Mipafox (BioDeep_00000012552)

 

Secondary id: BioDeep_00001867972

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


bis[(propan-2-yl)amino]phosphinoyl fluoride

化学式: C6H16FN2OP (182.09842279999998)
中文名称: 丙胺氟磷
谱图信息: 最多检出来源 Homo sapiens(blood) 97.56%

分子结构信息

SMILES: CC(C)NP(=O)(F)NC(C)C
InChI: InChI=1S/C6H16FN2OP/c1-5(2)8-11(7,10)9-6(3)4/h5-6H,1-4H3,(H2,8,9,10)

描述信息

同义名列表

7 个代谢物同义名

bis[(propan-2-yl)amino]phosphinoyl fluoride; N,N-di-isopropylphosphorodiamidic fluoride; N,N-diisopropylphosphorodiamidic fluoride; PHOSPHORODI(ISOPROPYLAMIDIC) FLUORIDE; isopestox; MIPAFOX; Mipafox



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Miriam González-González, Jorge Estévez, Eva Del Río, Eugenio Vilanova, Miguel A Sogorb. Hydrolyzing activities of phenyl valerate sensitive to organophosphorus compounds paraoxon and mipafox in human neuroblastoma SH-SY5Y cells. Toxicology. 2018 08; 406-407(?):123-128. doi: 10.1016/j.tox.2018.07.016. [PMID: 30118792]
  • Ping-An Chang, Ding-Xin Long, Yi-Jun Wu. Molecular cloning and expression of the C-terminal domain of mouse NTE-related esterase. Molecular and cellular biochemistry. 2007 Dec; 306(1-2):25-32. doi: 10.1007/s11010-007-9550-2. [PMID: 17673953]
  • Ping-An Chang, Ding-Xin Long, Yi-Jun Wu. Molecular cloning and expression of chicken neuropathy target esterase activity domain. Toxicology letters. 2007 Nov; 174(1-3):42-8. doi: 10.1016/j.toxlet.2007.08.011. [PMID: 17913405]
  • G A Petroianu, M Y Hasan, K Arafat, S M Nurulain, A Schmitt. Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride. Journal of applied toxicology : JAT. 2005 Nov; 25(6):562-7. doi: 10.1002/jat.1097. [PMID: 16193528]
  • Gary B Quistad, John E Casida. Lysophospholipase inhibition by organophosphorus toxicants. Toxicology and applied pharmacology. 2004 May; 196(3):319-26. doi: 10.1016/j.taap.2004.01.005. [PMID: 15094302]
  • G Petroianu, F Kühn, K Arafat, K Zuleger, A Missler. In vitro protection of plasma cholinesterases by metoclopramide from inhibition by mipafox. Journal of applied toxicology : JAT. 2004 Mar; 24(2):143-6. doi: 10.1002/jat.964. [PMID: 15052610]
  • Georg Petroianu, Kholoud Arafat, Melita Kosanovic, Ayman Saleh, Vijayasarathy Camasamudram, Mohamed Y Hasan. In vitro protection of red blood cell acetylcholinesterase by metoclopramide from inhibition by organophosphates (paraoxon and mipafox). Journal of applied toxicology : JAT. 2003 Nov; 23(6):447-51. doi: 10.1002/jat.936. [PMID: 14635269]
  • Adolfo G Garcia-Pérez, José Barril, Jorge Estévez, Eugenio Vilanova. Properties of phenyl valerate esterase activities from chicken serum are comparable with soluble esterases of peripheral nerves in relation with organophosphorus compounds inhibition. Toxicology letters. 2003 Apr; 142(1-2):1-10. doi: 10.1016/s0378-4274(02)00469-1. [PMID: 12765233]
  • J M Chemnitius, K H Haselmeyer, B D Gonska, H Kreuzer, R Zech. Mipafox differential inhibition assay for heart muscle cholinesterases: substrate specificity and inhibition of three isoenzymes by physostigmine and quinidine. General pharmacology. 1997 Apr; 28(4):567-75. doi: 10.1016/s0306-3623(96)00287-x. [PMID: 9147026]
  • S Y Wu, J E Casida. Subacute neurotoxicity induced in mice by potent organophosphorus neuropathy target esterase inhibitors. Toxicology and applied pharmacology. 1996 Jul; 139(1):195-202. doi: 10.1006/taap.1996.0158. [PMID: 8685903]
  • M A Sogorb, S Viniegra, J A Reig, E Vilanova. Partial characterization of neuropathy target esterase and related phenyl valerate esterases from bovine adrenal medulla. Journal of biochemical toxicology. 1994 Jun; 9(3):145-52. doi: 10.1002/jbt.2570090306. [PMID: 7983680]
  • F C Hoskin. Inhibition of a soman- and diisopropyl phosphorofluoridate (DFP)-detoxifying enzyme by Mipafox. Biochemical pharmacology. 1985 Jun; 34(12):2069-72. doi: 10.1016/0006-2952(85)90396-x. [PMID: 4004925]
  • M Lotti, E T Wei, R C Spear, C E Becker. Neurotoxic esterase in rooster testis. Toxicology and applied pharmacology. 1985 Jan; 77(1):175-80. doi: 10.1016/0041-008x(85)90278-9. [PMID: 3966239]
  • D G Williams. Intramolecular group transfer is a characteristic of neurotoxic esterase and is independent of the tissue source of the enzyme. A comparison of the aging behaviour of di-isopropyl phosphorofluoridate-labelled proteins in brain, spinal cord, liver, kidney and spleen from hen and in human placenta. The Biochemical journal. 1983 Mar; 209(3):817-29. doi: 10.1042/bj2090817. [PMID: 6870792]
  • G MAJNO, M L KARNOVSKY. A biochemical and morphologic study of myelination and demyelination. III. Effect of an organo-phosphorus compound (Mipafox) on the biosynthesis of lipid by nervous tissue of rats and hens. Journal of neurochemistry. 1961 Oct; 8(?):1-16. doi: 10.1111/j.1471-4159.1961.tb13521.x. [PMID: 14468624]