methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,4R,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate (BioDeep_00001103781)
代谢物信息卡片
methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,4R,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
化学式: C17H24O10 (388.13694039999996)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC(=O)C1=COC(C2C1CC=C2CO)OC3C(C(C(C(O3)CO)O)O)O
InChI: InChI=1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10?,11-,12-,13-,14?,16+,17+/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinhai Lin, Xiaolong Wang, Mingyang Gu, Yuanyuan Chen, Jiongbo Xu, Nhi Van Chau, Junlong Li, Xiaodong Ji, Qingmin Chu, Lijin Qing, Wei Wu. Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1/PI3K/AKT signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155617. doi:
10.1016/j.phymed.2024.155617. [PMID: 38614041] - Lijuan Liu, Huiling Zhang, Xinran Tang, Mengge Zhang, Yayun Wu, Ya Zhao, Chuanjian Lu, Ruizhi Zhao. Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4/MyD88/NF-κB p65 signaling pathway and MMP9.
International immunopharmacology.
2024 May; 133(?):112082. doi:
10.1016/j.intimp.2024.112082. [PMID: 38652958] - Ruimin Tian, Xianfeng Liu, Yang Xiao, Lijia Jing, Honglin Tao, Lu Yang, Xianli Meng. Huang-Lian-Jie-Du decoction drug-containing serum inhibits IL-1β secretion from D-glucose and PA induced BV2 cells via autophagy/NLRP3 signaling.
Journal of ethnopharmacology.
2024 Apr; 323(?):117686. doi:
10.1016/j.jep.2023.117686. [PMID: 38160864] - Kanta Noguchi, Daisuke Imahori, Riko Nishiura, Poomraphie Nuntawong, Waraporn Putalun, Hiroyuki Tanaka, Satoshi Morimoto, Seiichi Sakamoto. Advanced quality assessment of Sanshishi (Gardenia jasminoides Ellis) and Kampo medicines using a monoclonal antibody against geniposide.
Fitoterapia.
2024 Apr; 174(?):105829. doi:
10.1016/j.fitote.2024.105829. [PMID: 38278422] - Zhenxian Li, Haimei Zhu, Hao Liu, Dayue Liu, Jianhe Liu, Yi Zhang, Zhang Qin, Yijia Xu, Yuan Peng, Lihua Ruan, Jintao Li, Yao He, Bin Liu, Yun Long. Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin.
Journal of nanobiotechnology.
2024 Mar; 22(1):129. doi:
10.1186/s12951-024-02389-5. [PMID: 38528554] - Yuhan Ding, Qian Xiang, Peiyuan Zhu, Manlu Fan, Huaqin Tong, Mengxi Wang, Songyi Cheng, Peng Yu, Haibo Shi, Haowen Zhang, Xiaohu Chen. Qihuang Zhuyu formula alleviates coronary microthrombosis by inhibiting PI3K/Akt/αIIbβ3-mediated platelet activation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Mar; 125(?):155276. doi:
10.1016/j.phymed.2023.155276. [PMID: 38295661] - Guiping Ma, Qinqin Dong, Feng Li, Zheng Jin, Jianbin Pi, Wei Wu, Junlong Li. Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
BMC complementary medicine and therapies.
2024 Jan; 24(1):53. doi:
10.1186/s12906-024-04356-x. [PMID: 38267978] - Huahua Li, Ziwei Peng, Yang Song, Minhang Dou, Xinying Lu, Minghui Li, Xiaofeng Zhai, Yan Gu, Rexidanmu Mamujiang, Shouying Du, Jie Bai. Study of the permeation-promoting effect and mechanism of solid microneedles on different properties of drugs.
Drug delivery.
2023 Dec; 30(1):2165737. doi:
10.1080/10717544.2023.2165737. [PMID: 36644816] - Meijuan Yi, Opeyemi B Fasina, Yajing Li, Lan Xiang, Jianhua Qi. Mixture of Peanut Skin Extract, Geniposide, and Isoquercitrin Improves the Hepatic Lipid Accumulation of Mice via Modification of Gut Microbiota Homeostasis and the TLR4 and AMPK Signaling Pathways.
International journal of molecular sciences.
2023 Nov; 24(23):. doi:
10.3390/ijms242316684. [PMID: 38069009] - Jin-Chao Xiao, Ling Wang, Li Zhang, Ming-Yan Chi, Yong Huang, Zi-Peng Gong, Lin Zheng, Feng He. [Determination of plasma protein binding rate of Shuganning Injection using equilibrium dialysis and UPLC-MS/MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Nov; 48(22):6183-6190. doi:
10.19540/j.cnki.cjcmm.20230618.204. [PMID: 38114225] - Yuxin Gan, Chenyu Wang, Chenfeng Xu, Pingping Zhang, Shutong Chen, Lei Tang, Junbing Zhang, Huahao Zhang, Shenhua Jiang. Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation.
Ultrasonics sonochemistry.
