Resolvin E2 (BioDeep_00000012126)
代谢物信息卡片
化学式: C20H30O4 (334.2144)
中文名称:
谱图信息:
最多检出来源 Mus musculus(plant) 24.36%
分子结构信息
SMILES: C(CCC[C@H](O)/C=C/C=C\C/C=C\C/C=C\C=C\[C@H](O)CC)(=O)O
InChI: InChI=1S/C20H30O4/c1-2-18(21)14-11-9-7-5-3-4-6-8-10-12-15-19(22)16-13-17-20(23)24/h3-4,7-12,14-15,18-19,21-22H,2,5-6,13,16-17H2,1H3,(H,23,24)/b4-3-,9-7-,10-8-,14-11+,15-12+/t18-,19-/m1/s1
描述信息
A member of the class of resolvins that is (6E,8Z,11Z,14Z,16E)-icosapentaenoic acid carrying two hydroxy substituents at positions 5 and 18 (the 5S,18R stereoisomer).
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:81560
- KEGG: C18173
- PubChem: 16061125
- PubChem: 73229384
- Metlin: METLIN36355
- ChEMBL: CHEMBL4168003
- LipidMAPS: LMFA03140011
- CAS: 865532-70-3
- PMhub: MS000026414
- MetaboLights: MTBLC81560
- PubChem: 96024389
- NIKKAJI: J2.719.149E
- RefMet: Resolvin E2
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
5 个相关的代谢反应过程信息。
Reactome(5)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of lipids:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biosynthesis of specialized proresolving mediators (SPMs):
DHA + Oxygen ⟶ 17-HDHA - Biosynthesis of EPA-derived SPMs:
18(R)-HpEPE + GSH ⟶ 18(R)-HEPE + GSSG + H2O - Biosynthesis of E-series 18(R)-resolvins:
18(R)-HpEPE + GSH ⟶ 18(R)-HEPE + GSSG + H2O
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Arzu Ulu, Abigail Burr, Art J Heires, Jacqueline Pavlik, Tricia Larsen, Pedro A Perez, Carissa Bravo, Nicholas V DiPatrizio, Michelle Baack, Debra J Romberger, Tara M Nordgren. A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts.
The Journal of nutritional biochemistry.
2021 11; 97(?):108797. doi:
10.1016/j.jnutbio.2021.108797. [PMID: 34126202] - Yuto Murakami, Hayato Fukuda, Ryuta Muromoto, Koki Hirashima, Kohei Ishimura, Koichi Fujiwara, Jun Ishihara, Tadashi Matsuda, Mizuki Watanabe, Satoshi Shuto. Design and Synthesis of Benzene Congeners of Resolvin E2, a Proresolving Lipid Mediator, as Its Stable Equivalents.
ACS medicinal chemistry letters.
2020 Apr; 11(4):479-484. doi:
10.1021/acsmedchemlett.9b00596. [PMID: 32292553] - F Echeverría, R Valenzuela, A Espinosa, A Bustamante, D Álvarez, D Gonzalez-Mañan, M Ortiz, S A Soto-Alarcon, L A Videla. Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2.
The Journal of nutritional biochemistry.
2019 01; 63(?):35-43. doi:
10.1016/j.jnutbio.2018.09.012. [PMID: 30321750] - Xavier Capó, Miquel Martorell, Carla Busquets-Cortés, Silvia Tejada, Josep A Tur, Antoni Pons, Antoni Sureda. Resolvins as proresolving inflammatory mediators in cardiovascular disease.
European journal of medicinal chemistry.
2018 Jun; 153(?):123-130. doi:
10.1016/j.ejmech.2017.07.018. [PMID: 28732558] - Romain A Colas, Anthony W Ashton, Shankar Mukherjee, Jesmond Dalli, Oscar B Akide-Ndunge, Huan Huang, Mahalia S Desruisseaux, Fangxia Guan, Linda A Jelicks, Fabiane Matos Dos Santos, Jyothi Nagajyothi, Michael A Zingman, Jinet Reyes, Louis M Weiss, Charles N Serhan, Herbert B Tanowitz. Trypanosoma cruzi Produces the Specialized Proresolving Mediators Resolvin D1, Resolvin D5, and Resolvin E2.
Infection and immunity.
2018 04; 86(4):. doi:
10.1128/iai.00688-17. [PMID: 29358332] - Satoshi Deyama, Kento Shimoda, Hiroe Suzuki, Yuka Ishikawa, Kohei Ishimura, Hayato Fukuda, Natsuko Hitora-Imamura, Soichiro Ide, Masamichi Satoh, Katsuyuki Kaneda, Satoshi Shuto, Masabumi Minami. Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23.
Psychopharmacology.
2018 01; 235(1):329-336. doi:
10.1007/s00213-017-4774-7. [PMID: 29090333] - Masanori Katakura, Michio Hashimoto, Takayuki Inoue, Abdullah Al Mamun, Yoko Tanabe, Makoto Arita, Osamu Shido. Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats.
PloS one.
2015; 10(10):e0140884. doi:
10.1371/journal.pone.0140884. [PMID: 26485038] - Sungwhan F Oh, Maria Dona, Gabrielle Fredman, Sriram Krishnamoorthy, Daniel Irimia, Charles N Serhan. Resolvin E2 formation and impact in inflammation resolution.
Journal of immunology (Baltimore, Md. : 1950).
2012 May; 188(9):4527-34. doi:
10.4049/jimmunol.1103652. [PMID: 22450811] - Chang Hoon Lee. Resolvins as new fascinating drug candidates for inflammatory diseases.
Archives of pharmacal research.
2012 Jan; 35(1):3-7. doi:
10.1007/s12272-012-0121-z. [PMID: 22297737] - Gerard L Bannenberg. Resolvins: Current understanding and future potential in the control of inflammation.
Current opinion in drug discovery & development.
2009 Sep; 12(5):644-58. doi:
". [PMID: 19736623] - Charles N Serhan. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators.
Journal of periodontology.
2008 Aug; 79(8 Suppl):1520-6. doi:
10.1902/jop.2008.080231. [PMID: 18673006]
