Licorice, Glycyrrhiza, and Ammoniated Glycyrrhizin (BioDeep_00001104044)
代谢物信息卡片
Licorice, Glycyrrhiza, and Ammoniated Glycyrrhizin
化学式: C42H62O16 (822.4037652)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C
InChI: InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23?,24?,25?,26?,27?,28?,29?,30?,31+,34?,35?,38+,39-,40-,41+,42+/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Juntong Li, Yan Gao, Liyuan Cui, Hongyuan He, Jianyong Zheng, Shu Mo, Xin Zhou, Shifeng Chu, Xiaoyun Sun, Naihong Chen, Hong Wang. Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway.
The Journal of pharmacy and pharmacology.
2022 May; 74(5):730-739. doi:
10.1093/jpp/rgab180. [PMID: 35355074] - Seshu Vardhan, Suban K Sahoo. Computational studies on the interaction of SARS-CoV-2 Omicron SGp RBD with human receptor ACE2, limonin and glycyrrhizic acid.
Computers in biology and medicine.
2022 05; 144(?):105367. doi:
10.1016/j.compbiomed.2022.105367. [PMID: 35247766] - Yongqing Li, Mingju Hao, Bingyang Zhang, Peijun Wang, Dantong Zhang, Sumei Lu, Wanshan Ma. Meta-analysis of the efficacy of glycyrrhizin for postoperative liver preservation in patients with liver cancer.
Journal of cancer research and therapeutics.
2022 Apr; 18(2):461-469. doi:
10.4103/jcrt.jcrt_1811_21. [PMID: 35645115] - Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam. Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights.
Pharmacological research.
2022 04; 178(?):106138. doi:
10.1016/j.phrs.2022.106138. [PMID: 35192957] - Adel A Gomaa, Hamdy S Mohamed, Rasha B Abd-Ellatief, Mohamed A Gomaa, Doaa S Hammam. Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial.
Inflammopharmacology.
2022 Apr; 30(2):477-486. doi:
10.1007/s10787-022-00939-7. [PMID: 35233748] - Yang Xin, Kaichen Yu, Yang Yu, Haijun Wang. Filtration and qualification for target biomarkers of traditional Chinese medicine formula "fuzi lizhong decoction" acting on stomach ulcer by UPLC/Q-TOF MS.
Pakistan journal of pharmaceutical sciences.
2022 Mar; 35(2):519-528. doi:
. [PMID: 35642408] - R Tan, X Xiang, W Chen, Z Yang, W Hu, H Qu, J Liu. Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized COVID-19 patients: a retrospective, observational study.
QJM : monthly journal of the Association of Physicians.
2022 Feb; 115(2):77-83. doi:
10.1093/qjmed/hcab184. [PMID: 34314507] - Pruthvi Gowda, Shruti Patrick, Shanker Datt Joshi, Rajesh Kumar Kumawat, Ellora Sen. Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer.
Inflammation.
2022 Feb; 45(1):172-179. doi:
10.1007/s10753-021-01536-6. [PMID: 34480250] - Vladislav V Fomenko, Nadezhda B Rudometova, Olga I Yarovaya, Artem D Rogachev, Anastasia A Fando, Anna V Zaykovskaya, Nina I Komarova, Dmitry N Shcherbakov, Oleg V Pyankov, Andrey G Pokrovsky, Larisa I Karpenko, Rinat A Maksyutov, Nariman F Salakhutdinov. Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 Viruses.
Molecules (Basel, Switzerland).
2022 Jan; 27(1):. doi:
10.3390/molecules27010295. [PMID: 35011529] - Tomoaki Ishida, Kohei Jobu, Kei Kawada, Shumpei Morisawa, Tetsushi Kawazoe, Hisashi Shiraishi, Hiroko Fujita, Satomi Nishimura, Hitomi Kanno, Mitsue Nishiyama, Kazuo Ogawa, Yasuyo Morita, Kazuhiro Hanazaki, Mitsuhiko Miyamura. Impact of Gut Microbiota on the Pharmacokinetics of Glycyrrhizic Acid in Yokukansan, a Kampo Medicine.
Biological & pharmaceutical bulletin.
2022; 45(1):104-113. doi:
10.1248/bpb.b21-00658. [PMID: 34980772] - Jian Li, Mingyi Zhao, Xinying Xiang, Qingnan He, Rong Gui. A novel biomimetic nanomedicine system with anti-inflammatory and anti-osteoporosis effects improves the therapy efficacy of steroid-resistant nephrotic syndrome.
Journal of nanobiotechnology.
2021 Dec; 19(1):417. doi:
10.1186/s12951-021-01165-z. [PMID: 34903236] - Somaye Heidari, Soghra Mehri, Hossein Hosseinzadeh. The genus Glycyrrhiza (Fabaceae family) and its active constituents as protective agents against natural or chemical toxicities.
