trans-Nonachlor (BioDeep_00000012111)

 

Secondary id: BioDeep_00001868150

human metabolite blood metabolite


代谢物信息卡片


(1R,2S,3R,4S,5S,6R,7S)-1,3,4,5,7,8,9,10,10-nonachlorotricyclo[5.2.1.0²,⁶]dec-8-ene

化学式: C10H5Cl9 (439.75880000000006)
中文名称: 反式－九氯标准溶液, 顺-九氯标准溶液
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C12C(C(C(C1Cl)Cl)Cl)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
InChI: InChI=1S/C10H5Cl9/c11-3-1-2(4(12)5(3)13)9(17)7(15)6(14)8(1,16)10(9,18)19/h1-5H

描述信息

trans-Nonachlor os one of the most common chlordane-related environmental contaminants. It is an organochlorine chemical, a class largely banned in the U.S. that builds up in the body over time, linked to cancer and reproductive harm. It is a bioaccumulating component of the pesticide chlordane, which can be detected in various environmental biota and in humans. Some studies also show that there is a dose-response relations between serum cencetrations of trans-nonachlor and the prevalence of diabetes. [PMID: 16801591]
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals

同义名列表

4 个代谢物同义名

(1R,2S,3R,4S,5S,6R,7S)-1,3,4,5,7,8,9,10,10-nonachlorotricyclo[5.2.1.0²,⁶]dec-8-ene; trans-nonachlor; cis-Nonachlor; NONACHLOR



