norBNI (BioDeep_00000012099)

 

Secondary id: BioDeep_00001869189


代谢物信息卡片


Norbinaltorphimine

化学式: C40H43N3O6 (661.3152)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C9C12CCN(C(C1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1
InChI: InChI=1S/C40H43N3O6/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2/t27-,28-,35+,36+,37+,38+,39-,40-/m1/s1

描述信息

D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists

同义名列表

4 个代谢物同义名

Norbinaltorphimine; LSM-1313; norBNI; Norbinaltorphimine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Edin Muratspahić, Nataša Tomašević, Johannes Koehbach, Leopold Duerrauer, Seid Hadžić, Joel Castro, Gudrun Schober, Spyridon Sideromenos, Richard J Clark, Stuart M Brierley, David J Craik, Christian W Gruber. Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain. Journal of medicinal chemistry. 2021 07; 64(13):9042-9055. doi: 10.1021/acs.jmedchem.1c00158. [PMID: 34162205]
  • Takaaki Komatsu, Soh Katsuyama, Fumihide Takano, Takemasa Okamura, Chikai Sakurada, Minoru Tsuzuki, Kakuyou Ogawa, Atsuhito Kubota, Osamu Morinaga, Kenji Tabata, Tsukasa Sakurada. Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice. Neuroscience letters. 2019 04; 699(?):103-108. doi: 10.1016/j.neulet.2019.01.035. [PMID: 30690119]
  • Mario García-Domínguez, Ana Lastra, Alicia R Folgueras, Rafael Cernuda-Cernuda, María Teresa Fernández-García, Agustín Hidalgo, Luis Menéndez, Ana Baamonde. The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4+ Lymphocytes and Met-Enkephalin. Molecular neurobiology. 2019 Mar; 56(3):1578-1595. doi: 10.1007/s12035-018-1176-8. [PMID: 29907903]
  • Shumiao Zhang, Yaguang Zhou, Lei Zhao, Xin Tian, Min Jia, Xiaoming Gu, Na Feng, Rui An, Lu Yang, Guoxu Zheng, Juan Li, Haitao Guo, Rong Fan, Jianming Pei. κ-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation. European journal of pharmacology. 2018 Aug; 833(?):100-108. doi: 10.1016/j.ejphar.2018.05.043. [PMID: 29856969]
  • Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Kiyohito Yano, Yiliyasi Mayila, Takako Tokui, Rie Yanagihara, Sumika Matsui, Takeshi Kato, Akira Kuwahara, Minoru Irahara. Neurokinin B receptor agonist and Dynorphin receptor antagonist stimulated luteinizing hormone secretion in fasted male rodents. Endocrine journal. 2018 Apr; 65(4):485-492. doi: 10.1507/endocrj.ej17-0136. [PMID: 29479004]
  • Farzaneh Rostamzadeh, Hamid Najafipour, Mahboobeh Yeganeh-Hajahmadi, Siyavash Joukar. Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension. Clinical and experimental pharmacology & physiology. 2018 02; 45(2):187-197. doi: 10.1111/1440-1681.12860. [PMID: 28945940]
  • Mahboobeh Yeganeh-Hajahmadi, Hamid Najafipour, Farzaneh Rostamzadeh. The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. 2017 Aug; 40(8):732-737. doi: 10.1038/hr.2017.28. [PMID: 28275232]
  • Jennifer Y Xie, Milena De Felice, Caroline M Kopruszinski, Nathan Eyde, Justin LaVigne, Bethany Remeniuk, Pablo Hernandez, Xu Yue, Naomi Goshima, Michael Ossipov, Tamara King, John M Streicher, Edita Navratilova, David Dodick, Hugh Rosen, Ed Roberts, Frank Porreca. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. Cephalalgia : an international journal of headache. 2017 Jul; 37(8):780-794. doi: 10.1177/0333102417702120. [PMID: 28376659]
  • José Luis Vázquez López, Lorenz Schild, Thomas Günther, Stefan Schulz, Hartmud Neurath, Axel Becker. The effects of kratom on restraint-stress-induced analgesia and its mechanisms of action. Journal of ethnopharmacology. 2017 Jun; 205(?):178-185. doi: 10.1016/j.jep.2017.05.008. [PMID: 28501425]