Phytotherapy research : PTR.
2021 Dec; 35(12):6552-6571. doi:
10.1002/ptr.7238. [PMID: 34414608] - Yulong Wen, Yidan Tang, Miaoyue Li, Yu Lai. Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials.
Pharmaceutical biology.
2021 Dec; 59(1):1276-1285. doi:
10.1080/13880209.2021.1973039. [PMID: 34517748] - Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin, Chien-Ming Hsieh. CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas.
Drug delivery.
2021 Dec; 28(1):2205-2217. doi:
10.1080/10717544.2021.1989087. [PMID: 34662257] - Jingjing Li, Dongge Xu, Lingling Wang, Mengyu Zhang, Guohai Zhang, Erguang Li, Susu He. Glycyrrhizic Acid Inhibits SARS-CoV-2 Infection by Blocking Spike Protein-Mediated Cell Attachment.
Molecules (Basel, Switzerland).
2021 Oct; 26(20):. doi:
10.3390/molecules26206090. [PMID: 34684671] - Tengfang Lai, Yong Shen, Chengcai Chen, Bo Huang, Tongyuan Deng, Zhuangzhi Zhao, Zhuohua Zhang, Zhaohe Huang, Xingshou Pan. Glycyrrhizic acid ameliorates myocardial ischemia-reperfusion injury in rats through inhibiting endoplasmic reticulum stress.
European journal of pharmacology.
2021 Oct; 908(?):174353. doi:
10.1016/j.ejphar.2021.174353. [PMID: 34274339] - Yanlan Xu, Xinyu Yang, Hua Bian, Mingfeng Xia. Metabolic dysfunction associated fatty liver disease and coronavirus disease 2019: clinical relationship and current management.
Lipids in health and disease.
2021 Oct; 20(1):126. doi:
10.1186/s12944-021-01564-z. [PMID: 34602072] - Giorgio Ciprandi, Luisa Maria Bellussi, Valerio Damiani, Desiderio Passali. HMGB1-antagonism exerted by glycyrrhizin could be fruitful against COVID-19.
Acta bio-medica : Atenei Parmensis.
2021 10; 92(S6):e2021455. doi:
10.23750/abm.v92is6.12111. [PMID: 34739475] - Erzhen Duan, Beibei Zhang, Xiaoqing Liang, Huiyuan Jing, Cen Liu, Fenghua Zhang, Jin Huang, Lanli Su, Jinrong Wang. Effects of glycyrrhizin on the growth cycle and ATPase activity of PRRSV-2-infected MARC-145 cells.
Research in veterinary science.
2021 Sep; 138(?):30-38. doi:
10.1016/j.rvsc.2021.05.011. [PMID: 34091227] - Carina Dargel, Friederike Gräbitz-Bräuer, Ramsia Geisler, Pascal Fandrich, Yvonne Hannappel, Lionel Porcar, Thomas Hellweg. Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM.
Molecules (Basel, Switzerland).
2021 Aug; 26(16):. doi:
10.3390/molecules26164959. [PMID: 34443547] - Hyewon Oh, Arom Choi, Nieun Seo, Joon Seok Lim, Je Sung You, Yong Eun Chung. Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on post-contrast acute kidney injury.
Scientific reports.
2021 08; 11(1):15625. doi:
10.1038/s41598-021-94928-5. [PMID: 34341389] - Xia Tian, Wenfan Gan, Yisen Nie, Rongtao Ying, Yongji Tan, Junli Chen, Mei Chen, Chuantao Zhang. Clinical efficacy and security of glycyrrhizic acid preparation in the treatment of anti-SARS-CoV-2 drug-induced liver injury: a protocol of systematic review and meta-analysis.
BMJ open.
2021 07; 11(7):e051484. doi:
10.1136/bmjopen-2021-051484. [PMID: 34244286] - Daniela Jezova, Peter Karailiev, Lucia Karailievova, Agnesa Puhova, Harald Murck. Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats-Possible Implications for COVID-19.
Nutrients.
2021 Jul; 13(7):. doi:
10.3390/nu13072321. [PMID: 34371831] - Kentaro Abe, Tsukasa Higurashi, Mio Takahashi, Ayako Maeda-Minami, Yohei Kawano, Satoru Miyazaki, Yasunari Mano. Concomitant Use of High-dose Methotrexate and Glycyrrhizin Affects Pharmacokinetics of Methotrexate, Resulting in Hepatic Toxicity.
In vivo (Athens, Greece).
2021 Jul; 35(4):2163-2169. doi:
10.21873/invivo.12487. [PMID: 34182493] - Sajjad Ahmad, Yasir Waheed, Asma Abro, Sumra Wajid Abbasi, Saba Ismail. Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2.
Journal of molecular modeling.