2023 Oct; 101(?):106658. doi:
10.1016/j.ultsonch.2023.106658. [PMID: 37913593] - Dewen Zhang, Jian He, Xian Ding, Rui Wang, Wei Chen. Geniposide improves CLP-induced sepsis model prognosis by upregulating PPARγ to modulate monocyte phenotype and cytokine network.
Shock (Augusta, Ga.).
2023 Oct; ?(?):. doi:
10.1097/shk.0000000000002239. [PMID: 37878499] - Jinhan Wu, Shiqi Mao, Xiang Wu, Yi Zhao, Weijun Zhang, Feng Zhu. Jasminoidin reduces ischemic stroke injury by regulating microglia polarization via PASK-EEF1A1 axis.
Chemical biology & drug design.
2023 Sep; ?(?):. doi:
10.1111/cbdd.14354. [PMID: 37743322] - Xuan Zhang, Xiangyi Su, Xiaoyue Yu, Xinyue Zhang, Xuelin Guo, Guige Hou, Chunhua Wang, Hongjuan Li. Preparative separation of iridoid glucosides and crocins from Gardeniae Fructus using sequential macroporous resin column chromatography and evaluation of their anti-inflammatory and antioxidant activities.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2023 Sep; 1229(?):123887. doi:
10.1016/j.jchromb.2023.123887. [PMID: 37714051] - Xinyu Zeng, Jiajie Jiang, Simiao Liu, Qichao Hu, Sihan Hu, Jinhao Zeng, Xiao Ma, Xiaomei Zhang. Bidirectional effects of geniposide in liver injury: Preclinical evidence construction based on meta-analysis.
Journal of ethnopharmacology.
2023 Aug; ?(?):117061. doi:
10.1016/j.jep.2023.117061. [PMID: 37598771] - Qian Zhou, Bin Chen, Yijiao Xu, Yue Wang, Ziheng He, Xueting Cai, Yu Qin, Juan Ye, Yang Yang, Jianping Shen, Peng Cao. Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways.
Journal of ethnopharmacology.
2023 Jul; ?(?):116914. doi:
10.1016/j.jep.2023.116914. [PMID: 37451492] - Xinyu Xu, Bihua Chen, Juan Zhang, Siren Lan, Shasha Wu, Weiwei Xie. Transcriptome and metabolome analysis revealed the changes of Geniposide and Crocin content in Gardenia jasminoides fruit.
Molecular biology reports.
2023 Jul; ?(?):. doi:
10.1007/s11033-023-08613-z. [PMID: 37392282] - Baitao Li, Yu Zhao, Xiaomao Zhou, Cheng Peng, Xiaotong Yan, Tianyu Zou. Geniposide improves depression by promoting the expression of synapse-related proteins through the Creb1/Six3os1 axis.
Gene.
2023 Jun; ?(?):147564. doi:
10.1016/j.gene.2023.147564. [PMID: 37311497] - Yajuan Bi, Yanchao Xing, Chunshan Gui, Yiqing Tian, Mingzhe Zhang, Yao Yao, Ge Hu, Lifeng Han, Feng He, Youcai Zhang. Potential Involvement of Organic Anion Transporters in Drug Interactions with Shuganning Injection, a Traditional Chinese Patent Medicine.
Planta medica.
2023 May; ?(?):. doi:
10.1055/a-2085-2367. [PMID: 37236232] - Xiaoju Zhuge, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Liwei Xue, Weilai Yu, Zijiao Quan, Haibin Tong, Fang Xu. Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway.
Journal of ethnopharmacology.
2023 May; 314(?):116626. doi:
10.1016/j.jep.2023.116626. [PMID: 37187359] - Peikun He, Hao Wang, Saibo Cheng, Fang Hu, Lifang Zhang, Weicong Chen, Yuling Xu, Yaxin Zhang, Yuyan Gu, Zhaoyong Li, Yao Jin, Xiaoyu Liu, Yuhua Jia. Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14.
Journal of ethnopharmacology.
2023 May; ?(?):116532. doi:
10.1016/j.jep.2023.116532. [PMID: 37149071] - Zhuorui Shan, Junfeng Jia, Qiuju Wang, Yizhe Cui. Network pharmacology-based analysis on geniposide, a component of gardenia jasminoides, beneficial effects to alleviate LPS-induced immune stress in piglets.
International immunopharmacology.
2023 Feb; 117(?):109894. doi:
10.1016/j.intimp.2023.109894. [PMID: 36863144] - Huajie Tian, Yi Fang, Wei Liu, Jun Wang, Jianan Zhao, Hao Tang, Yixiao Yin, Yiyang Hu, Jinghua Peng. Inhibition on XBP1s-driven lipogenesis by Qushi Huayu Decoction contributes to amelioration of hepatic steatosis induced by fructose.
Journal of ethnopharmacology.