  • Fei Tian, Xu-Yang Zheng, Juan Li, Shu-Miao Zhang, Na Feng, Hai-Tao Guo, Min Jia, Yue-Min Wang, Rong Fan, Jian-Ming Pei. κ-Opioid Receptor Stimulation Improves Endothelial Function via Akt-stimulated NO Production in Hyperlipidemic Rats. Scientific reports. 2016 05; 6(?):26807. doi: 10.1038/srep26807. [PMID: 27226238]
  • F Ivy Carroll, Moses G Gichinga, Chad M Kormos, Rangan Maitra, Scott P Runyon, James B Thomas, S Wayne Mascarella, Ann M Decker, Hernán A Navarro. Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents. Bioorganic & medicinal chemistry. 2015 Oct; 23(19):6379-88. doi: 10.1016/j.bmc.2015.08.025. [PMID: 26342544]
  • Ya-Chao Xu, Rui-Ping Li, Fu-Shan Xue, Xin-Long Cui, Shi-Yu Wang, Gao-Pu Liu, Gui-Zhen Yang, Chao Sun, Xu Liao. κ-Opioid receptors are involved in enhanced cardioprotection by combined fentanyl and limb remote ischemic postconditioning. Journal of anesthesia. 2015 Aug; 29(4):535-43. doi: 10.1007/s00540-015-1998-8. [PMID: 25808344]
  • John E Kelsey, Allison M S Verhaak, Kathryn C Schierberl. The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats. Behavioural brain research. 2015 Apr; 283(?):16-21. doi: 10.1016/j.bbr.2015.01.008. [PMID: 25591478]
  • Yulong Shang, Fan Guo, Juan Li, Rong Fan, Xinliang Ma, Yuemin Wang, Na Feng, Yue Yin, Min Jia, Shumiao Zhang, Jingjun Zhou, Hongbing Wang, Jianming Pei. Activation of κ-opioid receptor exerts the glucose-homeostatic effect in streptozotocin-induced diabetic mice. Journal of cellular biochemistry. 2015 Feb; 116(2):252-9. doi: 10.1002/jcb.24962. [PMID: 25186835]
  • Anne-Christin Stolt, Helmut Schröder, Hartmud Neurath, Gisela Grecksch, Volker Höllt, Markus R Meyer, Hans H Maurer, Nancy Ziebolz, Ursula Havemann-Reinecke, Axel Becker. Behavioral and neurochemical characterization of kratom (Mitragyna speciosa) extract. Psychopharmacology. 2014 Jan; 231(1):13-25. doi: 10.1007/s00213-013-3201-y. [PMID: 23846544]
  • Shiroh Kishioka, Norikazu Kiguchi, Yuka Kobayashi, Chizuko Yamamoto, Fumihiro Saika, Naoki Wakida, Mei-Chuan Ko, James H Woods. Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice. Neuroscience letters. 2013 Sep; 552(?):98-102. doi: 10.1016/j.neulet.2013.07.040. [PMID: 23933210]
  • Craig P Allen, Yan Zhou, Francesco Leri. Effect of food restriction on cocaine locomotor sensitization in Sprague-Dawley rats: role of kappa opioid receptors. Psychopharmacology. 2013 Apr; 226(3):571-8. doi: 10.1007/s00213-012-2930-7. [PMID: 23212389]
  • Alana de Freitas Pires, Ana Maria Sampaio Assreuy, Érika Augusta Batista Lopes, Natália Rocha Celedônio, Carlos Eduardo Alves Soares, Natália Velloso Fontenelle Camelo Rodrigues, Paloma Leão Sousa, Raquel Guimarães Benevides, Celso Shiniti Nagano, Benildo Sousa Cavada, José Henrique Leal-Cardoso, Andrelina Noronha Coelho-de-Souza, Cláudia Ferreira Santos. Opioid-like antinociceptive effects of oral administration of a lectin purified from the seeds of Canavalia brasiliensis. Fundamental & clinical pharmacology. 2013 Apr; 27(2):201-9. doi: 10.1111/j.1472-8206.2011.00987.x. [PMID: 21895762]
  • Go Obara, Yumiko Toyohira, Hirohide Inagaki, Keita Takahashi, Takafumi Horishita, Takashi Kawasaki, Susumu Ueno, Masato Tsutsui, Takeyoshi Sata, Nobuyuki Yanagihara. Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells. Journal of pharmacological sciences. 2013; 121(2):138-47. doi: 10.1254/jphs.12164fp. [PMID: 23370666]
  • Thomas A Munro, Xi-Ping Huang, Carmela Inglese, Maria Grazia Perrone, Ashlee Van't Veer, F Ivy Carroll, Cécile Béguin, William A Carlezon, Nicola A Colabufo, Bruce M Cohen, Bryan L Roth. Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters. PloS one. 2013; 8(8):e70701. doi: 10.1371/journal.pone.0070701. [PMID: 23976952]
