(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol (BioDeep_00001103464)
代谢物信息卡片
(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
化学式: C20H24N2O2 (324.18376839999996)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13?,14?,19?,20-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ryuta Asaumi, Ken-Ichi Nunoya, Yoshiyuki Yamaura, Kunal S Taskar, Yuichi Sugiyama. Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney.
CPT: pharmacometrics & systems pharmacology.
2022 07; 11(7):919-933. doi:
10.1002/psp4.12807. [PMID: 35570332] - Rajinder Bhardwaj, Julie L Collins, Joseph Stringfellow, Jennifer Madonia, Matt S Anderson, Jeri-Anne Finley, David A Stock, Vladimir Coric, Robert Croop, Richard Bertz. P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects.
Clinical pharmacology in drug development.
2022 07; 11(7):889-897. doi:
10.1002/cpdd.1088. [PMID: 35304977] - Tatsuya Kokawa, Hiroyuki Yamamoto, Mitsuaki Itoh, Akira Shimane, Hiroya Kawai, Tomofumi Takaya. Fever-Related Ventricular Fibrillation - Potential Adverse Effect of SARS-CoV-2 Vaccination in Patients With Brugada Syndrome.
Circulation journal : official journal of the Japanese Circulation Society.
2022 Feb; 86(3):474. doi:
10.1253/circj.cj-21-0750. [PMID: 34615807] - Alexander Burashnikov, Hector Barajas-Martinez, Robert Cox, Mark A Demitrack, Michael J Fossler, Michael Kramer, Robert B Kleiman, Peter Kowey, Charles Antzelevitch. Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk.
Heart rhythm.
2021 12; 18(12):2177-2186. doi:
10.1016/j.hrthm.2021.08.028. [PMID: 34481984] - J V Joviano-Santos, A Santos-Miranda, E A Neri, M H Fonseca-Alaniz, J E Krieger, A C Pereira, D Roman-Campos. SCN5A compound heterozygosity mutation in Brugada syndrome: Functional consequences and the implication for pharmacological treatment.
Life sciences.
2021 Aug; 278(?):119646. doi:
10.1016/j.lfs.2021.119646. [PMID: 34048814] - M Schneider, F Dron, E Cuinet, F Woehrlé. Comparative pharmacokinetic profile of cimicoxib in dogs and cats after IV administration.
Veterinary journal (London, England : 1997).
2021 Apr; 270(?):105625. doi:
10.1016/j.tvjl.2021.105625. [PMID: 33641805] - Tianjiao Lin, Jingyu Song, Xinting Pan, Youdong Wan, Ziqian Wu, Shaoyan Lv, Liangyu Mi, Yunyun Wang, Fei Tian. Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Feb; 27(?):e927968. doi:
10.12659/msm.927968. [PMID: 33582700] - Mutaib M Mashraqi, Navaneet Chaturvedi, Qamre Alam, Saleh Alshamrani, Mosa M Bahnass, Khurshid Ahmad, Amany I Alqosaibi, Mashael M Alnamshan, Syed Sayeed Ahmad, Mirza Masroor Ali Beg, Abha Mishra, Sibhghatulla Shaikh, Syed Mohd Danish Rizvi. Biocomputational Prediction Approach Targeting FimH by Natural SGLT2 Inhibitors: A Possible Way to Overcome the Uropathogenic Effect of SGLT2 Inhibitor Drugs.
Molecules (Basel, Switzerland).
2021 Jan; 26(3):. doi:
10.3390/molecules26030582. [PMID: 33499241] - Dong Ye, Anna Harder, Zhizhou Fang, Manuel Weinheimer, Loic Laplanche, Mario Mezler. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
Pharmaceutical research.
2020 Sep; 37(10):194. doi:
10.1007/s11095-020-02895-9. [PMID: 32918191] - Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Drug metabolism and pharmacokinetics.
2020 Aug; 35(4):389-396. doi:
10.1016/j.dmpk.2020.05.004. [PMID: 32690433] - Mauricio A García, Danae Contreras, Pablo M González. Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability.
Pharmaceutical research.
2020 Jun; 37(7):121. doi:
10.1007/s11095-020-02824-w. [PMID: 32514792] - Hans Friedrich Stabenau, Changyu Shen, Larisa G Tereshchenko, Jonathan W Waks. Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil.
Heart rhythm.