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jan Ove Bustnes, Bård-Jørgen Bårdsen, Børge Moe, Dorte Herzke, Manuel Ballesteros, Anette Fenstad, Katrine Borgå, Ingjerd S Krogseth, Igor Eulaers, Lovise P Skogeng, Geir W Gabrielsen, Sveinn-Are Hanssen. Impacts of a warming climate on concentrations of organochlorines in a fasting high arctic marine bird: Direct vs. indirect effects?. The Science of the total environment. 2023 Oct; 908(?):168096. doi: 10.1016/j.scitotenv.2023.168096. [PMID: 37914131]
  • Erin McDevitt, Lucie Henein, Anna Crawford, Sandeep Kondakala, Darian Young, Edward Meek, George E Howell. Alterations of Systemic and Hepatic Metabolic Function Following Exposure to Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats. International journal of toxicology. 2023 Sep; 42(5):407-419. doi: 10.1177/10915818231170527. [PMID: 37126671]
  • M Pavuk, P F Rosenbaum, M D Lewin, T C Serio, P Rago, M C Cave, L S Birnbaum. Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, pesticides, and diabetes in the Anniston Community Health Survey follow-up (ACHS II): single exposure and mixture analysis approaches. The Science of the total environment. 2023 Mar; 877(?):162920. doi: 10.1016/j.scitotenv.2023.162920. [PMID: 36934946]
  • Marion Ouidir, Pauline Mendola, Germaine M Buck Louis, Kurunthachalam Kannan, Cuilin Zhang, Fasil Tekola-Ayele. Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation. Clinical epigenetics. 2020 07; 12(1):103. doi: 10.1186/s13148-020-00894-6. [PMID: 32653021]
  • Xu Han, Feng Zhang, Lingling Meng, Yuedong Xu, Yingming Li, An Li, Mary E Turyk, Ruiqiang Yang, Pu Wang, Jianqing Zhang, Qinghua Zhang, Guibin Jiang. Exposure to organochlorine pesticides and the risk of type 2 diabetes in the population of East China. Ecotoxicology and environmental safety. 2020 Mar; 190(?):110125. doi: 10.1016/j.ecoenv.2019.110125. [PMID: 31887706]
  • Edward C Meek, Dana Dale Jones, J Allen Crow, Robert W Wills, William H Cooke, Janice E Chambers. Association of serum levels of p,p'- Dichlorodiphenyldichloroethylene (DDE) with type 2 diabetes in African American and Caucasian adult men from agricultural (Delta) and non-agricultural (non-Delta) regions of Mississippi. Journal of toxicology and environmental health. Part A. 2019; 82(6):387-400. doi: 10.1080/15287394.2019.1610678. [PMID: 31064277]
  • George Eli Howell, Erin McDevitt, Lucie Henein, Charlee Mulligan, Darian Young. Alterations in cellular lipid metabolism produce neutral lipid accumulation following exposure to the organochlorine compound trans-nonachlor in rat primary hepatocytes. Environmental toxicology. 2018 Sep; 33(9):962-971. doi: 10.1002/tox.22583. [PMID: 29964320]
  • George Eli Howell, Erin McDevitt, Lucie Henein, Charlee Mulligan, Darian Young. 'Trans-nonachlor increases extracellular free fatty acid accumulation and de novo lipogenesis to produce hepatic steatosis in McArdle-RH7777 cells'. Toxicology in vitro : an international journal published in association with BIBRA. 2018 Aug; 50(?):285-292. doi: 10.1016/j.tiv.2018.04.003. [PMID: 29654899]
  • Tanya M Brown, Sarah I Lord, David W Schindler, John E Elliott. Organohalogen contaminants in common loons (Gavia immer) breeding in Western Alberta, Canada. Chemosphere. 2018 Jul; 202(?):438-445. doi: 10.1016/j.chemosphere.2018.03.107. [PMID: 29579678]
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  • Lee C Mangum, Lauren H Mangum, Janice E Chambers, Matthew K Ross, Edward C Meek, Robert W Wills, J Allen Crow. The association of serum trans-nonachlor levels with atherosclerosis. Journal of toxicology and environmental health. Part A. 2016; 79(5):210-20. doi: 10.1080/15287394.2016.1143901. [PMID: 26953872]
  • Rachel G Felton, Cynthia C Steiner, Barbara S Durrant, Duane H Keisler, Matthew R Milnes, Christopher W Tubbs. Identification of California Condor Estrogen Receptors 1 and 2 and Their Activation by Endocrine Disrupting Chemicals. Endocrinology. 2015 Dec; 156(12):4448-57. doi: 10.1210/en.2015-1448. [PMID: 26372180]
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  • Pilar Suárez, Yolanda Ruiz, Ana Alonso, Fuencisla San Juan. Organochlorine compounds in mussels cultured in the Ría of Vigo: accumulation and origin. Chemosphere. 2013 Jan; 90(1):7-19. doi: 10.1016/j.chemosphere.2012.02.030. [PMID: 22391050]
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  • Warren G Foster, Anthony P Cheung, Karelyn Davis, Gillian Graves, John Jarrell, Alain Leblanc, Chun Lei Liang, Tara Leech, Mark Walker, Jean Philippe Weber, Jay Van Oostdam. Circulating metals and persistent organic pollutant concentrations in Canadian and non-Canadian born primiparous women from five Canadian centres: results of a pilot biomonitoring study. The Science of the total environment. 2012 Oct; 435-436(?):326-36. doi: 10.1016/j.scitotenv.2012.06.070. [PMID: 22863808]
  • Charlotte Bergkvist, Marie Aune, Ingrid Nilsson, Torkjel M Sandanger, Jena Derakhshani Hamadani, Fahmida Tofail, Jon Oyvind-Odland, Iqbal Kabir, Marie Vahter. Occurrence and levels of organochlorine compounds in human breast milk in Bangladesh. Chemosphere. 2012 Aug; 88(7):784-90. doi: 10.1016/j.chemosphere.2012.03.083. [PMID: 22551873]
