C42H82NO10P (BioDeep_00001103544)
代谢物信息卡片
C42H82NO10P
化学式: C42H82NO10P (791.5676042)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC
InChI: InChI=1S/C42H82NO10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ffion B Thomas, Deike J Omnus, Jakob M Bader, Gary Hc Chung, Nozomu Kono, Christopher J Stefan. Tricalbin proteins regulate plasma membrane phospholipid homeostasis.
Life science alliance.
2022 08; 5(8):. doi:
10.26508/lsa.202201430. [PMID: 35440494] - Dominik Herrmann, Heather M Hanson, Lynne W Zhou, Rayna Addabbo, Nora A Willkomm, Isaac Angert, Joachim D Mueller, Louis M Mansky, Jamil S Saad. Molecular Determinants of Human T-cell Leukemia Virus Type 1 Gag Targeting to the Plasma Membrane for Assembly.
Journal of molecular biology.
2022 Jun; 434(12):167609. doi:
10.1016/j.jmb.2022.167609. [PMID: 35490898] - Izabella A Andrianova, Alina I Khabirova, Anastasia A Ponomareva, Alina D Peshkova, Natalia G Evtugina, Giang Le Minh, Timur B Sibgatullin, John W Weisel, Rustem I Litvinov. Chronic Immune Platelet Activation Is Followed by Platelet Refractoriness and Impaired Contractility.
International journal of molecular sciences.
2022 Jun; 23(13):. doi:
10.3390/ijms23137336. [PMID: 35806341] - Mussie K Araya, Alemayehu A Gorfe. Phosphatidylserine and Phosphatidylethanolamine Asymmetry Have a Negligible Effect on the Global Structure, Dynamics, and Interactions of the KRAS Lipid Anchor.
The journal of physical chemistry. B.
2022 06; 126(24):4491-4500. doi:
10.1021/acs.jpcb.2c01253. [PMID: 35687481] - Mingming Ji, Meng Li, Long Sun, Hongyu Zhao, Ying Li, Lulu Zhou, Zhenni Yang, Xin Zhao, Wenyan Qu, Hanbing Xue, Ze Zheng, Yiming Li, Hongyu Deng, Yan G Zhao. VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection.
The Journal of cell biology.
2022 06; 221(6):. doi:
10.1083/jcb.202112081. [PMID: 35536318] - Mikhail Matveyenka, Stanislav Rizevsky, Dmitry Kurouski. The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates.
FEBS letters.
2022 06; 596(11):1424-1433. doi:
10.1002/1873-3468.14369. [PMID: 35510803] - Dianne E van der Wal, Laura M Rey Gomez, Thomas Hueneburg, Claire Linnane, Denese C Marks. Changes in glycans on platelet microparticles released during storage of apheresis platelets are associated with phosphatidylserine externalization and phagocytosis.
Transfusion.
2022 06; 62(6):1289-1301. doi:
10.1111/trf.16891. [PMID: 35467785] - Cheng Mei, Fang Peng, Wenyu Yin, Wei Xu, Run Yao, Bijuan Li, Rongrong Zhou, Xuegong Fan, Ning Li. Increased suicidal erythrocyte death in patients with hepatitis B-related acute-on-chronic liver failure.
American journal of physiology. Gastrointestinal and liver physiology.
2022 06; 323(1):G9-G20. doi:
10.1152/ajpgi.00050.2020. [PMID: 35411804] - Azadeh Alavizargar, Annegret Elting, Roland Wedlich-Söldner, Andreas Heuer. Lipid-Mediated Association of the Slg1 Transmembrane Domains in Yeast Plasma Membranes.
The journal of physical chemistry. B.
2022 05; 126(17):3240-3256. doi:
10.1021/acs.jpcb.2c00192. [PMID: 35446028] - Yuki Ochiai, Chigure Suzuki, Katsumori Segawa, Yasuo Uchiyama, Shigekazu Nagata. Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta.
Proceedings of the National Academy of Sciences of the United States of America.
2022 05; 119(18):e2200582119. doi:
10.1073/pnas.2200582119. [PMID: 35476530] - Maryam Darabi, Marie Lhomme, Veronica D Dahik, Isabelle Guillas, Eric Frisdal, Emilie Tubeuf, Lucie Poupel, Mili Patel, Emmanuel L Gautier, Thierry Huby, Maryse Guerin, Kerry-Anne Rye, Philippe Lesnik, Wilfried Le Goff, Anatol Kontush. Phosphatidylserine enhances anti-inflammatory effects of reconstituted HDL in macrophages via distinct intracellular pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2022 05; 36(5):e22274. doi:
10.1096/fj.201800810r. [PMID: 35416331] - Jaco Botha, Aase Handberg, Jens B Simonsen. Lipid-based strategies used to identify extracellular vesicles in flow cytometry can be confounded by lipoproteins: Evaluations of annexin V, lactadherin, and detergent lysis.
Journal of extracellular vesicles.