2020 03; 17(3):460-467. doi:
10.1016/j.hrthm.2019.09.017. [PMID: 31539628] - Hong Shen, Ming Yao, Michael Sinz, Punit Marathe, A David Rodrigues, Mingshe Zhu. Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Molecular pharmaceutics.
2019 09; 16(9):4065-4076. doi:
10.1021/acs.molpharmaceut.9b00472. [PMID: 31335150] - Jay W Mason, David G Strauss, Martino Vaglio, Fabio Badilini. Correction of the QRS duration for heart rate.
Journal of electrocardiology.
2019 May; 54(?):1-4. doi:
10.1016/j.jelectrocard.2019.02.005. [PMID: 30782546] - Shinsaku Yoshitomi, Yukitoshi Takahashi, Tokito Yamaguchi, Taikan Oboshi, Asako Horino, Hiroko Ikeda, Katsumi Imai, Tohru Okanishi, Mitsuko Nakashima, Hirotomo Saitsu, Naomichi Matsumoto, Jun Yoshimoto, Takako Fujita, Atsushi Ishii, Shinichi Hirose, Yushi Inoue. Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations.
Epileptic disorders : international epilepsy journal with videotape.
2019 Feb; 21(1):48-54. doi:
10.1684/epd.2019.1026. [PMID: 30782581] - Ana Leonor Pardo Campos Godoy, Natália Valadares de Moraes, Jhohann Richard de Lima Benzi, Vera Lucia Lanchote. Changes in tramadol enantioselective pharmacokinetics and metabolism in rats with experimental diabetes treated or not with insulin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Feb; 128(?):97-102. doi:
10.1016/j.ejps.2018.11.032. [PMID: 30502451] - Kenta Watanabe, Tadashi Tsubouchi, Toru Yamada, Eiichi Hinoi, Izuru Miyawaki. Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors.
The Journal of toxicological sciences.
2019; 44(7):441-457. doi:
10.2131/jts.44.441. [PMID: 31270301] - Qiong Wang, Haiyun Wang, Youyan Zhong, Qiang Zhang. Drug-Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats.
Drug design, development and therapy.
2019; 13(?):4207-4213. doi:
10.2147/dddt.s226948. [PMID: 31849452] - Stephy George, Margarita Taburyanskaya, Vicky Lewis. Probable drug-drug interaction between dabigatran and quinidine resulting in thrombin time rebound despite multiple idarucizumab doses.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2019 Jan; 30(1):42-46. doi:
10.1097/mbc.0000000000000782. [PMID: 30431448] - Ashish Dogra, Shipra Bhatt, Asmita Magotra, Anjna Sharma, Pankul Kotwal, Abhishek Gour, Priya Wazir, Gurdarshan Singh, Utpal Nandi. Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: A possible risk for long-term use.
Phytotherapy research : PTR.
2018 Oct; 32(10):1967-1974. doi:
10.1002/ptr.6123. [PMID: 29806225] - Juan G Ripoll, Mahrukh S Rizvi, Rebecca L King, Craig E Daniels. Severe Babesia microti infection presenting as multiorgan failure in an immunocompetent host.
BMJ case reports.
2018 May; 2018(?):. doi:
10.1136/bcr-2018-224647. [PMID: 29848533] - Sonia Goineau, Vincent Castagné. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers.
Journal of pharmacological and toxicological methods.
2018 Mar; 90(?):58-66. doi:
10.1016/j.vascn.2017.12.003. [PMID: 29274391] - Ryutaro Matsui, Ryutaro Hattori, Youhei Usami, Masumi Koyama, Yuki Hirayama, Emi Matsuba, Yukiya Hashimoto. Functional characteristics of a renal H+/lipophilic cation antiport system in porcine LLC-PK1 cells and rats.
Drug metabolism and pharmacokinetics.
2018 Feb; 33(1):96-102. doi:
10.1016/j.dmpk.2017.11.313. [PMID: 29338932] - Saul A Mullen, Patrick W Carney, Annie Roten, Michael Ching, Paul A Lightfoot, Leonid Churilov, Umesh Nair, Melody Li, Samuel F Berkovic, Steven Petrou, Ingrid E Scheffer. Precision therapy for epilepsy due to KCNT1 mutations: A randomized trial of oral quinidine.
Neurology.
