Chikusetsusaponin Ia (BioDeep_00000011751)
Secondary id: BioDeep_00001869685
human metabolite Endogenous
代谢物信息卡片
2-{[16-hydroxy-14-(2-hydroxy-6-methylhept-5-en-2-yl)-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-yl]oxy}-6-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxane-3,4,5-triol
化学式: C41H70O12 (754.486702)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)COC6C(C(C(CO6)O)O)O)O)O)O)C)C)O)C)O)C
InChI: InChI=1S/C41H70O12/c1-21(2)10-9-14-41(8,49)22-11-16-40(7)29(22)23(42)18-27-38(5)15-13-28(37(3,4)26(38)12-17-39(27,40)6)53-36-34(48)32(46)31(45)25(52-36)20-51-35-33(47)30(44)24(43)19-50-35/h10,22-36,42-49H,9,11-20H2,1-8H3
描述信息
Chikusetsusaponin Ia is found in tea. Chikusetsusaponin Ia is a constituent of Panax japonicum (Japanese ginseng)
Constituent of Panax japonicum (Japanese ginseng). Chikusetsusaponin Ia is found in tea.
D002491 - Central Nervous System Agents
同义名列表
7 个代谢物同义名
2-{[16-hydroxy-14-(2-hydroxy-6-methylhept-5-en-2-yl)-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-yl]oxy}-6-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxane-3,4,5-triol; Chikusetsusaponin Ia; sanchinoside C(1); ginsenoside-Rg(1); Ginsenoside Rg1; sanchinoside C1; panaxoside Rg1
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:81171
- KEGG: C17544
- PubChem: 13386145
- HMDB: HMDB0034994
- Metlin: METLIN71772
- foodb: FDB013597
- chemspider: 30791637
- CAS: 59252-86-7
- PMhub: MS000025893
- PubChem: 96023889
- NIKKAJI: J40.254K
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Han Li, Yun-Hang Gao, Ling Song, Teng-Fei Chen, Guang-Ping Zhang, Zu-Guang Ye, Yue Gao, Wang Huo. Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor.
Journal of ethnopharmacology.
2022 Aug; 294(?):115394. doi:
10.1016/j.jep.2022.115394. [PMID: 35595219] - Duoduo Zhang, Pengmin Ji, Ran Sun, Huimin Zhou, Lei Huang, Liangliang Kong, Weiping Li, Weizu Li. Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):112936. doi:
10.1016/j.biopha.2022.112936. [PMID: 35421784] - Zhijie Chen, Yingbo Lin, Qichun Zhou, Shilin Xiao, Chan Li, Rukun Lin, Jing Li, Yifei Chen, Chaohua Luo, Zhixian Mo. Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):112935. doi:
10.1016/j.biopha.2022.112935. [PMID: 35447543] - Hao Cheng, Juan Liu, Dandan Zhang, Jing Wang, Yuzhu Tan, Wuwen Feng, Cheng Peng. Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism.
Frontiers in immunology.
2022; 13(?):817600. doi:
10.3389/fimmu.2022.817600. [PMID: 35655785] - Xiao-Hu Liu, Shi-Zhong Cai, Yue Zhou, Ya-Ping Wang, Yan-Jun Han, Cui-Li Wang, Wen Zhou. Ginsenoside Rg1 Attenuates Premature Ovarian Failure of D-gal Induced POF Mice Through Downregulating p16INK4a and Upregulating SIRT1 Expression.
Endocrine, metabolic & immune disorders drug targets.
2022; 22(3):318-327. doi:
10.2174/1871523020666210830164152. [PMID: 34463232] - Teng-Teng Ren, Jia-Ying Yang, Jun Wang, Sheng-Rui Fan, Rongfeng Lan, Xiao-Yan Qin. Gisenoside Rg1 attenuates cadmium-induced neurotoxicity in vitro and in vivo by attenuating oxidative stress and inflammation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2021 Dec; 70(10-12):1151-1164. doi:
10.1007/s00011-021-01513-7. [PMID: 34661679] - Wenlong Wei, Zhenwei Li, Haojv Li, Yaling An, Hua Qu, Changliang Yao, Jianqing Zhang, Jiayuan Li, Gaole Zhang, Yanchao Shi, De-An Guo. Exploration of tissue distribution of ginsenoside Rg1 by LC-MS/MS and nanospray desorption electrospray ionization mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2021 May; 198(?):113999. doi:
10.1016/j.jpba.2021.113999. [PMID: 33706145] - Xiaolei Xu, Zhenting Qu, Honghao Qian, Zhongming Li, Xiuling Sun, Xinrui Zhao, Huan Li. Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di-N-butyl-phthalate.
Environmental toxicology.
2021 May; 36(5):789-799. doi:
10.1002/tox.23081. [PMID: 33331133] - Cheng Yang, Xiaoqing He, Jinqiu Zhao, Wenxiang Huang. Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease.
International immunopharmacology.