2022 04; 11(4):e12200. doi:
10.1002/jev2.12200. [PMID: 35362259] - Sarah L Millington-Burgess, Matthew T Harper. Maintaining flippase activity in procoagulant platelets is a novel approach to reducing thrombin generation.
Journal of thrombosis and haemostasis : JTH.
2022 04; 20(4):989-995. doi:
10.1111/jth.15641. [PMID: 35034417] - Ignazio Restivo, Alessandro Attanzio, Luisa Tesoriere, Mario Allegra, Guadalupe Garcia-Llatas, Antonio Cilla. Anti-Eryptotic Activity of Food-Derived Phytochemicals and Natural Compounds.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23063019. [PMID: 35328440] - Margarita A Savitskaya, Ilya I Zakharov, Galina E Onishchenko. Apoptotic Features in Non-Apoptotic Processes.
Biochemistry. Biokhimiia.
2022 Mar; 87(3):191-206. doi:
10.1134/s0006297922030014. [PMID: 35526851] - Stephan Hasse, Anne-Sophie Julien, Anne-Claire Duchez, Chenqi Zhao, Eric Boilard, Paul R Fortin, Sylvain G Bourgoin. Red blood cell-derived phosphatidylserine positive extracellular vesicles are associated with past thrombotic events in patients with systemic erythematous lupus.
Lupus science & medicine.
2022 03; 9(1):. doi:
10.1136/lupus-2021-000605. [PMID: 35260475] - Divyani Paul, James H Morrissey. Stoichiometric analysis reveals a unique phosphatidylserine binding site in coagulation factor X.
Journal of thrombosis and haemostasis : JTH.
2022 03; 20(3):600-604. doi:
10.1111/jth.15620. [PMID: 34894064] - Hugo Bisio, Aarti Krishnan, Jean-Baptiste Marq, Dominique Soldati-Favre. Toxoplasma gondii phosphatidylserine flippase complex ATP2B-CDC50.4 critically participates in microneme exocytosis.
PLoS pathogens.
2022 03; 18(3):e1010438. doi:
10.1371/journal.ppat.1010438. [PMID: 35325010] - Yohann Garnier, Livia Claude, Patricia Hermand, Evely Sachou, Aurélie Claes, Kassandra Desplan, Bassel Chahim, Pierre-Marie Roger, Frédéric Martino, Yves Colin, Caroline Le Van Kim, Véronique Baccini, Marc Romana. Plasma microparticles of intubated COVID-19 patients cause endothelial cell death, neutrophil adhesion and netosis, in a phosphatidylserine-dependent manner.
British journal of haematology.
2022 03; 196(5):1159-1169. doi:
10.1111/bjh.18019. [PMID: 34962643] - Tetsuo Mioka, Tian Guo, Shiyao Wang, Takuma Tsuji, Takuma Kishimoto, Toyoshi Fujimoto, Kazuma Tanaka. Characterization of micron-scale protein-depleted plasma membrane domains in phosphatidylserine-deficient yeast cells.
Journal of cell science.
2022 03; 135(5):. doi:
10.1242/jcs.256529. [PMID: 34000034] - Yuta Ryoden, Katsumori Segawa, Shigekazu Nagata. Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells.
Proceedings of the National Academy of Sciences of the United States of America.
2022 02; 119(7):. doi:
10.1073/pnas.2119286119. [PMID: 35140185] - Xiu Guo Gan, Hai Tao Xu, Zhi Hao Wang. Phosphatidylserine eversion regulated by phospholipid scramblase activated by TGF-β1/Smad signaling in the early stage of kidney stone formation.
Urolithiasis.
2022 Feb; 50(1):11-20. doi:
10.1007/s00240-021-01292-0. [PMID: 34860265] - Dianne E van der Wal, April M Davis, Denese C Marks. Donor citrate reactions influence the phenotype of apheresis platelets following storage.
Transfusion.
2022 02; 62(2):273-278. doi:
10.1111/trf.16729. [PMID: 34761380] - Nan Zuo, Wenhui Liu, Tenglong Hu, Yingmiao Liu, Baorong Li, Huan Liu, Haijiao Jing, Xiaojing Chen, Yueyue Li, Jingwen Du, Tianshui Hu, Zengxiang Dong, Yumei Niu, Jialan Shi. Microvesicles, blood cells, and endothelial cells mediate phosphatidylserine-related prothrombotic state in patients with periodontitis.
Journal of periodontology.
2022 02; 93(2):287-297. doi:
10.1002/jper.21-0025. [PMID: 34155635] - Svetlana Varyukhina, Antonin Lamazière, Jean Louis Delaunay, Anaëlle de Wreede, Jesus Ayala-Sanmartin. The Ca2+- and phospholipid-binding protein Annexin A2 is able to increase and decrease plasma membrane order.
Biochimica et biophysica acta. Biomembranes.
2022 02; 1864(1):183810. doi:
10.1016/j.bbamem.2021.183810. [PMID: 34699769] - Michael N Trinh, Michael S Brown, Joachim Seemann, Gonçalo Vale, Jeffrey G McDonald, Joseph L Goldstein, Feiran Lu. Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol.