2023 Jan; 301(?):115806. doi:
10.1016/j.jep.2022.115806. [PMID: 36216198] - Hong-Ying Chen, Peng-Fei Yao, Yan-Qi Han, Xu Xu, Jun Xu, Bi-Yan Pan, Dong-Sheng Ouyang, Tie-Jun Zhang. ["Component-target-efficacy" network analysis and experimental verification of Qingkailing Oral Preparation].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jan; 48(1):170-182. doi:
10.19540/j.cnki.cjcmm.20220920.401. [PMID: 36725269] - Yu Zhao, Qian Zhang, Yuzhu Yan, Xinbo Wang, Yin Shao, Cheng Mei, Tianyu Zou. Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks.
Phytotherapy research : PTR.
2022 Dec; ?(?):. doi:
10.1002/ptr.7702. [PMID: 36515407] - Mu-Xuan Wang, Min-Min Wang, Chao Liu, Jia-Shu Chen, Jian-Shu Liu, Xu Guo, Meng-Qi Zhang, Jing Zhang, Jin-Yue Sun, Zhi-Xin Liao. A geniposide-phospholipid complex ameliorates posthyperuricemia chronic kidney disease induced by inflammatory reactions and oxidative stress.
European journal of pharmacology.
2022 Sep; 930(?):175157. doi:
10.1016/j.ejphar.2022.175157. [PMID: 35870480] - Jia-Shu Chen, Mu-Xuan Wang, Min-Min Wang, Yu-Kai Zhang, Xu Guo, Ying-Ying Chen, Meng-Qi Zhang, Jin-Yue Sun, Yu-Fa Liu, Chao Liu. Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.
European journal of medicinal chemistry.
2022 Jul; 237(?):114379. doi:
10.1016/j.ejmech.2022.114379. [PMID: 35468514] - Jinshuang Wang, Qin Ye, Ningxiang Yu, Weiwei Huan, Jingliang Sun, Xiaohua Nie, Xianghe Meng. Preparation of multiresponsive hydrophilic molecularly imprinted microspheres for rapid separation of gardenia yellow and geniposide from gardenia fruit.
Food chemistry.
2022 Apr; 374(?):131610. doi:
10.1016/j.foodchem.2021.131610. [PMID: 34823938] - Sheng-Jie Dai, Qiao-Yun Zhang, Qing Lan, Yong Chen, You-Zhi Zhang, Qi Huang. [PK2/PKR1 signaling pathway participates in geniposide protection against diabetic nephropathy in mice].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Mar; 47(6):1611-1617. doi:
10.19540/j.cnki.cjcmm.20211122.401. [PMID: 35347960] - Jinxin Liu, Chunmei Song, Chenzhipeng Nie, Yujie Sun, Yu Wang, Lamei Xue, Mingcong Fan, Haifeng Qian, Li Wang, Yan Li. A novel regulatory mechanism of geniposide for improving glucose homeostasis mediated by circulating RBP4.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jan; 95(?):153862. doi:
10.1016/j.phymed.2021.153862. [PMID: 34856473] - Jing Leng, Hua-Jie Tian, Yi Fang, Yi-Yang Hu, Jing-Hua Peng. Amelioration of Non-Alcoholic Steatohepatitis by Atractylodes macrocephala Polysaccharide, Chlorogenic Acid, and Geniposide Combination Is Associated With Reducing Endotoxin Gut Leakage.
Frontiers in cellular and infection microbiology.
2022; 12(?):827516. doi:
10.3389/fcimb.2022.827516. [PMID: 35865826] - Siting Gao, Qin Feng. The Beneficial Effects of Geniposide on Glucose and Lipid Metabolism: A Review.
Drug design, development and therapy.
2022; 16(?):3365-3383. doi:
10.2147/dddt.s378976. [PMID: 36213380] - Yizhou Zheng, Yaosheng Xiao, Di Zhang, Shanshan Zhang, Jing Ouyang, Linfu Li, Weimei Shi, Rui Zhang, Hai Liu, Qi Jin, Zhixi Chen, Daohua Xu, Longhuo Wu. Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.
Cells.
2021 12; 10(12):. doi:
10.3390/cells10123424. [PMID: 34943934] - Muxuan Wang, Jiashu Chen, Ruirui Zhang, Xinyan Guo, Daxia Chen, Xu Guo, Yingying Chen, Yuhao Wu, Jinyue Sun, Yufa Liu, Chao Liu. Design, synthesis and bioactive evaluation of geniposide derivatives for antihyperuricemic and nephroprotective effects.
Bioorganic chemistry.
2021 11; 116(?):105321. doi:
10.1016/j.bioorg.2021.105321. [PMID: 34500305] - Xumin Zhang, Kai Liu, Mingyi Shi, Long Xie, Mao Deng, Huijuan Chen, Xiaofang Li. Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: A snapshot of their underlying mechanisms.
Brain research bulletin.
2021 09; 174(?):281-295. doi:
10.1016/j.brainresbull.2021.06.020. [PMID: 34216649] - Jinyan Wan, Yu Long, Songyu Liu, Yulu Zhang, Yan Xiang, Dan Li, Ai Shi, Yu Shuang, Ying Li, Yanan He, Nan Li, Yongmei Guan. Geniposide-Loaded Liposomes for Brain Targeting: Development, Evaluation, and In Vivo Studies.
