Folpet (BioDeep_00000012452)

 

Secondary id: BioDeep_00001867842

human metabolite Endogenous Volatile Flavor Compounds


代谢物信息卡片


2-[(trichloromethyl)sulfanyl]-2,3-dihydro-1H-isoindole-1,3-dione

化学式: C9H4Cl3NO2S (294.9028334)
中文名称: 灭菌丹标准溶液
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl
InChI: InChI=1S/C9H4Cl3NO2S/c10-9(11,12)16-13-7(14)5-3-1-2-4-6(5)8(13)15/h1-4H

描述信息

Folpet is an Agricultural fungicid
D016573 - Agrochemicals
D010575 - Pesticides

同义名列表

50 个代谢物同义名

2-[(trichloromethyl)sulfanyl]-2,3-dihydro-1H-isoindole-1,3-dione; 2-[(Trichloromethyl)thio]-1H-isoindole-1,3(2H)-dione, 9ci; 2-[(Trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione; 2-[(Trichloromethyl)thio]-1H-isoindole-1,3(2H)-dione; 2-((Trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione; 2-(Trichloromethylsulphanyl)isoindole-1,3-dione; Phthalic acid,imide,N-trichloromethyl sulfenyl; N-(Trichloromethanesulphenyl)phthalimide; Trichlormethylthioimid kyseliny ftalove; N-(Trichloromethanesulfenyl)phthalimide; N-(Trichloromethylmercapto)phthalimide; N-[(Trichloromethyl)thio]-phthalimide; N-((Trichloromethyl)thio)-phthalimide; N-[(Trichloromethyl)thio]phthalimide; N-(Trichloromethyl)thiophthalimide; N-(Trichlor-methylthio)-phthalamid; N-(Trichloromethylthio)phthalimide; N-(Trichlormethylthio)phthalimide; Trichloromethyl(thio)phthalimide; Trichloromethylthiophthalimide; MurphyS rose fungicide; Troysan anti-mildew O; Ortho phaltan 50W; Intercide TMP; Fungitrol II; Orthophaltan; Fungitrol 11; Phthaltan; Fungitrol; Spolacid; Phthalan; Thiophal; Acryptan; Phaltane; Vinicoll; Phalton; Cosan T; Cosan I; Phaltan; Diutrid; Trifol; Folpan; Folpet; Ftalan; Folpex; Folpel; Faltex; Folnit; Faltan; Folpet