Proceedings of the National Academy of Sciences of the United States of America.
2022 01; 119(2):. doi:
10.1073/pnas.2120411119. [PMID: 34992143] - Xiaoli Zhao, Xiaomin Ma, John H Dupius, Ruxi Qi, Jenny Jingxin Tian, Jiaxin Chen, Xiuyuan Ou, Zhaohui Qian, Dehai Liang, Peiyi Wang, Rickey Y Yada, Shenlin Wang. Negatively charged phospholipids accelerate the membrane fusion activity of the plant-specific insert domain of an aspartic protease.
The Journal of biological chemistry.
2022 01; 298(1):101430. doi:
10.1016/j.jbc.2021.101430. [PMID: 34801553] - Takeshi Yoshida, Rikinari Hanayama. TIM4-Affinity Methods Targeting Phosphatidylserine for Isolation or Detection of Extracellular Vesicles.
Methods in molecular biology (Clifton, N.J.).
2022; 2466(?):23-36. doi:
10.1007/978-1-0716-2176-9_2. [PMID: 35585308] - Walaa E Kattan, Junchen Liu, Dina Montufar-Solis, Hong Liang, Bhargavi Brahmendra Barathi, Ransome van der Hoeven, Yong Zhou, John F Hancock. Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2021 12; 118(51):. doi:
10.1073/pnas.2114126118. [PMID: 34903667] - Xiaoran Li, Siyu Chen, Demei Feng, Yuqiang Fu, Huang Wu, Jianzhong Lu, Junsheng Bao. Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression.
Renal failure.
2021 Dec; 43(1):465-476. doi:
10.1080/0886022x.2021.1881554. [PMID: 33678127] - Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim, Rudi Gruber, Elina F Oesterhaus, Linus Rinke, Johannes C Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Christopher Mandel, Michael Bergwelt-Baildon, Mikael Simons, Tobias Straub, Anne B Krug, Jan Kranich, Thomas Brocker. Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients.
Journal of extracellular vesicles.
2021 12; 10(14):e12173. doi:
10.1002/jev2.12173. [PMID: 34854246] - Souade Ikhlef, Nicolas-Frédéric Lipp, Vanessa Delfosse, Nicolas Fuggetta, William Bourguet, Maud Magdeleine, Guillaume Drin. Functional analyses of phosphatidylserine/PI(4)P exchangers with diverse lipid species and membrane contexts reveal unanticipated rules on lipid transfer.
BMC biology.
2021 11; 19(1):248. doi:
10.1186/s12915-021-01183-1. [PMID: 34801011] - Yasuyo Yamaoka, Seungjun Shin, Yuree Lee, Masaki Ito, Youngsook Lee, Ikuo Nishida. Phosphatidylserine Is Required for the Normal Progression of Cell Plate Formation in Arabidopsis Root Meristems.
Plant & cell physiology.
2021 Nov; 62(9):1396-1408. doi:
10.1093/pcp/pcab086. [PMID: 34115854] - Jianhui Weng, Yuqi Wang, Yan Zhang, Deju Ye. An Activatable Near-Infrared Fluorescence Probe for in Vivo Imaging of Acute Kidney Injury by Targeting Phosphatidylserine and Caspase-3.
Journal of the American Chemical Society.
2021 11; 143(43):18294-18304. doi:
10.1021/jacs.1c08898. [PMID: 34672197] - Daniel Kerr, Zhiliang Gong, Tiffany Suwatthee, Adrienne Luoma, Sobhan Roy, Renee Scarpaci, Hyeondo Luke Hwang, J Michael Henderson, Kathleen D Cao, Wei Bu, Binhua Lin, Gregory T Tietjen, Theodore L Steck, Erin J Adams, Ka Yee C Lee. How Tim proteins differentially exploit membrane features to attain robust target sensitivity.
Biophysical journal.
2021 11; 120(21):4891-4902. doi:
10.1016/j.bpj.2021.09.016. [PMID: 34529946] - Claudia Gomes, Marisol Zuniga, Kelly A Crotty, Kun Qian, Nubia Catalina Tovar, Lawrence Hsu Lin, Kimon V Argyropoulos, Robert Clancy, Peter Izmirly, Jill Buyon, David C Lee, Maria Fernanda Yasnot-Acosta, Huilin Li, Paolo Cotzia, Ana Rodriguez. Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19.
Life science alliance.
2021 11; 4(11):. doi:
10.26508/lsa.202101180. [PMID: 34504035] - Yoritaka Fujii, Makoto Taniguchi, Shingo Nagaya, Yoshibumi Ueda, Chieko Hashizume, Ken Watanabe, Hiroyuki Takeya, Takeo Kosaka, Toshiro Okazaki. A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency.
Blood advances.
2021 10; 5(20):4265-4277. doi:
10.1182/bloodadvances.2020002922. [PMID: 34478523] - Benjamin Marchandot, Adrien Carmona, Antonin Trimaille, Anais Curtiaud, Olivier Morel. Procoagulant microparticles: a possible link between vaccine-induced immune thrombocytopenia (VITT) and cerebral sinus venous thrombosis.
