Emodepside (BioDeep_00000012255)
代谢物信息卡片
BAY 44-4400
化学式: C60H90N6O14 (1118.651468)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC1C(=O)OC(Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N(C)C(CC(C)C)C(=O)OC(Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N1C
InChI: InChI=1S/C60H90N6O14/c1-37(2)31-47-57(71)77-41(9)53(67)61(11)50(34-40(7)8)60(74)80-52(36-44-17-21-46(22-18-44)66-25-29-76-30-26-66)56(70)64(14)48(32-38(3)4)58(72)78-42(10)54(68)62(12)49(33-39(5)6)59(73)79-51(55(69)63(47)13)35-43-15-19-45(20-16-43)65-23-27-75-28-24-65/h15-22,37-42,47-52H,23-36H2,1-14H3/t41-,42-,47+,48+,49+,50+,51-,52-/m1/s1
描述信息
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents
同义名列表
3 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:78739
- KEGG: C18390
- PubChem: 6918632
- PubChem: 9812173
- Metlin: METLIN72199
- DrugBank: DB11403
- ChEMBL: CHEMBL2104404
- CAS: 155030-63-0
- PMhub: MS000026554
- PubChem: 124489064
- PDB-CCD: 8I2
- KNApSAcK: 78739
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Frauke Assmus, Richard M Hoglund, Frédéric Monnot, Sabine Specht, Ivan Scandale, Joel Tarning. Drug development for the treatment of onchocerciasis: Population pharmacokinetic and adverse events modeling of emodepside.
PLoS neglected tropical diseases.
2022 03; 16(3):e0010219. doi:
10.1371/journal.pntd.0010219. [PMID: 35271567] - Jean-Yves Gillon, Jeremy Dennison, Frans van den Berg, Sophie Delhomme, Karen Dequatre Cheeseman, Claudia Peña Rossi, Nathalie Strub Wourgaft, Sabine Specht, Belén Pedrique, Frédéric Monnot, Susanne Skrabs, Maria-Luisa Rodriguez, Heino Stass. Safety, tolerability and pharmacokinetics of emodepside, a potential novel treatment for onchocerciasis (river blindness), in healthy male subjects.
British journal of clinical pharmacology.
2021 10; 87(10):3949-3960. doi:
10.1111/bcp.14816. [PMID: 33759250] - Shabnam Jawahar, Nancy Tricoche, Christina A Bulman, Judy Sakanari, Sara Lustigman. Drugs that target early stages of Onchocerca volvulus: A revisited means to facilitate the elimination goals for onchocerciasis.
PLoS neglected tropical diseases.
2021 02; 15(2):e0009064. doi:
10.1371/journal.pntd.0009064. [PMID: 33600426] - Paolo Emidio Crisi, Angela Di Cesare, Donato Traversa, Massimo Vignoli, Simone Morelli, Morena Di Tommaso, Francesca De Santis, Fabrizio Pampurini, Roland Schaper, Andrea Boari. Controlled field study evaluating the clinical efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural cat aelurostrongylosis.
The Veterinary record.
2020 Sep; 187(5):e34. doi:
10.1136/vr.105528. [PMID: 31754046] - Tanja Karpstein, Valérian Pasche, Cécile Häberli, Ivan Scandale, Anna Neodo, Jennifer Keiser. Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections.
Parasites & vectors.
2019 May; 12(1):226. doi:
10.1186/s13071-019-3476-x. [PMID: 31088525] - Nadja Rohdich, Eva Zschiesche, Oliver Wolf, Wolfgang Loehlein, Zvezdelina Kirkova, Petar Iliev, Dhimitër Rapti, Rezart Postoli, Balázs Capári, Róbert Farkas, Rainer K A Roepke. A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution (Bravecto® Plus).
Parasites & vectors.
