oxford, England).
2009 Dec; 197(4):297-304. doi:
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PloS one.
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Toxicology and applied pharmacology.
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Pancreas.
2009 Aug; 38(6):661-6. doi:
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Chemical research in toxicology.
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Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
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American journal of hypertension.
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Molecular and cellular biochemistry.
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Toxicology and applied pharmacology.
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Molecular and cellular biochemistry.
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Water research.
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Inflammopharmacology.
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Journal of inorganic biochemistry.
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Chemico-biological interactions.
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Journal of plant physiology.
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Molecular and cellular biochemistry.
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Toxicology.
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Chemical research in toxicology.
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Nitric oxide : biology and chemistry.
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Bulletin of experimental biology and medicine.
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Biochimie.
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