AAPS PharmSciTech.
2021 Aug; 22(7):222. doi:
10.1208/s12249-021-02093-9. [PMID: 34409515] - Fengtao Li, Lijun Song, Jing Chen, Yu Chen, Yongjun Li, Meizi Huang, Wenchang Zhao. Effect of genipin-1-β-d-gentiobioside on diabetic nephropathy in mice by activating AMP-activated protein kinase/silencing information regulator-related enzyme 1/ nuclear factor-κB pathway.
The Journal of pharmacy and pharmacology.
2021 Aug; 73(9):1201-1211. doi:
10.1093/jpp/rgab041. [PMID: 33792721] - Yusha Luo, Fangyuan Gao, Ruirui Chang, Xingjie Zhang, Jie Zhong, Jun Wen, Jianlin Wu, Tingting Zhou. Metabolomics based comprehensive investigation of Gardeniae Fructus induced hepatotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jul; 153(?):112250. doi:
10.1016/j.fct.2021.112250. [PMID: 33964367] - HuiMin Li, Yan Wang, Bin Wang, Min Li, JiPing Liu, HongLian Yang, YongHeng Shi. Baicalin and Geniposide Inhibit Polarization and Inflammatory Injury of OGD/R-Treated Microglia by Suppressing the 5-LOX/LTB4 Pathway.
Neurochemical research.
2021 Jul; 46(7):1844-1858. doi:
10.1007/s11064-021-03305-1. [PMID: 33891262] - Bo Zhang, Hong-Sheng Chang, Kai-Li Hu, Xue Yu, Li-Na Li, Xiang-Qing Xu. Combination of Geniposide and Eleutheroside B Exerts Antidepressant-like Effect on Lipopolysaccharide-Induced Depression Mice Model.
Chinese journal of integrative medicine.
2021 Jul; 27(7):534-541. doi:
10.1007/s11655-019-3051-5. [PMID: 31784933] - Yang Wen, You-Wei Chen, Ai-Hong Meng, Ming Zhao, Song-Hua Fang, Yan-Qing Ma. Idiopathic mesenteric phlebosclerosis associated with long-term oral intake of geniposide.
World journal of gastroenterology.
2021 Jun; 27(22):3097-3108. doi:
10.3748/wjg.v27.i22.3097. [PMID: 34168411] - Deng Ran, Wu Hong, Wang Yan, Wang Mengdie. Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases.
Journal of ethnopharmacology.
2021 Jun; 273(?):113958. doi:
10.1016/j.jep.2021.113958. [PMID: 33639206] - Menglin Zheng, Ke Li, Tong Chen, Shengnan Liu, Ling He. Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice.
Brain research bulletin.
2021 05; 170(?):65-73. doi:
10.1016/j.brainresbull.2021.02.008. [PMID: 33561536] - Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park. Geniposide Improves Diabetic Nephropathy by Enhancing ULK1-Mediated Autophagy and Reducing Oxidative Stress through AMPK Activation.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041651. [PMID: 33562139] - Kena Lv, Jingjing Zhu, Shuangshuang Zheng, Zeren Jiao, Yi Nie, Fei Song, Tianqing Liu, Kedong Song. Evaluation of inhibitory effects of geniposide on a tumor model of human breast cancer based on 3D printed Cs/Gel hybrid scaffold.
Materials science & engineering. C, Materials for biological applications.
2021 Feb; 119(?):111509. doi:
10.1016/j.msec.2020.111509. [PMID: 33321605] - Xin Xin, Yue Jin, Xin Wang, Beiyu Cai, Ziming An, Yi-Yang Hu, Qin Feng. A Combination of Geniposide and Chlorogenic Acid Combination Ameliorates Nonalcoholic Steatohepatitis in Mice by Inhibiting Kupffer Cell Activation.
BioMed research international.
2021; 2021(?):6615881. doi:
10.1155/2021/6615881. [PMID: 34095305] - Yang Fu, Pei-Pei Yuan, Yan-Gang Cao, Ying-Ying Ke, Qi Zhang, Ying Hou, Yan-Li Zhang, Wei-Sheng Feng, Xiao-Ke Zheng. Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors.
The Journal of pharmacy and pharmacology.
2020 Dec; 72(12):1956-1969. doi:
10.1111/jphp.13361. [PMID: 32830328] - Jinhong Liu, Ning Zhao, Guiling Shi, Hai Wang. Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ.
Aging.
2020 11; 12(22):22744-22758. doi:
10.18632/aging.103902. [PMID: 33197894] - Fengtao Li, Yu Chen, Yongjun Li, Meizi Huang, Wenchang Zhao. Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway.
European journal of pharmacology.
2020 Nov; 886(?):173449. doi:
10.1016/j.ejphar.2020.173449. [PMID: 32758570] - Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang. High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide.
Frontiers of medicine.
