Disulfoton (BioDeep_00000012263)

 

Secondary id: BioDeep_00001867869

human metabolite blood metabolite


代谢物信息卡片


Phosphorodithioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester

化学式: C8H19O2PS3 (274.0284764)
中文名称: 乙拌磷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOP(=S)(OCC)SCCSCC
InChI: InChI=1S/C8H19O2PS3/c1-4-9-11(12,10-5-2)14-8-7-13-6-3/h4-8H2,1-3H3

描述信息

C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals

同义名列表

21 个代谢物同义名

Phosphorodithioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester; S-[2-(Ethylsulphanyl)ethyl] O,O-dimethyl dithiophosphoric acid; O,O-diethyl {[2-(ethylsulfanyl)ethyl]sulfanyl}phosphonothioate; S-[2-(Ethylsulfanyl)ethyl] O,O-dimethyl dithiophosphoric acid; Phosphorodithioate, O,O-diethyl S-(2-(ethylthio)ethyl) ester; O,O-diethyl [2-(ethylsulfanyl)ethyl]sulfanylphosphonothioate; O,O-Diethyl S-(2-ethylmercaptoethyl) dithiophosphoric acid; O,O-Diethyl S-(2-(ethylthio)ethyl) dithiophosphoric acid; S-[2-(Ethylsulphanyl)ethyl] O,O-dimethyl dithiophosphate; S-[2-(Ethylsulfanyl)ethyl] O,O-dimethyl dithiophosphate; O,O-Diethyl S-(2-ethylmercaptoethyl) dithiophosphate; O,O-Diethyl S-(2-(ethylthio)ethyl) dithiophosphate; Ethylthiometon; Disulphoton; Thiodemeton; Disulfaton; disulfoton; Di syston; Di-syston; Disyston; Demeton