Journal of thrombosis and thrombolysis.
2021 10; 52(3):689-691. doi:
10.1007/s11239-021-02505-4. [PMID: 34129181] - Akvile Haeckel, Lena Ascher, Nicola Beindorff, Sonal Prasad, Karolina Garczyńska, Jing Guo, Eyk Schellenberger. Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications.
Apoptosis : an international journal on programmed cell death.
2021 10; 26(9-10):534-547. doi:
10.1007/s10495-021-01686-w. [PMID: 34405304] - Long Xie, Da-Ming Xu, Xin-Jian Cai, Ze-Wen Zhang, Wen-Jun Yu, Jin-Feng Qiu, Cheng-Wei Xu, Chun-Ling He, Xian-Ru Xu, Jun Yin. Apoptosis in platelets from adult patients with chronic idiopathic thrombocytopenic purpura.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2021 Oct; 32(7):434-442. doi:
10.1097/mbc.0000000000001054. [PMID: 34102655] - Ingrid Nygren Rognes, Marit Hellum, William Ottestad, Kristi Grønvold Bache, Torsten Eken, Carola Elisabeth Henriksson. Extracellular vesicle-associated procoagulant activity is highest the first 3 hours after trauma and thereafter declines substantially: A prospective observational pilot study.
The journal of trauma and acute care surgery.
2021 10; 91(4):681-691. doi:
10.1097/ta.0000000000003333. [PMID: 34225342] - Stephan Hasse, Anne-Claire Duchez, Paul Fortin, Eric Boilard, Sylvain G Bourgoin. Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes.
Biochemical pharmacology.
2021 10; 192(?):114667. doi:
10.1016/j.bcp.2021.114667. [PMID: 34216604] - Surbhi Chaudhary, Anil Patidar, Asmita Dhiman, Gaurav Kumar Chaubey, Rahul Dilawari, Sharmila Talukdar, Radheshyam Modanwal, Manoj Raje. Exposure of a specific pleioform of multifunctional glyceraldehyde 3-phosphate dehydrogenase initiates CD14-dependent clearance of apoptotic cells.
Cell death & disease.
2021 09; 12(10):892. doi:
10.1038/s41419-021-04168-8. [PMID: 34593755] - Marissa D Acciani, Maria F Lay Mendoza, Katherine E Havranek, Avery M Duncan, Hersha Iyer, Olivia L Linn, Melinda A Brindley. Ebola Virus Requires Phosphatidylserine Scrambling Activity for Efficient Budding and Optimal Infectivity.
Journal of virology.
2021 09; 95(20):e0116521. doi:
10.1128/jvi.01165-21. [PMID: 34319156] - Hema Adhikari, Walaa E Kattan, Shivesh Kumar, Pei Zhou, John F Hancock, Christopher M Counter. Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
Nature communications.
2021 09; 12(1):5248. doi:
10.1038/s41467-021-25523-5. [PMID: 34504076] - Tamara Muhlberger, Melisa Micaela Balach, Carlos Gastón Bisig, Verónica Silvina Santander, Noelia Edith Monesterolo, Cesar Horacio Casale, Alexis Nazareno Campetelli. Inhibition of flippase-like activity by tubulin regulates phosphatidylserine exposure in erythrocytes from hypertensive and diabetic patients.
Journal of biochemistry.
2021 Sep; 169(6):731-745. doi:
10.1093/jb/mvab016. [PMID: 33576821] - Andrew King On Wong, Barry Paul Young, Christopher J R Loewen. Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism.
The Journal of cell biology.
2021 09; 220(9):. doi:
10.1083/jcb.201910161. [PMID: 34259806] - Efthimia G Pavlou, Hara T Georgatzakou, Sotirios P Fortis, Konstantina A Tsante, Andreas G Tsantes, Efrosyni G Nomikou, Athanasia I Kapota, Dimitrios I Petras, Maria S Venetikou, Effie G Papageorgiou, Marianna H Antonelou, Anastasios G Kriebardis. Coagulation Abnormalities in Renal Pathology of Chronic Kidney Disease: The Interplay between Blood Cells and Soluble Factors.
Biomolecules.
2021 09; 11(9):. doi:
10.3390/biom11091309. [PMID: 34572522] - Hongyin Yu, Zelong Wang, Zhanni Li, Yao An, Meishan Yan, Shuting Ji, Minghui Xu, Liqiu Wang, Weijun Dong, Jialan Shi, Chunyan Gao. Hyperuricemia enhances procoagulant activity of vascular endothelial cells through TMEM16F regulated phosphatidylserine exposure and microparticle release.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 09; 35(9):e21808. doi:
10.1096/fj.202100426r. [PMID: 34390515] - Takuya Shimura, Makoto Kurano, Koh Okamoto, Daisuke Jubishi, Kuniyuki Kano, Koji Igarashi, Satoshi Shimamoto, Junken Aoki, Kyoji Moriya, Yutaka Yatomi. Increase in serum levels of phosphatidylserine-specific phospholipase A1 in COVID-19 patients.
Cellular & molecular immunology.