2018 01; 90(1):e67-e72. doi:
10.1212/wnl.0000000000004769. [PMID: 29196578] - Zhou Meng, Harma Ellens, Joe Bentz. Extrapolation of Elementary Rate Constants of P-glycoprotein-Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells.
Drug metabolism and disposition: the biological fate of chemicals.
2017 02; 45(2):190-197. doi:
10.1124/dmd.116.072140. [PMID: 27856526] - Ricardo P Garay, George T Grossberg. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type.
Expert opinion on investigational drugs.
2017 Jan; 26(1):121-132. doi:
10.1080/13543784.2017.1267726. [PMID: 27936965] - Rao Mukkavilli, Gajanan Jadhav, Subrahmanyam Vangala. Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines.
Current pharmaceutical biotechnology.
2017; 18(14):1151-1158. doi:
10.2174/1389201019666180308091855. [PMID: 29521222] - Miki Fukao, Eri Kondo, Hiroki Nishino, Ryutaro Hattori, Asuka Horie, Yukiya Hashimoto. Presence of an H+/Quinidine Antiport System in Madin-Darby Canine Kidney Cells.
European journal of drug metabolism and pharmacokinetics.
2016 Dec; 41(6):819-824. doi:
10.1007/s13318-015-0314-1. [PMID: 26628429] - Suneetha Achanti, Raja Rajeswari Katta. High-throughput liquid chromatography tandem mass spectrometry method for simultaneous determination of fampridine, paroxetine, and quinidine in rat plasma: Application to in vivo perfusion study.
Journal of food and drug analysis.
2016 10; 24(4):866-875. doi:
10.1016/j.jfda.2016.03.004. [PMID: 28911626] - Charles P Taylor, Stephen F Traynelis, Joao Siffert, Laura E Pope, Rae R Matsumoto. Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use.
Pharmacology & therapeutics.
2016 08; 164(?):170-82. doi:
10.1016/j.pharmthera.2016.04.010. [PMID: 27139517] - Magdalena Bamburowicz-Klimkowska, Tadeusz Szost, Anna Małkowska, Mirosław Szutowski. QUINIDINE AND DOMPERIDONE INTERACTIONS IN THE RAT EXPERIMENTAL MODEL OF REPEATED ADMINISTRATION.
Acta poloniae pharmaceutica.
2016 07; 73(4):1057-1066. doi:
NULL. [PMID: 29648732] - Ken-Ichi Miyata, Yoshiaki Nakagawa, Yasuhisa Kimura, Kazumitsu Ueda, Miki Akamatsu. In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines.
Toxicology and applied pharmacology.
2016 May; 298(?):40-7. doi:
10.1016/j.taap.2016.03.008. [PMID: 26995013] - Adebanjo J Adegbola, Julius O Soyinka, Babatunde A Adeagbo, Sharon I Igbinoba, Thomas I Nathaniel. Alteration of the Disposition of Quinine in Healthy Volunteers After Concurrent Ciprofloxacin Administration.
American journal of therapeutics.
2016 Mar; 23(2):e398-404. doi:
10.1097/mjt.0000000000000087. [PMID: 25406952] - Li Liu, Ann C Collier, Jeanne M Link, Karen B Domino, David A Mankoff, Janet F Eary, Charles F Spiekerman, Peng Hsiao, Anand K Deo, Jashvant D Unadkat. Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Nov; 43(11):1795-804. doi:
10.1124/dmd.114.058685. [PMID: 26354948] - Jose Vicente, Jacob Simlund, Lars Johannesen, Frida Sundh, Jeffry Florian, Martin Ugander, Galen S Wagner, Raymond L Woosley, David G Strauss. Investigation of potential mechanisms of sex differences in quinidine-induced torsade de pointes risk.
Journal of electrocardiology.
2015 Jul; 48(4):533-8. doi:
10.1016/j.jelectrocard.2015.03.011. [PMID: 25796102] - Jianguo Sun, Ying Peng, Hui Wu, Xueyuan Zhang, Yunxi Zhong, Yanan Xiao, Fengyi Zhang, Huanhuan Qi, Lili Shang, Jianping Zhu, Yue Sun, Ke Liu, Jinghan Liu, Jiye A, Rodney J Y Ho, Guangji Wang. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms.
Drug metabolism and disposition: the biological fate of chemicals.
