Algoneurina (BioDeep_00000012248)

   


代谢物信息卡片


Thiamine Disulfide Hydrate

化学式: C24H34N8O4S2 (562.2144324000001)
中文名称: 硫胺素二硫化物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=C(CCO)SSC(CCO)=C(C)N(C=O)Cc1cnc(C)[nH]c1=N)N(C=O)Cc1cnc(C)[nH]c1=N
InChI: InChI=1S/C24H34N8O4S2/c1-15(31(13-35)11-19-9-27-17(3)29-23(19)25)21(5-7-33)37-38-22(6-8-34)16(2)32(14-36)12-20-10-28-18(4)30-24(20)26/h9-10,13-14,33-34H,5-8,11-12H2,1-4H3,(H2,25,27,29)(H2,26,28,30)/b21-15-,22-16-

描述信息

同义名列表

3 个代谢物同义名

Thiamine Disulfide Hydrate; thiamine disulfide; Algoneurina



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mahtab Ghanbari Rad, Mohammadreza Sharifi, Rokhsareh Meamar, Nepton Soltani. The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide. Nutrition & diabetes. 2022 06; 12(1):32. doi: 10.1038/s41387-022-00211-5. [PMID: 35725834]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Dian Xiao, Fan-Hua Meng, Wei Dai, Zheng Yong, Jin-Qiu Liu, Xin-Bo Zhou, Song Li. Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001. Molecules (Basel, Switzerland). 2016 Apr; 21(4):488. doi: 10.3390/molecules21040488. [PMID: 27089316]
  • Marie-Laure Volvert, Sandrine Seyen, Marie Piette, Brigitte Evrard, Marjorie Gangolf, Jean-Christophe Plumier, Lucien Bettendorff. Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC pharmacology. 2008 Jun; 8(?):10. doi: 10.1186/1471-2210-8-10. [PMID: 18549472]
  • I I Stepuro. Thiamine and vasculopathies. Prostaglandins, leukotrienes, and essential fatty acids. 2005 Feb; 72(2):115-27. doi: 10.1016/j.plefa.2004.10.009. [PMID: 15626594]
  • Yasunori Miyazaki, Kanako Ogihara, Shigeru Yakou, Tsuneji Nagai, Kozo Takayama. Bioavailability of theophylline and thiamine disulfide incorporated into mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate. Biological & pharmaceutical bulletin. 2003 Dec; 26(12):1744-7. doi: 10.1248/bpb.26.1744. [PMID: 14646183]
  • Y Komata, A Kaneko, T Fujie. In vitro percutaneous absorption of thiamine disulfide through rat skin from a mixture of propylene glycol and fatty acid or its analog. Chemical & pharmaceutical bulletin. 1992 Aug; 40(8):2173-6. doi: 10.1248/cpb.40.2173. [PMID: 1423776]
  • J Greenwood, O E Pratt. Comparison of the effects of some thiamine analogues upon thiamine transport across the blood-brain barrier of the rat. The Journal of physiology. 1985 Dec; 369(?):79-91. doi: 10.1113/jphysiol.1985.sp015889. [PMID: 4093890]
  • H Pointner, U Flegel. [Treatment of exocrine pancreatic insufficiency with fungal lipase (author's transl)]. Arzneimittel-Forschung. 1975 Nov; 25(11):1833-5. doi: . [PMID: 1053]
  • Z G BANHIDI. Thiamine-sparing action of ascorbic acid on some lactobacilli and the rat due to thiamine disulfide activation. Annals of the New York Academy of Sciences. 1961 Apr; 92(?):324-32. doi: 10.1111/j.1749-6632.1961.tb46133.x. [PMID: 13686586]