2021 09; 18(9):2275-2277. doi:
10.1038/s41423-021-00744-2. [PMID: 34321622] - Shuoqi Zhang, Yuze Cao, Jingwen Du, Huan Liu, Xiaojing Chen, Mengdi Li, Mengqi Xiang, Chengyue Wang, Xiaoming Wu, Langjiao Liu, Chunli Wang, Yinsong Wu, Zhuxin Li, Shaohong Fang, Jialan Shi, Lihua Wang. Neutrophil extracellular traps contribute to tissue plasminogen activator resistance in acute ischemic stroke.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 09; 35(9):e21835. doi:
10.1096/fj.202100471rr. [PMID: 34449927] - Nícolas Glanzmann, Luciana Maria Ribeiro Antinarelli, Isabelle Karine da Costa Nunes, Henrique Marcelo Gualberto Pereira, Eduardo Antonio Ferraz Coelho, Elaine Soares Coimbra, Adilson David da Silva. Synthesis and biological activity of novel 4-aminoquinoline/1,2,3-triazole hybrids against Leishmania amazonensis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111857. doi:
10.1016/j.biopha.2021.111857. [PMID: 34323702] - Juan Rivera-Correa, Joseph Verdi, Julian Sherman, Jeremy M Sternberg, Jayne Raper, Ana Rodriguez. Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.
PLoS neglected tropical diseases.
2021 09; 15(9):e0009814. doi:
10.1371/journal.pntd.0009814. [PMID: 34587165] - Yeming Yang, Kuanxiang Sun, Wenjing Liu, Xiao Li, Wanli Tian, Ping Shuai, Xianjun Zhu. The phosphatidylserine flippase β-subunit Tmem30a is essential for normal insulin maturation and secretion.
Molecular therapy : the journal of the American Society of Gene Therapy.
2021 09; 29(9):2854-2872. doi:
10.1016/j.ymthe.2021.04.026. [PMID: 33895325] - Anne Sofie Busk Heitmann, Ali Asghar Hakami Zanjani, Martin Berg Klenow, Anna Mularski, Stine Lauritzen Sønder, Frederik Wendelboe Lund, Theresa Louise Boye, Catarina Dias, Poul Martin Bendix, Adam Cohen Simonsen, Himanshu Khandelia, Jesper Nylandsted. Phenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair.
The Journal of biological chemistry.
2021 08; 297(2):101012. doi:
10.1016/j.jbc.2021.101012. [PMID: 34324830] - Shuli Chou, Qiuke Li, Hua Wu, Jinze Li, Yung-Fu Chang, Lu Shang, Jiawei Li, Zhihua Wang, Anshan Shan. Selective Antifungal Activity and Fungal Biofilm Inhibition of Tryptophan Center Symmetrical Short Peptide.
International journal of molecular sciences.
2021 Jul; 22(15):. doi:
10.3390/ijms22158231. [PMID: 34360998] - Hao-Hao Shi, Cheng-Cheng Wang, Lin Ding, Xiang-Zhao Mao, Chang-Hu Xue, Teruyoshi Yanagita, Tian-Tian Zhang, Yu-Ming Wang. Comparative evaluation of phosphatidylcholine and phosphatidylserine with different fatty acids on nephrotoxicity in vancomycin-induced mice.
Bioscience, biotechnology, and biochemistry.
2021 Jul; 85(8):1873-1884. doi:
10.1093/bbb/zbab105. [PMID: 34196365] - Kristen A Johnson, Nisha Bhattarai, Melissa R Budicini, Carolyn M LaBonia, Sarah Catherine B Baker, Bernard S Gerstman, Prem P Chapagain, Robert V Stahelin. Cysteine Mutations in the Ebolavirus Matrix Protein VP40 Promote Phosphatidylserine Binding by Increasing the Flexibility of a Lipid-Binding Loop.
Viruses.
2021 07; 13(7):. doi:
10.3390/v13071375. [PMID: 34372582] - Marta Vomero, Annacarla Finucci, Cristiana Barbati, Tania Colasanti, Fulvia Ceccarelli, Lucia Novelli, Laura Massaro, Simona Truglia, Chiara Pensa, Francesca Romana Mauro, Roberto Foà, Guido Valesini, Fabrizio Conti, Cristiano Alessandri. Increased eryptosis in patients with primary antiphospholipid syndrome (APS): a new actor in the pathogenesis of APS.
Clinical and experimental rheumatology.
2021 Jul; 39(4):838-843. doi:
NULL. [PMID: 33124577] - Yang Zhao, Stephan Hasse, Sylvain G Bourgoin. Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise.
Progress in lipid research.
2021 07; 83(?):101112. doi:
10.1016/j.plipres.2021.101112. [PMID: 34166709] - Senthil Arumugam, Stefanie Schmieder, Weria Pezeshkian, Ulrike Becken, Christian Wunder, Dan Chinnapen, John Hjort Ipsen, Anne K Kenworthy, Wayne Lencer, Satyajit Mayor, Ludger Johannes. Ceramide structure dictates glycosphingolipid nanodomain assembly and function.