2020 Oct; 14(5):651-663. doi:
10.1007/s11684-019-0709-5. [PMID: 31901116] - Huiju Yang, Yinzi Yue, Yan Li, Lianlin Su, Shuai Yan. Geniposide attenuates dextran sulfate sodium-induced colitis in mice via Nrf-2/HO-1/NF-κB pathway.
Annals of palliative medicine.
2020 Sep; 9(5):2826-2836. doi:
10.21037/apm-20-279. [PMID: 32787366] - Yong-Liang Zhu, Shuang-Long Li, Jun-Li Jin, Jia-Ao Fang, Xiang-Die Wang, Ling-Yun Chen, Xiang-Jun Qiu. Simultaneous determination of six components of Danzhi Xiaoyao Pill in beagle plasma by HPLC-MS/MS and a study of pharmacokinetic of paeoniflorin and geniposide after single-dose administration.
Journal of pharmaceutical and biomedical analysis.
2020 Jul; 186(?):113269. doi:
10.1016/j.jpba.2020.113269. [PMID: 32247162] - Li-Juan Li, Zhi-Fen Han, Ling-Xin Li, Bo Yan. [Effects of Geniposide on the Neuroinflammation in Chronic Cerebral Hypoperfusion Rat Model].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2020 Jul; 51(4):480-487. doi:
10.12182/20200760104. [PMID: 32691554] - Bingyu Shen, Haihua Feng, Jiaqi Cheng, Zheng Li, Meiyu Jin, Lilei Zhao, Qi Wang, Haiyan Qin, Guowen Liu. Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways.
Journal of cellular and molecular medicine.
2020 05; 24(9):5097-5108. doi:
10.1111/jcmm.15139. [PMID: 32293113] - Zhuo Chen, Weiming Liu, Zhigang Qin, Xiaoting Liang, Gengren Tian. Geniposide exhibits anticancer activity to medulloblastoma cells by downregulating microRNA-373.
Journal of biochemical and molecular toxicology.
2020 May; 34(5):e22471. doi:
10.1002/jbt.22471. [PMID: 32057176] - Jianwei Yuan, Jinghua Zhang, Juan Cao, Guangxing Wang, Hansheng Bai. Geniposide Alleviates Traumatic Brain Injury in Rats Via Anti-Inflammatory Effect and MAPK/NF-kB Inhibition.
Cellular and molecular neurobiology.
2020 May; 40(4):511-520. doi:
10.1007/s10571-019-00749-6. [PMID: 31677006] - Zheng Jin, Junlong Li, Jianbin Pi, Qingmin Chu, Weichao Wei, Zhiyi Du, Lijin Qing, Xinjun Zhao, Wei Wu. Geniposide alleviates atherosclerosis by regulating macrophage polarization via the FOS/MAPK signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 May; 125(?):110015. doi:
10.1016/j.biopha.2020.110015. [PMID: 32187958] - Xue Yu, Yu Wang, Shujun Tao, Shulun Sun. Geniposide plays anti-tumor effects by down-regulation of microRNA-224 in HepG2 and Huh7 cell lines.
Experimental and molecular pathology.
2020 02; 112(?):104349. doi:
10.1016/j.yexmp.2019.104349. [PMID: 31778668] - Shengnan Liu, Menglin Zheng, Yixuan Li, Ling He, Tong Chen. The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway.
Psychopharmacology.
2020 Feb; 237(2):465-477. doi:
10.1007/s00213-019-05379-w. [PMID: 31811349] - Jinxin Liu, Yan Li, Chao Sun, Shengnan Liu, Ying Yan, Haiou Pan, Mingcong Fan, Lamei Xue, Chenzhipeng Nie, Hui Zhang, Haifeng Qian, Hao Ying, Li Wang. Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.
Pharmacological research.
2020 02; 152(?):104631. doi:
10.1016/j.phrs.2020.104631. [PMID: 31911244] - Yu-Ling Xu, Xiao-Yu Liu, Sai-Bo Cheng, Pei-Kun He, Mu-Keng Hong, Yu-Yao Chen, Feng-Hua Zhou, Yu-Hua Jia. Geniposide Enhances Macrophage Autophagy through Downregulation of TREM2 in Atherosclerosis.
The American journal of Chinese medicine.
2020; 48(8):1821-1840. doi:
10.1142/s0192415x20500913. [PMID: 33308094] - Di Shen, Dezhang Zhao, Xi Yang, Jun Zhang, Hui He, Chao Yu. Geniposide against atherosclerosis by inhibiting the formation of foam cell and lowering reverse lipid transport via p38/MAPK signaling pathways.
European journal of pharmacology.
2019 Dec; 864(?):172728. doi:
10.1016/j.ejphar.2019.172728. [PMID: 31600492] - Xia Li, Aijing Ma, Kun Liu. Geniposide alleviates lipopolysaccharide-caused apoptosis of murine kidney podocytes by activating Ras/Raf/MEK/ERK-mediated cell autophagy.
Artificial cells, nanomedicine, and biotechnology.
