2-Deoxy-7,8-dihydro-8-oxoadenosine (BioDeep_00001103818)
代谢物信息卡片
2-Deoxy-7,8-dihydro-8-oxoadenosine
化学式: C10H13N5O4 (267.09674980000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(OC1N2C3=NC=NC(=C3NC2=O)N)CO)O
InChI: InChI=1S/C10H13N5O4/c11-8-7-9(13-3-12-8)15(10(18)14-7)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H,14,18)(H2,11,12,13)/t4-,5+,6?/m0/s1
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Emil List Larsen, Lucia Padella, Helle Kirstine Mørup Bergholdt, Trine Henriksen, Lucia Santoro, Orazio Gabrielli, Henrik Enghusen Poulsen, Gian Paolo Littarru, Patrick Orlando, Luca Tiano. The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome.
Neurobiology of aging.
2018 07; 67(?):159-161. doi:
10.1016/j.neurobiolaging.2018.03.001. [PMID: 29665577] - Daisuke Matsuda, Takuya Matsumoto, Kenichi Honma, Ayae Ikawa-Yoshida, Mitsuho Onimaru, Tadashi Furuyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yoshihiko Maehara. BUBR1 Insufficiency in Mice Increases their Sensitivity to Oxidative Stress.
In vivo (Athens, Greece).
2016 11-; 30(6):769-776. doi:
10.21873/invivo.10993. [PMID: 27815460] - Maria João Gouveia, Júlio Santos, Paul J Brindley, Gabriel Rinaldi, Carlos Lopes, Lúcio L Santos, José Manuel Correia da Costa, Nuno Vale. Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer.
Cancer letters.
2015 Apr; 359(2):226-32. doi:
10.1016/j.canlet.2015.01.018. [PMID: 25615421] - Chiung-Wen Hu, Marcus S Cooke, Yi-Hung Tsai, Mu-Rong Chao. 8-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine concentrations in various human body fluids: implications for their measurement and interpretation.
Archives of toxicology.
2015 Feb; 89(2):201-10. doi:
10.1007/s00204-014-1255-1. [PMID: 24792325] - S Simone, F Rascio, G Castellano, C Divella, A Chieti, P Ditonno, M Battaglia, A Crovace, F Staffieri, B Oortwijn, G Stallone, L Gesualdo, G Pertosa, G Grandaliano. Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury.
Free radical biology & medicine.
2014 Sep; 74(?):263-73. doi:
10.1016/j.freeradbiomed.2014.07.003. [PMID: 25017967] - Ravichandran Beerappa, Dhananjayan Venugopal, Somnath Sen, Mala Ambikapathy, Rajmohan Hirehal Raghavendra Rao. Assessment of 8-oxo-7,8-dihydro-2'-deoxyguanosine as a marker of oxidative DNA damage in gasoline filling station attendants.
International journal of occupational medicine and environmental health.
2013 Oct; 26(5):780-9. doi:
10.2478/s13382-013-0149-0. [PMID: 24326913] - Peter Møller, Marcus S Cooke, Andrew Collins, Ryszard Olinski, Rafal Rozalski, Steffen Loft. Harmonising measurements of 8-oxo-7,8-dihydro-2'-deoxyguanosine in cellular DNA and urine.
Free radical research.
2012 Apr; 46(4):541-53. doi:
10.3109/10715762.2011.644241. [PMID: 22117555] - Sanjeewa Gamagedara, Yinfa Ma. Biomarker analysis for prostate cancer diagnosis using LC-MS and CE-MS.
Bioanalysis.
2011 Sep; 3(18):2129-42. doi:
10.4155/bio.11.203. [PMID: 21942523] - Naushad Shaik Mohammad, Rupasree Yedluri, Pavani Addepalli, Suryanarayana Raju Gottumukkala, Raghunadha Rao Digumarti, Vijay Kumar Kutala. Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer.
Molecular and cellular biochemistry.
2011 Mar; 349(1-2):159-67. doi:
10.1007/s11010-010-0670-8. [PMID: 21113649] - Ana-Marija Domijan, Maja Peraica. Determination of 8-hydroxy-2'deoxyguanosine in urine using HPLC with electrochemical detection.
Arhiv za higijenu rada i toksikologiju.
2008 Dec; 59(4):277-82. doi:
10.2478/10004-1254-59-2008-1879. [PMID: 19064365] - Mark D Evans, Rajinder Singh, Vilas Mistry, Karendeep Sandhu, Peter B Farmer, Marcus S Cooke. Analysis of urinary 8-oxo-7,8-dihydro-purine-2'-deoxyribonucleosides by LC-MS/MS and improved ELISA.
Free radical research.
2008 Oct; 42(10):831-40. doi:
10.1080/10715760802506323. [PMID: 18985483] - Laura E Barnett, Anne M Broomfield, Wouter H Hendriks, Martin B Hunt, Tony K McGhie. The in vivo antioxidant action and the reduction of oxidative stress by boysenberry extract is dependent on base diet constituents in rats.
Journal of medicinal food.
2007 Jun; 10(2):281-9. doi:
10.1089/jmf.2006.027. [PMID: 17651064] - M Abul Kalam, Kazuhiro Haraguchi, Sushil Chandani, Edward L Loechler, Maasaki Moriya, Marc M Greenberg, Ashis K Basu. Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells.
Nucleic acids research.
2006; 34(8):2305-15. doi:
10.1093/nar/gkl099. [PMID: 16679449] - Y Hinokio, S Suzuki, M Hirai, C Suzuki, M Suzuki, T Toyota. Urinary excretion of 8-oxo-7, 8-dihydro-2'-deoxyguanosine as a predictor of the development of diabetic nephropathy.
Diabetologia.
2002 Jun; 45(6):877-82. doi:
10.1007/s00125-002-0831-8. [PMID: 12107732] - A Weimann, D Belling, H E Poulsen. Measurement of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA and human urine by high performance liquid chromatography-electrospray tandem mass spectrometry.
Free radical biology & medicine.
2001 Apr; 30(7):757-64. doi:
10.1016/s0891-5849(01)00462-2. [PMID: 11275475] - X Tan, A P Grollman, S Shibutani. Comparison of the mutagenic properties of 8-oxo-7,8-dihydro-2'-deoxyadenosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA lesions in mammalian cells.
Carcinogenesis.
1999 Dec; 20(12):2287-92. doi:
10.1093/carcin/20.12.2287. [PMID: 10590221] - J L Ravanat, P Guicherd, Z Tuce, J Cadet. Simultaneous determination of five oxidative DNA lesions in human urine.
Chemical research in toxicology.
1999 Sep; 12(9):802-8. doi:
10.1021/tx980194k. [PMID: 10490501]