Nature communications.
2021 06; 12(1):3675. doi:
10.1038/s41467-021-23961-9. [PMID: 34135326] - Rahul Vijay, Jenna J Guthmiller, Alexandria J Sturtz, Sequoia Crooks, Jordan T Johnson, Lei Li, Linda Yu-Ling Lan, Rosemary L Pope, Yani Chen, Kai J Rogers, Nirmal Dutta, Jason E Toombs, Mary E Wilson, Patrick C Wilson, Wendy Maury, Rolf A Brekken, Noah S Butler. Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation.
The Journal of experimental medicine.
2021 06; 218(6):. doi:
10.1084/jem.20202359. [PMID: 33830176] - Wenjing Liu, Lei Peng, Wanli Tian, Yi Li, Ping Zhang, Kuanxiang Sun, Yeming Yang, Xiao Li, Guisen Li, Xianjun Zhu. Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis.
Disease models & mechanisms.
2021 06; 14(6):. doi:
10.1242/dmm.048777. [PMID: 34080006] - Masahiro Maruoka, Jun Suzuki. Regulation of phospholipid dynamics in brain.
Neuroscience research.
2021 Jun; 167(?):30-37. doi:
10.1016/j.neures.2021.01.003. [PMID: 33476682] - Arsila P K Ashraf, Volker Gerke. Plasma membrane wound repair is characterized by extensive membrane lipid and protein rearrangements in vascular endothelial cells.
Biochimica et biophysica acta. Molecular cell research.
2021 06; 1868(7):118991. doi:
10.1016/j.bbamcr.2021.118991. [PMID: 33667528] - Keigo Murakami, Masashi Sato, Yoshiya Miyasaka, Kuniyuki Hatori. Selective association of desmin intermediate filaments with a phospholipid layer in droplets.
Biochemical and biophysical research communications.
2021 05; 555(?):109-114. doi:
10.1016/j.bbrc.2021.03.131. [PMID: 33813269] - Rachel A Smith, Tosti J Mankelow, Despoina Drizou, Thomas Bullock, Tom Latham, Sara Trompeter, Allison Blair, David J Anstee. Large red cell-derived membrane particles are major contributors to hypercoagulability in sickle cell disease.
Scientific reports.
2021 05; 11(1):11035. doi:
10.1038/s41598-021-90477-z. [PMID: 34040079] - Yafeng Zhou, Shanshan Tian, Li Qian, Su Jiang, Yunping Tang, Tao Han. DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet.
Food & function.
2021 May; 12(9):4021-4033. doi:
10.1039/d0fo03471a. [PMID: 33977946] - Tamihiro Kawakami, Yuto Tamura, Yupeng Dong, Miku Yoshinari, Yuka Nishibata, Sakiko Masuda, Utano Tomaru, Akihiro Ishizu. Anti-phosphatidylserine/prothrombin complex antibodies in patients with cutaneous vasculitis: Possible involvement in the pathogenesis.
The Journal of dermatology.
2021 May; 48(5):703-706. doi:
10.1111/1346-8138.15810. [PMID: 33600009] - Jihe Li, Dongxia Tong, Fuyang Chen, Bin Song, Ying Wang, Yue Liu, Xiaohui Zhang, Na Liu, Yang Xu, Yang Li, Xinhua Yin, Wenxiu Liu. Inflammatory cytokines enhance procoagulant activity of platelets and endothelial cells through phosphatidylserine exposure in patients with essential hypertension.
Journal of thrombosis and thrombolysis.
2021 May; 51(4):933-940. doi:
10.1007/s11239-020-02342-x. [PMID: 33219895] - Bruna Taciane da Silva Bortoleti, Manoela Daiele Gonçalves, Fernanda Tomiotto-Pellissier, Virginia Marcia Contato, Taylon Felipe Silva, Ricardo Luís Nascimento de Matos, Mariana Barbosa Detoni, Ana Carolina Jacob Rodrigues, Amanda Cristina Carloto, Danielle Bidóia Lazarin, Nilton Syogo Arakawa, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Pryscilla Fanini Wowk, Wander Rogério Pavanelli. Solidagenone acts on promastigotes of L. amazonensis by inducing apoptosis-like processes on intracellular amastigotes by IL-12p70/ROS/NO pathway activation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 May; 85(?):153536. doi:
10.1016/j.phymed.2021.153536. [PMID: 33765552] - Sang-Ah Lee, Juyeon Lee, Kwanhyeong Kim, Hyunji Moon, Chanhyuk Min, Byeongjin Moon, Deokhwan Kim, Susumin Yang, Hyunjin Park, Gwangrog Lee, Raekil Park, Daeho Park. The Peroxisomal Localization of Hsd17b4 Is Regulated by Its Interaction with Phosphatidylserine.
Molecules and cells.
2021 Apr; 44(4):214-222. doi:
10.14348/molcells.2021.2217. [PMID: 33935042] - Jozef Pisko, Alexandra Špirková, Štefan Čikoš, Lucia Olexiková, Veronika Kovaříková, Zuzana Šefčíková, Dušan Fabian. Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres.