2021 Mar; 92(?):107327. doi:
10.1016/j.intimp.2020.107327. [PMID: 33412392] - Wei Xue, Yan Gao, Pan-Pan Xie, Yang Liu, Wen-Yuan Qi, Ai-Xin Shi, Ke-Xin Li. Plasma and intracerebral pharmacokinetics and pharmacodynamics modeling for the acetylcholine releasing effect of ginsenoside Rg1 in mPFC of Aβ model rats.
Journal of Asian natural products research.
2021 Mar; 23(3):294-306. doi:
10.1080/10286020.2020.1803289. [PMID: 33771049] - Danshan Gu, Haoan Yi, Kerong Jiang, Syed Hassam Fakhar, Jing Shi, Yongshu He, Bo Liu, Yunping Guo, Xiaoming Fan, Shude Li. Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease.
Life sciences.
2021 Feb; 267(?):118986. doi:
10.1016/j.lfs.2020.118986. [PMID: 33385408] - Jie Zhang, Sheng-Lan Liu, Hui Wang, Li-Ying Shi, Jin-Ping Li, Lu-Juan Jia, Bao-Ping Xie. The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats.
Chinese journal of natural medicines.
2021 Feb; 19(2):153-160. doi:
10.1016/s1875-5364(21)60016-x. [PMID: 33641786] - Tong Hou, Yang Liu, Xiaoyun Wang, Danli Jiao, Hao Xu, Qi Shi, Yongjun Wang, Wei Li, Tao Wu, Qianqian Liang. Ginsenoside Rg1 promotes lymphatic drainage and improves chronic inflammatory arthritis.
Journal of musculoskeletal & neuronal interactions.
2020 12; 20(4):526-534. doi:
NULL. [PMID: 33265080] - Xiping Mei, Huibin Feng, Bibo Shao. Alleviation of sepsis-associated encephalopathy by ginsenoside via inhibition of oxidative stress and cell apoptosis: An experimental study.
Pakistan journal of pharmaceutical sciences.
2020 Nov; 33(6):2567-2577. doi:
. [PMID: 33867332] - Anling Hu, Zhiqin Shuai, Jiajia Liu, Bo Huang, Yunmei Luo, Jiang Deng, Jie Liu, Limei Yu, Lisheng Li, Shangfu Xu. Ginsenoside Rg1 prevents vascular intimal hyperplasia involved by SDF-1α/CXCR4, SCF/c-kit and FKN/CX3CR1 axes in a rat balloon injury.
Journal of ethnopharmacology.
2020 Oct; 260(?):113046. doi:
10.1016/j.jep.2020.113046. [PMID: 32504784] - Jin He, Qingtan Yu, Chunlan Wu, Zhimin Sun, Xiaoyong Wu, Rong Liu, Hong Zhang. Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome.
Annals of palliative medicine.
2020 Sep; 9(5):3436-3446. doi:
10.21037/apm-20-1714. [PMID: 33065794] - Tianqian Jin, Zuhui Liu, Yang Chu, Xiaohui Ma, Shuming Li, Xiangyang Wang, Genbei Wang, Shuiping Zhou, He Sun, Jin Yang. UFLC-MS/MS Determination and Population Pharmacokinetic Study of Tanshinol, Ginsenoside Rb1 and Rg1 in Rat Plasma After Oral Administration of Compound Danshen Dripping Pills.
European journal of drug metabolism and pharmacokinetics.
2020 Aug; 45(4):523-533. doi:
10.1007/s13318-020-00618-4. [PMID: 32304023] - Wei Sun, Fengyi Zhang, Hui Wang, Chen Wang, Zangong Zhou, Yu Zhou. Ginsenoside Rg1 fails to rescue PTSD-like behaviors in a mice model of single-prolonged stress.
Biochemical and biophysical research communications.
2020 07; 528(2):243-248. doi:
10.1016/j.bbrc.2020.05.159. [PMID: 32482388] - Qing Xiao, Shujun Zhang, Huina Ren, Ruoyang Du, Jiajun Li, Jinqiu Zhao, Yue Gao, Yali Zhu, Wenxiang Huang. Ginsenoside Rg1 alleviates ANIT-induced intrahepatic cholestasis in rats via activating farnesoid X receptor and regulating transporters and metabolic enzymes.
Chemico-biological interactions.
2020 Jun; 324(?):109062. doi:
10.1016/j.cbi.2020.109062. [PMID: 32198087] - Yanwen Xu, Liang Yang, Kun Liang, Rui An, Xinhong Wang, Hai Zhang. Pharmacokinetic effects of ginsenoside Rg1 on aconitine, benzoylaconine and aconine by UHPLC-MS/MS.
Biomedical chromatography : BMC.
2020 Apr; 34(4):e4793. doi:
10.1002/bmc.4793. [PMID: 31919877] - Xiaojuan Guo, Jingyuan Zhang, Min Liu, Guo Chen Zhao. Protective effect of ginsenoside Rg1 on attenuating anti-GBM glomerular nephritis by activating NRF2 signalling.