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kiyotaka Usui, Yoshie Hayashizaki, Takashi Minagawa, Masaki Hashiyada, Anri Nakano, Masato Funayama. Rapid determination of disulfoton and its oxidative metabolites in human whole blood and urine using QuEChERS extraction and liquid chromatography-tandem mass spectrometry. Legal medicine (Tokyo, Japan). 2012 Nov; 14(6):309-16. doi: 10.1016/j.legalmed.2012.06.005. [PMID: 22818267]
  • Alison L Clune, P Barry Ryan, Dana Boyd Barr. Have regulatory efforts to reduce organophosphorus insecticide exposures been effective?. Environmental health perspectives. 2012 Apr; 120(4):521-5. doi: 10.1289/ehp.1104323. [PMID: 22251442]
  • Rachad Alnamer, Katim Alaoui, El Houcine Bouidida, Abdelaziz Benjouad, Yahia Cherrah. Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco. Advances in pharmacological sciences. 2012; 2012(?):270824. doi: 10.1155/2012/270824. [PMID: 22162677]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Kim G Harley, Karen Huen, Raul Aguilar Schall, Nina T Holland, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi. Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women. PloS one. 2011; 6(8):e23923. doi: 10.1371/journal.pone.0023923. [PMID: 21904599]
  • Hagai Yasuor, Wei Zou, Vladimir V Tolstikov, Ronald S Tjeerdema, Albert J Fischer. Differential oxidative metabolism and 5-ketoclomazone accumulation are involved in Echinochloa phyllopogon resistance to clomazone. Plant physiology. 2010 May; 153(1):319-26. doi: 10.1104/pp.110.153296. [PMID: 20207709]
  • Hagai Yasuor, Patti L TenBrook, Ronald S Tjeerdema, Albert J Fischer. Responses to clomazone and 5-ketoclomazone by Echinochloa phyllopogon resistant to multiple herbicides in Californian rice fields. Pest management science. 2008 Oct; 64(10):1031-9. doi: 10.1002/ps.1604. [PMID: 18493924]
  • Sandra Yucra, Kyle Steenland, Arturo Chung, Fredy Choque, Gustavo F Gonzales. Dialkyl phosphate metabolites of organophosphorus in applicators of agricultural pesticides in Majes - Arequipa (Peru). Journal of occupational medicine and toxicology (London, England). 2006 Dec; 1(?):27. doi: 10.1186/1745-6673-1-27. [PMID: 17177990]
  • G David Buntin, Kathy L Flanders, Robert W Slaughter, Zandra D DeLamar. Damage loss assessment and control of the cereal leaf beetle (Coleoptera: Chrysomelidae) in winter wheat. Journal of economic entomology. 2004 Apr; 97(2):374-82. doi: 10.1093/jee/97.2.374. [PMID: 15154458]
  • D B Fragoso, R N C Guedes, R N C Guedes, M C Picanço, L Zambolim. Insecticide use and organophosphate resistance in the coffee leaf miner Leucoptera coffeella (Lepidoptera: Lyonetiidae). Bulletin of entomological research. 2002 Jun; 92(3):203-12. doi: 10.1079/ber2002156. [PMID: 12088537]
  • R D Jones, T F Hastings, A M Landes. Absence of neurovisual effects due to tissue and blood cholinesterase depression in a chronic disulfoton feeding study in dogs. Toxicology letters. 1999 Jun; 106(2-3):181-90. doi: 10.1016/s0378-4274(99)00064-8. [PMID: 10403662]
  • H Arnold, H J Pluta, T Braunbeck. Sublethal effects of prolonged exposure to disulfoton in rainbow trout (Oncorhynchus mykiss): cytological alterations in the liver by a potent acetylcholine esterase inhibitor. Ecotoxicology and environmental safety. 1996 Jun; 34(1):43-55. doi: 10.1006/eesa.1996.0043. [PMID: 8793319]
  • T Zahn, H Arnold, T Braunbeck. Cytological and biochemical response of R1 cells and isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) to subacute in vitro exposure to disulfoton. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 1996 Jan; 48(1):47-64. doi: 10.1016/s0940-2993(96)80093-5. [PMID: 8919271]
  • K Futagami, K Otsubo, Y Nakao, T Aoyama, E Iimori, S Urakami, M Ide, R Oishi. Acute organophosphate poisoning after disulfoton ingestion. Journal of toxicology. Clinical toxicology. 1995; 33(2):151-5. doi: 10.3109/15563659509000465. [PMID: 7897754]
  • R A Chapman, J H Tolman, C Cole. The effect of multiple soil applications of disulfoton on enhanced microbial degradation in soil and subsequent uptake of insecticidal chemicals by potato plants. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1994 May; 29(3):485-506. doi: 10.1080/03601239409372892. [PMID: 8201175]
  • A Dzwonkowska, H Hübner. Studies on commercial insecticides with the dominant lethal mutations test. Polish journal of occupational medicine and environmental health. 1991; 4(1):43-53. doi: ". [PMID: 1818645]
  • E Shimada, M Yoshida, S Yamanaka, H Aoyama, Y Yamamura. [Erythrocyte and plasma cholinesterase activities on poisoning by disyston, fenitrothion and malathion]. Sangyo igaku. Japanese journal of industrial health. 1986 Sep; 28(5):368-9. doi: 10.1539/joh1959.28.368. [PMID: 3820777]
  • C D Brokopp, J L Wyatt, J Gabica. Dialkyl phosphates in urine samples from pesticide formulators exposed to disulfoton and phorate. Bulletin of environmental contamination and toxicology. 1981 Apr; 26(4):524-9. doi: 10.1007/bf01622131. [PMID: 7236911]
  • M M Fawade, S S Pawar. Effect of phenobarbital pretreatment on mixed function oxidases & lipid peroxidation during thiodemeton toxicity. Indian journal of experimental biology. 1980 Jun; 18(6):645-7. doi: ". [PMID: 7439951]
  • P K Gopal, S P Ahuja. Lipid & growth changes in organs of chicks (Gallus domesticus) during acute & chronic toxicity with disyston & folithion. Indian journal of experimental biology. 1979 Oct; 17(10):1153-4. doi: ". [PMID: 546750]
  • A Bélanger, H A Hamilton. Determination of disulfoton and permethrin residues in an organic soil and their translocation into lettuce, onion and carrot. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1979; 14(2):213-26. doi: 10.1080/03601237909372123. [PMID: 438462]
  • H R Wolfe, D C Staiff, J F Armstrong, J E Davis. Exposure of fertilizer mixing plant workers to disulfoton. Bulletin of environmental contamination and toxicology. 1978 Jul; 20(1):79-86. doi: 10.1007/bf01683489. [PMID: 698422]
  • M M Fawade, S S Pawar. Alteration in mixed function oxidase system during thiodemeton (o-o diethyl S-2(ethylthio) ethyl phosphorothioate) toxicity. Indian journal of experimental biology. 1978 Apr; 16(4):481-4. doi: ". [PMID: 680855]
  • W C Felsenstein, D C Staiff, G C Miller. Acute demeton poisoning in a child. Archives of environmental health. 1976 Sep; 31(5):266-9. doi: 10.1080/00039896.1976.10667231. [PMID: 973741]
  • R L Smith. The estimation of serum cholinesterase in the presence of anti-cholinesterase insecticides. Clinica chimica acta; international journal of clinical chemistry. 1974 May; 52(3):315-9. doi: 10.1016/0009-8981(74)90117-x. [PMID: 4209143]
  • J Brzeziński. The effect of atropine on the levels of adrenaline and noradrenaline changed by acute poisoning with disyston in rats. Polish journal of pharmacology and pharmacy. 1973 Nov; 25(6):611-5. doi: NULL. [PMID: 4792483]
  • T Shafik, D E Bradway, H F Enos, A R Yobs. gas-liquid chromatographic analysis of alkyl phosphate metabolites in urine. Journal of agricultural and food chemistry. 1973 Jul; 21(4):625-9. doi: 10.1021/jf60188a036. [PMID: 4268895]
  • J Brzeziński, K Ludwicki. The interrelationship of the changes of acetylcholine esterase and catecholamines blood and urine levels in rats poisoned with disyston. Polish journal of pharmacology and pharmacy. 1973 May; 25(3):313-6. doi: NULL. [PMID: 4781488]
  • K M Bhirud, H N Pitre. Comparative susceptibility of three cicadellid vectors of the corn stunt disease agent to carbofuran and disulfoton in greenhouse tests. Journal of economic entomology. 1972 Oct; 65(5):1236-8. doi: 10.1093/jee/65.5.1236. [PMID: 5085777]
  • E E Burgess, H E Williams, R E Wilkinson, E A Heinrichs. Field tests of insecticides against Plagiotrochus cornigerus. Journal of economic entomology. 1972 Oct; 65(5):1484-5. doi: 10.1093/jee/65.5.1484. [PMID: 5085816]
  • D L BULL. METABOLISM OF DI-SYSTON BY INSECTS, ISOLATED COTTON LEAVES, AND RATS. Journal of economic entomology. 1965 Apr; 58(?):249-54. doi: 10.1093/jee/58.2.249. [PMID: 14317629]