2021 Jun; 27(7):206. doi:
10.1007/s00894-021-04816-y. [PMID: 34169390] - Luisa Diomede, Marten Beeg, Alessio Gamba, Oscar Fumagalli, Marco Gobbi, Mario Salmona. Can Antiviral Activity of Licorice Help Fight COVID-19 Infection?.
Biomolecules.
2021 06; 11(6):. doi:
10.3390/biom11060855. [PMID: 34201172] - Yingying Luo, Jian Li, Bin Wang, Qin Zhang, Yajie Bian, Ruipei Wang. Protective effect of glycyrrhizin on osteoarthritis cartilage degeneration and inflammation response in a rat model.
Journal of bioenergetics and biomembranes.
2021 06; 53(3):285-293. doi:
10.1007/s10863-021-09889-1. [PMID: 33725224] - Pruthvi Gowda, Shruti Patrick, Shanker Datt Joshi, Rajesh Kumar Kumawat, Ellora Sen. Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication.
Cytokine.
2021 06; 142(?):155496. doi:
10.1016/j.cyto.2021.155496. [PMID: 33773396] - Huang Qiong, Ling Han, Nanxue Zhang, Huyan Chen, Kexiang Yan, Zhenghua Zhang, Ying Ma, Jinhua Xu. Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.
BMC immunology.
2021 05; 22(1):34. doi:
10.1186/s12865-021-00421-z. [PMID: 34044769] - Zhaoyan Zhao, Yuchen Xiao, Lingqing Xu, Ye Liu, Guanmin Jiang, Wei Wang, Bin Li, Tianchuan Zhu, Qingqin Tan, Lantian Tang, Haibo Zhou, Xi Huang, Hong Shan. Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment.
ACS applied materials & interfaces.
2021 May; 13(18):20995-21006. doi:
10.1021/acsami.1c02755. [PMID: 33930273] - Noha A Emara, Mona F Mahmoud, Hassan M El Fayoumi, Amr A A Mahmoud. The renoprotective effect of glycyrrhizic acid in insulin-resistant rats exposed to aluminum involves the inhibition of TLR4/NF-κB signaling pathway.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 05; 394(5):863-872. doi:
10.1007/s00210-020-02012-y. [PMID: 33165681] - Xue-Liang Dang, Long-Fei Yang, Lei Shi, Long-Fei Li, Ping He, Jie Chen, Bei-Jie Zheng, Peng Yang, Ai-Dong Wen. Post-treatment with glycyrrhizin can attenuate hepatic mitochondrial damage induced by acetaminophen in mice.
Experimental biology and medicine (Maywood, N.J.).
2021 05; 246(10):1219-1227. doi:
10.1177/1535370220977823. [PMID: 33342284] - Jing Zhao, Saisai Tian, Dong Lu, Jian Yang, Huawu Zeng, Feng Zhang, Dongzhu Tu, Guangbo Ge, Yuejuan Zheng, Ting Shi, Xin Xu, Shiyi Zhao, Yili Yang, Weidong Zhang. Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 May; 85(?):153315. doi:
10.1016/j.phymed.2020.153315. [PMID: 32978039] - Lukas van de Sand, Maren Bormann, Mira Alt, Leonie Schipper, Christiane Silke Heilingloh, Eike Steinmann, Daniel Todt, Ulf Dittmer, Carina Elsner, Oliver Witzke, Adalbert Krawczyk. Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease.
Viruses.
2021 04; 13(4):. doi:
10.3390/v13040609. [PMID: 33918301] - Yahang Wang, Yuanyuan Li, Hua Zhang, Leilei Zhu, Jie Zhong, Jiakai Zeng, Cong Meng, Jiasheng Wu, Tianming Wang, Rong Shi, Weian Yuan, Jian Jiang, Ping Liu, Yueming Ma. Pharmacokinetics-based comprehensive strategy to identify multiple effective components in Huangqi decoction against liver fibrosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Apr; 84(?):153513. doi:
10.1016/j.phymed.2021.153513. [PMID: 33647776] - Rong Li, Ka Wu, Yu Li, Xiao Liang, Keng Po Lai, Jian Chen. Integrative pharmacological mechanism of vitamin C combined with glycyrrhizic acid against COVID-19: findings of bioinformatics analyses.
Briefings in bioinformatics.
2021 03; 22(2):1161-1174. doi:
10.1093/bib/bbaa141. [PMID: 32662814] - Yu-Xi Huang, Wen-Xiao Wang, Yu-Ping Tang, Shi-Jun Yue. Drug repurposing for COVID-19: could vitamin C combined with glycyrrhizic acid be at play by the findings of Li et al.'s database-based network pharmacology analysis?.
Briefings in bioinformatics.
