1,2-Dichloropropane (BioDeep_00000012570)

 

Secondary id: BioDeep_00001867876

human metabolite blood metabolite


代谢物信息卡片


Propylene dichloride

化学式: C3H6Cl2 (111.9846536)
中文名称: 1,2-二氯丙烷
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC(CCl)Cl
InChI: InChI=1S/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3

描述信息

同义名列表

3 个代谢物同义名

Propylene dichloride; 12-Dichloro-propane; 1,2-DICHLOROPROPANE



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Y Rong, L Tang, H F Yin, D Y Sun. [Changes of serum markers in acute liver injury induced by oral 1, 2-dichloropropane in BALB/cA-nu mice]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2020 Aug; 38(8):602-605. doi: 10.3760/cma.j.cn121094-20190927-00414. [PMID: 32892589]
  • Tadashi Hirata, Young-Man Cho, Takeshi Toyoda, Jun-Ichi Akagi, Isamu Suzuki, Akiyoshi Nishikawa, Kumiko Ogawa. Lack of in vivo mutagenicity of 1,2-dichloropropane and dichloromethane in the livers of gpt delta rats administered singly or in combination. Journal of applied toxicology : JAT. 2017 06; 37(6):683-691. doi: 10.1002/jat.3416. [PMID: 27896817]
  • Makoto Take, Tetsuya Takeuchi, Shigeyuki Hirai, Kenji Takanobu, Michiharu Matsumoto, Shoji Fukushima, Jun Kanno. Distribution of 1,2-dichloropropane in blood and other tissues of rats after oral administration. The Journal of toxicological sciences. 2017; 42(2):121-128. doi: 10.2131/jts.42.121. [PMID: 28321038]
  • Toshio Kawai, Koji Mitsuyoshi, Masayuki Ikeda. Promising biological monitoring for occupational 1,2-Dichloropropane exposure by urinalysis for unmetabolized solvent. Journal of occupational health. 2015; 57(2):197-9. doi: 10.1539/joh.14-0234-oa. [PMID: 25735626]
  • Shinji Kumagai, Norio Kurumatani, Akira Arimoto, Gaku Ichihara. Time course of blood parameters in printing workers with cholangiocarcinoma. Journal of occupational health. 2014; 56(4):279-84. doi: 10.1539/joh.13-0263-oa. [PMID: 24826961]
  • Makoto Take, Michiharu Matsumoto, Tetsuya Takeuchi, Mitsuru Haresaku, Hitomi Kondo, Hideki Senoh, Yumi Umeda, Takeji Takamura-Enya, Shoji Fukushima. Inhalation exposure to 1,2-dichloropropane: Distribution of blood and tissue concentrations of 1,2-dichloropropane in rats during and after exposure. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2014; 49(12):1341-8. doi: 10.1080/10934529.2014.928193. [PMID: 25072765]
  • Enrico Fiaccadori, Umberto Maggiore, Carlo Rotelli, Roberto Giacosa, Diego Ardissino, Giuseppe De Palma, Enrico Bergamaschi, Antonio Mutti. Acute renal and hepatic failure due to accidental percutaneous absorption of 1,2-dichlorpropane contained in a commercial paint fixative. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2003 Jan; 18(1):219-20. doi: 10.1093/ndt/18.1.219. [PMID: 12480995]
  • A Odinecs, S Maso, G Nicoletto, L Secondin, A Trevisan. Mechanism of sex-related differences in nephrotoxicity of 1.2-dichloropropane in rats. Renal failure. 1995 Sep; 17(5):517-24. doi: 10.3109/08860229509037616. [PMID: 8570864]
  • A Trevisan, P Meneghetti, S Maso, O Troso. In-vitro mechanisms of 1,2-dichloropropane nephrotoxicity using the renal cortical slice model. Human & experimental toxicology. 1993 Mar; 12(2):117-21. doi: 10.1177/096032719301200204. [PMID: 8096708]
  • C Lucantoni, S Grottoli, R Gaetti. 1,2-Dichloropropane is a renal and liver toxicant. Toxicology and applied pharmacology. 1992 Nov; 117(1):133. doi: 10.1016/0041-008x(92)90228-k. [PMID: 1440608]