2015 May; 43(5):713-24. doi:
10.1124/dmd.114.060905. [PMID: 25681130] - Jose Vicente, Lars Johannesen, Jay W Mason, William J Crumb, Esther Pueyo, Norman Stockbridge, David G Strauss. Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil.
Journal of the American Heart Association.
2015 Apr; 4(4):. doi:
10.1161/jaha.114.001615. [PMID: 25870186] - Toyofumi Suzuki, Toshiro Fukami, Kazuo Tomono. Possible involvement of cationic-drug sensitive transport systems in the blood-to-brain influx and brain-to-blood efflux of amantadine across the blood-brain barrier.
Biopharmaceutics & drug disposition.
2015 Mar; 36(2):126-37. doi:
10.1002/bdd.1926. [PMID: 25410756] - Matthew R Durk, Jianghong Fan, Huadong Sun, Yingbo Yang, Henrianna Pang, K Sandy Pang, Inés A M de Lannoy. Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.
Pharmaceutical research.
2015 Mar; 32(3):1128-40. doi:
10.1007/s11095-014-1524-y. [PMID: 25319098] - Sharon I Igbinoba, Cyprian O Onyeji, Moses A Akanmu, Julius O Soyinka, Srirama Sarma V V Pullela, James M Cook, Thomas I Nathaniel. Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers.
Journal of clinical pharmacology.
2015 Mar; 55(3):348-54. doi:
10.1002/jcph.414. [PMID: 25328082] - Bogna Badyra, Bartosz Lisowski, Sebastian Polak, John Kudolo, Barbara Wiśniowska. How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction.
Folia medica Cracoviensia.
2015; 55(4):5-19. doi:
. [PMID: 26867116] - Lily P H Yang, Emma D Deeks. Dextromethorphan/quinidine: a review of its use in adults with pseudobulbar affect.
Drugs.
2015 Jan; 75(1):83-90. doi:
10.1007/s40265-014-0328-z. [PMID: 25420446] - Motoya Suzuki, Hiroshi Komura, Tomonori Yoshikawa, Seiji Enya, Akemi Nagao, Hiroaki Takubo, Motohiro Kogayu. Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Nov; 44(11):1039-45. doi:
10.3109/00498254.2014.920551. [PMID: 24839994] - Gang Xie, Ka-Wing Cheng, Liqun Huang, Basil Rigas. The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent.
Biochemical pharmacology.
2014 Sep; 91(2):249-55. doi:
10.1016/j.bcp.2014.07.007. [PMID: 25044307] - Laura Kervezee, Robin Hartman, Dirk-Jan van den Berg, Shinji Shimizu, Yumi Emoto-Yamamoto, Johanna H Meijer, Elizabeth C M de Lange. Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain.
The AAPS journal.
2014 Sep; 16(5):1029-37. doi:
10.1208/s12248-014-9625-4. [PMID: 24917180] - Yan Liu, Mingmao Chen, Shuaihua Wang, Jingjing Lin, Lizhen Cai, Ling Song. New insight into the stereoselective interactions of quinine and quinidine, with bovine serum albumin.
Journal of molecular recognition : JMR.
2014 May; 27(5):239-49. doi:
10.1002/jmr.2355. [PMID: 24700591] - Mitesh Patel, Nanda K Mandava, Dhananjay Pal, Ashim K Mitra. Amino acid prodrug of quinidine: an approach to circumvent P-glycoprotein mediated cellular efflux.
International journal of pharmaceutics.
2014 Apr; 464(1-2):196-204. doi:
10.1016/j.ijpharm.2014.01.006. [PMID: 24440401] - Dominik Gartzke, Gert Fricker. Establishment of optimized MDCK cell lines for reliable efflux transport studies.
Journal of pharmaceutical sciences.
2014 Apr; 103(4):1298-304. doi:
10.1002/jps.23901. [PMID: 24532159] - Kassoum Kayentao, Etienne A Guirou, Ogobara K Doumbo, Meera Venkatesan, Christopher V Plowe, Teresa L Parsons, Craig W Hendrix, Myaing M Nyunt. Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection.
The American journal of tropical medicine and hygiene.
2014 Mar; 90(3):530-534. doi:
10.4269/ajtmh.13-0655. [PMID: 24420779] - Xiaochun Zhu, Yuping Chen, Raju Subramanian. Comparison of information-dependent acquisition, SWATH, and MS(All) techniques in metabolite identification study employing ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Analytical chemistry.