Artificial cells, nanomedicine, and biotechnology.
2019 Dec; 47(1):2972-2979. doi:
10.1080/21691401.2019.1640712. [PMID: 31322005] - Xiaoming Fan, Chao Zhang, Shiwei Niu, Biao Fan, Danshan Gu, Kerong Jiang, Ruonan Li, Shude Li. Ginsenoside Rg1 attenuates hepatic insulin resistance induced by high-fat and high-sugar by inhibiting inflammation.
European journal of pharmacology.
2019 Jul; 854(?):247-255. doi:
10.1016/j.ejphar.2019.04.027. [PMID: 31002778] - Wei Li, Yi Wu, Mali Wan, Yang Chu, Xiangyang Wang, Shuming Li, Zuhui Liu, Xue Chen, Navaneethakrishnan Polachi, Shuiping Zhou, He Sun. Simultaneous determination of three saponins in human plasma after oral administration of compound danshen dripping pills by LC-MS/MS and its application in a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2019 May; 169(?):254-259. doi:
10.1016/j.jpba.2019.03.008. [PMID: 30878903] - Lan Luo, Jiazhen Kang, Qiong He, Yue Qi, Xingyu Chen, Shumei Wang, Shengwang Liang. A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091831. [PMID: 31086027] - Ge Li, Ning Zhang, Fang Geng, Guoliang Liu, Bin Liu, Xia Lei, Guang Li, Xi Chen. High-throughput metabolomics and ingenuity pathway approach reveals the pharmacological effect and targets of Ginsenoside Rg1 in Alzheimer's disease mice.
Scientific reports.
2019 05; 9(1):7040. doi:
10.1038/s41598-019-43537-4. [PMID: 31065079] - Chenqing Ning, Xiaoguang Gao, Changyuan Wang, Yulong Kong, Zhihao Liu, Huijun Sun, Pengyuan Sun, Xiaokui Huo, Xiaodong Ma, Qiang Meng, Kexin Liu. Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Regulatory toxicology and pharmacology : RTP.
2018 Oct; 98(?):58-68. doi:
10.1016/j.yrtph.2018.07.012. [PMID: 30030101] - Chenqing Ning, Xiaoguang Gao, Changyuan Wang, Xiaokui Huo, Zhihao Liu, Huijun Sun, Xiaobo Yang, Pengyuan Sun, Xiaodong Ma, Qiang Meng, Kexin Liu. Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice.
Environmental toxicology.
2018 Oct; 33(10):1050-1060. doi:
10.1002/tox.22616. [PMID: 29964319] - Fugeng Zhang, Yu Zhang, Xiaofeng Li, Shaoqiang Zhang, Mingdan Zhu, Wuxun Du, Xuefeng Xiao. Research on Q-markers of Qiliqiangxin capsule for chronic heart failure treatment based on pharmacokinetics and pharmacodynamics association.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 May; 44(?):220-230. doi:
10.1016/j.phymed.2018.03.003. [PMID: 29699844] - Zi-Ling Wang, Lin-Bo Chen, Zhu Qiu, Xiong-Bin Chen, Ying Liu, Jing Li, Lu Wang, Ya-Ping Wang. Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.
Molecular medicine reports.
2018 05; 17(5):6269-6276. doi:
10.3892/mmr.2018.8659. [PMID: 29512726] - Xiao-Nan Chen, Dan-Qi Li, Meng-di Zhao, Gang-Yan Yu, Shou-Ying Du, Yang Lu, Jie Bai, Peng-Yue Li, Ya-Li Wu, Zhi-Hao Tian, Yan-Ying Zeng. Pharmacokinetics of Panax notoginseng Saponins in Adhesive and Normal Preparation of Fufang Danshen.
European journal of drug metabolism and pharmacokinetics.
2018 Apr; 43(2):215-225. doi:
10.1007/s13318-017-0433-y. [PMID: 28916980] - Le Wang, Hong Zhao, Zhen-Zhen Zhai, Li-Xin Qu. Protective effect and mechanism of ginsenoside Rg1 in cerebral ischaemia-reperfusion injury in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Mar; 99(?):876-882. doi:
10.1016/j.biopha.2018.01.136. [PMID: 29710487] - Jin-Bo Li, Rui Zhang, Xiao Han, Chun-Li Piao. Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2018 Mar; 51(4):e7139. doi:
10.1590/1414-431x20177139. [PMID: 29513799] - Ping Yang, Lu Ling, Wenjing Sun, Junquan Yang, Ling Zhang, Guoji Chang, Jiazhi Guo, Jun Sun, Lin Sun, Di Lu. Ginsenoside Rg1 inhibits apoptosis by increasing autophagy via the AMPK/mTOR signaling in serum deprivation macrophages.
Acta biochimica et biophysica Sinica.