2021 03; 22(2):1508-1510. doi:
10.1093/bib/bbaa330. [PMID: 33253353] - Taeheum Cho, Hyo-Sang Han, Junhyuk Jeong, Eun-Mi Park, Kyu-Sik Shim. A Novel Computational Approach for the Discovery of Drug Delivery System Candidates for COVID-19.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062815. [PMID: 33802169] - Guifeng Wang, Keiichi Hiramoto, Ning Ma, Nobuji Yoshikawa, Shiho Ohnishi, Mariko Murata, Shosuke Kawanishi. Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer.
International journal of molecular sciences.
2021 Mar; 22(5):. doi:
10.3390/ijms22052609. [PMID: 33807620] - Tianbao Lv, Dianjun Wu, Ning Song, Shilei Zhang, Siwei He, Jiaqi Wang, Yue Ding, Wenlong Zhang, Yongguo Cao. Dipotassium glycyrrhizinate relieves leptospira-induced nephritis in vitro and in vivo.
Microbial pathogenesis.
2021 Mar; 152(?):104770. doi:
10.1016/j.micpath.2021.104770. [PMID: 33545326] - Toshiaki Makino. Exploration for the real causative agents of licorice-induced pseudoaldosteronism.
Journal of natural medicines.
2021 Mar; 75(2):275-283. doi:
10.1007/s11418-021-01484-3. [PMID: 33481180] - Fang Liu, Xiuzhi Yang, Junxiang Xing, Ke Han, Yuan Sun. Glycyrrhizin potentially suppresses the inflammatory response in preeclampsia rat model.
Pregnancy hypertension.
2021 Mar; 23(?):34-40. doi:
10.1016/j.preghy.2020.10.007. [PMID: 33189014] - Julian Chrzanowski, Alicja Chrzanowska, Wojciech Graboń. Glycyrrhizin: An old weapon against a novel coronavirus.
Phytotherapy research : PTR.
2021 Feb; 35(2):629-636. doi:
10.1002/ptr.6852. [PMID: 32902005] - Ruonan Chen, Chenlin Shen, Qingqing Xu, Yaru Liu, Bo Li, Cheng Huang, Taotao Ma, Xiaoming Meng, Maomao Wu, Jun Li. The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Feb; 51(2):239-248. doi:
10.1080/00498254.2017.1359433. [PMID: 28745128] - Yonggang Yuan, Bing Li, Wanzhong Peng, Zesheng Xu. Protective effect of glycyrrhizin on coronary microembolization-induced myocardial dysfunction in rats.
Pharmacology research & perspectives.
2021 02; 9(1):e00714. doi:
10.1002/prp2.714. [PMID: 33507583] - Fa-Quan Zhao, Gui-Fang Wang, Dong Xu, Hai-Yun Zhang, Yuan-Lu Cui, Qiang-Song Wang. Glycyrrhizin mediated liver-targeted alginate nanogels delivers quercetin to relieve acute liver failure.
International journal of biological macromolecules.
2021 Jan; 168(?):93-104. doi:
10.1016/j.ijbiomac.2020.11.204. [PMID: 33278444] - D Passali, G Ciprandi, V Damiani, A M De Marco, F Cianfrone, F M Passali. Glycyrrhizin for topical use and prophylaxis of COVID-19: an interesting pharmacological perspective.
Journal of biological regulators and homeostatic agents.
2021 Jan; 35(1 Suppl. 2):15-19. doi:
10.23812/21-1supp2-4. [PMID: 33982533] - Habeb Al-Kamel, Oliver Grundmann. Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19).
Mini reviews in medicinal chemistry.
2021; 21(16):2204-2208. doi:
10.2174/1389557521666210210160237. [PMID: 33568033] - Hao Wang, Lin Dong, Fangfei Qu, Huimin He, Wei Sun, Yuqing Man, Hongjie Jiang. Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism.
Pharmaceutical biology.
2020 Dec; 58(1):352-356. doi:
10.1080/13880209.2020.1751661. [PMID: 32298152] - Mingfang Wu, Chen Zhong, Yiping Deng, Qian Zhang, Xiaoxue Zhang, Xiuhua Zhao. Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability.
Drug delivery.
2020 Dec; 27(1):81-90. doi:
10.1080/10717544.2019.1704944. [PMID: 31858857] - Naveen Vankadari, Nandhini Nisha Jeyasankar, Wilma Jerom Lopes. Structure of the SARS-CoV-2 Nsp1/5'-Untranslated Region Complex and Implications for Potential Therapeutic Targets, a Vaccine, and Virulence.
The journal of physical chemistry letters.
2020 Nov; 11(22):9659-9668. doi:
10.1021/acs.jpclett.0c02818. [PMID: 33135884] - Christian Bailly, Gérard Vergoten. Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?.
Pharmacology & therapeutics.