2019 Dec; 47(1):1524-1532. doi:
10.1080/21691401.2019.1601630. [PMID: 30982359] - Qianqian Zhang, Fang Feng. The Effects of Different Varieties of Aurantii Fructus Immaturus on the Potential Toxicity of Zhi-Zi-Hou-Po Decoction Based on Spectrum-Toxicity Correlation Analysis.
Molecules (Basel, Switzerland).
2019 Nov; 24(23):. doi:
10.3390/molecules24234254. [PMID: 31766682] - Chenzhao Du, Shengyun Dai, Anbang Zhao, Yanjiang Qiao, Zhisheng Wu. Optimization of PLS modeling parameters via quality by design concept for Gardenia jasminoides Ellis using online NIR sensor.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Nov; 222(?):117267. doi:
10.1016/j.saa.2019.117267. [PMID: 31247389] - Junying Wei, Qiong Man, Chen Ding, Yanzhen Hu, Mingwei Liu, Hui Li, Feifei Guo, Yi Zhang, Defeng Li, Lei Song, Hongjun Yang, Shihuan Tang. Proteomic Investigations of Transcription Factors Critical in Geniposide-Mediated Suppression of Alcoholic Steatosis and in Overdose-Induced Hepatotoxicity on Liver in Rats.
Journal of proteome research.
2019 11; 18(11):3821-3830. doi:
10.1021/acs.jproteome.9b00140. [PMID: 31612718] - Chunnan Li, Meng Lan, Jingwei Lv, Ye Zhang, Xiaochen Gao, Xu Gao, Lihua Dong, Guangming Luo, Hui Zhang, Jiaming Sun. Screening of the Hepatotoxic Components in Fructus Gardeniae and Their Effects on Rat Liver BRL-3A Cells.
Molecules (Basel, Switzerland).
2019 Oct; 24(21):. doi:
10.3390/molecules24213920. [PMID: 31671698] - Yan-Zhen Hu, De-Feng Li, Yi Zhang, Jun-Ying Wei, Hong-Jun Yang. [Marker genes of geniposide-induced hepatotoxicity based on genomic strategy].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Oct; 44(19):4234-4240. doi:
10.19540/j.cnki.cjcmm.20190710.401. [PMID: 31872704] - Zhi-Qiang Li, Xiu-Ying Huang, Chun-Yan Hu, Zhong-Sheng Zhu, Yang Chen, Min Gong. Geniposide protects against ox-LDL-induced foam cell formation through inhibition of MAPKs and NF-kB signaling pathways.
Die Pharmazie.
2019 10; 74(10):601-605. doi:
10.1691/ph.2019.9506. [PMID: 31685085] - Minyi Jin, Tong Zhang, Yue Ding, Tingpeng Huang, Zhenzhen Cai. Enhancement effect of geniposide on solubility and intestinal absorption of baicalin.
Pakistan journal of pharmaceutical sciences.
2019 Sep; 32(5):1933-1940. doi:
. [PMID: 31813855] - Yongtao Bai, Lihua Song, Yongheng Zhang, Guoliang Dai, Weidong Zhang, Shanshan Song, Hong Sun, Wen Jing, Meijuan Xu, Wenzheng Ju. Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi-Zi-Hou-Po decoction in normal and corticosterone-induced depressive rats.
Biomedical chromatography : BMC.
2019 Sep; 33(9):e4542. doi:
10.1002/bmc.4542. [PMID: 30947404] - Changxiang Li, Xueqian Wang, Fafeng Cheng, Xin Du, Juntang Yan, Changming Zhai, Jie Mu, Qingguo Wang. Geniposide protects against hypoxia/reperfusion-induced blood-brain barrier impairment by increasing tight junction protein expression and decreasing inflammation, oxidative stress, and apoptosis in an in vitro system.
European journal of pharmacology.
2019 Jul; 854(?):224-231. doi:
10.1016/j.ejphar.2019.04.021. [PMID: 30995438] - Wei Yang, Shuyao Wang, Guangping Zhang, Siyang Wu, Tengfei Chen, Qiutao Wang, Mengmeng Wei, Wenhao Cheng, Yang Gao, Yingfei Li, Zuguang Ye. LC-electrolyte switch in a contiguous time segments to analyze multi-components: Simultaneous determination of phenolic acids and iridoids in rat plasma after inhalation administration of Reduning aerosol.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Jul; 1120(?):104-112. doi:
10.1016/j.jchromb.2019.05.002. [PMID: 31078127] - Dai Xuejing, Wang Wenyu, Wu Hong, Zhang Zhengrong, Dai Li, Fu Jun, Deng Ran, Li Feng, Wang Yan, Zhan Xiang. UHPLC-MS/MS analysis of sphingosine 1-phosphate in joint cavity dialysate and hemodialysis solution of adjuvant arthritis rats: Application to geniposide pharmacodynamic study.
Biomedical chromatography : BMC.
