Deltorphin B (BioDeep_00000012071)

 

Secondary id: BioDeep_00001869522


代谢物信息卡片


Deltorphin II

化学式: C38H54N8O10 (782.3962704)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C(=O)NC(C(C)C)C(=O)NCC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C)NC(=O)C(CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C38H54N8O10/c1-20(2)31(37(55)41-19-29(40)48)46-38(56)32(21(3)4)45-35(53)27(15-16-30(49)50)43-36(54)28(18-23-9-7-6-8-10-23)44-33(51)22(5)42-34(52)26(39)17-24-11-13-25(47)14-12-24/h6-14,20-22,26-28,31-32,47H,15-19,39H2,1-5H3,(H2,40,48)(H,41,55)(H,42,52)(H,43,54)(H,44,51)(H,45,53)(H,46,56)(H,49,50)/t22-,26+,27+,28+,31+,32+/m1/s1

描述信息

同义名列表

3 个代谢物同义名

Deltorphin II; Deltorphin B; Deltorphin 2



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Robert J Cassell, Kendall L Mores, Breanna L Zerfas, Amr H Mahmoud, Markus A Lill, Darci J Trader, Richard M van Rijn. Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2019 03; 29(3):450-456. doi: 10.1016/j.euroneuro.2018.12.013. [PMID: 30591345]
  • Dave Dubois, Louis Gendron. Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice. The European journal of neuroscience. 2010 Dec; 32(11):1921-9. doi: 10.1111/j.1460-9568.2010.07466.x. [PMID: 21044181]
  • Michael M Morgan, Michelle D Ashley, Susan L Ingram, MacDonald J Christie. Behavioral consequences of delta-opioid receptor activation in the periaqueductal gray of morphine tolerant rats. Neural plasticity. 2009; 2009(?):516328. doi: 10.1155/2009/516328. [PMID: 19266049]
  • Aurore André, Gérald Gaibelet, Laurent Le Guyader, Michèle Welby, André Lopez, Chantal Lebrun. Membrane partitioning of various delta-opioid receptor forms before and after agonist activations: the effect of cholesterol. Biochimica et biophysica acta. 2008 Jun; 1778(6):1483-92. doi: 10.1016/j.bbamem.2008.03.017. [PMID: 18423369]
  • Ahmed Hasbi, Tuan Nguyen, Theresa Fan, Regina Cheng, Asim Rashid, Mohammad Alijaniaram, Mark M Rasenick, Brian F O'Dowd, Susan R George. Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists. Biochemistry. 2007 Nov; 46(45):12997-3009. doi: 10.1021/bi701436w. [PMID: 17941650]
  • K Dettmer, D Hanna, P Whetstone, R Hansen, B D Hammock. Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory. Analytical and bioanalytical chemistry. 2007 Aug; 388(8):1643-51. doi: 10.1007/s00216-007-1301-4. [PMID: 17520243]
  • Edita Navratilova, Sue Waite, Dagmar Stropova, Miriam C Eaton, Isabel D Alves, Victor J Hruby, William R Roeske, Henry I Yamamura, Eva V Varga. Quantitative evaluation of human delta opioid receptor desensitization using the operational model of drug action. Molecular pharmacology. 2007 May; 71(5):1416-26. doi: 10.1124/mol.106.030023. [PMID: 17322005]
  • Sarah V Holdridge, Stacey A Armstrong, Anna M W Taylor, Catherine M Cahill. Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance. Molecular pain. 2007 Mar; 3(?):7. doi: 10.1186/1744-8069-3-7. [PMID: 17352824]
  • Min Zhou, Eri Nakatani, Luisa S Gronenberg, Takahira Tokimoto, Mary J Wirth, Victor J Hruby, Amber Roberts, Ronald M Lynch, Indraneel Ghosh. Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules. Bioconjugate chemistry. 2007 Mar; 18(2):323-32. doi: 10.1021/bc0601929. [PMID: 17373766]
  • Peng Huang, Wei Xu, Su-In Yoon, Chongguang Chen, Parkson Lee-Gau Chong, Lee-Yuan Liu-Chen. Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Biochemical pharmacology. 2007 Feb; 73(4):534-49. doi: 10.1016/j.bcp.2006.10.032. [PMID: 17141202]