  • Abigail G Schindler, Daniel I Messinger, Jeffrey S Smith, Haripriya Shankar, Richard M Gustin, Selena S Schattauer, Julia C Lemos, Nicholas W Chavkin, Catherine E Hagan, John F Neumaier, Charles Chavkin. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Dec; 32(49):17582-96. doi: 10.1523/jneurosci.3220-12.2012. [PMID: 23223282]
  • Thomas A Munro, Loren M Berry, Ashlee Van't Veer, Cécile Béguin, F Ivy Carroll, Zhiyang Zhao, William A Carlezon, Bruce M Cohen. Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity. BMC pharmacology. 2012 May; 12(?):5. doi: 10.1186/1471-2210-12-5. [PMID: 22642416]
  • Tânia C Chicre-Alcântara, Karla E Torres-Chávez, Luana Fischer, Juliana T Clemente-Napimoga, Vilma Melo, Carlos Amílcar Parada, Claudia Herrera Tambeli. Local kappa opioid receptor activation decreases temporomandibular joint inflammation. Inflammation. 2012 Feb; 35(1):371-6. doi: 10.1007/s10753-011-9329-1. [PMID: 21484425]
  • Krisztina Csabafi, Miklós Jászberényi, Zsolt Bagosi, Géza Tóth, Mária Wollemann, Gyula Telegdy. The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses. Peptides. 2011 Aug; 32(8):1656-60. doi: 10.1016/j.peptides.2011.05.029. [PMID: 21722680]
  • Guiyun Wu, Wenqi Huang, Hui Zhang, Qiaobo Li, Jun Zhou, Haihua Shu. Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats. Journal of ethnopharmacology. 2011 Jun; 136(1):254-9. doi: 10.1016/j.jep.2011.04.041. [PMID: 21549821]
  • Ana Paula Botelho, Gustavo Hauber Gameiro, Carlos Eduardo da Silva Nossa Tuma, Fernanda Klein Marcondes, Maria Cecília Ferraz de Arruda Veiga. The effects of acute restraint stress on nociceptive responses evoked by the injection of formalin into the temporomandibular joint of female rats. Stress (Amsterdam, Netherlands). 2010 May; 13(3):269-75. doi: 10.3109/10253890903362645. [PMID: 20392197]
  • Victoria Scott, Valerie R Bishop, Gareth Leng, Colin H Brown. Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity. The Journal of physiology. 2009 Dec; 587(Pt 23):5679-89. doi: 10.1113/jphysiol.2009.180232. [PMID: 19822541]
  • Shintaro Iwama, Yoshihisa Sugimura, Takashi Murase, Maiko Hiroi, Motomitsu Goto, Masayuki Hayashi, Hiroshi Arima, Yutaka Oiso. Central adiponectin functions to inhibit arginine vasopressin release in conscious rats. Journal of neuroendocrinology. 2009 Sep; 21(9):753-9. doi: 10.1111/j.1365-2826.2009.01894.x. [PMID: 19523167]
  • Fan Rong, Zhang Peng, Ming-Xiang Ye, Quan-Yu Zhang, Yin Zhao, Shu-Miao Zhang, Hai-Tao Guo, Bi Hui, Yue-Min Wang, Cheng Liang, Chun-Hu Gu, Chen Tao, Qin Cui, Shi-Qiang Yu, Ding-Hua Yi, Jian-Ming Pei. Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by kappa-opioid receptor agonist. Archives of medical research. 2009 May; 40(4):227-34. doi: 10.1016/j.arcmed.2009.04.009. [PMID: 19608010]
  • Walter Wittmann, Eduard Schunk, Iris Rosskothen, Stefano Gaburro, Nicolas Singewald, Herbert Herzog, Christoph Schwarzer. Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009 Feb; 34(3):775-85. doi: 10.1038/npp.2008.142. [PMID: 18800067]
  • Marc L Weber, Mariya Farooqui, Julia Nguyen, Michael Ansonoff, John E Pintar, Robert P Hebbel, Kalpna Gupta. Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors. American journal of physiology. Renal physiology. 2008 Jun; 294(6):F1388-97. doi: 10.1152/ajprenal.00389.2007. [PMID: 18385270]