2019 Jul; 33(7):e4526. doi:
10.1002/bmc.4526. [PMID: 30834567] - Chi-Chen Yeh, Shih-Shan Huang, Po-Yu Liu, Bo-Cheng Wang, Chia-Fen Tsai, Der-Yuan Wang, Hwei-Fang Cheng. Simultaneous quantification of six indicator compounds in Wen-Qing-Yin by high-performance liquid chromatography-diode array detection.
Journal of food and drug analysis.
2019 07; 27(3):749-757. doi:
10.1016/j.jfda.2018.12.003. [PMID: 31324290] - Qiang Tian, Fang Liu, Zhou Xu, Huan Liu, Hao Yin, Zhaolin Sun, Mingcang Chen, Zhixiong Li, Lin Ma, Chenggang Huang. Evaluation of the chemical consistency of Yin-Chen-Hao-Tang prepared by combined and separated decoction methods using high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis.
Journal of separation science.
2019 May; 42(9):1664-1675. doi:
10.1002/jssc.201800961. [PMID: 30784184] - Saibo Cheng, Fenghua Zhou, Yuling Xu, Xiaoyu Liu, Yu Zhang, Minhua Gu, Zhijie Su, Dandan Zhao, Lei Zhang, Yuhua Jia. Geniposide regulates the miR-101/MKP-1/p38 pathway and alleviates atherosclerosis inflammatory injury in ApoE-/- mice.
Immunobiology.
2019 03; 224(2):296-306. doi:
10.1016/j.imbio.2018.12.005. [PMID: 30630636] - Yaya Hu, Xin Liu, Qiang Xia, Tianpeng Yin, Chuan Bai, Ze Wang, Lianfeng Du, Xiaobo Li, Wenjun Wang, Lin Sun, Yinhua Liu, Hao Zhang, Liang Deng, Yang Chen. Comparative anti-arthritic investigation of iridoid glycosides and crocetin derivatives from Gardenia jasminoides Ellis in Freund's complete adjuvant-induced arthritis in rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Feb; 53(?):223-233. doi:
10.1016/j.phymed.2018.07.005. [PMID: 30668402] - Yunji Wang, Fang Feng. Evaluation of the Hepatotoxicity of the Zhi-Zi-Hou-Po Decoction by Combining UPLC-Q-Exactive-MS-Based Metabolomics and HPLC-MS/MS-Based Geniposide Tissue Distribution.
Molecules (Basel, Switzerland).
2019 Jan; 24(3):. doi:
10.3390/molecules24030511. [PMID: 30708983] - Zhihua Zhang, Xiaojian Wang, Di Zhang, Yueze Liu, Lin Li. Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease.
Aging.
2019 01; 11(2):536-548. doi:
10.18632/aging.101759. [PMID: 30684442] - Hwa-Young Lee, Geum-Hwa Lee, Young Yoon, Han-Jung Chae. Rhus verniciflua and Eucommia ulmoides Protects Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing Anti-Oxidation and AMPK Activation.
The American journal of Chinese medicine.
2019; 47(6):1253-1270. doi:
10.1142/s0192415x19500642. [PMID: 31488034] - Jinlan Lu, Ling Liu, Xingyu Zhu, Li Wu, Zhipeng Chen, Zisheng Xu, Weidong Li. Evaluation of the Absorption Behavior of Main Component Compounds of Salt-Fried Herb Ingredients in Qing'e Pills by Using Caco-2 Cell Model.
Molecules (Basel, Switzerland).
2018 Dec; 23(12):. doi:
10.3390/molecules23123321. [PMID: 30558187] - Tun-Pin Hsueh, Tung-Hu Tsai. Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method.
Molecules (Basel, Switzerland).
2018 Oct; 23(10):. doi:
10.3390/molecules23102716. [PMID: 30360359] - Xiang Tian, Rui-Xue Ding, Gen-Na Ba, Yu-Xia Bai, Na-Mu-Ji-la Laxi, Xiao-Yong Rao, Xiao-Jian Luo. [Fingerprinting and multi-indicator quantitative analysis of Mongolian drug Digeda-4 decoction].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Oct; 43(19):3962-3969. doi:
10.19540/j.cnki.cjcmm.20180726.009. [PMID: 30453724] - Jing Yu, Xiucai Guo, Qingqing Zhang, Ying Peng, Jiang Zheng. Metabolite profile analysis and pharmacokinetic study of emodin, baicalin and geniposide in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2018 Sep; 48(9):927-937. doi:
10.1080/00498254.2017.1382748. [PMID: 28967290] - Dong Wu, Danmeng Yu, Yujia Zhang, Juane Dong, Dengwu Li, Dongmei Wang. Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Eucommia ulmoides Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree.
Molecules (Basel, Switzerland).
2018 Jul; 23(8):. doi:
10.3390/molecules23081898. [PMID: 30061494] - Shao-Qing Yang, Ye-Dan Chen, Heng Li, Xian Hui, Wen-Yun Gao. Geniposide and Gentiopicroside Suppress Hepatic Gluconeogenesis via Regulation of AKT-FOXO1 Pathway.