Scientific reports.
2021 04; 11(1):9228. doi:
10.1038/s41598-021-88752-0. [PMID: 33927296] - Sulian Lv, Fang Tai, Jie Guo, Ping Jiang, Kangqi Lin, Duoliya Wang, Xuan Zhang, Yinxin Li. Phosphatidylserine Synthase from Salicornia europaea Is Involved in Plant Salt Tolerance by Regulating Plasma Membrane Stability.
Plant & cell physiology.
2021 Mar; 62(1):66-79. doi:
10.1093/pcp/pcaa141. [PMID: 33141223] - Audrey Connolly, Rébecca Panes, Margaux Tual, Raphaël Lafortune, Angélique Bellemare-Pelletier, Etienne Gagnon. TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation.
Science signaling.
2021 03; 14(675):. doi:
10.1126/scisignal.abb5146. [PMID: 33758060] - Bilge Ercan, Tomoki Naito, Dylan Hong Zheng Koh, Dennis Dharmawan, Yasunori Saheki. Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.
The EMBO journal.
2021 03; 40(6):e106524. doi:
10.15252/embj.2020106524. [PMID: 33604931] - Souade Ikhlef, Nicolas-Frédéric Lipp, Maud Magdeleine, Guillaume Drin. Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes.
Journal of visualized experiments : JoVE.
2021 03; ?(169):. doi:
10.3791/62177. [PMID: 33779604] - Steven J Foltz, Yuan Yuan Cui, Hyojung J Choo, H Criss Hartzell. ANO5 ensures trafficking of annexins in wounded myofibers.
The Journal of cell biology.
2021 03; 220(3):. doi:
10.1083/jcb.202007059. [PMID: 33496727] - Yong Zhou, Nicholas Ariotti, James Rae, Hong Liang, Vikas Tillu, Shern Tee, Michele Bastiani, Adekunle T Bademosi, Brett M Collins, Frederic A Meunier, John F Hancock, Robert G Parton. Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae.
The Journal of cell biology.
2021 03; 220(3):. doi:
10.1083/jcb.202005138. [PMID: 33496726] - Elena Pontara, Maria Grazia Cattini, Chunyan Cheng, Elisa Bison, Gentian Denas, Vittorio Pengo. Insight into the hypercoagulable state of high-risk thrombotic APS patients: Contribution of aβ2GPI and aPS/PT antibodies.
Journal of thrombosis and haemostasis : JTH.
2021 03; 19(3):805-813. doi:
10.1111/jth.15199. [PMID: 33249717] - Ning Wu, Hua Song, André Veillette. Plasma membrane lipid scrambling causing phosphatidylserine exposure negatively regulates NK cell activation.
Cellular & molecular immunology.
2021 03; 18(3):686-697. doi:
10.1038/s41423-020-00600-9. [PMID: 33469162] - Karina Althaus, Irene Marini, Jan Zlamal, Lisann Pelzl, Anurag Singh, Helene Häberle, Martin Mehrländer, Stefanie Hammer, Harald Schulze, Michael Bitzer, Nisar Malek, Dominik Rath, Hans Bösmüller, Bernard Nieswandt, Meinrad Gawaz, Tamam Bakchoul, Peter Rosenberger. Antibody-induced procoagulant platelets in severe COVID-19 infection.
Blood.
2021 02; 137(8):1061-1071. doi:
10.1182/blood.2020008762. [PMID: 33512415] - Yong Zhou, Priyanka S Prakash, Hong Liang, Alemayehu A Gorfe, John F Hancock. The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure.
Proceedings of the National Academy of Sciences of the United States of America.
2021 02; 118(6):. doi:
10.1073/pnas.2014605118. [PMID: 33526670] - Laura-Marie Winterstein, Kerri Kukovetz, Ulf-Peter Hansen, Indra Schroeder, James L Van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh. Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function.
The Journal of general physiology.
2021 02; 153(2):. doi:
10.1085/jgp.202012731. [PMID: 33439243] - Fatemeh Kiani Nodeh, Ehteramolsadat Hosseini, Mehran Ghasemzadeh. The effect of gamma irradiation on platelet redox state during storage.
Transfusion.
2021 02; 61(2):579-593. doi:
10.1111/trf.16207. [PMID: 33231307] - Merryn Fraser, Weidong Jing, Stefan Bröer, Florian Kurth, Leif-Erik Sander, Kai Matuschewski, Alexander G Maier. Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells.
PLoS pathogens.
2021 02; 17(2):e1009259. doi:
10.1371/journal.ppat.1009259. [PMID: 33600495] - Katherine J Kearney, Juliet Butler, Olga M Posada, Clare Wilson, Samantha Heal, Majid Ali, Lewis Hardy, Josefin Ahnström, David Gailani, Richard Foster, Emma Hethershaw, Colin Longstaff, Helen Philippou. Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI.
Proceedings of the National Academy of Sciences of the United States of America.