2018 Feb; 50(2):144-155. doi:
10.1093/abbs/gmx136. [PMID: 29324976] - Jiajun Li, Cheng Yang, Shu Zhang, Shu Liu, Luole Zhao, Huan Luo, Yatang Chen, Wenxiang Huang. Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis.
International journal of molecular medicine.
2018 Feb; 41(2):899-907. doi:
10.3892/ijmm.2017.3297. [PMID: 29207044] - Sha-Sha Li, Ao-Lin He, Zhi-Yong Deng, Qi-Feng Liu. Ginsenoside-Rg1 Protects against Renal Fibrosis by Regulating the Klotho/TGF-β1/Smad Signaling Pathway in Rats with Obstructive Nephropathy.
Biological & pharmaceutical bulletin.
2018; 41(4):585-591. doi:
10.1248/bpb.b17-00934. [PMID: 29607931] - Na Du, Zhiping Xu, Mingyue Gao, Peng Liu, Bo Sun, Xia Cao. Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy.
Drug design, development and therapy.
2018; 12(?):3517-3524. doi:
10.2147/dddt.s171286. [PMID: 30425453] - Shi-Zhong Cai, Yue Zhou, Jun Liu, Cheng-Peng Li, Dao-Yong Jia, Meng-Si Zhang, Ya-Ping Wang. Alleviation of ginsenoside Rg1 on hematopoietic homeostasis defects caused by lead-acetate.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):1204-1211. doi:
10.1016/j.biopha.2017.10.148. [PMID: 29145145] - X J Ni, Z Q Xu, H Jin, S L Zheng, Y Cai, J J Wang. Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2017 Dec; 51(2):e6611. doi:
10.1590/1414-431x20176611. [PMID: 29267498] - Xiujun Wu, Yang You, Gonglin Qu, Ran Ma, Mingxue Zhang. Simultaneous determination of ginsenoside Rb1, ginsenoside Rg1, paeoniflorin, albiflorin and oxypaeoniflorin in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study of wen-Yang-Huo-Xue soft capsule.
Biomedical chromatography : BMC.
2017 Dec; 31(12):. doi:
10.1002/bmc.4019. [PMID: 28557007] - Peihe Zheng, Yinbin Chen, Yangyang Fu, Hecheng Wang, Jia Wang, Siwen Zheng, Shengyuan Xiao, Yingping Wang. Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration.
Journal of medicinal food.
2017 Nov; 20(11):1127-1132. doi:
10.1089/jmf.2017.3922. [PMID: 28880748] - Benquan Qi, Suzhi Zhang, Daohua Guo, Sanxing Guo, Xiaodong Jiang, Xiling Zhu. Protective effect and mechanism of ginsenoside Rg1 on carbon tetrachloride‑induced acute liver injury.
Molecular medicine reports.
2017 Sep; 16(3):2814-2822. doi:
10.3892/mmr.2017.6920. [PMID: 28677756] - Zheng Mou, Qian Huang, Shi-Feng Chu, Mei-Jin Zhang, Jin-Feng Hu, Nai-Hong Chen, Jun-Tian Zhang. Antidepressive effects of ginsenoside Rg1 via regulation of HPA and HPG axis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Aug; 92(?):962-971. doi:
10.1016/j.biopha.2017.05.119. [PMID: 28618657] - Yaping Shao, Wen Zhang, Ling Tong, Jingyi Huang, Dongxiang Li, Wei Nie, Yan Zhu, Yunfei Li, Tao Lu. Simultaneous determination of eight bioactive components of Qishen Yiqi dripping pills in rat plasma using UFLC-MS/MS and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2017 Aug; 31(8):. doi:
10.1002/bmc.3941. [PMID: 28146302] - Jiachun Li, Dongpo Li, Youzhi Pan, Jun-Hua Hu, Wenzhe Huang, Zhen-Zhong Wang, Wei Xiao, Yu Wang. Simultaneous determination of ten bioactive constituents of Sanjie Zhentong Capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jun; 1054(?):20-26. doi:
10.1016/j.jchromb.2017.03.001. [PMID: 28415020] - Tingyang Li, Yang Chu, Kaijing Yan, Shuming Li, Xiangyang Wang, Ying Wang, Wei Li, Xiaohui Ma, Jin Yang, Changxiao Liu. Simultaneous determination of tanshinol, protocatechuic aldehyde, protocatechuic acid, notoginsenoside R1, ginsenoside Rg1 and Rb1 in rat plasma by LC-MS/MS and its application.
Biomedical chromatography : BMC.
2017 Jun; 31(6):. doi:
10.1002/bmc.3889. [PMID: 28164352] - Ma Shi-Tang, Guo-Liang Dal, Xiao-Gui Cheng, Wen-Zhu Zhao, Bing-Ting Sun, Wen-Zheng Ju, Heng-Shan Tan. [Effect of Clopidogrel on Plasma Protein Binding Rates of Ginsenoside Rg1].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2017 04; 37(4):480-484. doi:
. [PMID: 30650510] - Huan-Huan Pang, Meng-Yi Li, Yuan Wang, Min-Ke Tang, Chang-Hua Ma, Jian-Mei Huang. Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule.