2020 10; 214(?):107618. doi:
10.1016/j.pharmthera.2020.107618. [PMID: 32592716] - Nivedita Roy, Sweta Ghosh, Subir Kumar Juin, Rishila Ghosh, Suchandra Bhattacharya Majumdar, Subrata Majumdar. Immunomodulator mediated changes in plasma membrane calcium ATPase in controlling visceral leishmaniasis.
Experimental parasitology.
2020 Oct; 217(?):107948. doi:
10.1016/j.exppara.2020.107948. [PMID: 32698076] - Hansen Chen, Binghe Guan, Bin Wang, Haiwei Pu, Xiaoyu Bai, Xi Chen, Jihong Liu, Caiming Li, Jinhua Qiu, Dan Yang, Kejian Liu, Qi Wang, Suhua Qi, Jiangang Shen. Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling.
Translational stroke research.
2020 10; 11(5):967-982. doi:
10.1007/s12975-019-00772-1. [PMID: 31872339] - Yuan Li, Na Yao, Ting Zhang, Fengying Guo, Xiangying Niu, Zhihui Wu, Shaozhang Hou. Ability of Post-treatment Glycyrrhizic Acid to Mitigate Cerebral Ischemia/Reperfusion Injury in Diabetic Mice.
Medical science monitor : international medical journal of experimental and clinical research.
2020 Sep; 26(?):e926551. doi:
10.12659/msm.926551. [PMID: 32981927] - Yuri I Glazachev, Anna A Schlotgauer, Viktor A Timoshnikov, Polina A Kononova, Olga Yu Selyutina, Ekaterina A Shelepova, Maxim V Zelikman, Mikhail V Khvostov, Nikolay E Polyakov. Effect of Glycyrrhizic Acid and Arabinogalactan on the Membrane Potential of Rat Thymocytes Studied by Potential-Sensitive Fluorescent Probe.
The Journal of membrane biology.
2020 08; 253(4):343-356. doi:
10.1007/s00232-020-00132-3. [PMID: 32725429] - Xiaoxuan Zhao, Yuepeng Jiang, Yang Zhao, Hongyan Xi, Chang Liu, Fan Qu, Xiaoling Feng. Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2020 Jul; 39(7):1209-1220. doi:
10.1007/s10096-020-03897-6. [PMID: 32328850] - Ruocong Yang, Hao Liu, Chen Bai, Yingchao Wang, Xiaohui Zhang, Rui Guo, Siying Wu, Jianxun Wang, Elaine Leung, Hang Chang, Peng Li, Tiegang Liu, Yi Wang. Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study.
Pharmacological research.
2020 07; 157(?):104820. doi:
10.1016/j.phrs.2020.104820. [PMID: 32360484] - Pan Luo, Dong Liu, Juan Li. Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19.
International journal of antimicrobial agents.
2020 Jun; 55(6):105995. doi:
10.1016/j.ijantimicag.2020.105995. [PMID: 32335281] - Yao Wang, Haiyue Zhang, Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Jian Lv, Hong Zhang, Luwen Wang, Zuojiong Gong. TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Cell proliferation.
2020 Jun; 53(6):e12829. doi:
10.1111/cpr.12829. [PMID: 32419317] - Mengying Li, Zishuai Wen, Yurun Xue, Xue Han, Donglai Ma, Zhihong Ma, Zhonglin Wu, Shengjiang Guan, Shijiang Sun, Li Chu. Cardioprotective effects of glycyrrhizic acid involve inhibition of calcium influx via L-type calcium channels and myocardial contraction in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 06; 393(6):979-989. doi:
10.1007/s00210-019-01767-3. [PMID: 31807838] - Pengcheng Huang, Yinghong Tang, Chang Li, Huifen Zhou, Li Yu, Haitong Wan, Yu He. Correlation study between the pharmacokinetics of seven main active ingredients of Mahuang decoction and its pharmacodynamics in asthmatic rats.
Journal of pharmaceutical and biomedical analysis.
2020 May; 183(?):113144. doi:
10.1016/j.jpba.2020.113144. [PMID: 32070931] - Wenxia Lin, Qianying Yu, Yuesi Qin, Li Dai, Jianhua Xiao, Liang Jiao, Shan Liu, Shengzhen Ye, Jiahao Zhang, Mingling Chen. To explore the clinical efficacy of Traditional Chinese Medicine bath in the treatment of psoriasis vulgaris with blood-heat syndrome and its effect on related cytokines based on different temperature and different concentration.
Medicine.
2020 May; 99(19):e20172. doi:
10.1097/md.0000000000020172. [PMID: 32384509] - Zhi-Yong Cao, Yun-Zi Liu, Jia-Mei Li, Yi-Ming Ruan, Wen-Jie Yan, Shi-Yang Zhong, Ting Zhang, Lin-Lin Liu, Ran Wu, Bo Wang, Wei Wang, Xiao-Ying Bi, Yun-Xia Wang, Wen-Jun Su, Chun-Lei Jiang. Glycyrrhizic acid as an adjunctive treatment for depression through anti-inflammation: A randomized placebo-controlled clinical trial.
