Osaterone acetate (BioDeep_00000012247)

   

Volatile Flavor Compounds


代谢物信息卡片


Osaterone acetate

化学式: C22H27ClO5 (406.15469220000006)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)OCC34C)Cl)C)OC(=O)C
InChI: InChI=1S/C22H27ClO5/c1-12(24)22(28-13(2)25)8-6-16-14-9-18(23)17-10-19(26)27-11-20(17,3)15(14)5-7-21(16,22)4/h9-10,14-16H,5-8,11H2,1-4H3/t14-,15+,16+,20-,21+,22+/m1/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000726 - Androgen Antagonists

同义名列表

2 个代谢物同义名

Osaterone acetate; Osaterone acetate



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kouichi Minato, Seijirou Honma, Yoshihiko Shinohara, Takao Hashimoto. Metabolism of osaterone acetate in dogs and humans. Steroids. 2005 Aug; 70(9):563-72. doi: 10.1016/j.steroids.2005.03.012. [PMID: 15923016]
  • Kouichi Minato, Naoyuki Koizumi, Seijirou Honma, Kunio Tsukamoto, Satoshi Iwamura. Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs. Drug metabolism and disposition: the biological fate of chemicals. 2002 Feb; 30(2):167-72. doi: 10.1124/dmd.30.2.167. [PMID: 11792686]
  • K Minato, N Koizumi, S Honma, S Iwamura, K Tsukamoto. Characterizations of mouse hepatic microsomal monooxygenase catalyzing 11beta-hydroxylation of osaterone acetate. Biochemical pharmacology. 1999 Jul; 58(2):335-41. doi: 10.1016/s0006-2952(99)00098-2. [PMID: 10423176]
  • H Fuse, S Fukumoto, H Sone, Y Miyata, T Saito, K Nakayama, H Takahashi, T Matsumoto, E Ogata. A new synthetic steroid, osaterone acetate (TZP-4238), increases cortical bone mass and strength by enhancing bone formation in ovariectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 1997 Apr; 12(4):590-7. doi: 10.1359/jbmr.1997.12.4.590. [PMID: 9101370]
  • S Honma, Y Takezawa, H Yamanaka. [The effects of antiandrogen TZP-4238 on plasma testosterone and LH and steroidogenesis in rat and canine testis]. Nihon Naibunpi Gakkai zasshi. 1995 Jul; 71(5):679-94. doi: 10.1507/endocrine1927.71.5_679. [PMID: 7556779]
  • Y Ohta, K Minato, T Hoshino, N Hirabayashi, S Honma. [The effect of antiandrogen TZP-4238 on corticosteroid hormone in the dog]. Nihon Naibunpi Gakkai zasshi. 1994 Oct; 70(8):913-24. doi: 10.1507/endocrine1927.70.8_913. [PMID: 7528147]
  • S Honma, K Suzuki, Y Takezawa, K Minato, Y Fukabori, H Yamanaka. [Effects of antiandrogen TZP-4238 on the prostatic androgen receptor and prostatic androgen in rat]. Nihon Naibunpi Gakkai zasshi. 1994 Oct; 70(8):925-40. doi: 10.1507/endocrine1927.70.8_925. [PMID: 7528148]
  • M Mieda, Y Ohta, T Saito, H Takahashi, E Shimazawa, K Miyasaka. Antiandrogenic activity and endocrinological profile of a novel antiandrogen, TZP-4238, in the rat. Endocrine journal. 1994 Aug; 41(4):445-52. doi: 10.1507/endocrj.41.445. [PMID: 8528361]
  • T Nakatani, R Yasumoto, S Wada, T Maekawa, N Nishisaka, K Yamamoto, T Kishimoto. [The effect of TZP-4238, an anti-androgen drug, on renal function]. Hinyokika kiyo. Acta urologica Japonica. 1994 Aug; 40(8):735-43. doi: NULL. [PMID: 7524290]
  • T Ichikawa, S Akimoto, J Shimazaki. An inhibitory effect of TZP-4238 on the growth of androgen-sensitive rat prostatic tumor (Dunning R3327). Endocrine journal. 1993 Aug; 40(4):425-30. doi: 10.1507/endocrj.40.425. [PMID: 7522799]
  • M Murakoshi, M Tagawa, R Inada, M Suzuki, A Mizokami, K Watanabe. Inhibition of steroid-induced prostatic hyperplasia in rats by treatment with anti-androgen (TZP-4238). Endocrine journal. 1993 Aug; 40(4):479-88. doi: 10.1507/endocrj.40.479. [PMID: 7522800]
  • M Murakoshi, M Tagawa, R Inada, M Shoji, M Suzuki, K Watanabe. The effects of new steroidal anti-androgen, TZP-4238, and chlormadinone acetate on the pituitary, prostate and adrenal gland of the rat: histopathological and immunocytochemical studies. Endocrinologia japonica. 1992 Aug; 39(4):331-40. doi: 10.1507/endocrj1954.39.331. [PMID: 1280213]
  • M Murakoshi, R Inada, M Tagawa, M Makino, M Suzuki, M Mieda, S Honma, Y Takezawa, H Yamanaka. Inhibitory influence of a new steroidal anti-androgen, TZP-4238, on prostatic hyperplasia in the beagle dog. Acta pathologica japonica. 1992 Mar; 42(3):151-7. doi: 10.1111/j.1440-1827.1992.tb01666.x. [PMID: 1373927]
  • K Tatsumi, M Mikami, T Kuriyama, Y Fukuda. Respiratory stimulation by female hormones in awake male rats. Journal of applied physiology (Bethesda, Md. : 1985). 1991 Jul; 71(1):37-42. doi: 10.1152/jappl.1991.71.1.37. [PMID: 1717425]