Journal of Zhejiang University. Science. B.
2017 Apr; 18(4):343-352. doi:
10.1631/jzus.b1600235. [PMID: 28378572] - Jie Zhang, Sheng-Lan Liu, Hui Wang, Guo-Ping Yang, Jin-Ping Li, Shi-Kun Liu, Zhi Tang, Qi Pei, Pan-Hao Huang. [UPLC-MS/MS determination of tanshinone ⅡA, salvianolic acid B and ginsenoside Rg₁ in Fufang Danshen preparation in rat plasma and brain tissues].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Feb; 42(3):580-586. doi:
10.19540/j.cnki.cjcmm.2017.0014. [PMID: 28952268] - Qun Liu, Fei-Ge Zhang, Wen-Song Zhang, An Pan, Yi-Lin Yang, Jin-Feng Liu, Ping Li, Bao-Lin Liu, Lian-Wen Qi. Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction.
Theranostics.
2017; 7(16):4001-4012. doi:
10.7150/thno.18788. [PMID: 29109794] - Xiqian Zhang, Rujun Ma, Xiaojuan Liu, Xuehua Jiang, Ling Wang. Simultaneous determination of ginsenoside Rg1 , Re and notoginsenoside R1 in human plasma by LC-MS/MS and its application in a pharmacokinetic study in Chinese volunteers.
Biomedical chromatography : BMC.
2016 Dec; 30(12):1915-1921. doi:
10.1002/bmc.3766. [PMID: 27219100] - Yanling Fan, Jieyu Xia, Daoyong Jia, Mengsi Zhang, Yanyan Zhang, Guoning Huang, Yaping Wang. Mechanism of ginsenoside Rg1 renal protection in a mouse model of d-galactose-induced subacute damage.
Pharmaceutical biology.
2016 Sep; 54(9):1815-21. doi:
10.3109/13880209.2015.1129543. [PMID: 26730750] - Yan Gao, Shi-Feng Chu, Cong-Yuan Xia, Zhao Zhang, Shuai Zhang, Nai-Hong Chen. Rg1 Attenuates alcoholic hepatic damage through regulating AMP-activated protein kinase and nuclear factor erythroid 2-related factor 2 signal pathways.
Journal of Asian natural products research.
2016 Aug; 18(8):765-78. doi:
10.1080/10286020.2016.1162787. [PMID: 27229011] - Jing-Rong Wang, Tian-Tian Tong, Lee-Fong Yau, Cheng-Yu Chen, Li-Ping Bai, Jing Ma, Ming Hu, Liang Liu, Zhi-Hong Jiang. Characterization of oxygenated metabolites of ginsenoside Rg1 in plasma and urine of rat.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jul; 1026(?):75-86. doi:
10.1016/j.jchromb.2015.12.028. [PMID: 26809375] - Haitao Yu, Juan Zhen, Yang Yang, Jinning Gu, Suisheng Wu, Quan Liu. Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model.
Journal of cellular and molecular medicine.
2016 Apr; 20(4):623-31. doi:
10.1111/jcmm.12739. [PMID: 26869403] - Qun Zhao, Min Yang, Yanping Deng, Haitao Yu, Linlin Wang, Fukang Teng, Kenka Cho, Hongmei Ma, Peng Wu, Xue Li, Wanying Wu, Xuan Liu, Feng Xu, Baohong Jiang, De-An Guo. The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice.
International journal of molecular sciences.
2015 Dec; 16(12):29345-56. doi:
10.3390/ijms161226176. [PMID: 26690140] - Ting-Ting Zhou, Guo Zu, Xi Wang, Xiao-Gang Zhang, Shao Li, Zhan-Hua Liang, Jie Zhao. Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease.
International immunopharmacology.
2015 Dec; 29(2):334-343. doi:
10.1016/j.intimp.2015.10.032. [PMID: 26548343] - Zhongli Wang, Kexuan Zhu, Lin Chen, Liufeng Ou Yang, Yufang Huang, Yunan Zhao. Preventive effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD)-like behavior in male C57/B6 mice.
Neuroscience letters.
2015 Sep; 605(?):24-8. doi:
10.1016/j.neulet.2015.08.017. [PMID: 26277823] - Yan Gao, Shifeng Chu, Jingwei Li, Jianping Li, Zhao Zhang, Congyuan Xia, Yang Heng, Meijin Zhang, Jinfeng Hu, Guining Wei, Yueting Li, Naihong Chen. Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway.
Journal of ethnopharmacology.