Journal of affective disorders.
2020 03; 265(?):247-254. doi:
10.1016/j.jad.2020.01.048. [PMID: 32090748] - Ruixian Niu, Jiangtao Zheng, Dongmei Ding, Weian Kuang, Fengyan Lu, Xunguo Yin. Giant pyoderma gangrenosum in a patient with ulcerative colitis: A case report.
Medicine.
2020 Feb; 99(6):e18795. doi:
10.1097/md.0000000000018795. [PMID: 32028391] - Xiaowei Huo, Xiangbo Meng, Jun Zhang, Yanyan Zhao. Hepatoprotective effect of different combinations of 18α-and 18β-Glycyrrhizic acid against CCl4-induced liver injury in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Feb; 122(?):109354. doi:
10.1016/j.biopha.2019.109354. [PMID: 31918260] - Yung-Chien Hsu, Pey-Jium Chang, Chun-Wu Tung, Ya-Hsueh Shih, Wen-Chiu Ni, Yi-Chen Li, Takuhiro Uto, Yukihiro Shoyama, Cheng Ho, Chun-Liang Lin. De-Glycyrrhizinated Licorice Extract Attenuates High Glucose-Stimulated Renal Tubular Epithelial-Mesenchymal Transition via Suppressing the Notch2 Signaling Pathway.
Cells.
2020 01; 9(1):. doi:
10.3390/cells9010125. [PMID: 31948095] - Xiao Yu, Qishu Jiao, Yanyan Jiang, Shuzhen Guo, Wei Zhang, Bin Liu. Study on the Plasma Protein Binding Rate and Compatibility Regularity of the Constituents Migrating to Blood of Simiao Yong'an Decoction.
Current drug metabolism.
2020; 21(12):979-993. doi:
10.2174/1567201817666200731170731. [PMID: 32735517] - Jin Wang, Lixin Fu, Hao Yang, Kai Cao, Qiaomei Sun, Tao Chen. The Anti-inflammatory Effects of HMGB1 Blockades in a Mouse Model of Cutaneous Vasculitis.
Frontiers in immunology.
2020; 11(?):2032. doi:
10.3389/fimmu.2020.02032. [PMID: 33133061] - Harald Murck. Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection?.
Frontiers in immunology.
2020 ; 11(?):1239. doi:
10.3389/fimmu.2020.01239. [PMID: 32574273] - Lei Zheng, Qian Zhu, Cheng Xu, Min Li, Huan Li, Pei-Qiang Yi, Fei-Fei Xu, Lu Cao, Jia-Yi Chen. Glycyrrhizin mitigates radiation-induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway.
Journal of cellular and molecular medicine.
2020 01; 24(1):214-226. doi:
10.1111/jcmm.14703. [PMID: 31657123] - Zhifeng Zhao, Miaomiao Liu, Yuanyuan Zhang, Yingran Liang, Donglai Ma, Hongfang Wang, Zhihong Ma, Shengjiang Guan, Zhonglin Wu, Xi Chu, Yue Lin, Li Chu. Cardioprotective Effect of Monoammonium Glycyrrhizinate Injection Against Myocardial Ischemic Injury in vivo and in vitro: Involvement of Inhibiting Oxidative Stress and Regulating Ca2+ Homeostasis by L-Type Calcium Channels.
Drug design, development and therapy.
2020; 14(?):331-346. doi:
10.2147/dddt.s232130. [PMID: 32158189] - Huibo Li, Yang Hu, Huilin Tang, Shanshan Li, Hong Ding, Suodi Zhai, Rongsheng Zhao. The Potential of Glycyrrhizinate in the Management of COVID-19: A Systematic Review of the Efficacy and Safety of Glycyrrhizin Preparations in the Treatment of SARS and MERS.
The American journal of Chinese medicine.
2020; 48(7):1539-1552. doi:
10.1142/s0192415x20500767. [PMID: 33202150] - Niyaz Ahmad, Abeer M Al-Subaiec, Rizwan Ahmad, Sonali Sharma, Md Aftab Alam, Mohammad Ashafaq, Rehan Abdur Rub, Farhan Jalees Ahmad. Brain-targeted glycyrrhizic-acid-loaded surface decorated nanoparticles for treatment of cerebral ischaemia and its toxicity assessment.
Artificial cells, nanomedicine, and biotechnology.
2019 Dec; 47(1):475-490. doi:
10.1080/21691401.2018.1561458. [PMID: 30739499] - Xinjie Liu, Yuzheng Pan, Zongxuan Huang, Lingling Peng, Chunzhu Wei, Jinxin Wei. [Diammonium glycyrrhizinate promotes the regeneration and repair of central nervous system in rats with severe traumatic brain injury by Wnt/β-catenin signaling pathway].