2014 Jan; 86(2):1202-9. doi:
10.1021/ac403385y. [PMID: 24383719] - Makoto Miyazaki, Chisako Nishimura, Minori Minamida, Kazunori Iwanaga, Masawo Kakemi. Pharmacokinetic assessment of absorptive interaction of oral etoposide and morphine in rats.
Biological & pharmaceutical bulletin.
2014; 37(3):371-7. doi:
10.1248/bpb.b13-00716. [PMID: 24351551] - Linda Björkhem-Bergman, Tobias Bäckström, Hanna Nylén, Yuko Rönquist-Nii, Eva Bredberg, Tommy B Andersson, Leif Bertilsson, Ulf Diczfalusy. Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.
Drug metabolism and pharmacokinetics.
2014; 29(4):352-5. doi:
10.2133/dmpk.dmpk-13-sh-138. [PMID: 24522201] - Gary N Y Chan, Victor Saldivia, Yingbo Yang, Henrianna Pang, Inés de Lannoy, Reina Bendayan. In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study.
Journal of neurochemistry.
2013 Nov; 127(3):342-52. doi:
10.1111/jnc.12344. [PMID: 23777437] - Joost Westerhout, Jean Smeets, Meindert Danhof, Elizabeth C M de Lange. The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid.
Journal of pharmacokinetics and pharmacodynamics.
2013 Jun; 40(3):327-42. doi:
10.1007/s10928-013-9314-4. [PMID: 23539188] - Seok-Jeong Oh, Hyo-Kyung Han, Keon-Wook Kang, Young-Joo Lee, Moo-Yeol Lee. Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity.
Archives of pharmacal research.
2013 Apr; 36(4):509-16. doi:
10.1007/s12272-013-0052-3. [PMID: 23435914] - Swaroop Kumar Pandey, Hemlata Dwivedi, Sarika Singh, Waseem Ahmad Siddiqui, Renu Tripathi. Antimalarial interaction of quinine and quinidine with clarithromycin.
Parasitology.
2013 Mar; 140(3):406-13. doi:
10.1017/s003118201200176x. [PMID: 23137860] - Nilufer Rahmioglu, James Heaton, Gail Clement, Raj Gill, Gabriela Surdulescu, Karolina Zlobecka, Dylan Hodgkiss, Norman W Smith, Kourosh R Ahmadi. Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity.
European journal of drug metabolism and pharmacokinetics.
2013 Mar; 38(1):63-7. doi:
10.1007/s13318-012-0103-z. [PMID: 22945461] - Hania Habeeb, Jill R Ripper, Alice Cohen, Patrick B Hinfey. A case of imported severe plasmodium falciparum malaria in the emergency department and the current role of exchange transfusion treatment.
The Journal of emergency medicine.
2013 Feb; 44(2):e211-5. doi:
10.1016/j.jemermed.2012.02.051. [PMID: 22609412] - Georg B Ehret, Youssef Daali, Jocelyne Chabert, Michela Rebsamen, Adriana Wolff, Alain Forster, Fouzia Moursli, Daniel Fritschy, Michel F Rossier, Valérie Piguet, Pierre Dayer, Marianne Gex-Fabry, Jules A Desmeules. Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain.
Pain physician.
2013 Jan; 16(1):45-56. doi:
. [PMID: 23340533] - Sebastian Polak. In vitro to human in vivo translation - pharmacokinetics and pharmacodynamics of quinidine.
ALTEX.
2013; 30(3):309-18. doi:
10.14573/altex.2013.3.309. [PMID: 23861085] - Annie Albin Lumen, Libin Li, Jiben Li, Zeba Ahmed, Zhou Meng, Albert Owen, Harma Ellens, Ismael J Hidalgo, Joe Bentz. Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp.
PloS one.
2013; 8(8):e69394. doi:
10.1371/journal.pone.0069394. [PMID: 23976943] - Kazuya Ishida, Asuka Horie, Maki Nishimura, Masato Taguchi, Nozomu Fujii, Takashi Nozawa, Hiroshi Inoue, Yukiya Hashimoto. Variability of bioavailability and intestinal absorption characteristics of bisoprolol.
Drug metabolism and pharmacokinetics.