2015 Sep; 173(?):231-40. doi:
10.1016/j.jep.2015.07.020. [PMID: 26196399] - Li Wang, Nan Mao, Rui-Zhi Tan, Hong-Lian Wang, Ji Wen, Yu-Hang Liu, Md Furhad, Jun-Ming Fan. Ginsenoside Rg1 reduces aldosterone-induced autophagy via the AMPK/mTOR pathway in NRK-52E cells.
International journal of molecular medicine.
2015 Aug; 36(2):518-26. doi:
10.3892/ijmm.2015.2242. [PMID: 26063203] - Sha-sha Li, Jian-ming Ye, Zhi-yong Deng, Li-xia Yu, Xiao-xia Gu, Qi-feng Liu. Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats.
Renal failure.
2015 Jun; 37(5):890-5. doi:
10.3109/0886022x.2015.1015427. [PMID: 25707520] - Hai-tao Yu, Juan Zhen, Bo Pang, Jin-ning Gu, Sui-sheng Wu. Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats.
Journal of Zhejiang University. Science. B.
2015 May; 16(5):344-54. doi:
10.1631/jzus.b1400204. [PMID: 25990051] - Tao Li, Ya-Jun Shu, Jia-Yin Cheng, Run-Cheng Liang, Shao-Na Dian, Xiao-Xun Lv, Meng-Qi Yang, Shu-Ling Huang, Gang Chen, Fan Yang. Pharmacokinetics and efficiency of brain targeting of ginsenosides Rg1 and Rb1 given as Nao-Qing microemulsion.
Drug development and industrial pharmacy.
2015 Feb; 41(2):224-31. doi:
10.3109/03639045.2013.858734. [PMID: 24237326] - Huichao Wu, Huimin Liu, Jie Bai, Yang Lu, Shouying Du. Simultaneous determination of notoginsenoside R₁, ginsenoside Rg₁, ginsenoside Re and 20(S) protopanaxatriol in beagle dog plasma by ultra high performance liquid mass spectrometry after oral administration of a Panax notoginseng saponin preparation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jan; 974(?):42-7. doi:
10.1016/j.jchromb.2014.10.025. [PMID: 25463196] - Wei Long, Shi-chang Zhang, Lu Wen, Lei Mu, Fan Yang, Gang Chen. In vivo distribution and pharmacokinetics of multiple active components from Danshen and Sanqi and their combination via inner ear administration.
Journal of ethnopharmacology.
2014 Oct; 156(?):199-208. doi:
10.1016/j.jep.2014.08.041. [PMID: 25218322] - Xiaoying Wang, Chengcheng Wang, Feifei Pu, Peiyan Lin, Tianxiu Qian. Metabolite profiling of ginsenoside Rg1 after oral administration in rat.
Biomedical chromatography : BMC.
2014 Oct; 28(10):1320-4. doi:
10.1002/bmc.3164. [PMID: 24616108] - Tianzhu Tao, Feng Chen, Lulong Bo, Qun Xie, Wenjing Yi, Yun Zou, Baoji Hu, Jinbao Li, Xiaoming Deng. Ginsenoside Rg1 protects mouse liver against ischemia-reperfusion injury through anti-inflammatory and anti-apoptosis properties.
The Journal of surgical research.
2014 Sep; 191(1):231-8. doi:
10.1016/j.jss.2014.03.067. [PMID: 24750984] - Jian-ping Li, Yan Gao, Shi-feng Chu, Zhao Zhang, Cong-yuan Xia, Zheng Mou, Xiu-yun Song, Wen-bin He, Xiao-feng Guo, Nai-hong Chen. Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis.
Acta pharmacologica Sinica.
2014 Aug; 35(8):1031-44. doi:
10.1038/aps.2014.41. [PMID: 24976156] - Nan Mao, Yuan Cheng, Xin-li Shi, Li Wang, Ji Wen, Qiong Zhang, Qiong-dan Hu, Jun-ming Fan. Ginsenoside Rg1 protects mouse podocytes from aldosterone-induced injury in vitro.
Acta pharmacologica Sinica.
2014 Apr; 35(4):513-22. doi:
10.1038/aps.2013.187. [PMID: 24632846] - Shu-Yu Zhan, Qing Shao, Zheng Li, Yi Wang, Xiao-Hui Fan. [Study on PK-PD characteristics of ginsenoside Rg1 and Rb1, in rats with myocardial ischemia following intravenous administration of shengmai injection].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 Apr; 39(7):1300-5. doi:
. [PMID: 25011272] - Shuyu Zhan, Wenjing Guo, Qing Shao, Xiaohui Fan, Zheng Li, Yiyu Cheng. A pharmacokinetic and pharmacodynamic study of drug-drug interaction between ginsenoside Rg1, ginsenoside Rb1 and schizandrin after intravenous administration to rats.
Journal of ethnopharmacology.