2018 Nov; 11(1):589. doi:
10.1186/s13071-018-3169-x. [PMID: 30449275] - Ž Vienažindienė, D E Joekel, R Schaper, P Deplazes, M Šarkūnas. Longitudinal study for anthelmintic efficacy against intestinal helminths in naturally exposed Lithuanian village dogs: critical analysis of feasibility and limitations.
Parasitology research.
2018 May; 117(5):1581-1590. doi:
10.1007/s00436-018-5843-5. [PMID: 29574514] - Claudia Böhm, Gabriele Petry, Roland Schaper, Sonja Wolken, Christina Strube. Prevention of Lactogenic Toxocara cati Infections in Kittens by Application of an Emodepside/Praziquantel Spot-on (Profender®) to the Pregnant Queen.
Parasitology research.
2015 Aug; 114 Suppl 1(?):S175-84. doi:
10.1007/s00436-015-4523-y. [PMID: 26152418] - Angela Di Cesare, Raffaella Iorio, Paolo Crisi, Barbara Paoletti, Romina Di Costanzo, Carmelo Flavio Dimitri, Donato Traversa. Treatment of Troglostrongylus brevior (Metastrongyloidea, Crenosomatidae) in mixed lungworm infections using spot-on emodepside.
Journal of feline medicine and surgery.
2015 Feb; 17(2):181-5. doi:
10.1177/1098612x14533552. [PMID: 24793743] - Gabriele Petry, Gertraut Altreuther, Sonja Wolken, Petro Swart, Dawie J Kok. Efficacy of emodepside plus toltrazuril oral suspension for dogs (Procox®, Bayer) against Trichuris vulpis in naturally infected dogs.
Parasitology research.
2013 Aug; 112 Suppl 1(?):133-8. doi:
10.1007/s00436-013-3287-5. [PMID: 23756961] - Piyanan Taweethavonsawat, Sudchit Chungpivat, Supoj Watanapongchati, Rebecca J Traub, Roland Schaper. Comparative efficacy of a spot-on formulation containing emodepside and praziquantel (Profender ®, Bayer) and praziquantel and pyrantel oral tablets (Drontal ® for Cats) against experimental Ancylostoma ceylanicum infections in cats.
Veterinary parasitology.
2013 Jan; 191(1-2):172-6. doi:
10.1016/j.vetpar.2012.08.024. [PMID: 23026558] - Gertraut Altreuther, Nadine Gasda, Kerstin Adler, Klaus Hellmann, Heloise Thurieau, Annette Schimmel, Douglas Hutchens, Klemens J Krieger. Field evaluations of the efficacy and safety of Emodepside plus toltrazuril (Procox® oral suspension for dogs) against naturally acquired nematode and Isospora spp. infections in dogs.
Parasitology research.
2011 Aug; 109 Suppl 1(?):S21-8. doi:
10.1007/s00436-011-2399-z. [PMID: 21739372] - David J Buttle, Jerzy M Behnke, Yvonne Bartley, Hany M Elsheikha, David J Bartley, Martin C Garnett, Alison A Donnan, Frank Jackson, Ann Lowe, Ian R Duce. Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus.
Parasites & vectors.
2011 Mar; 4(?):36. doi:
10.1186/1756-3305-4-36. [PMID: 21406090] - Gertraut Altreuther, Annette Schimmel, Iris Schroeder, Thomas Bach, Samuel Charles, Dawid J Kok, Friederike Kraemer, Sonja Wolken, David Young, Klemens J Krieger. Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature infections with Toxocara canis and Toxascaris leonina in dogs.
Parasitology research.
2009 Aug; 105 Suppl 1(?):S1-8. doi:
10.1007/s00436-009-1489-7. [PMID: 19575219] - Annette Schimmel, Gertraut Altreuther, Iris Schroeder, Samuel Charles, Larry Cruthers, Jennifer Ketzis, Dawid J Kok, Friederike Kraemer, John W McCall, Klemens J Krieger. Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Ancylostoma caninum and Uncinaria stenocephala infections in dogs.
Parasitology research.