Archives of medical research.
2018 07; 49(5):314-322. doi:
10.1016/j.arcmed.2018.10.005. [PMID: 30409503] - Haiou Pan, Yan Li, Haifeng Qian, Xiguang Qi, Gangcheng Wu, Hui Zhang, Meijuan Xu, Zhiming Rao, Jin-Long Li, Li Wang, Hao Ying. Effects of Geniposide from Gardenia Fruit Pomace on Skeletal-Muscle Fibrosis.
Journal of agricultural and food chemistry.
2018 Jun; 66(23):5802-5811. doi:
10.1021/acs.jafc.8b00739. [PMID: 29771121] - Peng-Qian Wang, Qiong Liu, Wen-Juan Xu, Ya-Nan Yu, Ying-Ying Zhang, Bing Li, Jun Liu, Zhong Wang. Pure mechanistic analysis of additive neuroprotective effects between baicalin and jasminoidin in ischemic stroke mice.
Acta pharmacologica Sinica.
2018 Jun; 39(6):961-974. doi:
10.1038/aps.2017.145. [PMID: 29345255] - Ennian Leng, Yuan Xiao, Zhentao Mo, Yiqi Li, Yueyue Zhang, Xiaosi Deng, Min Zhou, Chaochao Zhou, Zengxuan He, Jingyi He, Lu Xiao, Junming Li, Wenna Li. Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells.
BMC complementary and alternative medicine.
2018 Apr; 18(1):122. doi:
10.1186/s12906-018-2189-6. [PMID: 29622007] - Chenzhao Du, Shengyun Dai, Yanjiang Qiao, Zhisheng Wu. Error propagation of partial least squares for parameters optimization in NIR modeling.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Mar; 192(?):244-250. doi:
10.1016/j.saa.2017.10.069. [PMID: 29154215] - Fuguo Shi, Hong Pan, Yi Li, Linyan Huang, Qin Wu, Yuanfu Lu. A sensitive LC-MS/MS method for simultaneous quantification of geniposide and its active metabolite genipin in rat plasma and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2018 Mar; 32(3):. doi:
10.1002/bmc.4126. [PMID: 29088500] - Jingzhuo Tian, Yan Yi, Yong Zhao, Chunying Li, Yushi Zhang, Lianmei Wang, Chen Pan, Jiayin Han, Guiqin Li, Xiaolong Li, Jing Liu, Nuo Deng, Yue Gao, Aihua Liang. Oral chronic toxicity study of geniposide in rats.
Journal of ethnopharmacology.
2018 Mar; 213(?):166-175. doi:
10.1016/j.jep.2017.11.008. [PMID: 29128573] - Yishun Yang, Yue Ding, Tong Zhang. Biotransformation of Geniposide into Genipin by Immobilized Trichoderma reesei and Conformational Study of Genipin.
BioMed research international.
2018; 2018(?):2079195. doi:
10.1155/2018/2079195. [PMID: 29850488] - Yuan Chen, Kangquan Shou, Chunlong Gong, Huarui Yang, Yi Yang, Tongzhu Bao. Anti-Inflammatory Effect of Geniposide on Osteoarthritis by Suppressing the Activation of p38 MAPK Signaling Pathway.
BioMed research international.
2018; 2018(?):8384576. doi:
10.1155/2018/8384576. [PMID: 29682561] - Bing Li, Jun Liu, Yanan Yu, Pengqian Wang, Yingying Zhang, Xumin Ni, Qiong Liu, Xiaoxu Zhang, Zhong Wang, Yongyan Wang. Network-Wide Screen Identifies Variation of Novel Precise On-Module Targets Using Conformational Modudaoism.
CPT: pharmacometrics & systems pharmacology.
2018 01; 7(1):16-25. doi:
10.1002/psp4.12253. [PMID: 28925077] - Haixia Li, Jingtao Wang, Pengqian Wang, Yingying Zhang, Jun Liu, Yanan Yu, Bing Li, Zhong Wang. Gene Expression Profiling Confirms the Dosage-Dependent Additive Neuroprotective Effects of Jasminoidin in a Mouse Model of Ischemia-Reperfusion Injury.
BioMed research international.
2018; 2018(?):2785636. doi:
10.1155/2018/2785636. [PMID: 29862259] - Yubin Xu, Song Guo, Guirong Chen, Mingbo Zhang, Xu Zhang, Deqiang Dou. Evaluation of anti-sepsis activity by compounds with high affinity to lipid a from HuanglianJiedu decoction.
Immunopharmacology and immunotoxicology.
2017 Dec; 39(6):364-370. doi:
10.1080/08923973.2017.1380661. [PMID: 28975862] - Wei-Wei Ma, Ye Tao, Yan-Ying Wang, I-Feng Peng. Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease.
Chinese journal of natural medicines.
2017 Dec; 15(12):899-904. doi:
10.1016/s1875-5364(18)30005-0. [PMID: 29329646]