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Emmanuel Orman, Samuel Oppong Bekoe, Samuel Asare-Nkansah, Ina Kralisch, Jonathan Jato, Verena Spiegler, Christian Agyare, Emelia Oppong Bekoe, Andreas Hensel. Development of an Analytical Workflow to Support the Establishment of Monographs in African Pharmacopoeias - Combretum mucronatum Leaves as Example. Planta medica. 2023 Aug; 89(9):860-878. doi: 10.1055/a-2002-2260. [PMID: 36539209]
  • Garam An, Junho Park, Whasun Lim, Gwonhwa Song. Folpet promotes apoptosis of bovine mammary epithelial cells via disruption of redox homeostasis and activation of MAPK cascades. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 May; 175(?):113709. doi: 10.1016/j.fct.2023.113709. [PMID: 36889428]
  • Sunwoo Park, Bo Hyun Yun, Hyocheol Bae, Whasun Lim, Gwonhwa Song. Reproductive toxicity of folpet through deregulation of calcium homeostasis in porcine trophectoderm and luminal epithelial cells during early pregnancy. Pesticide biochemistry and physiology. 2021 Nov; 179(?):104974. doi: 10.1016/j.pestbp.2021.104974. [PMID: 34802524]
  • George P Balayiannis, Helen Karasali. Determination of azoxystrobin, topramezone, acetamiprid, fluometuron and folpet in their commercially available pesticide formulations by liquid chromatography. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2021; 56(5):503-511. doi: 10.1080/03601234.2021.1903285. [PMID: 33970794]
  • Verena Christen, Jana Krebs, Karl Fent. Fungicides chlorothanolin, azoxystrobin and folpet induce transcriptional alterations in genes encoding enzymes involved in oxidative phosphorylation and metabolism in honey bees (Apis mellifera) at sublethal concentrations. Journal of hazardous materials. 2019 09; 377(?):215-226. doi: 10.1016/j.jhazmat.2019.05.056. [PMID: 31170570]
  • Roberto Heredia-Ortiz, Aurélie Berthet, Michèle Bouchard. Toxicokinetic modeling of folpet fungicide and its ring-biomarkers of exposure in humans. Journal of applied toxicology : JAT. 2013 Jul; 33(7):607-17. doi: 10.1002/jat.1782. [PMID: 22180346]
  • Aurélie Berthet, Roberto Heredia-Ortiz, David Vernez, Brigitta Danuser, Michèle Bouchard. A detailed urinary excretion time course study of captan and folpet biomarkers in workers for the estimation of dose, main route-of-entry and most appropriate sampling and analysis strategies. The Annals of occupational hygiene. 2012 Aug; 56(7):815-28. doi: 10.1093/annhyg/mes011. [PMID: 22425654]
  • Aurélie Berthet, Michèle Bouchard, David Vernez. Toxicokinetics of captan and folpet biomarkers in dermally exposed volunteers. Journal of applied toxicology : JAT. 2012 Mar; 32(3):202-9. doi: 10.1002/jat.1659. [PMID: 21381058]
  • Aurélie Berthet, Michèle Bouchard, Brigitta Danuser. Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers. Journal of applied toxicology : JAT. 2012 Mar; 32(3):194-201. doi: 10.1002/jat.1653. [PMID: 21381057]
  • Stanisław Walorczyk, Dariusz Drożdżyński, Bogusław Gnusowski. Multiresidue determination of 160 pesticides in wines employing mixed-mode dispersive-solid phase extraction and gas chromatography-tandem mass spectrometry. Talanta. 2011 Sep; 85(4):1856-70. doi: 10.1016/j.talanta.2011.07.029. [PMID: 21872030]
  • Aurélie Berthet, Michèle Berode, Michèle Bouchard. Gas-chromatography mass-spectrometry determination of phthalic acid in human urine as a biomarker of folpet exposure. Analytical and bioanalytical chemistry. 2011 Apr; 400(2):493-502. doi: 10.1007/s00216-011-4753-5. [PMID: 21336936]
  • Aurélie Berthet, Michèle Bouchard, Patrick Schüpfer, David Vernez, Brigitta Danuser, Cong Khanh Huynh. Liquid chromatography-tandem mass spectrometry (LC/APCI-MS/MS) methods for the quantification of captan and folpet phthalimide metabolites in human plasma and urine. Analytical and bioanalytical chemistry. 2011 Feb; 399(6):2243-55. doi: 10.1007/s00216-010-4601-z. [PMID: 21229238]
  • Alberto Pozzebon, Michele Borgo, Carlo Duso. The effects of fungicides on non-target mites can be mediated by plant pathogens. Chemosphere. 2010 Mar; 79(1):8-17. doi: 10.1016/j.chemosphere.2010.01.064. [PMID: 20172588]
  • Mireille Canal-Raffin, Béatrice l'Azou, Joana Jorly, Annabelle Hurtier, Jean Cambar, Patrick Brochard. Cytotoxicity of folpet fungicide on human bronchial epithelial cells. Toxicology. 2008 Jul; 249(2-3):160-6. doi: 10.1016/j.tox.2008.05.003. [PMID: 18586372]
  • Mireille Canal-Raffin, Mathilde Receveur, Béatrice Martinez, Karine Titier, Celine Ohayon, Isabelle Baldi, Mathieu Molimard, Nicholas Moore, Patrick Brochard. Quantification methods of folpet degradation products in plasma with HPLC-UV/DAD: application to an in vivo toxicokinetic study in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Apr; 865(1-2):106-13. doi: 10.1016/j.jchromb.2008.02.011. [PMID: 18343208]