2014 Mar; 152(2):333-9. doi:
10.1016/j.jep.2014.01.014. [PMID: 24462784] - Zhen-Dong Zhong, Chun-Mei Wang, Wei Wang, Li Shen, Zhong-Hua Chen. [Major hypoglycemic ingredients of Panax notoginseng saponins for treating diabetes].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2014 Mar; 45(2):235-9. doi:
. [PMID: 24749347] - Qi Zhou, Lei Jiang, Chunhua Xu, Dongjiao Luo, Chunlai Zeng, Pu Liu, Ming Yue, Yangyang Liu, Xiaosheng Hu, Hu Hu. Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis.
Thrombosis research.
2014 Jan; 133(1):57-65. doi:
10.1016/j.thromres.2013.10.032. [PMID: 24196231] - Eun-Young Park, Mi-Hwi Kim, Eung-Hwi Kim, Eun-Kyu Lee, In-Sun Park, Duck-Choon Yang, Hee-Sook Jun. Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
The American journal of Chinese medicine.
2014; 42(1):173-87. doi:
10.1142/s0192415x14500128. [PMID: 24467543] - C T Li, H B Wang, B J Xu. A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2.
Pharmaceutical biology.
2013 Aug; 51(8):1077-80. doi:
10.3109/13880209.2013.775164. [PMID: 23742679] - Lijun Cao, Yun Zou, Jiali Zhu, Xiaohua Fan, Jinbao Li. Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration.
Molecular and cellular biochemistry.
2013 Aug; 380(1-2):203-10. doi:
10.1007/s11010-013-1674-y. [PMID: 23666740] - Zhen-Yuan Tan, Wang-Na Xiong, Xing-Zhen Huang, Jian-Qin Liang. [Pharmacokinetics and bioavailability of ginsenoside Rg1 in rats].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2013 Jul; 36(7):1121-3. doi:
NULL. [PMID: 24417150] - Xiaoduo Guan, Huichao Chang, Fanlu Sun, Xiaohui Chen, Wen Zhang, Guorong Fan. Determination of esculentoside A in dog plasma by LC-MS/MS method: application to pre-clinical pharmacokinetics.
Journal of pharmaceutical and biomedical analysis.
2013 Jan; 72(?):261-6. doi:
10.1016/j.jpba.2012.09.002. [PMID: 23010600] - Bo Jiang, Zhe Xiong, Jun Yang, Wei Wang, Yue Wang, Zhuang-Li Hu, Fang Wang, Jian-Guo Chen. Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus.
British journal of pharmacology.
2012 Jul; 166(6):1872-87. doi:
10.1111/j.1476-5381.2012.01902.x. [PMID: 22335772] - Mei Liu, Li Wang, Kaili Hu, Jianfang Feng. [Tissue distribution of ginsenoside Rg1 before and after modification by PEG].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Jun; 37(12):1747-50. doi:
". [PMID: 22997817] - Hui Chen, Jun Yin, Yanpin Deng, Min Yang, Lingling Xu, Fukang Teng, Defang Li, Yufan Cheng, Sha Liu, Dong Wang, Tingting Zhang, Wanying Wu, Xuan Liu, Shuhong Guan, Baohong Jiang, Dean Guo. The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats.
BMC complementary and alternative medicine.
2012 Apr; 12(?):53. doi:
10.1186/1472-6882-12-53. [PMID: 22533478] - Chun Shi, Dong-dan Zheng, Li Fang, Fengming Wu, Wing Hang Kwong, Jie Xu. Ginsenoside Rg1 promotes nonamyloidgenic cleavage of APP via estrogen receptor signaling to MAPK/ERK and PI3K/Akt.
Biochimica et biophysica acta.
2012 Apr; 1820(4):453-60. doi:
10.1016/j.bbagen.2011.12.005. [PMID: 22178929] - Gang Chen, Lei Mu, Xiao Zhang, Shixiang Hou, Haijun Nan. [In vivo distribution and pharmacokinetics of multiple effective components contained in Panax notoginseng saponins after intratympanic administration].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 Jul; 36(13):1815-20. doi:
10.4268/cjcmm20111326. [PMID: 22032151] - Liang Feng, Ling Wang, Changjiang Hu, Xuehua Jiang. Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats.
Archives of pharmacal research.
2010 Dec; 33(12):1975-84. doi:
10.1007/s12272-010-1213-2. [PMID: 21191763] - Si-yun Zhang, Min Song, Jun-Gang Lu, Tai-Jun Hang. [Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].
Yao xue xue bao = Acta pharmaceutica Sinica.
2010 Nov; 45(11):1433-9. doi:
. [PMID: 21361045] - Xi-Sheng Xie, Heng-Chuan Liu, Feng-Ping Wang, Cheng-Long Zhang, Chuan Zuo, Yao Deng, Jun-Ming Fan. Ginsenoside Rg1 modulation on thrombospondin-1 and vascular endothelial growth factor expression in early renal fibrogenesis in unilateral obstruction.
Phytotherapy research : PTR.