Zhonghua wei zhong bing ji jiu yi xue.
2019 Dec; 31(12):1451-1456. doi:
10.3760/cma.j.issn.2095-4352.2019.12.004. [PMID: 32029028] - Ashraf M Morgan, Marwa A Ibrahim, Ahmed M Hussien. Glycyrrhizic acid modulates the atrazine-induced apoptosis in rabbit spleen.
Environmental science and pollution research international.
2019 Dec; 26(34):34924-34930. doi:
10.1007/s11356-019-06604-x. [PMID: 31659708] - Kanon Takahashi, Tetsuhiro Yoshino, Yasuhito Maki, Kan'ichiro Ishiuchi, Takao Namiki, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Toshiaki Makino, Tomonori Nakamura, Masaru Mimura, Kenji Watanabe. Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study.
Archives of toxicology.
2019 11; 93(11):3111-3119. doi:
10.1007/s00204-019-02588-2. [PMID: 31605160] - Min Yu, He Huang, Shiyang Dong, Huanhuan Sha, Wei Wei, Cunming Liu. High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats.
Brain, behavior, and immunity.
2019 11; 82(?):167-177. doi:
10.1016/j.bbi.2019.08.007. [PMID: 31430517] - Sunhong Yan, Chuanqin Fang, Lei Cao, Long Wang, Jing Du, Yue Sun, Xuanxia Tong, Ying Lu, Xiaosan Wu. Protective effect of glycyrrhizic acid on cerebral ischemia/reperfusion injury via inhibiting HMGB1-mediated TLR4/NF-κB pathway.
Biotechnology and applied biochemistry.
2019 Nov; 66(6):1024-1030. doi:
10.1002/bab.1825. [PMID: 31545873] - Noha M Shafik, Rasha Osama El-Esawy, Darin A Mohamed, Ehsan A Deghidy, Omnia Safwat El-Deeb. Regenerative effects of glycyrrhizin and/or platelet rich plasma on type-II collagen induced arthritis: Targeting autophay machinery markers, inflammation and oxidative stress.
Archives of biochemistry and biophysics.
2019 10; 675(?):108095. doi:
10.1016/j.abb.2019.108095. [PMID: 31476301] - Ying Li, Ning Yu, Dandan Han, Yangfeng Ding, Yueming Xu. A first report of porphyria cutanea tarda successfully treated with glycyrrhizin.
Dermatologic therapy.
2019 09; 32(5):e13014. doi:
10.1111/dth.13014. [PMID: 31269308] - Shu-Wen Mu, Yuan Dang, Ya-Cao Fan, Hao Zhang, Jian-He Zhang, Wei Wang, Shou-Sen Wang, Jian-Jun Gu. Effect of HMGB1 and RAGE on brain injury and the protective mechanism of glycyrrhizin in intracranial‑sinus occlusion followed by mechanical thrombectomy recanalization.
International journal of molecular medicine.
2019 Sep; 44(3):813-822. doi:
10.3892/ijmm.2019.4248. [PMID: 31257456] - Lu Han, Rong Wang, Bin Wu, Yanqiu Gu, Yongfang Yuan. Effect of diammonium glycyrrhizinate on pharmacokinetics of omeprazole by regulating cytochrome P450 enzymes and plasma protein binding rate.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Aug; 49(8):975-980. doi:
10.1080/00498254.2018.1523486. [PMID: 30215539] - Jun-Jin Liu, Yao Cheng, Yun-Yun Shao, Zhuang-Peng Chang, Yi-Ting Guo, Xiao-Juan Feng, Ding Xu, Jing-Ping Zhang, Yan Song, Rui-Gang Hou. Comparative pharmacokinetics and metabolites study of seven major bioactive components of Shaoyao-Gancao decoction in normal and polycystic ovary syndrome rats by ultra high pressure liquid chromatography with tandem mass spectrometry.
Journal of separation science.
2019 Aug; 42(15):2534-2549. doi:
10.1002/jssc.201900002. [PMID: 31144455] - Guifeng Jia, Wei Chai, Zhiwei He, Xiaojing Liu, Yan Wen, Lifeng Cui, Fengyan Gong. Low-dose methotrexate-induced vulvar edema: A case report.
Medicine.
2019 Aug; 98(35):e16895. doi:
10.1097/md.0000000000016895. [PMID: 31464920] - Yumeng Shen, Xiang Cui, Shu Jiang, Da-Wei Qian, Jin-Ao Duan. Comparative pharmacokinetics of nine major bioactive components in normal and ulcerative colitis rats after oral administration of Lizhong decoction extracts by UPLC-TQ-MS/MS.
Biomedical chromatography : BMC.