2009 Aug; 105 Suppl 1(?):S9-16. doi:
10.1007/s00436-009-1490-1. [PMID: 19575220] - Annette Schimmel, Gertraut Altreuther, Iris Schroeder, Samuel Charles, Larry Cruthers, Dawid J Kok, Friederike Kraemer, Klemens J Krieger. Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Trichuris vulpis infections in dogs.
Parasitology research.
2009 Aug; 105 Suppl 1(?):S17-22. doi:
10.1007/s00436-009-1491-0. [PMID: 19575221] - Gertraut Altreuther, Isabelle Radeloff, Christophe LeSueur, Annette Schimmel, Klemens J Krieger. Field evaluation of the efficacy and safety of emodepside plus praziquantel tablets (Profender tablets for dogs) against naturally acquired nematode and cestode infections in dogs.
Parasitology research.
2009 Aug; 105 Suppl 1(?):S23-9. doi:
10.1007/s00436-009-1492-z. [PMID: 19575222] - Iris Schroeder, Gertraut Altreuther, Annette Schimmel, Peter Deplazes, Dawid J Kok, Manuela Schnyder, Klemens J Krieger. Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature cestode infections in dogs.
Parasitology research.
2009 Aug; 105 Suppl 1(?):S31-8. doi:
10.1007/s00436-009-1493-y. [PMID: 19575223] - Sonja Wolken, Roland Schaper, Norbert Mencke, Friederike Kraemer, Thomas Schnieder. Treatment and prevention of vertical transmission of Toxocara cati in cats with an emodepside/praziquantel spot-on formulation.
Parasitology research.
2009 Aug; 105 Suppl 1(?):S75-81. doi:
10.1007/s00436-009-1498-6. [PMID: 19575228] - Donato Traversa, Piermarino Milillo, Angela Di Cesare, Beate Lohr, Raffaella Iorio, Fabrizio Pampurini, Roland Schaper, Roberto Bartolini, Josef Heine. Efficacy and safety of emodepside 2.1\%/praziquantel 8.6\% spot-on formulation in the treatment of feline aelurostrongylosis.
Parasitology research.
2009 Aug; 105 Suppl 1(?):S83-9. doi:
10.1007/s00436-009-1499-5. [PMID: 19575229] - Jerzy M Behnke, David J Buttle, Gillian Stepek, Ann Lowe, Ian R Duce. Developing novel anthelmintics from plant cysteine proteinases.
Parasites & vectors.
2008 Sep; 1(1):29. doi:
10.1186/1756-3305-1-29. [PMID: 18761736] - A Harder, L Holden-Dye, R Walker, F Wunderlich. Mechanisms of action of emodepside.
Parasitology research.
2005 Oct; 97 Suppl 1(?):S1-S10. doi:
10.1007/s00436-005-1438-z. [PMID: 16228263] - R Jeschke, K Iinuma, A Harder, M Schindler, T Murakami. Influence of the cyclooctadepsipeptides PF1022A and PF1022E as natural products on the design of semi-synthetic anthelmintics such as emodepside.
Parasitology research.
2005 Oct; 97 Suppl 1(?):S11-S16. doi:
10.1007/s00436-005-1439-y. [PMID: 16228266] - Achim Harder, Hans-Peter Schmitt-Wrede, Jürgen Krücken, Predrag Marinovski, Frank Wunderlich, James Willson, Kiran Amliwala, Lindy Holden-Dye, Robert Walker. Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action.
International journal of antimicrobial agents.
2003 Sep; 22(3):318-31. doi:
10.1016/s0924-8579(03)00219-x. [PMID: 13678839] - J M Relton, N S Gee, R Matsas, A J Turner, A J Kenny. Purification of endopeptidase-24.11 ('enkephalinase') from pig brain by immunoadsorbent chromatography.
The Biochemical journal.
1983 Dec; 215(3):519-23. doi:
10.1042/bj2150519. [PMID: 6419725]