  • Seung R Han, Min K Lee, Koang H Lim, Gwi Y Yang, Hye J Jeon, Jin S Ju, Young W Yoon, Sung K Kim, Dong K Ahn. Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats. European journal of pain (London, England). 2008 Apr; 12(3):361-70. doi: 10.1016/j.ejpain.2007.07.002. [PMID: 17768078]
  • Daniela Braida, Valeria Limonta, Valeria Capurro, Paola Fadda, Tiziana Rubino, Paola Mascia, Alessia Zani, Enzo Gori, Walter Fratta, Daniela Parolaro, Mariaelvina Sala. Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward. Biological psychiatry. 2008 Feb; 63(3):286-92. doi: 10.1016/j.biopsych.2007.07.020. [PMID: 17920565]
  • R Frithiof, S Eriksson, M Rundgren. Central inhibition of opioid receptor subtypes and its effect on haemorrhagic hypotension in conscious sheep. Acta physiologica (Oxford, England). 2007 Sep; 191(1):25-34. doi: 10.1111/j.1748-1716.2007.01720.x. [PMID: 17550406]
  • Peter L Katavic, Kenneth Lamb, Hernan Navarro, Thomas E Prisinzano. Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships. Journal of natural products. 2007 Aug; 70(8):1278-82. doi: 10.1021/np070194x. [PMID: 17685652]
  • Danxin Wang, Xiaochun Sun, Wolfgang Sadee. Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment. The Journal of pharmacology and experimental therapeutics. 2007 May; 321(2):544-52. doi: 10.1124/jpet.106.118810. [PMID: 17267582]
  • Maike A Grosse Hartlage, Marc M Theisen, Nelson P Monteiro de Oliveira, Hugo Van Aken, Manfred Fobker, Thomas P Weber. Kappa-opioid receptor antagonism improves recovery from myocardial stunning in chronically instrumented dogs. Anesthesia and analgesia. 2006 Oct; 103(4):822-32. doi: 10.1213/01.ane.0000237246.40665.34. [PMID: 17000788]
  • Haihua Shu, Hideko Arita, Masakazu Hayashida, Shunsuke Chiba, Hiroshi Sekiyama, Kazuo Hanaoka. Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors. Journal of ethnopharmacology. 2006 Jun; 106(2):263-71. doi: 10.1016/j.jep.2006.01.004. [PMID: 16446067]
  • Hongmeng Xu, Hideko Arita, Masakazu Hayashida, Liang Zhang, Hiroshi Sekiyama, Kazuo Hanaoka. Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats. Journal of ethnopharmacology. 2006 Feb; 103(3):392-7. doi: 10.1016/j.jep.2005.08.050. [PMID: 16183224]
  • Christopher R McCurdy, Kenneth J Sufka, Grant H Smith, Jason E Warnick, Marcelo J Nieto. Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist. Pharmacology, biochemistry, and behavior. 2006 Jan; 83(1):109-13. doi: 10.1016/j.pbb.2005.12.011. [PMID: 16434091]
  • William E Fantegrossi, Kelly M Kugle, Leander J Valdes, Masato Koreeda, James H Woods. Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse. Behavioural pharmacology. 2005 Dec; 16(8):627-33. doi: 10.1097/00008877-200512000-00005. [PMID: 16286814]
  • Helmut B Gottlieb, Daniel R Kapusta. Endogenous central kappa-opioid systems augment renal sympathetic nerve activity to maximally retain urinary sodium during hypotonic saline volume expansion. American journal of physiology. Regulatory, integrative and comparative physiology. 2005 Nov; 289(5):R1289-96. doi: 10.1152/ajpregu.00302.2005. [PMID: 15976307]
  • Eva Maria Marco, Ricardo Llorente, Laura Pérez-Alvarez, Enrique Moreno, Carmen Guaza, Maria Paz Viveros. The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety. Behavioural brain research. 2005 Sep; 163(2):212-8. doi: 10.1016/j.bbr.2005.05.005. [PMID: 15979169]
  • Juliana T Clemente, Carlos A Parada, Maria C Arruda Veiga, Robert W Gear, Cláudia H Tambeli. Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint. Neuroscience letters. 2004 Dec; 372(3):250-5. doi: 10.1016/j.neulet.2004.09.048. [PMID: 15542250]
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