2021 01; 118(3):. doi:
10.1073/pnas.2014810118. [PMID: 33397811] - Monika Komeili, Farshid Noorbakhsh, Jamileh Esmaili, Ahad Muhammadnejad, Gholamreza Hassanzadeh, Ahmad Reza Dehpour, Ramin Goudarzi, Alireza Partoazar. Combination therapy of phosphatidylserine liposome with cyclosporine A improves nephrotoxicity and attenuates delayed-type hypersensitivity response.
Life sciences.
2021 Jan; 265(?):118780. doi:
10.1016/j.lfs.2020.118780. [PMID: 33217444] - Aml A Alnaas, Abena Watson-Siriboe, Sherleen Tran, Mikias Negussie, Jack A Henderson, J Ryan Osterberg, Nara L Chon, Beckston M Harrott, Julianna Oviedo, Tatyana Lyakhova, Cole Michel, Nichole Reisdorph, Richard Reisdorph, Colin T Shearn, Hai Lin, Jefferson D Knight. Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.
The Journal of biological chemistry.
2021 Jan; 296(?):100159. doi:
10.1074/jbc.ra120.014618. [PMID: 33277360] - Amber D Ide, Elise M Wight, Cynthia K Damer. Phosphatidylserine exposure promotes increased adhesion in Dictyostelium Copine A mutants.
PloS one.
2021; 16(5):e0250710. doi:
10.1371/journal.pone.0250710. [PMID: 34043641] - Eisuke Tomiyama, Kazutoshi Fujita, Norio Nonomura. Urinary Extracellular Vesicles: Ultracentrifugation Method.
Methods in molecular biology (Clifton, N.J.).
2021; 2292(?):173-181. doi:
10.1007/978-1-0716-1354-2_15. [PMID: 33651361] - Cong Zhang, Zhuowen Yang, Peng Zhou, Muxin Yu, Baorong Li, Yingmiao Liu, Jiaqi Jin, Wenhui Liu, Haijiao Jing, Jingwen Du, Jie Tian, Zhiyu Zhao, Jianxin Wang, Yinzhu Chu, ChunMei Zhang, Valerie A Novakovic, Jialan Shi, Changjun Wu. Phosphatidylserine-exposing tumor-derived microparticles exacerbate coagulation and cancer cell transendothelial migration in triple-negative breast cancer.
Theranostics.
2021; 11(13):6445-6460. doi:
10.7150/thno.53637. [PMID: 33995667] - Alana MacDonald, Brandon Lam, John Lin, Louise Ferrall, Yu Jui Kung, Ya Chea Tsai, T-C Wu, Chien-Fu Hung. Delivery of IL-2 to the T Cell Surface Through Phosphatidylserine Permits Robust Expansion of CD8 T Cells.
Frontiers in immunology.
2021; 12(?):755995. doi:
10.3389/fimmu.2021.755995. [PMID: 34804041] - Shuko Mishima, Kayoko Kaneko, Yuka Okazaki, Chie Kohno, Atsuko Murashima. A woman with systemic lupus erythematosus, multiple pregnancy complications, and cerebral infarction who was only positive for phosphatidylserine-dependent antiprothrombin antibodies.
Modern rheumatology case reports.
2021 01; 5(1):47-51. doi:
10.1080/24725625.2020.1782030. [PMID: 33269657] - Qian-Long Peng, Chuang-Ye Li, Yao-Wang Zhao, Xin-Yuan Sun, Hong Liu, Jian-Ming Ouyang. Protective Effect of Degraded Porphyra yezoensis Polysaccharides on the Oxidative Damage of Renal Epithelial Cells and on the Adhesion and Endocytosis of Nanocalcium Oxalate Crystals.
Oxidative medicine and cellular longevity.
2021; 2021(?):6463281. doi:
10.1155/2021/6463281. [PMID: 33763169] - Mathivanan Chinnaraj, Vittorio Pengo, Nicola Pozzi. A Novel ELISA Assay for the Detection of Anti-Prothrombin Antibodies in Antiphospholipid Syndrome Patients at High Risk of Thrombosis.
Frontiers in immunology.
2021; 12(?):741589. doi:
10.3389/fimmu.2021.741589. [PMID: 34567006] - Gustavo A Argañaraz, Julys da Fonseca Palmeira, Enrique R Argañaraz. Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19.
Cell communication and signaling : CCS.
2020 12; 18(1):190. doi:
10.1186/s12964-020-00687-7. [PMID: 33357215] - Lizhou Zhang, Audrey S Richard, Cody B Jackson, Amrita Ojha, Hyeryun Choe. Phosphatidylethanolamine and Phosphatidylserine Synergize To Enhance GAS6/AXL-Mediated Virus Infection and Efferocytosis.
Journal of virology.
2020 12; 95(2):. doi:
10.1128/jvi.02079-20. [PMID: 33115868] - Partha Dabke, Graham Brogden, Hassan Y Naim, Anibh M Das. Ketogenic Diet: Impact on Cellular Lipids in Hippocampal Murine Neurons.
Nutrients.
2020 Dec; 12(12):. doi:
10.3390/nu12123870. [PMID: 33352829]