  • A Bermúdez-Couso, M Arias-Estévez, J C Nóvoa-Muñoz, E López-Periago, B Soto-González, J Simal-Gándara. Seasonal distributions of fungicides in soils and sediments of a small river basin partially devoted to vineyards. Water research. 2007 Nov; 41(19):4515-25. doi: 10.1016/j.watres.2007.06.029. [PMID: 17624393]
  • R M Hajjo, F U Afifi, A H Battah. Multiresidue pesticide analysis of the medicinal plant Origanum syriacum. Food additives and contaminants. 2007 Mar; 24(3):274-9. doi: 10.1080/02652030600986198. [PMID: 17364929]
  • Cristiane G Manzon, Anderson D Grützmacher, Fabrizio P Giolo, Crislaine A B Lima de Lima, Sandro D Nörnberg, Cristiane Müller, Wagner da R Härter. [Susceptibility of Trichogramma pretiosum Riley (Hymenoptera: Trichogrammatidae) adults to fungicides used to control apple diseases]. Neotropical entomology. 2006 Mar; 35(2):223-30. doi: 10.1590/s1519-566x2006000200011. [PMID: 17348134]
  • Jean-Luc Genet, Grazyna Jaworska, Francine Deparis. Effect of dose rate and mixtures of fungicides on selection for QoI resistance in populations of Plasmopara viticola. Pest management science. 2006 Feb; 62(2):188-94. doi: 10.1002/ps.1146. [PMID: 16411165]
  • J-M Durgnat, J Heuser, D Andrey, C Perrin. Quality and safety assessment of ginseng extracts by determination of the contents of pesticides and metals. Food additives and contaminants. 2005 Dec; 22(12):1224-30. doi: 10.1080/02652030500199439. [PMID: 16356886]
  • Richard A Fenske, Asa Bradman, Robin M Whyatt, Mary S Wolff, Dana B Barr. Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studies. Environmental health perspectives. 2005 Oct; 113(10):1455-62. doi: 10.1289/ehp.7674. [PMID: 16203262]
  • Asa Bradman, Robin M Whyatt. Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children's Study: a review of monitoring and measurement methodologies. Environmental health perspectives. 2005 Aug; 113(8):1092-9. doi: 10.1289/ehp.7769. [PMID: 16079084]
  • Ock Kyoung Chun, Hee Gon Kang, Myung Hee Kim. Multiresidue method for the determination of pesticides in Korean domestic crops by gas chromatography/mass selective detection. Journal of AOAC International. 2003 Jul; 86(4):823-31. doi: 10.1093/jaoac/86.4.823. [PMID: 14509443]
  • Robin M Whyatt, Dana B Barr, David E Camann, Patrick L Kinney, John R Barr, Howard F Andrews, Lori A Hoepner, Robin Garfinkel, Yair Hazi, Andria Reyes, Judyth Ramirez, Yesenia Cosme, Frederica P Perera. Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environmental health perspectives. 2003 May; 111(5):749-56. doi: 10.1289/ehp.5768. [PMID: 12727605]
  • Dana B Barr, John R Barr, Vincent L Maggio, Ralph D Whitehead, Melissa A Sadowski, Robin M Whyatt, Larry L Needham. A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Oct; 778(1-2):99-111. doi: 10.1016/s0378-4347(01)00444-3. [PMID: 12376118]
  • P Cabras, A Angioni, V L Garau, M Melis, F M Pirisi, F Cabitza, M Pala. The effect of simulated rain on folpet and mancozeb residues on grapes and on vine leaves. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2001 Sep; 36(5):609-18. doi: 10.1081/pfc-100106189. [PMID: 11599724]
  • P Cabras, A Angioni, P Caboni, V L Garau, M Melis, F M Pirisi, F Cabitza. Distribution of folpet on the grape surface after treatment. Journal of agricultural and food chemistry. 2000 Mar; 48(3):915-6. doi: 10.1021/jf990069u. [PMID: 10725173]
  • J A Quest, P A Fenner-Crisp, W Burnam, M Copley, K L Dearfield, K L Hamernik, D S Saunders, R J Whiting, R Engler. Evaluation of the carcinogenic potential of pesticides. 4. Chloroalkylthiodicarboximide compounds with fungicidal activity. Regulatory toxicology and pharmacology : RTP. 1993 Feb; 17(1):19-34. doi: 10.1006/rtph.1993.1003. [PMID: 8441825]
  • W M Ashley, R E Smith, R R Dalvi. Hepatotoxicity of orally and intraperitoneally administered folpet in male rats. Journal of toxicology and environmental health. 1982 May; 9(5-6):867-76. doi: 10.1080/15287398209530209. [PMID: 7120514]
  • B Büttler, W D Hörmann. High-pressure liquid chromatographic determination of captan, captafol, and folpet residues in plant material. Journal of agricultural and food chemistry. 1981 Mar; 29(2):257-60. doi: 10.1021/jf00104a012. [PMID: 7229209]
  • J P O'Neill, N L Forbes, A W Hsie. Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells CHO/HGPRT system). Environmental mutagenesis. 1981; 3(3):233-7. doi: 10.1002/em.2860030306. [PMID: 7274179]
  • J Zadrozińska. [Use of fungi as a biological test for determination of fungicide residues in plant material. II. Determination of benomyl, dichlofluanide, folpet, captane, carbendazyme, methyl thiophanate and thiram in fruit, vegetables and champignons]. Roczniki Panstwowego Zakladu Higieny. 1979; 30(5):433-40. doi: . [PMID: 575574]