2013; 28(6):491-6. doi:
10.2133/dmpk.dmpk-13-rg-017. [PMID: 23719964] - Karran A Phillips, Glenn A Hirsch, David H Epstein, Kenzie L Preston. Cardiac complications of unwitting co-injection of quinine/quinidine with heroin in an intravenous drug user.
Journal of general internal medicine.
2012 Dec; 27(12):1722-5. doi:
10.1007/s11606-012-2089-2. [PMID: 22592353] - Jianmin Duan, Gordon Bolger, Michel Garneau, Ma'an Amad, Joëlle Batonga, Hélène Montpetit, François Otis, Martin Jutras, Nicole Lapeyre, Manon Rhéaume, George Kukolj, Peter W White, Richard C Bethell, Michael G Cordingley. The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans.
Antimicrobial agents and chemotherapy.
2012 Oct; 56(10):5381-6. doi:
10.1128/aac.01028-12. [PMID: 22869578] - Liyue Huang, April Chen, John Roberts, Brett Janosky, Xuhai Be, Loren Berry, Min-Hwa Jasmine Lin. Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.
Xenobiotica; the fate of foreign compounds in biological systems.
2012 Sep; 42(9):830-40. doi:
10.3109/00498254.2012.667847. [PMID: 22439758] - Oluwaseun O Falade-Nwulia, Gurpreet Dhaliwal, Matthew P Schreiber, Sanjay Saint, Andrew F Shorr. A 36-year-old Haitian man with coma, acute kidney injury, lactic acidosis, and respiratory failure.
Chest.
2012 Sep; 142(3):798-801. doi:
10.1378/chest.11-3209. [PMID: 22948586] - Laura E Pope, Kerri A Schoedel, Cynthia Bartlett, Edward M Sellers. A study of potential pharmacokinetic and pharmacodynamic interactions between dextromethorphan/quinidine and memantine in healthy volunteers.
Clinical drug investigation.
2012 Aug; 32(8):e1-15. doi:
10.1007/bf03261905. [PMID: 22712629] - Nicholas G Spiropulos, Jennifer M Heemstra. Templating effect in DNA proximity ligation enables use of non-bioorthogonal chemistry in biological fluids.
Artificial DNA, PNA & XNA.
2012 Jul; 3(3):123-8. doi:
10.4161/adna.23842. [PMID: 23370267] - Rajareddy Kallem, Chetan P Kulkarni, Dakshay Patel, Megha Thakur, Michael Sinz, Sheelendra P Singh, S Shahe Mahammad, Sandhya Mandlekar. A simplified protocol employing elacridar in rodents: a screening model in drug discovery to assess P-gp mediated efflux at the blood brain barrier.
Drug metabolism letters.
2012 Jun; 6(2):134-44. doi:
NULL. [PMID: 23061481] - Hanneke G M Wittgen, Rick Greupink, Jeroen J M W van den Heuvel, Petra H H van den Broek, Heike Dinter-Heidorn, Jan B Koenderink, Frans G M Russel. Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists.
Molecular pharmaceutics.
2012 May; 9(5):1351-60. doi:
10.1021/mp200617z. [PMID: 22428727] - N Mori, H Iwamoto, T Yokooji, T Murakami. Characterization of intestinal absorption of quinidine, a P-glycoprotein substrate, given as a powder in rats.
Die Pharmazie.
2012 May; 67(5):384-8. doi:
NULL. [PMID: 22764568] - Stina Syvänen, Maarten Schenke, Dirk-Jan van den Berg, Rob A Voskuyl, Elizabeth C de Lange. Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate.
The AAPS journal.
2012 Mar; 14(1):87-96. doi:
10.1208/s12248-011-9318-1. [PMID: 22215264] - Kerri A Schoedel, Laura E Pope, Edward M Sellers. Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers.
Clinical drug investigation.
2012 Mar; 32(3):157-69. doi:
10.2165/11599870-000000000-00000. [PMID: 22283559] - Gilles E O'Hara, François Philippon, Marcel Gilbert, Jean Champagne, Véronique Michaud, Lyne Charbonneau, Guylaine Pruneau, Bettina A Hamelin, Peter Geelen, Jacques Turgeon. Combined administration of quinidine and propafenone for atrial fibrillation: the CAQ-PAF study.
Journal of clinical pharmacology.