  • Laelie A Snook, Graeme Milligan, Brigitte L Kieffer, Dominique Massotte. Mu-delta opioid receptor functional interaction: Insight using receptor-G protein fusions. The Journal of pharmacology and experimental therapeutics. 2006 Aug; 318(2):683-90. doi: 10.1124/jpet.106.101220. [PMID: 16690720]
  • Peter R Oeltgen, Meera Govindaswami, Donald B Witzke. 24-hour pretreatment with delta opioid enhances survival from hemorrhagic shock. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2006 Feb; 13(2):127-33. doi: 10.1197/j.aem.2005.08.012. [PMID: 16461748]
  • Miaw-Chyi Luo, Dong-Qin Zhang, Shou-Wu Ma, Yuan-Yuan Huang, Sam J Shuster, Frank Porreca, Josephine Lai. An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Molecular pain. 2005 Sep; 1(?):29. doi: 10.1186/1744-8069-1-29. [PMID: 16191203]
  • Wooin Lee, Hartmut Glaeser, L Harris Smith, Richard L Roberts, Gilbert W Moeckel, Guillermo Gervasini, Brenda F Leake, Richard B Kim. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. The Journal of biological chemistry. 2005 Mar; 280(10):9610-7. doi: 10.1074/jbc.m411092200. [PMID: 15632119]
  • Anthony R Carroll, Garrie Arumugan, Ronald J Quinn, Joanne Redburn, Gordon Guymer, Paul Grimshaw. Grandisine A and B, novel indolizidine alkaloids with human delta-opioid receptor binding affinity from the leaves of the Australian rainforest tree Elaeocarpus grandis. The Journal of organic chemistry. 2005 Mar; 70(5):1889-92. doi: 10.1021/jo048525n. [PMID: 15730315]
  • Huankai Hu, Seiji Miyauchi, Christy C Bridges, Sylvia B Smith, Vadivel Ganapathy. Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat. The Biochemical journal. 2003 Oct; 375(Pt 1):17-22. doi: 10.1042/bj20031059. [PMID: 12924983]
  • G Han, J M Quillan, K Carlson, W Sadée, V J Hruby. Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist. Journal of medicinal chemistry. 2003 Feb; 46(5):810-9. doi: 10.1021/jm020355o. [PMID: 12593660]
  • C M Cahill, A Morinville, C Hoffert, D O'Donnell, A Beaudet. Up-regulation and trafficking of delta opioid receptor in a model of chronic inflammation: implications for pain control. Pain. 2003 Jan; 101(1-2):199-208. doi: 10.1016/s0304-3959(02)00333-0. [PMID: 12507715]
  • Z Salamon, V J Hruby, G Tollin, S Cowell. Binding of agonists, antagonists and inverse agonists to the human delta-opioid receptor produces distinctly different conformational states distinguishable by plasmon-waveguide resonance spectroscopy. The journal of peptide research : official journal of the American Peptide Society. 2002 Dec; 60(6):322-8. doi: 10.1034/j.1399-3011.2002.21060.x. [PMID: 12464110]
  • M Narita, M Ohsawa, H Mizoguchi, T Aoki, T Suzuki, L F Tseng. Role of the phosphatidylinositol-specific phospholipase C pathway in delta-opioid receptor-mediated antinociception in the mouse spinal cord. Neuroscience. 2000; 99(2):327-31. doi: 10.1016/s0306-4522(00)00202-5. [PMID: 10938438]
  • J Garzón, J DeFelipe, J R Rodríguez, I DeAntonio, A García-España, P Sánchez-Blázquez. Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity. Brain research. Molecular brain research. 1999 Mar; 65(2):151-66. doi: 10.1016/s0169-328x(98)00350-7. [PMID: 10064886]
  • S A Thomas, T J Abbruscato, V S Hau, T J Gillespie, J Zsigo, V J Hruby, T P Davis. Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. The Journal of pharmacology and experimental therapeutics. 1997 May; 281(2):817-25. doi: NULL. [PMID: 9152390]
  • J Garzón, M A Castro, J L Juarros, P Sánchez-Blázquez. Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice. Life sciences. 1994; 54(11):PL191-6. doi: 10.1016/0024-3205(94)90167-8. [PMID: 8107515]