2010 Nov; 24(11):1581-7. doi:
10.1002/ptr.3190. [PMID: 21031612] - Li Hua Peng, Chun Hay Ko, Sum Wing Siu, Chi Man Koon, Gar Lee Yue, Wai Hing Cheng, Tai Wai Lau, Quan Bin Han, Ka Ming Ng, Kwok Pui Fung, Clara Bik San Lau, Ping Chung Leung. In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment.
Journal of ethnopharmacology.
2010 Sep; 131(2):282-9. doi:
10.1016/j.jep.2010.06.039. [PMID: 20600749] - Yu-Chuan Huang, Cheng-Yu Lin, Su-Fen Huang, Han-Ching Lin, Wen-Liang Chang, Tsu-Chung Chang. Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3T3-L1 adipocytes.
Journal of agricultural and food chemistry.
2010 May; 58(10):6039-47. doi:
10.1021/jf9034755. [PMID: 20441170] - JiaWei Geng, Wei Peng, YouGuang Huang, Hong Fan, ShuDe Li. Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats.
European journal of pharmacology.
2010 May; 634(1-3):162-9. doi:
10.1016/j.ejphar.2010.02.022. [PMID: 20184879] - Liang Feng, Chang-Jiang Hu, Ling-Ying Yu. [Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats].
Yao xue xue bao = Acta pharmaceutica Sinica.
2010 May; 45(5):636-40. doi:
NULL. [PMID: 20931768] - Xiaofen Ma, Xisheng Xie, Chuan Zuo, Junming Fan. [Effects of ginsenoside Rg1 on streptozocin-induced diabetic nephropathy in rats].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.
2010 Apr; 27(2):342-7. doi:
NULL. [PMID: 20481316] - Xiaoying Wang, Shifeng Chu, Tianxiu Qian, Ji Chen, Juntian Zhang. Ginsenoside Rg1 improves male copulatory behavior via nitric oxide/cyclic guanosine monophosphate pathway.
The journal of sexual medicine.
2010 Feb; 7(2 Pt 1):743-50. doi:
10.1111/j.1743-6109.2009.01482.x. [PMID: 19751391] - Min-Xia Zhu, Bing Ran, Zhi-Qiang Feng, Qiang-Wen Pan. [Effects of Rb1 and Rg1 on the expression of Bcl-2, Bax in apoptosis of HK-2 cells induced by the serum of kidney ischemia/reperfusion].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2009 Nov; 25(4):496-9. doi:
NULL. [PMID: 21158042] - Li Xu, Wen-Fang Chen, Man-Sau Wong. Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway.
British journal of pharmacology.
2009 Oct; 158(3):738-48. doi:
10.1111/j.1476-5381.2009.00361.x. [PMID: 19703168] - Li Lin, Jian-Xun Liu, Ying Zhang, Chang-Ling Duan, Cheng-Ren Lin, Jian-Hua Fu. [Evaluation of different combinations of components of Chinese formulation shuangshentongguan by using AUC values].
Yao xue xue bao = Acta pharmaceutica Sinica.
2009 Sep; 44(9):1029-33. doi:
. [PMID: 20055180] - Xia Li, Ming-Hai Tang, Fan Zhang, Zhu Yuan, Li-Juan Chen, Xian-Huo Wang. [Quantitative determination of ginsenoside Re and Rg1 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2009 Sep; 40(5):912-7. doi:
NULL. [PMID: 19950613] - Li-na Zhang, Xi-sheng Xie, Chuan Zuo, Jun-ming Fan. [Effect of ginsenoside Rgl on the expression of TNF-alpha and MCP-1 in rats with diabetic nephropathy].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2009 May; 40(3):466-71. doi:
NULL. [PMID: 19627007] - Jing Xiong, Minjie Sun, Jianxin Guo, Luosheng Huang, Shujing Wang, Boyu Meng, Qineng Ping. Enhancement by adrenaline of ginsenoside Rg1 transport in Caco-2 cells and oral absorption in rats.
The Journal of pharmacy and pharmacology.
2009 Mar; 61(3):347-52. doi:
10.1211/jpp/61.03.0009. [PMID: 19222907] - Xi-Sheng Xie, Man Yang, Heng-Chuan Liu, Chuan Zuo, Hui-Juan Li, Jun-Ming Fan. Ginsenoside Rg1, a major active component isolated from Panax notoginseng, restrains tubular epithelial to myofibroblast transition in vitro.
Journal of ethnopharmacology.
2009 Feb; 122(1):35-41. doi:
10.1016/j.jep.2008.11.020. [PMID: 19101622] - Liu Yang, Shun-Jun Xu, Zhi-Feng Wu, Yi-Ming Liu, Xing Zeng. Determination of ginsenoside-Rg(1) in human plasma and its application to pharmacokinetic studies following intravenous administration of 'Shenmai' injection.
Phytotherapy research : PTR.
2009 Jan; 23(1):65-71. doi:
10.1002/ptr.2558. [PMID: 18688886]