2012 Feb; 52(2):171-9. doi:
10.1177/0091270011399574. [PMID: 21508180] - Ke-Qing Zhao, Guoxiang Xiong, Morgan Wilber, Noam A Cohen, James L Kreindler. A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells.
American journal of physiology. Lung cellular and molecular physiology.
2012 Jan; 302(1):L4-L12. doi:
10.1152/ajplung.00102.2011. [PMID: 21964404] - Hiroshi Kodaira, Hiroyuki Kusuhara, Takuya Fujita, Junko Ushiki, Eiichi Fuse, Yuichi Sugiyama. Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate.
The Journal of pharmacology and experimental therapeutics.
2011 Dec; 339(3):935-44. doi:
10.1124/jpet.111.180398. [PMID: 21934030] - Yasuo Uchida, Sumio Ohtsuki, Junichi Kamiie, Tetsuya Terasaki. Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice.
The Journal of pharmacology and experimental therapeutics.
2011 Nov; 339(2):579-88. doi:
10.1124/jpet.111.184200. [PMID: 21828264] - Nilufer Rahmioglu, James Heaton, Gail Clement, Raj Gill, Gabriela Surdulescu, Karolina Zlobecka, Dylan Hodgkiss, Yongmin Ma, Robert C Hider, Norman W Smith, Kourosh R Ahmadi. Genetic epidemiology of induced CYP3A4 activity.
Pharmacogenetics and genomics.
2011 Oct; 21(10):642-51. doi:
10.1097/fpc.0b013e3283498ecf. [PMID: 21750469] - K Maeda, J Takano, Y Ikeda, T Fujita, Y Oyama, K Nozawa, Y Kumagai, Y Sugiyama. Nonlinear pharmacokinetics of oral quinidine and verapamil in healthy subjects: a clinical microdosing study.
Clinical pharmacology and therapeutics.
2011 Aug; 90(2):263-70. doi:
10.1038/clpt.2011.108. [PMID: 21716273] - James Heaton, Nilufer Rahmioglu, Kourosh R Ahmadi, Cristina Legido-Quigley, Norman W Smith. Rapid quantification of quinine and its major metabolite (3S)-3-hydroxyquinine in diluted urine by UPLC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2011 Jun; 55(3):494-9. doi:
10.1016/j.jpba.2011.02.004. [PMID: 21377309] - Sami F Noujaim, Jeanne A Stuckey, Daniela Ponce-Balbuena, Tania Ferrer-Villada, Angelica López-Izquierdo, Sandeep V Pandit, José A Sánchez-Chapula, José Jalife. Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine.
Cardiovascular research.
2011 Mar; 89(4):862-9. doi:
10.1093/cvr/cvr008. [PMID: 21233253] - Enrique Ochoa-Aranda, Josep Esteve-Romero, Maria Rambla-Alegre, Adrià Martinavarro-Domínguez, Devasish Bose. Monitoring disopyramide, lidocaine, and quinidine by micellar liquid chromatography.
Journal of AOAC International.
2011 Mar; 94(2):537-42. doi:
. [PMID: 21563688] - Trude Rakel Balstad, Harald Carlsen, Mari C W Myhrstad, Marit Kolberg, Hanne Reiersen, Lene Gilen, Kanae Ebihara, Ingvild Paur, Rune Blomhoff. Coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo - studies in electrophile response element transgenic mice.
Molecular nutrition & food research.
2011 Feb; 55(2):185-97. doi:
10.1002/mnfr.201000204. [PMID: 20827676] - Nuggehally R Srinivas. Pharmacokinetics of tolbutamide in acute renal failure induced by glycerol: speculative thoughts and perspectives.
Drug metabolism and pharmacokinetics.
2011; 26(2):216-7. doi:
10.2133/dmpk.dmpk-09-le-101. [PMID: 21532212] - S J C Davies, A A Westin, I Castberg, G Lewis, M S Lennard, S Taylor, O Spigset. Characterisation of zuclopenthixol metabolism by in vitro and therapeutic drug monitoring studies.
Acta psychiatrica Scandinavica.
2010 Dec; 122(6):444-53. doi:
10.1111/j.1600-0447.2010.01619.x. [PMID: 20946203] - Ketan Hippalgaonkar, Ramesh Srirangam, Bharathi Avula, Ikhlas A Khan, Soumyajit Majumdar. Interaction between topically and systemically coadministered P-glycoprotein substrates/inhibitors: effect on vitreal kinetics.