  • Nieves Carro, Isabel García, María Ignacio, Ana Mouteira. Organochlorine pesticide levels in Ensis siliqua (Linnaeus, 1758) from Ría de Vigo, Galicia (N.W. Spain): influence of season, condition index and lipid content. Bulletin of environmental contamination and toxicology. 2012 Apr; 88(4):491-6. doi: 10.1007/s00128-011-0508-4. [PMID: 22246466]
  • Britton Trabert, Matthew P Longnecker, John W Brock, Mark A Klebanoff, Katherine A McGlynn. Maternal pregnancy levels of trans-nonachlor and oxychlordane and prevalence of cryptorchidism and hypospadias in boys. Environmental health perspectives. 2012 Mar; 120(3):478-82. doi: 10.1289/ehp.1103936. [PMID: 21975279]
  • Samira Salihovic, Lisa Mattioli, Gunilla Lindström, Lars Lind, P Monica Lind, Bert van Bavel. A rapid method for screening of the Stockholm Convention POPs in small amounts of human plasma using SPE and HRGC/HRMS. Chemosphere. 2012 Feb; 86(7):747-53. doi: 10.1016/j.chemosphere.2011.11.006. [PMID: 22153485]
  • Thierry Comlan Marc Medehouenou, Pierre Ayotte, Pierre-Hugues Carmichael, Edeltraut Kröger, René Verreault, Joan Lindsay, Éric Dewailly, Suzanne L Tyas, Alexandre Bureau, Danielle Laurin. Polychlorinated biphenyls and organochlorine pesticides in plasma of older Canadians. Environmental research. 2011 Nov; 111(8):1313-20. doi: 10.1016/j.envres.2011.09.017. [PMID: 22001220]
  • Eva C Bonefeld-Jorgensen, Manhai Long, Rossana Bossi, Pierre Ayotte, Gert Asmund, Tanja Krüger, Mandana Ghisari, Gert Mulvad, Peder Kern, Peter Nzulumiki, Eric Dewailly. Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study. Environmental health : a global access science source. 2011 Oct; 10(?):88. doi: 10.1186/1476-069x-10-88. [PMID: 21978366]
  • Jin-Young Min, Jae-Sung Cho, Kyung-Jong Lee, Jae-Beom Park, Shin-Goo Park, Jang Yong Kim, Kyoung-Bok Min. Potential role for organochlorine pesticides in the prevalence of peripheral arterial diseases in obese persons: results from the National Health and Nutrition Examination Survey 1999-2004. Atherosclerosis. 2011 Sep; 218(1):200-6. doi: 10.1016/j.atherosclerosis.2011.04.044. [PMID: 21620405]
  • Riikka Airaksinen, Panu Rantakokko, Johan G Eriksson, Paul Blomstedt, Eero Kajantie, Hannu Kiviranta. Association between type 2 diabetes and exposure to persistent organic pollutants. Diabetes care. 2011 Sep; 34(9):1972-9. doi: 10.2337/dc10-2303. [PMID: 21816981]
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  • N Bodin, R N'Gom Ka, F Le Loc'h, J Raffray, H Budzinski, L Peluhet, L Tito de Morais. Are exploited mangrove molluscs exposed to Persistent Organic Pollutant contamination in Senegal, West Africa?. Chemosphere. 2011 Jun; 84(3):318-27. doi: 10.1016/j.chemosphere.2011.04.012. [PMID: 21550627]
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  • J S Lim, H-K Son, S-K Park, D R Jacobs, D-H Lee. Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants. International journal of obesity (2005). 2011 May; 35(5):744-7. doi: 10.1038/ijo.2010.188. [PMID: 20820170]
  • George W Yu, John Laseter, Charles Mylander. Persistent organic pollutants in serum and several different fat compartments in humans. Journal of environmental and public health. 2011; 2011(?):417980. doi: 10.1155/2011/417980. [PMID: 21647350]
  • Hae-Sook Lee, Je-Chul Lee, In-Kyu Lee, Hyo-Bang Moon, Yoon-Seok Chang, David R Jacobs, Duk-Hee Lee. Associations among organochlorine pesticides, Methanobacteriales, and obesity in Korean women. PloS one. 2011; 6(11):e27773. doi: 10.1371/journal.pone.0027773. [PMID: 22114690]
  • Frank Rigét, Katrin Vorkamp, Derek Muir. Temporal trends of contaminants in Arctic char (Salvelinus alpinus) from a small lake, southwest Greenland during a warming climate. Journal of environmental monitoring : JEM. 2010 Dec; 12(12):2252-8. doi: 10.1039/c0em00154f. [PMID: 20941435]
  • Veerle L B Jaspers, Rune Dietz, Christian Sonne, Robert J Letcher, Marcel Eens, Hugo Neels, Erik W Born, Adrian Covaci. A screening of persistent organohalogenated contaminants in hair of East Greenland polar bears. The Science of the total environment. 2010 Oct; 408(22):5613-8. doi: 10.1016/j.scitotenv.2010.07.059. [PMID: 20800875]
  • Duk-Hee Lee, Michael W Steffes, Andreas Sjödin, Richard S Jones, Larry L Needham, David R Jacobs. Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study. Environmental health perspectives. 2010 Sep; 118(9):1235-42. doi: 10.1289/ehp.0901480. [PMID: 20444671]
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  • Hélène Arguin, Marina Sánchez, George A Bray, Jennifer C Lovejoy, John C Peters, Ronald J Jandacek, Jean-Philippe Chaput, Angelo Tremblay. Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations: results from two pilot studies. The British journal of nutrition. 2010 May; 103(10):1433-41. doi: 10.1017/s000711450999331x. [PMID: 20030906]
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