  • A Trevisan, P Meneghetti, S Maso, L Secondin, G Nicoletto. Sex- and age-related nephrotoxicity due to 1,2-dichloropropane in vitro. Archives of toxicology. 1992; 66(9):641-5. doi: 10.1007/bf01981503. [PMID: 1482287]
  • A Trevisan, O Troso, S Maso. Recovery of biochemical changes induced by 1,2-dichloro propane in rat liver and kidney. Human & experimental toxicology. 1991 Jul; 10(4):241-4. doi: 10.1177/096032719101000402. [PMID: 1679646]
  • C Timchalk, M D Dryzga, F A Smith, M J Bartels. Disposition and metabolism of [14C]1,2-dichloropropane following oral and inhalation exposure in Fischer 344 rats. Toxicology. 1991; 68(3):291-306. doi: 10.1016/0300-483x(91)90076-d. [PMID: 1897000]
  • A Di Nucci, C Gregotti, L Manzo, M Imbriani, S Ghittori, L Bianco, L Maestri, E Capodaglio. 1,2-Dichloropropane hepatotoxicity in rats after inhalation exposure. Journal of applied toxicology : JAT. 1990 Dec; 10(6):391-4. doi: 10.1002/jat.2550100602. [PMID: 2084176]
  • M J Bartels, C Timchalk. 1,2-Dichloropropane: investigation of the mechanism of mercapturic acid formation in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1990 Oct; 20(10):1035-42. doi: 10.3109/00498259009046824. [PMID: 2082593]
  • R Imberti, A Mapelli, P Colombo, P Richelmi, F Bertè, G Bellomo. 1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutathione (GSH) depletion and is modulated by factors affecting intracellular GSH. Archives of toxicology. 1990; 64(6):459-65. doi: 10.1007/bf01977627. [PMID: 1980407]
  • J V Bruckner, W F MacKenzie, R Ramanathan, S Muralidhara, H J Kim, C E Dallas. Oral toxicity of 1,2-dichloropropane: acute, short-term, and long-term studies in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1989 May; 12(4):713-30. doi: 10.1016/0272-0590(89)90003-1. [PMID: 2744274]
  • A Trevisan, E Rizzi, A Scapinello, F Gioffrè, P Chiesura. Liver toxicity due to 1,2-dichloropropane in the rat. Archives of toxicology. 1989; 63(6):445-9. doi: 10.1007/bf00316446. [PMID: 2619558]
  • S L Linnett, D G Clark, D Blair, S L Cassidy. Effects of subchronic inhalation of D-D (1,3-dichloropropene/1,2-dichloropropane) on reproduction in male and female rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1988 Feb; 10(2):214-23. doi: 10.1016/0272-0590(88)90305-3. [PMID: 3356308]
  • A Trevisan, L Pozzobon, E Rizzi, A Bungaro, F Gioffré, P Chiesura. [Behavior of the excretion of mercapturic acid after administration of 1,2-dichloropropane to the rat]. La Medicina del lavoro. 1988 Jan; 79(1):65-9. doi: NULL. [PMID: 3173224]
  • S Ghittori, M L Fiorentino, M Imbriani. [Use of gas chromatography with flame ionization (GC-FID) in the measurement of solvents in the urine]. Giornale italiano di medicina del lavoro. 1987 Jan; 9(1):21-4. doi: NULL. [PMID: 3505220]
  • C Pozzi, P Marai, R Ponti, C Dell'Oro, C Sala, S Zedda, F Locatelli. Toxicity in man due to stain removers containing 1,2-dichloropropane. British journal of industrial medicine. 1985 Nov; 42(11):770-2. doi: 10.1136/oem.42.11.770. [PMID: 4063220]
  • C M Parker, W B Coate, R W Voelker. Subchronic inhalation toxicity of 1,3-dichloropropene/1,2-dichloropropane (D-D) in mice and rats. Journal of toxicology and environmental health. 1982 May; 9(5-6):899-910. doi: 10.1080/15287398209530212. [PMID: 7120516]
  • A R Jones, J Gibson. 1,2-Dichloropropane: metabolism and fate in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1980 Nov; 10(11):835-46. doi: 10.3109/00498258009033814. [PMID: 7467399]