2019 Jul; 33(7):e4521. doi:
10.1002/bmc.4521. [PMID: 30818413] - Zhao-Guang Zheng, You-Hua Xu, Fang Liu, Ting-Ting Zhao, Rui-Xue Wang, Pei-Ying Huang, Ru-Shang Wang, An-Ping Yang, Quan Zhu. Screening bioactive components of Glycyrrhiza uralensis Fisch. with isolated perfused lung extraction and HPLC-ESI-MSn analysis.
Journal of pharmaceutical and biomedical analysis.
2019 May; 169(?):127-132. doi:
10.1016/j.jpba.2019.03.007. [PMID: 30861404] - You Jin Han, Bitna Kang, Eun-Ju Yang, Min-Koo Choi, Im-Sook Song. Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091816. [PMID: 31083444] - Asieh Karimani, Mohammad Heidarpour, Amir Moghaddam Jafari. Protective effects of glycyrrhizin on sub-chronic diazinon-induced biochemical, hematological alterations and oxidative stress indices in male Wistar rats.
Drug and chemical toxicology.
2019 May; 42(3):300-308. doi:
10.1080/01480545.2018.1497053. [PMID: 30203683] - Akihiro Komatsu, Tetsuhiro Yoshino, Takeshi Suzuki, Tomonori Nakamura, Takanori Kanai, Kenji Watanabe. Risk factors associated with pseudoaldosteronism in patients with chronic hepatitis: A retrospective cohort study.
Basic & clinical pharmacology & toxicology.
2019 May; 124(5):607-614. doi:
10.1111/bcpt.13178. [PMID: 30471199] - Yue Zhang, Peng Cao, Fang Lu, Xin Yan, Bingqian Jiang, Jinjun Cheng, Huihua Qu. Generation of Monoclonal Antibodies Against Natural Products.
Journal of visualized experiments : JoVE.
2019 04; ?(146):. doi:
10.3791/57116. [PMID: 31009007] - Delei Kong, Zanfeng Wang, Jie Tian, Tingwei Liu, Hui Zhou. Glycyrrhizin inactivates toll-like receptor (TLR) signaling pathway to reduce lipopolysaccharide-induced acute lung injury by inhibiting TLR2.
Journal of cellular physiology.
2019 04; 234(4):4597-4607. doi:
10.1002/jcp.27242. [PMID: 30203548] - Keiichi Akutagawa, Tsuyoshi Fujita, Kazuhisa Ouhara, Tasuku Takemura, Misako Tari, Mikihito Kajiya, Shinji Matsuda, Shohei Kuramitsu, Noriyoshi Mizuno, Hideki Shiba, Hidemi Kurihara. Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice.
International immunopharmacology.
2019 Mar; 68(?):30-38. doi:
10.1016/j.intimp.2018.12.045. [PMID: 30599445] - Ya-Jun Li, Lin Wang, Bei Zhang, Fei Gao, Chun-Mei Yang. Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus.
The Journal of pharmacy and pharmacology.
2019 Mar; 71(3):390-399. doi:
10.1111/jphp.13040. [PMID: 30417405] - Kan'ichiro Ishiuchi, Osamu Morinaga, Takeshi Ohkita, Chuanting Tian, Asuka Hirasawa, Miaki Mitamura, Yasuhito Maki, Tsubasa Kondo, Tomoya Yasujima, Hiroaki Yuasa, Kiyoshi Minamizawa, Takao Namiki, Toshiaki Makino. 18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism.
Scientific reports.
2019 02; 9(1):1587. doi:
10.1038/s41598-018-38182-2. [PMID: 30733510] - Yuanyue Zhang, Lingyun Li, Chang Qi, Shuyao Hua, Xiaoyuan Fei, Feili Gong, Min Fang. Glycyrrhizin alleviates Con A-induced hepatitis by differentially regulating the production of IL-17 and IL-25.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Feb; 110(?):692-699. doi:
10.1016/j.biopha.2018.12.025. [PMID: 30553196] - Meng Liu, Jie Yuan, Wen-Juan Hu, Chang-Qiang Ke, Yi-Fan Zhang, Yang Ye, Da-Fang Zhong, Guang-Rong Zhao, Sheng Yao, Jia Liu. Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration.
Acta pharmacologica Sinica.
2019 Feb; 40(2):288-296. doi:
10.1038/s41401-018-0011-0. [PMID: 29773886] - Mao Dai, Rui Xiao, Luyao Cai, Tong Ge, Liping Zhu, Qinghua Hu. HMGB1 is mechanistically essential in the development of experimental pulmonary hypertension.
American journal of physiology. Cell physiology.
2019 02; 316(2):C175-C185. doi:
10.1152/ajpcell.00148.2018. [PMID: 30517029] - Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun He. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats.
Journal of neurotrauma.
2019 02; 36(3):421-435. doi:
10.1089/neu.2018.5642. [PMID: 29929431]