Drug metabolism and disposition: the biological fate of chemicals.
2010 Oct; 38(10):1790-7. doi:
10.1124/dmd.110.032672. [PMID: 20595378] - K L Mealey, D Waiting, D L Raunig, K R Schmidt, F R Nelson. Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.
Journal of veterinary pharmacology and therapeutics.
2010 Oct; 33(5):453-60. doi:
10.1111/j.1365-2885.2010.01170.x. [PMID: 20840389] - Froylan Gomez-Lagunas. Quinidine interaction with Shab K+ channels: pore block and irreversible collapse of the K+ conductance.
The Journal of physiology.
2010 Aug; 588(Pt 15):2691-706. doi:
10.1113/jphysiol.2010.193128. [PMID: 20547671] - Hiroshi Kodaira, Hiroyuki Kusuhara, Junko Ushiki, Eiichi Fuse, Yuichi Sugiyama. Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
The Journal of pharmacology and experimental therapeutics.
2010 Jun; 333(3):788-96. doi:
10.1124/jpet.109.162321. [PMID: 20304939] - C F Samer, Y Daali, M Wagner, G Hopfgartner, C B Eap, M C Rebsamen, M F Rossier, D Hochstrasser, P Dayer, J A Desmeules. The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone.
British journal of pharmacology.
2010 Jun; 160(4):907-18. doi:
10.1111/j.1476-5381.2010.00673.x. [PMID: 20590587] - Jackson K Mukonzo, Paul Waako, Jasper Ogwal-Okeng, Lars L Gustafsson, Eleni Aklillu. Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans.
Therapeutic drug monitoring.
2010 Jun; 32(3):346-52. doi:
10.1097/ftd.0b013e3181da79d6. [PMID: 20357698] - Nicholas Olney, Howard Rosen. AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain.
IDrugs : the investigational drugs journal.
2010 Apr; 13(4):254-65. doi:
. [PMID: 20373255] - Stefan R Braam, Leon Tertoolen, Anja van de Stolpe, Thomas Meyer, Robert Passier, Christine L Mummery. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.
Stem cell research.
2010 Mar; 4(2):107-16. doi:
10.1016/j.scr.2009.11.004. [PMID: 20034863] - Annie Albin Lumen, Poulomi Acharya, Joseph W Polli, Andrew Ayrton, Harma Ellens, Joe Bentz. If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?.
Drug metabolism and disposition: the biological fate of chemicals.
2010 Feb; 38(2):260-9. doi:
10.1124/dmd.109.029843. [PMID: 19889884] - Laurie A Zawertailo, Rachel F Tyndale, U Busto, Edward M Sellers. Effect of metabolic blockade on the psychoactive effects of dextromethorphan.
Human psychopharmacology.
2010 Jan; 25(1):71-9. doi:
10.1002/hup.1086. [PMID: 20041473] - Yanbo Zeng, Liling Cai, Haidong Wang, Lei Li, Weijing You, Longhua Guo, Guonan Chen. Resonance light scattering study on the interaction between quinidine sulfate and congo red and its analytical application.
Luminescence : the journal of biological and chemical luminescence.
2010 Jan; 25(1):30-5. doi:
10.1002/bio.1139. [PMID: 19572383] - Miki Masago, Mari Takaai, Jumpei Sakata, Asuka Horie, Toshikazu Ito, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto. Membrane transport mechanisms of quinidine and procainamide in renal LLC-PK1 and intestinal LS180 cells.
Biological & pharmaceutical bulletin.
2010; 33(8):1407-12. doi:
10.1248/bpb.33.1407. [PMID: 20686239] - Christophe Duranton, Isabelle Rubera, Sebastien L'hoste, Marc Cougnon, Philippe Poujeol, Jacques Barhanin, Michel Tauc. KCNQ1 K+ channels are involved in lipopolysaccharide-induced apoptosis of distal kidney cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2010; 25(4-5):367-78. doi:
10.1159/000303041. [PMID: 20332617] - Vanessa Bergamin Boralli, Eduardo Barbosa Coelho, Vera Lucia Lanchote. Influence of quinidine, cimetidine, and ketoconazole on the enantioselective pharmacokinetics and metabolism of metoprolol in rats.
Chirality.
2009 Nov; 21(10):886-93. doi:
10.1002/chir.20682. [PMID: 19161215]